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71. 发明授权

US4633014A Substituted 3-hydrazinopropionates 失效
标题翻译：取代的3-肼基丙酸酯
公开(公告)号：US4633014A
公开(公告)日：1986-12-30
申请号：US628240
申请日：1984-07-06
申请人： Gunar A. Bremanis , Ivars Y. Kalvinsh , Irene B. Antsena , Edmund Y. Lukevits , Maris M. Veveris , Valeryans Y. Kauss , Peter T. Trapentsier , Edvards E. Liepinsh
发明人： Gunar A. Bremanis , Ivars Y. Kalvinsh , Irene B. Antsena , Edmund Y. Lukevits , Maris M. Veveris , Valeryans Y. Kauss , Peter T. Trapentsier , Edvards E. Liepinsh
IPC分类号： A61K31/16 , A61K31/15 , A61K31/165 , A61K31/17 , A61K31/175 , A61K31/19 , A61K31/195 , A61K31/205 , A61K31/215 , A61K31/22 , A61K31/27 , A61K31/275 , A61K31/31 , A61P9/06 , C07C67/00 , C07C239/00 , C07C241/00 , C07C243/26 , C07C243/28 , C07C243/30 , C07C243/34 , C07C243/36 , C07C243/38 , C07C253/00 , C07C255/66 , C07C281/02 , C07C281/06 , C07C325/00 , C07C327/00 , C07C327/06 , C07C327/22 , C07C327/40 , C07C333/02 , C07C337/00 , C07C337/06 , C07C157/05 , C07C127/15 , C07C127/17 , C07C127/19 , C07C133/02 , C07C153/057 , C07C157/07 , C07C157/09
CPC分类号： C07C243/00 , C07C243/38 , C07C255/00
摘要： Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,R.sup.9 =OH, an alkoxy, an aralkoxy, an alkyl, an unsaturated alkyl, an aryl, a substituted aryl, an aralkyl;R.sup.4 is --C.tbd.N, --COR.sup.10, wherein R.sup.10 =OR.sup.11, NR.sup.12 R.sup.13, where R.sup.11 is H, an alkyl, an aralkyl and an alkali metal, R.sup.11 and R.sup.12 are each H, an alkyl, an aralkyl, an aryl;R.sup.5, R.sup.6 = an alkyl, an aryl, an aralkyl.
摘要翻译：其中R1，R2 = H，烷基，取代的烷基，羟基羰基，烷氧基羰基，芳基，芳烷基，不饱和烷基，取代的芳基或取代的芳烷基的取代的3-肼基丙酸酯：其中R7，R8 = H，烷基，不饱和烷基，芳烷基，芳基，取代烷基，R9 = OH，烷氧基，芳烷氧基，烷基，不饱和烷基，芳基，取代芳基，芳烷基; R4是-C3NN，-COR10，其中R10 = OR11，NR12R13，其中R11是H，烷基，芳烷基和碱金属，R11和R12各自为H，烷基，芳烷基，芳基; R5，R6 =烷基，芳基，芳烷基。

72. 发明授权

US4613687A Polyisocyanates of the diphenyl methane series 失效
标题翻译：二苯甲烷系列的多异氰酸酯
公开(公告)号：US4613687A
公开(公告)日：1986-09-23
申请号：US293748
申请日：1981-08-17
申请人： Hartmut Knofel , Michael Brockelt
发明人： Hartmut Knofel , Michael Brockelt
IPC分类号： C08G18/00 , C07C67/00 , C07C205/06 , C07C209/00 , C07C209/36 , C07C211/51 , C07C241/00 , C07C263/10 , C07C265/12 , C07C265/14 , C08G18/76 , C07C119/048
CPC分类号： C07C265/12 , C07C205/06 , C07C209/36 , C08G18/7664
摘要： A polyisocyanate or mixture of polyisocyanates in which the main component(s) correspond to the formula: ##STR1## in which R.sub.1, R.sub.2, and R.sub.3 each represent hydrogen or a saturated alkyl group containing from 1 to 12 carbon atoms, provided that at least two of these radicals represent hydrogen; andm, n, o and p each represent 0 or 1, provided that when m, n, o and/or p represent 0, the free valency is taken up by a hydrogen atom and that the sum of m+n+o+p is greater than 1 on a statistical average.Such polyisocyanate or mixture of polyisocyanates may be produced by first reacting a 4-nitrobenzyl halide, a 3-nitrobenzyl halide, a benzyl halide, a benzyl alcohol or a nitrobenzyl chloride isomer mixture with nitrobenzene, an alkyl-substituted nitrobenzene, an alkyl benzene or benzene in the presence of a Friedel-Crafts or an acid catalyst. This reaction product is then nitrated, the nitro groups are converted to amino groups by reduction or hydrogenation and the amino compound(s) subsequently phosgenated to form the polyisocyanate(s). The purity of the product polyisocyanate may be improved by distilling off secondary products before and/or after the phosgenation.
摘要翻译：多异氰酸酯或多异氰酸酯的混合物，其中主要成分对应于下式：其中R 1，R 2和R 3各自表示氢或含有1至12个碳原子的饱和烷基，条件是至少这些基团中的两个表示氢; 并且m，n，o和p各自表示0或1，条件是当m，n，o和/或p表示0时，游离的价态被氢原子吸收，并且m + n + o + 统计平均数p大于1。这种多异氰酸酯或多异氰酸酯的混合物可以通过首先使4-硝基苄基卤，3-硝基苄基卤，苄基卤，苯甲醇或硝基苄基氯异构体混合物与硝基苯，烷基取代的硝基苯，烷基苯或苯在Friedel-Crafts或酸催化剂存在下。然后将该反应产物硝化，通过还原或氢化将硝基转化为氨基，随后将氨基化合物气化以形成多异氰酸酯。产物多异氰酸酯的纯度可以通过在光气化之前和/或之后蒸馏二次产物来改善。

73. 发明授权

US4609757A Hydrazides of amino-polyacetic acids as chelants 失效
公开(公告)号：US4609757A
公开(公告)日：1986-09-02
申请号：US522068
申请日：1983-08-10
申请人： Thomas F. D'Muhala , Robert C. Ward
发明人： Thomas F. D'Muhala , Robert C. Ward
IPC分类号： C02F5/00 , C02F5/08 , C02F5/10 , C02F5/12 , C07C67/00 , C07C239/00 , C07C241/00 , C07C241/04 , C07C243/34 , C07C281/06 , C09K3/00 , C11D7/32 , C07C109/08
CPC分类号： C07C243/34 , C02F5/12
摘要： Amino-polyacetic acids such as ethylenediaminetetraacetic acid, diethylene triaminepentaacetic acid and nitrilotriacetic acid are reacted with alkanols and then with hydrazine to form the hydrazides which may be converted to carboxyhydrazides, i.e. carbazic acids. The products perform well as chelants and sequestering agents.

74. 发明授权

US4603189A Triisocyanates and a process for their preparation 失效
标题翻译：三异氰酸酯及其制备方法
公开(公告)号：US4603189A
公开(公告)日：1986-07-29
申请号：US728351
申请日：1985-04-29
申请人： Hartmut Knofel , Stefan Penninger , Michael Brockelt , Gunter Hammen , Herbert Stutz
发明人： Hartmut Knofel , Stefan Penninger , Michael Brockelt , Gunter Hammen , Herbert Stutz
IPC分类号： C08G18/00 , C07C67/00 , C07C241/00 , C07C263/10 , C07C265/12 , C07C265/14 , C08G18/72 , C08G18/74 , C09D175/00
CPC分类号： C07C265/12 , C08G18/74
摘要： Triisocyanates and isomeric mixtures of triisocyanates corresponding to the formula ##STR1## in which R represents hydrogen or an alkyl group having from 1 to 4 carbon atoms are made by phosgenating the corresponding triamine. These triisocyanates are particularly useful in the production of polyurethanes, especially polyurethane lacquer coats.
摘要翻译：对应于其中R表示氢或具有1至4个碳原子的烷基的式“IMAGE”的三异氰酸酯的三异氰酸酯和异构体混合物通过对相应的三胺进行光气化而制备。这些三异氰酸酯特别可用于生产聚氨酯，特别是聚氨酯漆包衣。

75. 发明授权

US4602044A .beta.-phenethanolamine antiobesity agents 失效
标题翻译： β-苯乙醇胺抗肥胖剂
公开(公告)号：US4602044A
公开(公告)日：1986-07-22
申请号：US562960
申请日：1983-12-19
申请人： Klaus K. Schmiegel , Walter N. Shaw
发明人： Klaus K. Schmiegel , Walter N. Shaw
IPC分类号： A61K31/135 , A61K20060101 , A61K31/04 , A61K31/10 , A61K31/165 , A61K31/205 , A61P3/04 , C07C20060101 , C07C67/00 , C07C213/00 , C07C215/30 , C07C241/00 , C07C251/16 , C07C313/00 , C07C317/32 , C07C323/32
CPC分类号： C07C215/30 , C07C317/32
摘要： .beta.-Phenethanolamines are useful as antiobesity agents.
摘要翻译： β-苯乙醇胺可用作抗肥胖剂。

76. 发明授权

US4596678A Multiple-step process for the preparation of hexamethylene diisocyanate-1,6 and/or isomeric aliphatic diisocyanates with six carbon atoms in the alkylene residue 失效
标题翻译：用于制备在亚烷基残基中具有6个碳原子的六亚甲基二异氰酸酯-1,6-和/或异构脂族二异氰酸酯的多步法
公开(公告)号：US4596678A
公开(公告)日：1986-06-24
申请号：US600143
申请日：1984-04-13
申请人： Franz Merger , Friedrich Towae , Hans Hellbach , Gunther Isbarn , Waldemar Koehler
发明人： Franz Merger , Friedrich Towae , Hans Hellbach , Gunther Isbarn , Waldemar Koehler
IPC分类号： C07C265/14 , C07C67/00 , C07C69/00 , C07C241/00 , C07C263/04 , C07C263/06 , C07C265/04
CPC分类号： C07C263/04
摘要： Hexamethylene diisocyanate and/or isomeric alkylene diisocyanates having 6 carbon atoms in the alkylene radical, preferably 2-methylpentamethylene 1,5-diisocyanate and/or 2-ethyltetramethylene 1,4-diisocyanate are prepared without the use of phosgene in a multiple-step process by means of(a) reacting hexamethylene 1,6-diamine and/or isomeric alkylene diamines having 6 carbon atoms in the alkylene radical with urea and alcohol in the presence of dialkyl carbonate and/or carbamic acid alkyl ester as well as, in some cases, catalysts to form hexamethylene 1,6-dialkylurethane and/or isomeric alkylene dialkylurethanes having 6 carbon atoms in the alkylene radical,(b) separation and return to reaction step (a) of alcohol, dialkyl carbonate, and/or carbamic acid alkyl ester from the reaction mixture(c) evaporation of the hexamethylene 1,6-dialkylurethane and/or isomeric alkylene dialkylurethanes having 6 carbon atoms in the alkylene radical,(d) cleavage of the vaporized diurethanes into hexamethylene diisocyanate and/or isomeric alkylene diisocyanate having 6 carbon atoms in the alkylene radical and alcohol, and(e) fractional condensation of the cleavage products.
摘要翻译：在多步法中不使用光气制备在亚烷基中具有6个碳原子的六亚甲基二异氰酸酯和/或异构亚烷基二异氰酸酯，优选2-甲基五亚甲基-1,5-二异氰酸酯和/或2-乙基四亚甲基1,4-二异氰酸酯通过（a）在碳酸二烷基酯和/或氨基甲酸烷基酯的存在下，使亚烷基中的六亚甲基1,6-二胺和/或具有6个碳原子的异构亚烷基二胺与脲和醇反应，以及在一些情况下，在亚烷基中形成具有6个碳原子的六亚甲基1,6-二烷基氨基甲酸酯和/或异构亚烷基二烷基氨基甲酸酯的催化剂，（b）分离并返回到醇，碳酸二烷基酯和/或氨基甲酸烷基酯的反应步骤（a）（c）在亚烷基中蒸发具有6个碳原子的六亚甲基1,6-二烷基氨基甲酸酯和/或异构亚烷基二烷基氨基甲酸酯，（d）将汽化的二氨基甲酸酯裂解成h 亚烷基二异氰酸酯和/或亚烷基和醇中具有6个碳原子的异构亚烷基二异氰酸酯，和（e）裂解产物的分级缩合。

77. 发明授权

US4587261A Cycloalkane derivatives and fodder compositions containing the same 失效
标题翻译：含有它们的环烷烃衍生物和饲料组合物
公开(公告)号：US4587261A
公开(公告)日：1986-05-06
申请号：US491083
申请日：1983-05-03
申请人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
发明人： Zoltan Budai , Pal Benko , Ildiko Ratz nee Simonek , Eva Rakoczy nee Pinter , Karoly Magyar , Jozsef Kelemen , Attila Mandi
IPC分类号： A23K1/16 , A23K1/18 , A23K1/22 , A61K31/15 , C07C67/00 , C07C239/00 , C07C241/00 , C07C251/84 , C07C281/02 , C07C281/04 , C07C125/065 , A61K31/27 , C07C125/067
CPC分类号： C07C251/72 , A23K20/105 , A23K50/30
摘要： The invention relates to new cycloalkane derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds of the present invention correspond to the general formula I ##STR1## wherein n is 3, 4, 5 or 6;R denotes a phenyl group optionally carrying one or more substituent/s/ selected from the group consisting of halogen, lower alkoxy and lower alkyl;R.sup.1 and R.sup.2 each represent hydrogen or form together a valence bond;R.sup.3 represents lower alkoxy or a phenyl optionally substituted by one or more C.sub.1-12 alkoxy.The fodder additives and fodders according to the invention contain as active ingredient an amount of 1 ppm to 85% by weight of a compound of the general formula I in admixture with inert solid or liquid carriers or diluents and can be used to advantage in animal husbandry.
摘要翻译：本发明涉及新的环烷烃衍生物，其制备方法和组合物，特别是饲料添加剂和含有它们的动物饲料。本发明的新化合物对应于通式I其中n为3,4,5或6; R表示任选携带一个或多个选自卤素，低级烷氧基和低级烷基的取代基的苯基; R1和R2各自表示氢或一起形成价键; R3表示低级烷氧基或任选被一个或多个C 1-12烷氧基取代的苯基。根据本发明的饲料添加剂和饲料以惰性固体或液体载体或稀释剂的混合物的形式含有1至85重量％的通式I化合物作为活性成分，并可用于畜牧业。

78. 发明授权

US4587058A Diisocyanates of the diphenyl methane series and processes for the production thereof 失效
标题翻译：二苯甲烷系二异氰酸酯及其制备方法
公开(公告)号：US4587058A
公开(公告)日：1986-05-06
申请号：US290983
申请日：1981-08-07
申请人： Hartmut Knofel , Michael Brockelt
发明人： Hartmut Knofel , Michael Brockelt
IPC分类号： C08G18/00 , C07C67/00 , C07C205/06 , C07C241/00 , C07C263/10 , C07C265/12 , C07C265/14 , C08G18/76 , C07C118/02 , C07C119/048
CPC分类号： C07C265/12 , C07C205/06 , C08G18/7671
摘要： A diisocyanate corresponding to the general formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 represent hydrogen or a C.sub.2 -C.sub.12 alkyl group provided that two of the radicals R.sub.1, R.sub.2 and R.sub.3 represent hydrogen and the third represents an alkyl group containing from 2 to 12 carbon atoms. Mixtures of diisocyanates in which the described diisocyanate is a major substituent are also within the scope of this disclosure. Such compounds and mixtures are made by reacting a nitrobenzyl halide, an unsubstituted benzyl halide or a benzyl alcohol in the presence of a Friedel-Crafts catalyst with an alkylbenzene or a nitroalkylbenzene and then converting the nitro groups to amino groups by hydrogenation or reduction. The thus-produced amino compound is then phosgenated to form the diisocyanate.The compounds and mixtures of the present invention are useful in the production of polyurethane plastics.
摘要翻译：其中R 1，R 2和R 3表示氢或C 2 -C 12烷基的通式为：其中R1，R2和R3中的两个表示氢，第三个表示含有2个至12个碳原子。其中所述二异氰酸酯是主要取代基的二异氰酸酯的混合物也在本公开的范围内。这样的化合物和混合物通过硝基苄基卤，未取代的苄基卤或苯甲醇在Friedel-Crafts催化剂存在下与烷基苯或硝基烷基苯反应，然后通过氢化或还原将硝基转化成氨基来制备。然后将由此产生的氨基化合物光气化以形成二异氰酸酯。本发明的化合物和混合物可用于生产聚氨酯塑料。

79. 发明授权

US4582948A 3-chloro-4-fluoro-5-nitrobenzotrifluoride 失效
标题翻译： 3-氯-4-氟-5-硝基三氟甲苯
公开(公告)号：US4582948A
公开(公告)日：1986-04-15
申请号：US604715
申请日：1984-04-27
申请人： David Y. Tang , Byron R. Cotter , Fredrick J. Goetz
发明人： David Y. Tang , Byron R. Cotter , Fredrick J. Goetz
IPC分类号： C07C43/225 , C07B31/00 , C07B39/00 , C07C17/00 , C07C17/093 , C07C25/13 , C07C37/02 , C07C39/24 , C07C39/26 , C07C41/00 , C07C51/00 , C07C51/097 , C07C51/363 , C07C63/70 , C07C67/00 , C07C201/08 , C07C201/12 , C07C205/12 , C07C241/00 , C07C253/00 , C07C255/50 , C07C265/12 , C07C79/12
CPC分类号： C07C63/70 , C07B39/00 , C07C17/093 , C07C201/12 , C07C205/12 , C07C25/13 , C07C37/00 , C07C37/02 , C07C41/22 , C07C51/097 , C07C51/363 , C07C51/62
摘要： Chloro-aromatic compounds of the formula ##STR1## wherein R is CF.sub.3, OCF.sub.3, OC.sub.2 F.sub.5, CN, NCO, or COCl, m is 0, 1 or 2; n is 0, 1 or 2; q is 1 or 2; q+m+n is less than 6; and when q is 1, m is 2; are prepared by the vapor phase chloro-denitration reaction of a chlorinating agent with a nitro-aromatic compound of the formula ##STR2## where R, m, n and q are as defined above.
摘要翻译：其中R为CF 3，OCF 3，OC 2 F 5，CN，NCO或COCl，m为0,1或2的式（I）的氯芳族化合物; n为0,1或2; q为1或2; q + m + n小于6; 当q为1时，m为2; 通过氯化剂与式（I）的硝基芳族化合物的气相氯 - 脱硝反应制备，其中R，m，n和q如上所定义。

80. 发明授权

US4572909A 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents 失效
标题翻译： 2-（仲氨基烷氧基甲基）二氢吡啶衍生物作为抗缺血和抗高血压药
公开(公告)号：US4572909A
公开(公告)日：1986-02-25
申请号：US576982
申请日：1984-02-03
申请人： Simon F. Campbell , Peter E. Cross , John K. Stubbs
发明人： Simon F. Campbell , Peter E. Cross , John K. Stubbs
IPC分类号： C07D211/36 , A61K31/44 , A61K31/4422 , A61K31/4427 , A61K31/455 , A61P9/06 , A61P9/10 , A61P9/12 , C07C67/00 , C07C213/00 , C07C241/00 , C07C247/04 , C07D209/48 , C07D211/00 , C07D211/86 , C07D211/90 , C07D401/04 , C07D401/12
CPC分类号： C07D209/48 , C07C247/00 , C07D211/90 , C07D401/12
摘要： A dihydropyridine compound of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, whereinY is --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --;R is aryl or heteroaryl;R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; andR.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, 2-(C.sub.1 -C.sub.4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or --(CH.sub.2).sub.m COR.sup.4 where m is 1, 2 or 3 andR.sup.4 is hydroxy, C.sub.1 -C.sub.4 alkoxy or --NR.sup.5 R.sup.6 where R.sup.5 and R.sup.6 are each independently hydrogen or C.sub.1 -C.sub.4 alkylcan be employed for treating or preventing a heart condition or hypertension.
摘要翻译：其中Y是 - （CH 2）2 - ， - （CH 2）3 - ， - CH 2 CH（CH 3） - 或-CH 2 C（CH 3）2 - ）的二氢吡啶化合物或其药学上可接受的酸加成盐。 R是芳基或杂芳基; R 1和R 2各自独立地为C 1 -C 4烷基或2-甲氧基乙基; （C 1 -C 4烷氧基）乙基，环丙基甲基，苄基或 - （CH 2）m COOR 4，其中m为1,2或3，R 4为羟基，C 1 -C 4烷氧基或-NR 5 R 6 其中R5和R6各自独立地为氢或C1-C4烷基，可用于治疗或预防心脏病或高血压。

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