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71. 发明申请

US20100274029A1 METHOD OF PREPARING (6R)-3-HEXYL-4-HYDROXY-6-UNDECYL-5, 6-DIHYDROPYRAN-2-ONE, AND INTERMEDIATE USED IN THE METHOD 失效
标题翻译：制备（6R）-3-异丙基-4-羟基-6-二乙基-5,6-二氢吡喃-2-酮的方法和方法中使用的方法
公开(公告)号：US20100274029A1
公开(公告)日：2010-10-28
申请号：US12740827
申请日：2008-10-29
申请人： Sang Min Yun , Young Ho Moon , Young-Kil Chang , Dong Jin Hong , Ji-Yeon Chang , Moon Sub Lee , Jaeho Yoo , Ji Sook Kim , Cheol Kyung Kim
发明人： Sang Min Yun , Young Ho Moon , Young-Kil Chang , Dong Jin Hong , Ji-Yeon Chang , Moon Sub Lee , Jaeho Yoo , Ji Sook Kim , Cheol Kyung Kim
IPC分类号： C07D309/30 , C07C229/00
CPC分类号： C07D309/32 , C07C249/02 , C07C251/08 , C07F7/1804 , Y02P20/55
摘要： Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate.
摘要翻译：提供制备（6R）-3-己基-4-羟基-6-十一烷基-5,6-二氢吡喃-2-酮和（5R）-2-己基-5-羟基-3-亚氨基十六酸酯的方法所述方法中使用的衍生物作为中间体。

72. 发明申请

US20100272726A1 Assays, methods and means 有权
标题翻译：测定方法和方法
公开(公告)号：US20100272726A1
公开(公告)日：2010-10-28
申请号：US12654993
申请日：2010-01-12
申请人： Patrick Henry Maxwell , Christopher William Pugh , Peter John Ratcliffe , Christopher Joseph Schofield
发明人： Patrick Henry Maxwell , Christopher William Pugh , Peter John Ratcliffe , Christopher Joseph Schofield
IPC分类号： A61K38/16 , A61K39/395 , G01N33/573 , C12Q1/34 , C12N9/14 , C12N15/63 , A61K31/7088 , A61K31/44 , A61K31/225 , A61K31/195 , C07K7/08 , C07K14/435 , C07K16/00 , C07H21/04 , C07H21/02 , C07D213/80 , C07C229/00
CPC分类号： A61K31/455 , A01K2217/05 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/221 , A61K31/223 , A61K31/225 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/327 , A61K31/44 , A61K31/4412 , A61K38/00 , A61K39/3955 , C07C235/80 , C07C323/60 , C07C327/32 , C07D213/80 , C07D213/81 , C07D213/82 , C07K14/4702 , C07K16/40 , C07K2317/30 , C12N9/0071 , C12Q1/26 , C12Q1/34 , G01N33/573 , G01N2333/90245 , G01N2500/04 , G01N2500/20
摘要： A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
摘要翻译：描述了一类新型的羟化酶，其具有SEQ ID NO：2,4,6和8的氨基酸序列，其变体和片段具有HIF羟基化活性。本发明的多肽特别是脯氨酰羟化酶活性。测定方法监测HIF羟化酶与底物的相互作用。提供HIF羟化酶的调节剂用于治疗与增加或降低的HIF水平或活性有关的病症，或用于治疗期望调节HIF水平或活性的病症。

73. 发明申请

US20100261754A1 NOVEL RAR RECEPTOR AGONIST LIGANDS AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS 有权
标题翻译：新型雷达受体激动剂配体及其在人体药物和化妆品中的应用
公开(公告)号：US20100261754A1
公开(公告)日：2010-10-14
申请号：US12599624
申请日：2008-04-24
申请人： Thibaud Biadatti-Portal
发明人： Thibaud Biadatti-Portal
IPC分类号： A61K31/445 , C07C229/00 , A61K31/24 , A61P17/10 , A61P17/06 , C07D207/04 , A61K31/40 , C07D211/08
CPC分类号： C07C229/52 , C07D207/06 , C07D211/14
摘要： The invention relates to compounds corresponding to general formula (I) below: to the compositions containing same, to methods for the preparation thereof and to the use thereof in pharmaceutical compositions for use in human or veterinary medicine, or else in cosmetic compositions.
摘要翻译：本发明涉及对应于下列通式（I）的化合物：含有该化合物的组合物，其制备方法及其用于人或兽医药物或化妆品组合物的药物组合物中的用途。

74. 发明申请

US20100258764A1 POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTALLINE POLYMER, AND OPTICAL ANISOTROPIC ARTICLE 有权
标题翻译：可聚合液晶，可聚合液晶组合物，液晶聚合物和光学非均质制品
公开(公告)号：US20100258764A1
公开(公告)日：2010-10-14
申请号：US12597122
申请日：2008-04-24
申请人： Kei Sakamoto , Naoto Kogoshi , Yoshihide Yachi
发明人： Kei Sakamoto , Naoto Kogoshi , Yoshihide Yachi
IPC分类号： C09K19/20 , C07C229/00 , C08F20/10
CPC分类号： C09K19/24 , C08F222/1006 , C09K19/3852 , C09K19/588 , C09K2019/0407 , C09K2019/0448 , G02B5/3016 , G02F1/133788 , G02F2001/133726 , G02F2202/023 , G02F2202/40 , Y10T428/10
摘要： A polymerizable liquid crystal compound shown by the following formula (I), a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optical anisotropic article that includes the liquid crystalline polymer. The polymerizable liquid crystal compound shows a liquid crystal phase over a wider temperature range, is chemically stable, can be inexpensively produced, and has a wide selective reflection wavelength band Δλ (i.e., a large value Δn). The polymerizable liquid crystal composition includes the polymerizable liquid crystal compound, the liquid crystalline polymer is obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and the optical anisotropic article includes the liquid crystalline polymer. wherein Y1 to Y6 represent —O—, —O—C(═O)—, —C(═O)—O—, or the like, G1 and G2 represent divalent aliphatic groups having 1 to 20 carbon atoms, Z1 and Z2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A1 and A2 represent divalent organic groups A having 1 to 30 carbon atoms, X1 to X8 represent a hydrogen atom or the like, and a and b represent 0 or 1.
摘要翻译：由下述通式（I）表示的可聚合液晶化合物，包含可聚合液晶化合物的可聚合液晶组合物和可聚合液晶化合物可聚合的手性化合物，通过聚合可聚合液晶化合物或可聚合液晶组合物，以及包含液晶聚合物的光学各向异性制品。可聚合液晶化合物在更宽的温度范围内显示出液晶相，化学稳定，可以廉价地制造，并且具有宽的选择反射波长带＆Dgr;λ（即大的值＆Dgr; n）。聚合性液晶组合物包含聚合性液晶化合物，通过使聚合性液晶性化合物或聚合性液晶组合物聚合而得到液晶聚合物，光学各向异性物质包含液晶聚合物。其中Y 1至Y 6表示-O-，-O-C（= O） - ， - C（= O）-O-等，G 1和G 2表示具有1至20个碳原子的二价脂族基，Z 1和Z 2 代表具有2〜10个碳原子的烯基等，A1和A2表示碳原子数1〜30的二价有机基团A，X 8〜X 8表示氢原子等，a和b表示0或1。

75. 发明申请

US20100233781A1 Tubular nanostructure targeted to cell membrane 审中-公开
公开(公告)号：US20100233781A1
公开(公告)日：2010-09-16
申请号：US12322366
申请日：2009-01-30
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C07C49/00 , C07C69/00 , C07C43/00 , C07C229/00 , C07C47/00 , C07C211/00 , C07C35/00 , C07K16/00 , C07K14/00 , C12N9/10 , C07K2/00 , C07D323/00 , C07H21/04 , C07K14/765 , C07H1/00 , C07D207/40 , C07K14/415 , D01F9/12 , C08G63/91
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.

76. 发明申请

US20100233761A1 ALGAE BIOMASS FRACTIONATION 审中-公开
标题翻译： ALGAE生物质分解
公开(公告)号：US20100233761A1
公开(公告)日：2010-09-16
申请号：US12721077
申请日：2010-03-10
申请人： Thomas J. Czartoski , Robert Perkins , Jorge L. Villanueva , Glenn Richards
发明人： Thomas J. Czartoski , Robert Perkins , Jorge L. Villanueva , Glenn Richards
IPC分类号： C07K2/00 , C22C38/00 , C22C24/00 , C22C23/00 , C22C27/04 , C22C22/00 , C22C9/00 , C22C18/00 , C01B35/02 , C01B25/00 , C01B21/00 , C01B31/20 , C01B7/01 , C01B19/02 , C01B17/00 , C12P21/00 , C12P7/64 , C12P7/04 , C12N13/00 , C12N1/12 , C07K14/00 , C07H3/02 , C08B37/00 , C07H3/04 , C09B5/00 , C07J1/00 , C08G63/48 , C07C229/00 , C07F9/06 , C07C35/00 , C07C31/22 , C07C9/00 , C07C15/24 , C07H3/06 , C07C11/02
CPC分类号： C12N1/06 , C12N1/12 , C12N13/00 , Y02E50/343
摘要： A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass solution, and recovering cell and cell derived products from the non-polar solvent solution and polar biomass solution. Products recovered from the above method. A method of operating a renewable and sustainable plant for growing and processing algae.
摘要翻译：通过将悬浮在至少一种水基极性溶剂的pH调节溶液中的生物质的渗透调节生物质分解生物质的方法，以形成调节的生物质，将pH调节的溶液与至少一种非极性溶剂紧密接触，非极性溶剂溶液和极性生物质溶液，并从非极性溶剂溶液和极性生物质溶液中回收细胞和细胞衍生产物。从上述方法回收产品。一种用于生长和加工藻类的可再生和可持续植物的方法。

77. 发明授权

US07772428B2 Creatine hydroxycitric acids salts and methods for their production and use in individuals 有权
标题翻译：肌酸羟基柠檬酸盐及其生产和使用方法
公开(公告)号：US07772428B2
公开(公告)日：2010-08-10
申请号：US12108822
申请日：2008-04-24
申请人： Marvin Heuer , Michele Molino
发明人： Marvin Heuer , Michele Molino
IPC分类号： C07C229/00 , C07C391/00
CPC分类号： C07C59/285 , A23L33/175 , A23V2002/00 , C07C279/14 , A23V2250/306 , A23V2200/30 , A23V2200/332 , A23V2200/33
摘要： Methods of production for Tricreatine Hydroxycitrate are disclosed. Tricreatine hydroxycitrate can be used as supplemental dietary ingredient for the purposes of reducing adiposity, suppression of appetite, improvement of muscle and exercise performance and recovery. The salts are useful in the dietetic, food supplement and food industries.
摘要翻译：公开了三羟甲基柠檬酸的生产方法。羟基柠檬酸肌酸可用作补充膳食成分，用于减少肥胖，抑制食欲，改善肌肉和锻炼性能和恢复。这些盐可用于饮食，食品添加剂和食品工业。

78. 发明申请

US20100197783A1 Radiation Protection Using Single Wall Carbon Nanotube Derivatives 审中-公开
标题翻译：使用单壁碳纳米管衍生物的辐射防护
公开(公告)号：US20100197783A1
公开(公告)日：2010-08-05
申请号：US12593585
申请日：2008-03-26
申请人： James M. Tour , Meng Lu , Rebecca Lucente-Schultz , Ashley Leonard , Condell Dewayne Doyle , Dmitry V. Kosynkin , Brandi Katherine Price
发明人： James M. Tour , Meng Lu , Rebecca Lucente-Schultz , Ashley Leonard , Condell Dewayne Doyle , Dmitry V. Kosynkin , Brandi Katherine Price
IPC分类号： A61K31/215 , A61P43/00 , C07C229/00
CPC分类号： A61K9/0092 , A61K8/19 , A61K47/60 , A61K47/6925 , A61K2800/413 , A61Q17/04 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B2202/02 , C01B2202/04 , C01B2202/06
摘要： A method of reducing side effects of damage in a human subject exposed to radiation includes administering to the human subject carbon nanotubes in a pharmaceutically acceptable carrier after or prior to exposure to radiation. A composition for reducing radical damage includes a carbon nanotube which is functionalized (1) for substantial water solubility and (2) with a radical trapping agent appended to the carbon nanotube forming a radical scavenger-carbon nanotube conjugate.
摘要翻译：在暴露于辐射的人类受试者中减少损伤的副作用的方法包括在暴露于辐射之后或暴露于辐射之前向人受试者在药学上可接受的载体中施用碳纳米管。用于还原自由基损伤的组合物包括官能化（1）用于大量水溶性的碳纳米管和（2）附着到形成自由基清除剂 - 碳纳米管缀合物的碳纳米管上的自由基捕获剂。

79. 发明授权

US07745651B2 Cationic lipids and methods of use 有权
标题翻译：阳离子脂质和使用方法
公开(公告)号：US07745651B2
公开(公告)日：2010-06-29
申请号：US11148430
申请日：2005-06-07
申请人： James Heyes , Ian MacLachlan , Lorne R. Palmer
发明人： James Heyes , Ian MacLachlan , Lorne R. Palmer
IPC分类号： C07C229/00 , C07B35/00 , C07B37/00 , A01N31/70 , A01N43/04 , A61K31/70 , A61K9/48 , A61B8/00
CPC分类号： A61K48/0025 , A61K9/0019 , A61K9/1271 , A61K9/1617 , A61K47/26 , A61K47/6911 , A61K48/00 , C07C217/28 , C07C217/40 , C12N15/88
摘要： The present invention provides compositions comprising cationic lipids, liposomes and nucleic acid-lipid particles comprising the cationic lipids, and methods of using such compositions, liposomes, and nucleic acid-lipid particles.
摘要翻译：本发明提供包含阳离子脂质，脂质体和包含阳离子脂质的核酸 - 脂质颗粒的组合物，以及使用这些组合物，脂质体和核酸 - 脂质颗粒的方法。

80. 发明申请

US20100160248A1 ISOTOPICALLY MODIFIED COMPOUNDS AND THEIR USE AS FOOD SUPPLEMENTS 有权
标题翻译：同位素改性化合物及其作为食品补充用途
公开(公告)号：US20100160248A1
公开(公告)日：2010-06-24
申请号：US12281957
申请日：2007-03-08
申请人： Mikhail Sergeevich Shchepinov
发明人： Mikhail Sergeevich Shchepinov
IPC分类号： A61K31/195 , C07C229/02 , C07C229/00 , C07C57/03 , C07H19/167 , C07K2/00 , A61K31/708 , A61K31/20
CPC分类号： A23L33/12 , A23D9/00 , A23D9/007 , A23K10/12 , A23K50/80 , A23L33/10 , A23L33/105 , A23L33/13 , A23L33/135 , A23L33/175 , A23L33/18 , A23L33/20 , A23V2002/00 , A61K9/0019 , A61K31/201 , C07B2200/05 , C07C57/03 , C07C229/26 , C07C255/30 , C07C279/14 , C07H19/16 , A23V2200/302 , A23V2200/30 , A23V2250/1872 , A23V2250/063 , A23V2250/0606 , A23V2250/206
摘要： A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, reactive oxygen species.
摘要翻译：营养成分包含其中至少一个可交换H原子为2H和/或至少一个C原子为13 C的必需营养物质。因此，保护营养物不受其他活性氧的影响。

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