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71. 发明授权

US09549677B2 Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm 有权
标题翻译：使用小波变换最大模数算法的检测方法，装置和系统
公开(公告)号：US09549677B2
公开(公告)日：2017-01-24
申请号：US13554367
申请日：2012-07-20
申请人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
发明人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
IPC分类号： G01N33/50 , A61B5/0205 , A61B5/00 , A61B5/048 , A61B5/024 , A61B5/0476 , A61B5/04 , A61B5/08 , A61B5/11
CPC分类号： A61B5/02055 , A61B5/0205 , A61B5/024 , A61B5/04001 , A61B5/0476 , A61B5/048 , A61B5/0816 , A61B5/0833 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/4094 , A61B5/4836 , A61B5/726 , A61B5/746
摘要： Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method.
摘要翻译：通过使用应用于身体数据的小波变换最大模量（WTMM）算法来检测癫痫发作的方法。用于存储当由处理器执行时执行这种方法的数据的非传递式计算机可读存储设备。

72. 发明授权

US09538950B1 Method for amplifying abnormal pattern signal in observed brain activity of a subject for diagnosis or treatment 有权
标题翻译：用于诊断或治疗受试者观察到的脑活动中异常模式信号的方法
公开(公告)号：US09538950B1
公开(公告)日：2017-01-10
申请号：US13731315
申请日：2012-12-31
申请人： NeuroWave Systems Inc.
发明人： Stéphane Bibian , Tatjana Zikov , Mo Modarres
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/04001 , A61B5/04012 , A61B5/048 , A61B5/1128 , A61B5/4094 , A61B5/4839 , A61B5/721 , A61B5/7235 , A61B5/743 , A61N1/36064
摘要： The present invention relates to a brain dysfunction and seizure detector monitor and system, and a method of detecting brain dysfunction and/or seizure of a subject. Preferably, the present invention also includes one or more seizure detection algorithms. The analysis method is specifically optimized to amplify abnormal brain activity and minimize normal background activity yielding a seizure index directly related to the current presence of ictal activity in the signal. Additionally, a seizure probability index based on historical values of the aforementioned seizure index, is derived for diagnostic purposes. The seizure probability index quantifies the probability that the patient has exhibited abnormal brain activity since the beginning of the recording. These indexes can be used in the context of emergency and/or clinical situations to assess the status and well-being of a patient's brain, or can be used to automatically administer treatment to stop the seizure before clinical signs appear.
摘要翻译：本发明涉及脑功能障碍和癫痫发作检测器监测和系统，以及检测受试者脑功能障碍和/或发作的方法。优选地，本发明还包括一个或多个发作检测算法。分析方法被特别优化以扩增异常脑活动，并使正常的背景活动最小化，产生与信号中目前存在的发作活动直接相关的癫痫发作指数。另外，为了诊断目的，导出了基于上述扣押指数的历史值的缉获概率指数。癫痫发作概率指数量化自记录开始以来患者表现出异常脑活动的可能性。这些指标可以在紧急情况和/或临床情况的情况下使用，以评估患者的大脑的状态和健康状况，或者可以在临床症状出现之前自动进行治疗以停止癫痫发作。

73. 发明授权

US09538949B2 Depth of consciousness monitor including oximeter 有权
标题翻译：意识深度监测仪包括血氧仪
公开(公告)号：US09538949B2
公开(公告)日：2017-01-10
申请号：US14470819
申请日：2014-08-27
申请人： Masimo Corporation
发明人： Ammar Al-Ali , Yassir Abdul-Hafiz
IPC分类号： A61B5/00 , A61B5/16 , A61B5/0478 , A61B5/1455 , A61B5/0476 , A61B5/048
CPC分类号： A61B5/0476 , A61B5/0006 , A61B5/0478 , A61B5/048 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/165 , A61B5/4821 , A61B5/6803 , A61B5/6814 , A61B5/6833 , A61B5/742 , A61B2562/164
摘要： The present disclosure relates to a sensor for monitoring the depth of consciousness of a patient. The sensor includes a plurality of light sources, light detectors, and in some embodiments, electrodes. In an embodiment, the sensor includes reusable and disposable portions.
摘要翻译：本公开涉及一种用于监测患者意识深度的传感器。传感器包括多个光源，光检测器，并且在一些实施例中，电极。在一个实施例中，传感器包括可重复使用的和一次性的部分。

74. 发明授权

US09538934B2 Brain-computer interface system and method 有权
标题翻译：脑机接口系统及方法
公开(公告)号：US09538934B2
公开(公告)日：2017-01-10
申请号：US13638355
申请日：2010-03-31
申请人： Kai Keng Ang , Cuntai Guan , Zheng Yang Chin , Haihong Zhang , Kok Soon Phua , Chuan Chu Wang
发明人： Kai Keng Ang , Cuntai Guan , Zheng Yang Chin , Haihong Zhang , Kok Soon Phua , Chuan Chu Wang
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0482 , A61B5/048 , G06F3/01
CPC分类号： A61B5/0482 , A61B5/04014 , A61B5/04017 , A61B5/048 , A61B5/7285 , A61B5/742 , G06F3/015 , G06F3/016
摘要： A method of training a classification algorithm for a Brain Computer Interface (BCI). The method includes the steps of: dividing a Electroencephalography (EEG) signal into a plurality of time segments; for each time segment, dividing a corresponding EEG signal portion into a plurality of frequency bands; for each frequency band, computing a spatial filtering projection matrix based on a Common Spatial Pattern (CSP) algorithm and a corresponding feature, and computing mutual information of each corresponding feature with respect to one or more motor imagery classes; for each time segment, summing the mutual information of all the corresponding features with respect to the respective classes; and selecting the corresponding features of the time segment with a maximum sum of mutual information for one class for training classifiers of the classification algorithm.
摘要翻译：一种训练大脑计算机接口（BCI）分类算法的方法。该方法包括以下步骤：将脑电图（EEG）信号分成多个时间段; 对于每个时间段，将相应的EEG信号部分分成多个频带; 对于每个频带，基于公共空间模式（CSP）算法和对应的特征来计算空间滤波投影矩阵，并且针对一个或多个运动图像类计算每个对应特征的相互信息; 对于每个时间段，对相应类别的所有相应特征的相互信息求和; 并且对于分类算法的训练分类器，对于一个等级的互信息的最大和来选择时间段的相应特征。

75. 发明授权

US09504415B1 Neuro-behavioral test method for screening and evaluating therapy for ADHD and system 有权
标题翻译：用于ADHD和系统的筛查和评估治疗的神经行为测试方法
公开(公告)号：US09504415B1
公开(公告)日：2016-11-29
申请号：US13899632
申请日：2013-05-22
申请人： Mo Modarres
发明人： Mo Modarres
IPC分类号： A61B5/048 , A61B5/0478 , A61B5/16 , A61B5/04 , A61B5/00 , A61B5/0484 , A61B5/0476
CPC分类号： A61B5/168 , A61B5/0006 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/048 , A61B5/0484 , A61B5/04842 , A61B5/04845 , A61B5/4088 , A61B5/4806 , A61B5/4848
摘要： A new neuro-behavioral test with analysis algorithms has been developed for use in screening individuals for attention deficit hyperactivity disorder (ADHD) and for the quantitative evaluation of ADHD medication/therapy in diagnosed patients. This technique combines a 15 minute auditory-based test of attention with simultaneous EEG monitoring by a wireless, portable data acquisition device. This system acquires both behavioral response (i.e., reaction times to target stimuli, as well as errors of omission/commission) and EEG waveforms. All of the data is simultaneously processed by the algorithms to produce several representative indices. These indices are then combined to produce an overall neuro-behavioral index that represents the degree by which both “behavioral” and “EEG” attention is maintained throughout the test.
摘要翻译：已经开发了一种新的具有分析算法的神经行为测试，用于筛选个体的注意缺陷多动障碍（ADHD）和用于诊断患者的ADHD药物/治疗的定量评估。该技术将基于听觉的15分钟听觉测试与无线便携式数据采集设备的同步脑电监测相结合。该系统获取行为响应（即，针对刺激的反应时间，以及省略/调试的错误）和EEG波形。所有数据由算法同时处理，以产生几个代表性的索引。然后将这些指数组合以产生整体神经行为指数，其表示在整个测试中保持“行为”和“脑电”注意力的程度。

76. 发明申请

US20160228673A1 HEAD BONE CONDUCTION DEVICE AND METHOD 审中-公开
标题翻译：头骨传导装置和方法
公开(公告)号：US20160228673A1
公开(公告)日：2016-08-11
申请号：US15025136
申请日：2015-01-21
申请人： Kacheung CHOW
发明人： Kacheung CHOW
IPC分类号： A61M21/00 , A61B5/04 , A61H23/00 , A61B5/048
CPC分类号： A61M21/00 , A61B5/04014 , A61B5/048 , A61B5/7415 , A61H23/004 , A61H2201/1604 , A61H2201/1607 , A61H2201/5048 , A61H2205/02 , A61H2205/021 , A61M2021/0022 , A61M2021/0027 , A61M2205/3375 , H04R2460/13
摘要： The present disclosure relates to a head bone conduction device and method. The head bone conduction device includes: a head fixing unit, a brain wave detection connecting ends, a frequency signal generating circuit, an audio device and an audio mixer. Seven independent bone conduction units are adopted for operation, and at least one bone conduction unit is adopted for operation and is arranged at a suitable position of a head. Audio information received by the bone conduction unit is converted into mechanical vibration, thus vibration force, vibration sensation and mechanical vibration are generated simultaneously on a region of a cranial cortex. Accompanying with the ear bone mechanical vibration, a user will feel a mixed sensation including auditory and positional sense, or namely ‘third auditory’. The frequency signal generation circuit generates specific frequency signals according to detected brain wave signals to the audio mixer. The frequency signals will then be mixed with regular audio signal, whose change would be aware by the user for secondary confirmation.
摘要翻译：头骨传导装置及方法技术领域本发明涉及头部骨传导装置及方法。头骨传导装置包括：头部固定单元，脑波检测连接端，频率信号发生电路，音频装置和音频混合器。采用七个独立的骨传导单元进行操作，并且至少一个骨传导单元用于操作，并且布置在头部的适当位置。由骨传导单元接收的音频信息被转换为机械振动，因此在颅脑皮质区域上同时产生振动力，振动感和机械振动。伴随耳骨机械振动，使用者将感觉到包括听觉和位置感在内的混合感，或即“第三听觉”。频率信号发生电路根据检测到的脑波信号产生特定频率信号给音频混频器。然后，频率信号将与常规音频信号混合，其变化将由用户识别以进行二次确认。

77. 发明授权

US09314182B2 Spatiotemporal pattern recognition for neurological event detection and prediction in an implantable device 有权
公开(公告)号：US09314182B2
公开(公告)日：2016-04-19
申请号：US13679925
申请日：2012-11-16
申请人： NeuroPace, Inc.
发明人： Brett M. Wingeier , Thomas K. Tcheng
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/048 , A61B5/0484 , A61B5/00 , A61B5/16 , A61B5/07
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/048 , A61B5/0484 , A61B5/076 , A61B5/16 , A61B5/4094 , A61B5/7257
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.

78. 发明授权

US09308385B2 rTMS at harmonics of biological signals 有权
标题翻译： rTMS在生物信号的谐波
公开(公告)号：US09308385B2
公开(公告)日：2016-04-12
申请号：US13858693
申请日：2013-04-08
申请人： Newport Brain Research Laboratory Inc.
发明人： Yi Jin
IPC分类号： A61N2/00 , A61B5/00 , A61B5/0245 , A61B5/048
CPC分类号： A61N2/006 , A61B5/0245 , A61B5/048 , A61B5/7257 , A61B5/7282 , A61N2/004
摘要： Repetitive Transcranial Magnetic Stimulation (rTMS) is administered at a pulse rate that is equal to or a harmonic of a biological metric of a patient. The purpose is to provide frequency coupling among different organs (e.g., heart, brain, breathing, and gastrointestinal movement) through rhythmic entrainment. The specific harmonic chosen is the one closest to a desired EEG frequency. The desired EEG frequency is chosen based on the cognitive element or symptom that is targeted.
摘要翻译：重复经颅磁刺激（rTMS）以与患者生物学量度相等或谐波的脉率施用。目的是通过节奏夹带提供不同器官之间的频率耦合（例如心脏，脑，呼吸和胃肠运动）。所选择的特定谐波是最接近所需EEG频率的谐波。基于目标的认知元素或症状来选择所需的脑电频率。

79. 发明授权

US09211078B2 Process and device for brain computer interface 有权
标题翻译：大脑计算机接口的过程和设备
公开(公告)号：US09211078B2
公开(公告)日：2015-12-15
申请号：US12875544
申请日：2010-09-03
申请人： Marco Antonio Meggiolaro , Alexandre Ormiga Galvao Barbosa
发明人： Marco Antonio Meggiolaro , Alexandre Ormiga Galvao Barbosa
IPC分类号： A61B5/04 , A61B5/048 , A61B5/00 , G06F3/01
CPC分类号： A61B5/048 , A61B5/7203 , A61B5/7264 , G06F3/015
摘要： A brain computer interface as an alternative communication channel to be used in various applications, such as robotics. In one embodiment of the invention, there is provided a process for the analysis and conversion of EEG signals obtained from the brain into movement commands through electric and/or mechanical devices. The process of the present invention provides substantial advantages over the similar systems/techniques known in the art, such as a 91% average hit rate, obtained in attempts to control a mobile robot. In other embodiment of the invention, there is provided an apparatus comprising: means for obtaining brain signals; an electroencephalograph (EEG); and means for transducing said signals into functional commands useful in several applications. Said means for transducing mental signals is the core of the invention and provides a number of technical advantages over the similar systems/techniques known in the art of identifying mental activities.
摘要翻译：大脑计算机接口作为可用于各种应用中的替代通信信道，例如机器人技术。在本发明的一个实施例中，提供了一种用于通过电和/或机械装置将从脑获得的脑电信号分析和转换为运动指令的方法。本发明的方法提供了与本领域已知的类似系统/技术相比的实质优点，例如在试图控制移动机器人时获得的91％的平均命中率。在本发明的其他实施例中，提供了一种装置，包括：用于获得脑信号的装置; 脑电图（EEG）; 以及用于将所述信号转换成在若干应用中有用的功能命令的装置。用于转导心理信号的所述手段是本发明的核心，并且提供了与识别心理活动的本领域已知的类似系统/技术相关的许多技术优点。

80. 发明申请

US20150351641A1 BIO INFORMATION MEASUREMENT DEVICE AND BIO INFORMATION MEASUREMENT METHOD 审中-公开
标题翻译：生物信息测量设备和生物信息测量方法
公开(公告)号：US20150351641A1
公开(公告)日：2015-12-10
申请号：US14655218
申请日：2014-01-17
申请人： Seung Wan KANG
发明人： Seung Wan KANG , Dae Keun KIM
IPC分类号： A61B5/0205 , A61B5/044 , A61B5/00 , A61B5/048 , A61B5/04
CPC分类号： A61B5/0205 , A61B5/02 , A61B5/02416 , A61B5/0245 , A61B5/04012 , A61B5/044 , A61B5/048 , A61B5/4035 , A61B5/4058 , A61B5/7246
摘要： A bio information measurement device and a bio information measurement method are provided. The bio information measurement device includes: a heart information acquisition unit for acquiring heart information; a brainwave information acquisition unit for acquiring brainwave information; a control unit for acquiring heart-brain synchronization information on the basis of the heart information and the brainwave information; and a display unit for displaying the heart-brain synchronization information. According to the present invention, it is possible to provide a health index reflecting the influence of both the automatic nervous system and the central nervous system.
摘要翻译：提供生物信息测量装置和生物信息测量方法。生物信息测量装置包括：心脏信息获取单元，用于获取心脏信息; 用于获取脑波信息的脑波信息获取单元; 控制单元，用于基于心脏信息和脑波信息获取心脑同步信息; 以及用于显示心脑同步信息的显示单元。根据本发明，可以提供反映自动神经系统和中枢神经系统的影响的健康指标。

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