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1. 发明申请

US20220125939A1 METHOD OF PREPARING PEGYLATED BIOMOLECULES HAVING CONTROLLABLE BINDING SITES 有权
公开(公告)号：US20220125939A1
公开(公告)日：2022-04-28
申请号：US17418671
申请日：2019-12-27
申请人： JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
发明人： Qingbin WANG , Jie QI , Yu LI , Xuan ZHAO
IPC分类号： A61K47/60 , A61K38/20 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/02 , C08G65/32
摘要： The present invention discloses a method of preparing PEGylated biomolecules having controllable binding sites, including the following steps: (1) binding a blocker to a biomolecule; (2) PEGylating the biomolecule; and (3) separating the blocker from the biomolecule. In another aspect, the present invention discloses a method for preparing PEGylated IL-2 having controllable binding sites, including the following steps: (1) binding IL-2 to an IL-2α receptor, closing the a binding site of the IL-2; (2) PEGylating, coupling PEG with the IL-2; and (3) separating the IL-2 from the IL-2α receptor. By regulating IL-2 binding sites and a PEGylation process only adding one or two polyethylene glycols, the IL-2 is caused to selectively bind to an IL-2R βγ-type receptor.

2. 发明授权

US10392474B2 Anionic linear polyglycerol derivatives, a method for manufacturing and applications 有权
公开(公告)号：US10392474B2
公开(公告)日：2019-08-27
申请号：US15545272
申请日：2016-01-20
申请人： FREIE UNIVERSITAET BERLIN , THE UNIVERSITY OF BRITISH COLUMBIA
发明人： Donald Brooks , Jayachandran Kizhakkedathu , Rajesh Shenoi , Marie Weinhart , Benjamin Lai , Rainer Haag , Dominic Groeger
IPC分类号： C08G65/32 , C08G65/334 , A61K31/255 , A61K38/36
摘要： The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

3. 发明授权

US09421276B2 Clickable polyoxetane carrier for drug delivery 有权
标题翻译：可点击的聚氧乙烯载体用于药物递送
公开(公告)号：US09421276B2
公开(公告)日：2016-08-23
申请号：US14425316
申请日：2013-09-03
申请人： VIRGINIA COMMONWEALTH UNIVERSITY
发明人： Hu Yang , Olga Zolotarskaya , Kenneth J. Wynne , Kristoffer Valerie
IPC分类号： C08G63/91 , A61K47/48 , C08G65/18 , C08G65/333 , A61K31/4745 , C08G65/32
CPC分类号： A61K47/48215 , A61K31/4745 , A61K47/60 , C08G65/18 , C08G65/333 , C08G65/33396 , C08G2650/30 , C08G2650/60 , C08L2205/05
摘要： A polymer is provided, comprising a subunit having the formula: wherein A, B, C, D, a, b, c, d, and p are defined herein. Compositions, methods of making, and methods of use are provided.
摘要翻译：提供聚合物，其包含具有下式的亚单元：其中A，B，C，D，a，b，c，d和p在本文中定义。提供了组合物，制备方法和使用方法。

4. 发明授权

US09040635B1 Renewable polymer and method of making 有权
标题翻译：可再生聚合物及其制备方法
公开(公告)号：US09040635B1
公开(公告)日：2015-05-26
申请号：US14158612
申请日：2014-01-17
申请人： TDA Research, Inc.
发明人： Silvia DeVito Luebben , James William Raebiger , Aaron Jeremy Skaggs
IPC分类号： C08G63/91 , C08G65/48 , C08G65/34 , C08G65/32
CPC分类号： C08G65/48 , C08G65/34
摘要： A polymer, optionally made from renewable sources, comprising a specific chemical structure that is a result of the polymerization of α-hydroxycarbonyl compounds (alpha-hydroxycarbonyl compounds), particularly α-hydroxyaldehydes (alpha-hydroxyaldehydes) and α-hydroxyketones (alpha-hydroxyketones), or glycolaldehyde. A method of polymerization, the method comprising the step of reacting trimethylsilyl trifluoromethanesulfonate with the cyclic dimer of one or more α-hydroxycarbonyl compounds. A method of making said polymer, the method comprising dehydrating a cyclic dimer of one or more α-hydroxycarbonyl compounds. An end-capped polymer made from one or more α-hydroxycarbonyl compounds and terminal end-cap groups.
摘要翻译：任选由可再生来源制成的聚合物，其包含由α-羟基羰基化合物（α-羟基羰基化合物）特别是α-羟基醛（α-羟基醛）和α-羟基酮（α-羟基酮）聚合的结果的特定化学结构）或乙二醇。一种聚合方法，该方法包括使三氟甲磺酸三甲基甲硅烷基酯与一种或多种α-羟基羰基化合物的环状二聚体反应的步骤。一种制备所述聚合物的方法，所述方法包括使一种或多种α-羟基羰基化合物的环状二聚体脱水。由一个或多个α-羟基羰基化合物和末端封端基团制成的封端聚合物。

5. 发明授权

US08937135B2 Biodegradable polymer mixture 有权
标题翻译：可生物降解的聚合物混合物
公开(公告)号：US08937135B2
公开(公告)日：2015-01-20
申请号：US13121298
申请日：2009-09-21
申请人： Tobias Heinz Steinke , Hans-Helmut Görtz , Jürgen Ahlers , Freddy Gruber , Gabriel Skupin
发明人： Tobias Heinz Steinke , Hans-Helmut Görtz , Jürgen Ahlers , Freddy Gruber , Gabriel Skupin
IPC分类号： C08G65/32
CPC分类号： C08L67/02 , C08K3/01 , C08K3/013 , C08K5/0008 , C08L33/062 , C08L33/08 , C08L33/10 , C08L35/06 , C08L63/10 , C08L67/025 , C08L67/04 , C08L69/00 , C08L97/02 , C08L2205/03 , C08L2666/02 , C08L2666/18
摘要： The present invention relates to biodegradable polymer mixtures comprising i) 40% to 95% by weight, based on the total weight of components i to ii, of at least one polyester based on aliphatic or aliphatic and aromatic dicarboxylic acids and aliphatic dihydroxy compounds; ii) 5% to 60% by weight, based on the total weight of said components i to ii, of polyalkylene carbonate, particularly polypropylene carbonate; iii) 0% to 60% by weight, based on the total weight of said components i to iii, of at least one biodegradable homo- or copolyester selected from the group consisting of polylactic acid, polycaprolactone and polyhydroxyalkanoate, and/or of an inorganic or organic filler; iv) 0% to 10% by weight, based on the total weight of said components i to ii, of an epoxy-containing copolymer based on styrene, acrylic ester and/or methacrylic ester, and v) 0% to 15% by weight of an additive selected from the group consisting of lubricant, antiblocking agent, antistat, UV absorber, UV stabilizer, thermal stabilizer, dye, pigment, colorant, plasticizer, fertilizer and active crop protection ingredient. The present invention further relates to processes for producing biodegradable polymer mixtures, to the use of biodegradable polymer mixtures in the production of moldings, films or fibers and also moldings, films or fibers comprising biodegradable polymer mixtures.
摘要翻译：本发明涉及可生物降解的聚合物混合物，其包含i）基于脂族或脂族和芳族二羧酸和脂族二羟基化合物的至少一种聚酯的基于组分i至ii的总重量的40重量％至95重量％ ii）5重量％至60重量％，基于所述组分i至ii的总重量，聚碳酸亚烷基酯，特别是聚碳酸丙烯酯; iii）基于所述组分i至iii的至少一种选自聚乳酸，聚己酸内酯和聚羟基链烷酸酯的至少一种可生物降解的均聚物或共聚酯的总重量为0重量％至60重量％，和/或无机或有机填料; iv）基于苯乙烯，丙烯酸酯和/或甲基丙烯酸酯的基于环氧基的共聚物，基于所述组分i至ii的总重量，0重量％至10重量％，和v）0重量％至15重量％选自润滑剂，防粘连剂，抗静电剂，UV吸收剂，UV稳定剂，热稳定剂，染料，颜料，着色剂，增塑剂，肥料和活性作物保护成分的添加剂。本发明还涉及用于生产可生物降解的聚合物混合物的方法，在生产模制品，薄膜或纤维中使用可生物降解的聚合物混合物，以及包含可生物降解的聚合物混合物的模制品，薄膜或纤维。

6. 发明授权

US08796391B2 Epoxy resin curing compositions and epoxy resin systems including same 有权
标题翻译：环氧树脂固化组合物和包含其的环氧树脂体系
公开(公告)号：US08796391B2
公开(公告)日：2014-08-05
申请号：US12642343
申请日：2009-12-18
申请人： Larry Steven Corley , Carlton E. Ash
发明人： Larry Steven Corley , Carlton E. Ash
IPC分类号： C08G65/32 , C08G59/56 , C08G59/50
CPC分类号： C08G59/50 , C08G59/504 , C08G59/56
摘要： Disclosed are epoxy resins exhibiting a highly favorable combination of tensile strength and elongation with respect to prior art epoxy systems. The elastomeric epoxy resin systems of the invention are prepared utilizing a curing agent containing at least one monoprimary amine, and are particularly useful in applications such as, for example, castings, potting, composites, crack sealing, coatings, adhesives, roofing materials, flooring or reinforced membranes.
摘要翻译：公开了相对于现有技术的环氧树脂体系，表现出非常有利的拉伸强度和伸长率组合的环氧树脂。本发明的弹性体环氧树脂体系是使用含有至少一种单原子胺的固化剂制备的，并且特别适用于诸如铸件，灌封，复合材料，裂缝密封，涂料，粘合剂，屋顶材料，地板或增强膜。

7. 发明授权

US08791211B2 High refractive polymers, optical elements, and photoelectric device employing the same 有权
$High refractive polymers, optical elements, and photoelectric device employing the same$
标题翻译：高折射聚合物，光学元件和使用其的光电装置
公开(公告)号：US08791211B2
公开(公告)日：2014-07-29
申请号：US13160119
申请日：2011-06-14
申请人： Ming-Jyh Chang , Zhi-Long Chen
发明人： Ming-Jyh Chang , Zhi-Long Chen
IPC分类号： C08G59/00 , C08G63/08 , C08G65/26 , C08G65/32 , G02B1/04
CPC分类号： G02B1/04
摘要： High refractive polymers, optical elements, and optical elements employing the same are provided. The polymer includes a repeat unit represented by Formula (I): wherein: R1 is independently an H, C1-8 alkyl group, C1-8 alkoxy group, or halides; R2 is independently an C1-8 alkyl group, C1-8 alkoxy group, or C1-8 alkanol group; n is 0, or 1; Y is R3 and R4 are each independently an H, C1-8 alkyl group, C1-8 alkoxy group, cycloalkyl group, aryl group, heteroaryl group, or heterocycloalkyl group, and two adjacent R3 groups are optionally combined with the carbon atoms which they are attached thereto, to form a cycloalkyl group, aryl group, heteroaryl group, or heterocycloalkyl group; and Z is independently a residual group of polycaprolactone diol, or a residual group of polyethylene glycol.
摘要翻译：提供了高折射聚合物，光学元件和采用其的光学元件。聚合物包括由式（I）表示的重复单元：其中：R1独立地为H，C1-8烷基，C1-8烷氧基或卤化物; R2独立地为C1-8烷基，C1-8烷氧基或C1-8烷醇基; n为0或1; Y是R 3和R 4各自独立地是H，C 1-8烷基，C 1-8烷氧基，环烷基，芳基，杂芳基或杂环烷基，并且两个相邻的R 3基团任选地与碳原子结合，与其形成环烷基，芳基，杂芳基或杂环烷基; Z独立地为聚己内酯二醇的残基或聚乙二醇的残基。

8. 发明授权

US08658742B2 Epoxy resin imbibed polymer particles 有权
标题翻译：环氧树脂吸收聚合物颗粒
公开(公告)号：US08658742B2
公开(公告)日：2014-02-25
申请号：US13457972
申请日：2012-04-27
申请人： Gary William Dombrowski , Zhenwen Fu , Caroline Slone , Andrew Swartz
发明人： Gary William Dombrowski , Zhenwen Fu , Caroline Slone , Andrew Swartz
IPC分类号： C08G65/32 , C08G67/00 , B05D3/02 , C09D5/44 , C08L63/00
CPC分类号： C09D163/00 , C08F220/18 , C08F265/06 , C08L33/14 , C08L51/00 , C09D5/08 , C09D133/14 , C09D151/00 , C08F2220/1825 , C08F220/14 , C08F212/14 , C08F220/56 , C08F230/02 , C08F2220/283 , C08L63/00 , C08F220/06 , C08F2220/1858 , C08F212/08 , C08F2220/325
摘要： The present invention relates to a stable aqueous dispersion of thermoplastic polymer particles imbibed with a thermosettable compound. The polymer particles are characterized by having a sufficient concentration of anti-agglomerating functional groups to stabilize the latex against agglomeration. The dispersion is useful as one part of a two-pack formulation.
摘要翻译：本发明涉及一种热固性聚合物颗粒的稳定的水分散体，该聚合物颗粒与可热固化的化合物一起吸收。聚合物颗粒的特征在于具有足够浓度的抗附聚官能团以稳定胶乳以防止聚集。分散体作为双组分配方的一部分是有用的。

9. 发明授权

US08530544B2 Modification of the surface chemistry of macromolecular species in the presence of a conjugated guanidine 有权
标题翻译：在共轭胍存在下改性大分子物质的表面化学性质
公开(公告)号：US08530544B2
公开(公告)日：2013-09-10
申请号：US12736293
申请日：2009-03-27
申请人： Vincent Gaud , Fabien Rouge
发明人： Vincent Gaud , Fabien Rouge
IPC分类号： B01J8/02 , C01B21/06 , C08F283/00 , C08F283/04 , C08F290/14 , C08G18/00 , C08G18/08 , C08G18/18 , C08G63/48 , C08G63/91 , C08G65/32 , C08G73/02 , C08K9/00 , C08L67/00 , C08L71/00 , C08L71/02 , C08L75/00 , C08L83/00
CPC分类号： C08J7/16 , B01J31/0251
摘要： The present invention relates to a method for preparing macromolecular species with a modified surface, comprising a step (e) in which macromolecular species (M), initially carrying —OH and/or —SH functions, are brought into contact with: a catalyst (C) carrying at least one conjugated guanidine function; and reactive species (E), comprising reactive groups including: (i) at least one group including an a,b-unsaturated carbonyl group C═C—C═O and/or an a,b-unsaturated thiocarbonyl group C═C—C═S; and/or (ii) at least one heterocyclic group comprising from 3 to 5 ring members, said group being selected from cyclic ethers, cyclic thioethers and aziridine rings; and/or (iii) at least one group selected from isocyanate —N═C═O or thioisocyanate —N═C═S groups, and trivalent groups of formula >C═CZ—, where Z is an electron-withdrawing group. The invention also relates to the macromolecular species with a modified surface that are obtained in this context.
摘要翻译：本发明涉及一种制备具有改性表面的高分子物质的方法，其包括步骤（e），其中最初携带-OH和/或-SH官能团的高分子物质（M）与下列物质接触：催化剂 C）携带至少一种共轭胍功能; 和反应性物质（E），其包含反应性基团，包括：（i）至少一个包括a，b不饱和羰基C = C-C = O和/或a，b-不饱和硫代羰基C = C-C = S的基团; 和/或（ii）至少一个包含3至5个环成员的杂环基，所述基团选自环醚，环硫醚和氮丙啶环; 和/或（iii）选自异氰酸酯-N = C = O或硫代异氰酸酯-N = C = S基团中的至少一个基团和式C = CZ-的三价基团，其中Z为吸电子基团。本发明还涉及在本文中获得的具有改性表面的大分子物质。

10. 发明授权

US08288590B2 N-substituted monomers and polymers 有权
标题翻译： N-取代的单体和聚合物
公开(公告)号：US08288590B2
公开(公告)日：2012-10-16
申请号：US13183051
申请日：2011-07-14
申请人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
发明人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
IPC分类号： C07C233/00 , C07C215/00 , C07C39/24 , C08G65/32 , C08G75/00 , A61K49/04 , A61K47/30
CPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , B33Y70/00 , B33Y80/00 , C08G63/6856 , C08G64/045 , C08G64/12 , C08G64/183 , C08G64/186 , C08G79/04 , C08L85/02 , C08L69/00
摘要： Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
摘要翻译：包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效，与没有N-取代的相同聚合物相比。

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