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1. 发明申请

US20230016848A1 METHOD OF CLEANING AN APPARATUS USED IN THE CONCENTRATION OF A MINERAL ACID 有权
公开(公告)号：US20230016848A1
公开(公告)日：2023-01-19
申请号：US17783375
申请日：2020-12-16
申请人： Covestro Intellectual Property GmbH & Co. KG
发明人： Bernd Pennemann , Kameh Tajvidi
IPC分类号： C01B17/88 , C01B21/44 , C07C201/08 , B01B1/00 , B01D53/26 , B01D53/28 , B01D3/14 , F28G9/00
摘要： The present invention relates to a method for preparing an apparatus (or a plant comprising a plurality of apparatuses), for example a heat exchanger, a vaporizer or a distillation column, for use in a process (in particular a continuously operated process) for concentrating a mineral acid by evaporation of water, wherein the apparatus or the plant comprises (at least) a device which is resistant to the mineral acid and the device is flushed with an aqueous alkali metal hydroxide solution having a concentration by mass of alkali metal hydroxide in the range from 1% to 30% at a temperature in the range from 40° C. to 90° C. for a time of from 2 hours to 7 days.

2. 发明申请

US20220298116A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF ELTROMBOPAG OR SALT THEREOF 有权
公开(公告)号：US20220298116A1
公开(公告)日：2022-09-22
申请号：US17619383
申请日：2019-07-04
申请人： F.l.S. - FABBRICA ITALIANA SINTETICI S.P.A
发明人： Paolo STABILE , Floriana SEMERARO
IPC分类号： C07D231/46 , B01J23/44 , C07C65/105 , C07C201/08 , C07C227/04
摘要： Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5′-Chloro-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal.

3. 发明授权

US10807997B2 Methods for making quinolinyldiamines 有权
公开(公告)号：US10807997B2
公开(公告)日：2020-10-20
申请号：US16550847
申请日：2019-08-26
申请人： ExxonMobil Chemical Patents Inc.
发明人： Oleg V. Samsonov , Mikhail I. Sharikov , Georgy P. Goryunov , Dmitry V. Uborsky , Alexander Z. Voskoboynikov , Michelle E. Titone , John R. Hagadorn , Jo Ann M. Canich
IPC分类号： C07D215/00 , C07D215/40 , C07F7/00 , C08F4/76 , C07C209/60 , C07F5/04 , C07C221/00 , C07C201/08 , C07C45/65
摘要： The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.

4. 发明申请

US20200301452A1 METHOD FOR CONTINUOUSLY PRODUCING A PRODUCT BY WAY OF AT LEAST TWO COUPLED-TOGETHER CHEMICAL REACTIONS 审中-公开
公开(公告)号：US20200301452A1
公开(公告)日：2020-09-24
申请号：US16878923
申请日：2020-05-20
申请人： Covestro Deutschland AG
发明人： Bernd Pennemann , Erwin Dieterich , Heinz-Josef Hamacher
IPC分类号： G05D7/06 , C07C201/08 , B01J19/00 , F16K31/02
摘要： A method for continuously producing a product (A1) by way of at least two coupled-together chemical reactions (C1, C2), wherein at least two input substances (E1, E2) are fed to a first chemical reaction (C1), wherein a plurality of intermediate substances (Z1, Z2) are produced from the input substances (E1, E2) by the first chemical reaction (C1), wherein at least one of the intermediate substances (Z2) is fed to a second chemical reaction (C2), wherein the at least one fed intermediate substance (Z2) is further processed by the second chemical reaction (C2), in particular using at least one further substance (W1, W2) in a second chemical reaction (C2) to form a plurality of output substances (A1, A2), that is to say to form the chemical product (A1) and at least one further output substance (A2), wherein the flow rates (Fi) of the fed substances (E1, E2, Z1, W1, W2, A2) that are fed to one of the reactions (C1, C2) are set by a respective actuating element (VE1, VE2, VW1, VW 2, VZ 2, VA1), wherein each of the fed substances is assigned a separate actuating element, wherein a manipulated variable (SE2,R, Si,R) that is stipulated by a controller (RE2, Ri) is respectively applied to at least one of the actuating elements, wherein, for changing the production rate of the chemical product (A1), a temporary manipulated variable (SE2,temp, Si,temp) is respectively applied during a transient phase (II, III) to at least one of these actuating elements (VE2, Vi) instead of the manipulated variables (SE2, R, Si,R) stipulated by the respective controllers (RE2, Ri), wherein the temporary manipulated variable (SE2,temp, Si,temp) or the temporary manipulated variables is/are generated by at least one control unit (SE) in dependence on a default value (NV).

5. 发明申请

US20200055811A1 METHOD OF SYNTHESIZING DICLOFENAC SODIUM 审中-公开
公开(公告)号：US20200055811A1
公开(公告)日：2020-02-20
申请号：US16288031
申请日：2019-02-27
申请人： FUDAN UNIVERSITY
发明人： Fener CHEN , Lingdong WANG , Ge MENG , Zedu HUANG , Dang CHENG , Haihui PENG , Guanfeng LIANG
IPC分类号： C07C227/18 , C07C201/08 , C07C227/06 , C07C227/16
摘要： The invention relates to the chemical synthesis of pharmaceutical API, and specifically to a method of synthesizing diclofenac sodium, which is a kind of nonsteroidal anti-inflammatory drug for relieving pain. The method includes: nitrating phenylacetate to prepare o-nitrophenylacetate (2); hydrogenating o-nitrophenylacetate (2) to prepare o-aminophenylacetate (3); amidating an amino group of o-aminophenylacetate (3) to obtain 2-(2-benzoylaminophenyl) acetate (4); 2-(2-benzoylaminophenyl) acetate (4) reacting with thionyl chloride to prepare a chloroimine intermediate, and then condensing the intermediate of chloroimine with 2,6-dichlorophenol using an inorganic base to prepare (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5); subjecting (E)-methyl-2-(2-((2,6-dichlorophenoxy)(phenyl)methyleneamino) phenyl ester (5) to Chapman rearrangement to afford methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6); and hydrolyzing methyl 2-(2-(N-(2,6-dichlorophenyl)benzoylamino)phenyl) ester (6) to provide the target compound as of diclofenac sodium API. The overall yield is up to 67% based on methyl phenylacetate.

6. 发明授权

US10377703B2 Method for producing 4-(trifluoromethylsulfonyl)phenol compound 有权
公开(公告)号：US10377703B2
公开(公告)日：2019-08-13
申请号：US15737492
申请日：2016-07-19
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Yuta Honda , Yohei Tanaka , Kazuya Ueki
IPC分类号： C07C315/02 , C07C315/04 , C07C317/22 , C07C317/36 , C07C209/36 , C07C201/08 , C07C53/128
摘要： A compound represented by formula (4): can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3): obtained by performing a nitration reaction by adding a nitrating agent to a solution containing a compound represented by formula (2): obtained by oxidizing a compound represented by formula (1): with hydrogen peroxide in the presence of sodium tungstate and a saturated C8 carboxylic acid, then adding water to the resultant mixture, and separating the resultant solution.

7. 发明申请

US20180186732A1 METHOD FOR PRODUCING 4-(TRIFLUOROMETHYLSULFONYL)PHENOL COMPOUND 审中-公开
公开(公告)号：US20180186732A1
公开(公告)日：2018-07-05
申请号：US15737492
申请日：2016-07-19
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Yuta HONDA , Yohei TANAKA , Kazuya UEKI
IPC分类号： C07C315/02 , C07C315/04 , C07C317/22 , C07C317/36 , C07C209/36 , C07C201/08
CPC分类号： C07C315/02 , C07C53/128 , C07C201/08 , C07C209/36 , C07C315/04 , C07C317/22 , C07C317/36 , C07C2523/42
摘要： A compound represented by formula (4): can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3): obtained by performing a nitration reaction by adding a nitrating agent to a solution containing a compound represented by formula (2): obtained by oxidizing a compound represented by formula (1): with hydrogen peroxide in the presence of sodium tungstate and a saturated C8 carboxylic acid, then adding water to the resultant mixture, and separating the resultant solution.

8. 发明授权

US09988333B2 Process for making 2,5-dihalogenated phenol 有权
公开(公告)号：US09988333B2
公开(公告)日：2018-06-05
申请号：US15311951
申请日：2015-05-18
申请人： BASF SE
发明人： Andreas Pletsch , Nicole Holub , Thomas Ulrich , Petr Kvita , Laurent Cavin
IPC分类号： C07C37/01 , C07C51/353 , C07C37/045 , C07C37/76 , C07C241/02 , C07C209/36 , C07C201/08 , C07C51/00 , C07C67/00
CPC分类号： C07C51/353 , C07C37/045 , C07C37/76 , C07C51/00 , C07C51/15 , C07C51/367 , C07C67/00 , C07C201/08 , C07C209/365 , C07C241/02 , C07C39/30 , C07C65/05 , C07C65/21
摘要： The present invention relates to a process for reacting chemical compounds comprising the step of reacting a compound of formula (IV) wherein Hal is independently selected from Cl or Br, and X− is a monovalent anion, in the presence of an inorganic acid, wherein the aqueous inorganic acid has a concentration of at least about 60%, at a temperature of about 140° C. to about 250° C., to obtain a compound of formula (V) wherein Hal is as defined above.

9. 发明授权

US09890177B2 Nitrated hydrocarbons, derivatives, and processes for their manufacture 有权
公开(公告)号：US09890177B2
公开(公告)日：2018-02-13
申请号：US14920156
申请日：2015-10-22
申请人： ANGUS Chemical Company
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07D498/10 , A01N43/76 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C205/06 , C07C205/18 , C07C215/08 , C07C215/42 , C07C239/10 , C07D263/04 , C07D263/52 , C07D498/04 , C08G18/32 , C07C205/04 , C07C205/05 , C07C205/15 , C07C205/16 , C07C215/20 , C07C215/28
CPC分类号： C07D498/10 , A01N43/76 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C205/04 , C07C205/05 , C07C205/06 , C07C205/15 , C07C205/16 , C07C205/18 , C07C215/08 , C07C215/20 , C07C215/28 , C07C215/42 , C07C239/10 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D263/04 , C07D263/52 , C07D498/04 , C08G18/3271 , Y02P20/582
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

10. 发明授权

US09758468B2 Halogenated aniline and method for producing same 有权
公开(公告)号：US09758468B2
公开(公告)日：2017-09-12
申请号：US15293507
申请日：2016-10-14
申请人： Nippon Soda Co., Ltd.
发明人： Hiroki Inoue , Yuzuru Sakata , Shinichi Kobayashi , Yoshikazu Ito , Takashi Kitayama
IPC分类号： C07C209/74 , C07C17/12 , C07C17/00 , C07C201/14 , C07C209/32 , C07C205/12 , C07C211/52 , C07C17/06 , C07C201/08
CPC分类号： C07C209/74 , C07C17/00 , C07C17/06 , C07C17/12 , C07C201/08 , C07C201/14 , C07C205/12 , C07C209/32 , C07C211/52 , C07C25/13
摘要： The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

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