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71. 发明授权

US5382657A Peg-interferon conjugates 失效
标题翻译：干扰素缀合物
公开(公告)号：US5382657A
公开(公告)日：1995-01-17
申请号：US935770
申请日：1992-08-26
申请人： Robert Karasiewicz , Carlo Nalin , Perry Rosen
发明人： Robert Karasiewicz , Carlo Nalin , Perry Rosen
IPC分类号： A61K38/21 , A61K38/00 , A61K39/00 , A61K47/48 , A61P43/00 , C07C69/96 , C07D213/56 , C07D213/64 , C07K1/107 , C07K1/113 , C07K14/52 , C07K14/555 , C07K14/56 , C07K17/08 , C08G65/32 , C08G65/34 , C07D213/89 , C07K3/08 , C07K15/26
CPC分类号： C07D213/64 , A61K47/48215 , C07C69/96 , C07K14/56 , A61K38/00
摘要： Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.
摘要翻译：式IA和IB的取代的PEG-干扰素缀合物，其中PEG通过式IIA，IIB或IIB-1的活化的连接试剂连接到干扰素中的氨基，以及式IIA，IIB或IIB的活化的连接试剂 -1。缀合物不容易受体内水解切割的影响，体内半衰期得到改善，并且在保持生物活性的同时降低干扰素的免疫原性。

72. 发明授权

US5371179A Polysuccinimide polymers and process for preparing polysuccinimide polymers 失效
标题翻译：聚琥珀酰亚胺聚合物和制备聚琥珀酰亚胺聚合物的方法
公开(公告)号：US5371179A
公开(公告)日：1994-12-06
申请号：US911862
申请日：1992-07-10
申请人： Yi H. Paik , Ethan S. Simon , Graham Swift
发明人： Yi H. Paik , Ethan S. Simon , Graham Swift
IPC分类号： C08G63/685 , C08G65/32 , C08G69/00 , C08G69/08 , C08G69/10
CPC分类号： C08G69/00 , C08G69/08
摘要： Polysuccinimide polymers of from about 5 to 100 percent by weight of methylenesuccinimide moieties, and from 0 to about 95 percent by weight of one or more amino acid moieties are provided. A process is provided for preparing polysuccinimide polymers by forming a polymerization mixture of poly(alkylene glycol), ammonia, one or more monoethylenically unsaturated poly(carboxylic acids) and, optionally, one or more other monoethylenically unsaturated compounds; heating the mixture to an elevated temperature; and maintaining the mixture at the elevated temperature to form polysuccinimide polymers.
摘要翻译：提供约5至100重量％的亚甲基琥珀酰亚胺部分和0至约95重量％的一个或多个氨基酸部分的聚琥珀酰亚胺聚合物。提供了通过形成聚（亚烷基二醇），氨，一种或多种单烯属不饱和聚（羧酸）和任选的一种或多种其它单烯属不饱和化合物的聚合混合物来制备聚琥珀酰亚胺聚合物的方法; 将混合物加热至高温; 并将混合物保持在升高的温度以形成聚琥珀酰亚胺聚合物。

73. 发明授权

US5359123A Polyoxyalkylene polyamines having secondary amino groups 失效
标题翻译：具有仲氨基的聚氧化烯多胺
公开(公告)号：US5359123A
公开(公告)日：1994-10-25
申请号：US37823
申请日：1993-03-29
申请人： Toshiyuki Ohshima , Hideo Ishibashi , Rie Tamura , Satoshi Yamamoto , Takaharu Izumo
发明人： Toshiyuki Ohshima , Hideo Ishibashi , Rie Tamura , Satoshi Yamamoto , Takaharu Izumo
IPC分类号： C08G65/48 , C07C221/00 , C07C225/06 , C07C227/06 , C07C227/08 , C07C229/16 , C07C253/18 , C07C255/24 , C08G18/32 , C08G18/50 , C08G65/32 , C08G65/331 , C08G65/332 , C08G65/333 , C08G65/334 , C08G73/02 , C08L71/02 , C07C69/66 , C07C229/08 , C09K3/00
CPC分类号： C07C227/06 , C08G18/3228 , C08G18/325 , C08G18/5024 , C08G65/331 , C08G65/332 , C08G65/3332 , C08G65/3344 , C08G73/024 , C08G2120/00
摘要： Trifunctional polyoxyalkylene polyamines having a plurality of 2-alkoxycarbonylethylamino groups at terminals are produced by reacting the corresponding primary amines with an alkyl acrylate. The trifunction secondary polyamines thus produced have a moderate reaction rate with a polyisocyanate component in polyurea RIM.
摘要翻译：通过使相应的伯胺与丙烯酸烷基酯反应制备在末端具有多个2-烷氧基羰基乙基氨基的三官能聚氧化烯多胺。这样制得的三官能二胺与聚脲RIM中的多异氰酸酯组分具有适度的反应速率。

74. 发明授权

US5354881A Silanes carrying water-solubilizing and hydrophobic moieties 失效
标题翻译：硅烷承载水溶性和疏水部分
公开(公告)号：US5354881A
公开(公告)日：1994-10-11
申请号：US776040
申请日：1991-10-15
申请人： Wen-Hsuan Chang , John F. Grunewalder , Mark A. Harley , Edward E. McEntire
发明人： Wen-Hsuan Chang , John F. Grunewalder , Mark A. Harley , Edward E. McEntire
IPC分类号： C08G65/32 , C07F7/12 , C07F7/18 , C08L71/02 , C07F7/08 , C07F7/10
CPC分类号： C07F7/182 , C07F7/12 , C07F7/1836
摘要： New organic silanes are claimed carrying at least one water-solubilizing moiety and at least one hydrophobic group suitable for preparing stable solutions or dispersions containing in excess of about five weight percent of such silanes.
摘要翻译：要求新的有机硅烷带有至少一个水溶性部分和至少一个适于制备含有超过约5重量％硅烷的稳定溶液或分散体的疏水基团。

75. 发明授权

US5308902A Biphosphites 失效
标题翻译：二亚磷酸酯
公开(公告)号：US5308902A
公开(公告)日：1994-05-03
申请号：US882993
申请日：1992-05-14
申请人： Holger Andreas , Alfred Renner , Horst Zinke
发明人： Holger Andreas , Alfred Renner , Horst Zinke
IPC分类号： C07F9/6571 , C07F9/6574 , C08G65/32 , C08K5/52 , C08K5/527 , C08L67/00 , C08L67/02 , C08L101/00 , C09K15/32 , C09K21/12 , C10M137/02 , C07F9/02
CPC分类号： C08K5/527 , C07F9/65748 , C10M137/02 , C10M2223/04 , C10M2223/042 , C10N2240/08
摘要： Biphosphites of formula I ##STR1## wherein m is 0, 1 or 2,n is 1 to 4 or 6,R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl and, if m=2, the radicals R.sub.1 are identical or different, and A is the radical of an at least n-hydric alcohol or phenol, which radical is attached to the P atom or atoms through the alcoholic or phenolic O atom or atoms, obtainable by reacting a compound of formula II ##STR2## wherein m is 0, 1 or 2, R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl and, if m=2, the radicals R.sub.1 are identical or different and R.sub.2 ' is phenyl, C.sub.1 -C.sub.12 alkylphenyl or C.sub.1 -C.sub.4 alkyl, with a polyether polyol or polyether/ester polyol, the hydroxy functions of said polyether polyol or polyether/ester polyol being partially or completely esterified with the ##STR3## are suitable for use as stabilizers, especially processing stabilizers, for organic polymers, preferably PVC resins, high density polyethylene and propylene.
摘要翻译：式I的亚磷酸酯其中m为0,1或2，n为1至4或6，R 1为氢或C 1 -C 4烷基，如果m = 2，基团R 1相同或不同，并且 A是至少n-羟基醇或苯酚的基团，其基团通过醇或酚O原子或原子连接到P原子或原子上，可通过使式II的化合物（II）与式 m为0,1或2，R1为氢或C1-C4烷基，如果m = 2，基团R1相同或不同，R2'为苯基，C1-C12烷基苯基或C1-C4烷基，与聚醚多元醇或聚醚/ 酯多元醇，所述聚醚多元醇或聚醚/酯多元醇的羟基官能团与“IMAGE”部分或完全酯化，适用于有机聚合物，优选PVC树脂，高密度聚乙烯和丙烯的稳定剂，特别是加工稳定剂。

76. 发明授权

US5294248A Polishes for metal surfaces containing cationic emulsifiers, and cationic emulsifiers contained therein 失效
标题翻译：含有阳离子乳化剂的金属表面的抛光剂和其中包含的阳离子乳化剂
公开(公告)号：US5294248A
公开(公告)日：1994-03-15
申请号：US20144
申请日：1993-02-19
申请人： Alba Chittofrati , Viviana Boselli , Giovanni Gavazzi , Ezio Strepparola , Renato Spiti , Silvia Tresoldi
发明人： Alba Chittofrati , Viviana Boselli , Giovanni Gavazzi , Ezio Strepparola , Renato Spiti , Silvia Tresoldi
IPC分类号： B01F17/46 , C08G65/00 , C08G65/32 , C08L71/02 , C09G1/10 , C09G1/04 , C09G1/12
CPC分类号： C09G1/10 , C08G65/007
摘要： Polishes for metal surfaces, based on dispersions of waxes, fluorinated polymers and perfluoropolyoxyalkylene oils acquire high gloss characteristics combined with improved water-repellency and resistance to soiling of 0.1-5% by weight of at least a cationic emulsifier comprised in the general formulaR--L--Q.sup.+ X.sup.-.sub.t (I)where:R=a chain of perfluoropolyoxyalkylene units;L=a divalent organic group;Q=a polar group;X=a halogen, or a group of formulaCH.sub.3 -Phenylene-SO.sub.3.sup.-R"SO.sub.3 --R"=F-(CF.sub.2).sub.m -;t=1 or 2;m=1-4.The polished containing the emulsifiers of formula (I) as well as the compounds comprised in said formula are claimed as new products.
摘要翻译：基于蜡，氟化聚合物和全氟聚氧化烯油的分散体，用于金属表面的抛光获得高光泽特性，结合改善的防水性和耐污染性至少为通式RL-中包含的至少一种阳离子乳化剂0.1-5重量％ Q + Xt（I）其中：R =全氟聚氧化烯单元链; L =二价有机基团; Q =极性基团; X =卤素或式为CH 3 - 亚苯基-SO 3 -R“SO 3 -R”= F-（CF 2）m - 的基团; t = 1或2; m = 1-4。含有式（I）的乳化剂的抛光剂以及所述式中包含的化合物被称为新产品。

77. 发明授权

US5288889A Fluorinated organic silicon compounds and method for making 失效
标题翻译：氟化有机硅化合物及其制备方法
公开(公告)号：US5288889A
公开(公告)日：1994-02-22
申请号：US60537
申请日：1993-05-13
申请人： Toshio Takago , Shinichi Sato , Hitoshi Kinami , Noriyuki Koike
发明人： Toshio Takago , Shinichi Sato , Hitoshi Kinami , Noriyuki Koike
IPC分类号： C07F7/18 , C08G65/02 , C08G65/04 , C08G65/32 , C08G65/333 , C08G65/336 , C08G65/48 , C09K3/00 , C09K3/18 , C07F7/10
CPC分类号： C08G65/33306 , C07F7/184 , C08G65/336
摘要： A fluorinated organic silicon compound of a structure having a fluorinated polyether group in its backbone and an isopropenoxysilyl group attached at either end forms a compliant coating on the surface of any substrate such as silicone rubber which is effective in imparting water and oil repellency and stain resistance to silicone rubber surface.
摘要翻译：在其主链上具有氟化聚醚基团的结构的氟化有机硅化合物和任一端连接的异丙烯氧基甲硅烷基在任何基材例如硅橡胶的表面上形成柔顺涂层，其有效地赋予拒水拒油性和抗污性到硅橡胶表面。

78. 发明授权

US5288376A Preparation of perfluorooligoether iodides 失效
标题翻译：全氟甘油醚碘化物的制备
公开(公告)号：US5288376A
公开(公告)日：1994-02-22
申请号：US17952
申请日：1993-02-16
申请人： Masayuki Oyama , Noriyuki Koike , Toshio Takago
发明人： Masayuki Oyama , Noriyuki Koike , Toshio Takago
IPC分类号： C07C41/01 , C07C43/12 , C07C51/58 , C08G65/22 , C08G65/32 , C08G65/323 , G07B39/00
CPC分类号： C08G65/323 , C07C41/01 , C07C43/126 , C07C51/58 , C08G65/226 , C08G65/32 , Y10S522/913 , Y10S522/914
摘要： A perfluorooligoether iodide is prepared by exposing a perfluoropolyether carboxylic iodide to UV light.
摘要翻译：通过将全氟聚醚羧酸碘化物暴露于UV光来制备全氟化硫醚碘化物。

79. 发明授权

US5280087A Preparation of block copolyether-ester-amides 失效
标题翻译：嵌段共聚醚 - 酯 - 酰胺的制备
公开(公告)号：US5280087A
公开(公告)日：1994-01-18
申请号：US7822
申请日：1993-01-22
申请人： Lie-Zen Chung , De-Lun Kou , Wen-Bin Shiu , Fu-Le Lin
发明人： Lie-Zen Chung , De-Lun Kou , Wen-Bin Shiu , Fu-Le Lin
IPC分类号： C08G65/333 , C08G69/44 , C08G63/04 , C08G65/32
CPC分类号： C08G69/44 , C08G65/33317
摘要： Disclosed is a novel two-step reaction method for preparing block copolyether-ester-amides. In the first step, caprolactam or other lactam is reacted with a polyether polyol in the presence of a catalyst to form an amino-terminated prepolymer with both a polyamide hard segment and a polyether soft segment. In the second step, the prepolymer is reacted with a dicarboxylic acid as a chain extender to form high molecular weight block copolyether-ester-amides.The block copolyether-ester-amides prepared by this method are transparent, easily moldable by conventional processing methods such as extrusion and injection molding, and exhibit excellent mechanical properties.
摘要翻译：公开了一种制备嵌段共聚醚 - 酯 - 酰胺的新型两步反应方法。在第一步中，己内酰胺或其它内酰胺与聚醚多元醇在催化剂存在下反应，形成具有聚酰胺硬链段和聚醚软链段的氨基封端的预聚物。在第二步中，预聚物与作为扩链剂的二羧酸反应形成高分子量嵌段共聚醚 - 酯 - 酰胺。通过该方法制备的嵌段共醚 - 酯 - 酰胺是透明的，通过常规加工方法如挤出和注射成型容易模塑，并且显示出优异的机械性能。

80. 发明授权

US5274180A Esters 失效
标题翻译：酯类
公开(公告)号：US5274180A
公开(公告)日：1993-12-28
申请号：US964986
申请日：1992-10-22
申请人： David Masheder
发明人： David Masheder
IPC分类号： C08G65/32 , C08G65/00 , C08G65/332 , C08G81/00 , C08L71/02 , C07C69/66
CPC分类号： C08G65/3322 , C08G65/007 , C08L71/02
摘要： Esters of hydroxy terminated monofunctional polyalkylene oxide derivatives and monofunctional perfluoropolyether carboxylic acids are novel compounds. They may be used to form emulsions and to modify droplet size in atomization.

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