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81. 发明申请

US20220163553A1 CELL PICKING DEVICE AND CELL PICKING METHOD 有权
公开(公告)号：US20220163553A1
公开(公告)日：2022-05-26
申请号：US17531065
申请日：2021-11-19
申请人： SHIMADZU CORPORATION
发明人： Mika OKADA , Yuki KUZUHARA , Yoshitake YAMAMOTO , Toru EZURE
IPC分类号： G01N35/10 , B01L3/02 , B01L9/00 , C12N1/02 , C12M1/26 , C12M1/00 , B01L3/00
摘要： A cell picking device that sucks cells from a liquid sample in a sample container and accommodates the sucked cells in any of a plurality of wells of an accommodating plate, includes a suction discharger that sucks cells in the sample container and discharges the sucked cells into any of the plurality of wells, the receiver that receives selection of a well in which cells are to be accommodated out of the plurality of wells of the accommodating plate as a selection well, a driver that adjusts a relative positional relationship between the suction discharger and the plurality of wells of the accommodating plate, and a work controller that controls the driver such that the suction discharger discharges cells into the received selection well out of the plurality of wells of the accommodating plate.

82. 发明授权

US11339807B2 Priority flow control valve 有权
公开(公告)号：US11339807B2
公开(公告)日：2022-05-24
申请号：US17053793
申请日：2018-05-10
申请人： Shimadzu Corporation
发明人： Shogo Sonokawa
IPC分类号： F15B13/02 , B62D5/08 , B66F9/22 , B62D5/07 , F15B13/04 , F15B11/16 , F15B13/06
摘要： A throttle check valve includes: a poppet valve body that has an orifice formed at one end and has a hole portion formed at a side portion; a plug that has a tubular shape to surround the poppet valve body, and functions as a valve seat to come into contact with the poppet valve body; and a spring that biases the poppet valve body and the plug functioning as the valve seat in directions to come into contact with each other. When the spool is at the second position, the plug forming the distal end portion of the spool and the plug arranged in the housing come into contact with each other. The plug is provided with a protruding portion that comes into contact with the poppet valve body.

83. 发明申请

US20220157586A1 ION ANALYZER 有权
公开(公告)号：US20220157586A1
公开(公告)日：2022-05-19
申请号：US17599136
申请日：2019-04-02
申请人： SHIMADZU CORPORATION , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
发明人： Hidenori TAKAHASHI , Daiki ASAKAWA
IPC分类号： H01J49/00 , H01J49/06
摘要： An ion analyzer includes a reaction chamber into which precursor ions derived from a sample component are introduced, a radical irradiation unit that generates and emits a predetermined type of radicals, a standard substance supply unit that individually supplies kinds of standard substances to the reaction chamber, where activation energy of radical addition reaction is known for each of the kinds of standard substances, and the activation energies are different in magnitude, an ion measurement unit that measures an amount of predetermined product ions generated from precursor ions derived from the standard substance by irradiation with the radicals, and a radical temperature calculation unit that obtains an amount of radicals that caused the radical addition reaction from the amount of the predetermined product ions and obtains a radical temperature based on a relationship between the amount of the radicals obtained for each kind of standard substance and activation energy.

84. 发明申请

US20220155255A1 ELECTROPHORESIS APPARATUS 有权
公开(公告)号：US20220155255A1
公开(公告)日：2022-05-19
申请号：US17439461
申请日：2019-03-19
申请人： SHIMADZU CORPORATION
发明人： Hiroyuki MATSUMOTO , Koki MIYAZAKI
IPC分类号： G01N27/447
摘要： An electrophoresis apparatus includes: a sample plate including a sample receptacle; a protective sheet; a rack that supports the sample plate; a cover mounted on the protective sheet; a rack receiving mechanism that receives the rack; a punch pin; a dispensing probe; and a chip holder, and the rack receiving mechanism includes: a rack holder that removably holds the rack; and an urging portion that urges the cover toward the sample plate while the rack is held by the rack holder.

85. 发明申请

US20220152204A1 PHOTOIMMUNOTHERAPY AND PHARMACEUTICAL AGENT USED THEREFOR 有权
公开(公告)号：US20220152204A1
公开(公告)日：2022-05-19
申请号：US17440461
申请日：2020-03-19
申请人： SHIMADZU CORPORATION
发明人： Taka-Aki SATO , Akihiro ISHIKAWA , Masayuki NISHIMURA
IPC分类号： A61K41/00 , A61K47/64 , A61P35/02
摘要： Provided is a method and pharmaceutical agent which make it possible to efficiently implement PIT, and a method characterized by a step of administering a pharmaceutical agent, in which a substance that binds to tumor blood vessel specific marker molecules present in new blood vessels has been conjugated with at least a labeling substance, to an object associated with a disease or pathology, and changing a physical property of the labeling substance after the administration step.

86. 发明申请

US20220146541A1 ANALYSIS DEVICE 有权
公开(公告)号：US20220146541A1
公开(公告)日：2022-05-12
申请号：US17436603
申请日：2019-03-12
申请人： SHIMADZU CORPORATION
发明人： Kazuya TAKAHASHI
IPC分类号： G01N35/00 , G01N30/02 , G06F1/26
摘要： There is provided an analysis device including one or a plurality of analysis units each including a unit main body that is a primary subject of an analysis operation, a first power supply configured to supply power to the unit main body, a unit controller configured to operate the unit main body according to a control signal input from an outside, and switch a connected state/disconnected state between the first power supply and the unit main body, and a second power supply configured to supply lower-voltage power to the unit controller than the first power supply (63); and a central controller configured to send a control signal to the unit controller of each of the one or plurality of analysis units.

87. 发明申请

US20220146469A1 LIQUID CHROMATOGRAPH 有权
公开(公告)号：US20220146469A1
公开(公告)日：2022-05-12
申请号：US17431762
申请日：2019-09-19
申请人： SHIMADZU CORPORATION
发明人： Takuya YONEKURA
IPC分类号： G01N30/74 , G01N30/86
摘要： A liquid chromatograph including a spectroscopic analysis unit (40) that performs spectroscopic analysis by irradiating a flow cell (90) through which an eluent eluted from a column (31) flows with light is provided with a cell information reading unit (49) that is provided in the spectroscopic analysis unit and accesses a storage device (91) attached to the flow cell to acquire cell information that is information unique to a type or an individual of the flow cell; a wavelength check control unit (51) that causes the spectroscopic analysis unit to execute wavelength check; a wavelength check information storage unit (53) in which a result of the wavelength check is stored in association with the cell information acquired at a time of executing the wavelength check; and a system check report creation unit (74) that creates a system check report in which the result of the wavelength check and the cell information acquired at the time of executing the wavelength check are described by referring to the wavelength check information storage unit. This makes it possible to sufficiently secure the reliability of the analysis result.

88. 发明申请

US20220145376A1 METHOD FOR DETECTING EXTRACELLUAR VESICLES 有权
公开(公告)号：US20220145376A1
公开(公告)日：2022-05-12
申请号：US17611603
申请日：2020-05-13
申请人： SHIMADZU CORPORATION
发明人： Makoto WATANABE , Hirotaka FUJIMOTO , Taka-Aki SATO
IPC分类号： C12Q1/6818 , G01N27/62
摘要： The present invention provides a method for quantifying a plurality of surface antigens simultaneously, thereby identifying an extracellular vesicle such as an exosome, and detecting and quantifying any surface antigen. Specifically, the present invention provides a method for detecting an extracellular vesicle, the method including: a step of labeling an extracellular vesicle in a sample using a first metal labeling reagent for labeling a nucleic acid and a second metal labeling reagent for labeling an extracellular vesicle surface antigen; and a step of identifying the first and second metal labeling reagents by mass spectrometry.

89. 发明授权

US11328921B2 Quadrupole mass filter and analytical device 有权
公开(公告)号：US11328921B2
公开(公告)日：2022-05-10
申请号：US17059683
申请日：2018-06-01
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Shinjiro Fujita
IPC分类号： H01J49/42
摘要： A quadrupole mass filter includes: four electrodes arranged to surround a central axis and constituting a quadrupole; attachment portions to which a plurality of electrical conductors are attached, at least one of the electrical conductors being arranged at a position that lies in a direction toward an area between each of the adjacent electrodes among the four electrodes, as viewed from the central axis; and a holder having a hollow portion and holding the four electrodes and the plurality of electrical conductors, wherein the electrical conductors are attached to the respective attachment portions and held by the holder with elasticity of a material constituting the electrical conductors.

90. 发明授权

US11327058B2 Peak detection method and data processing device 有权
公开(公告)号：US11327058B2
公开(公告)日：2022-05-10
申请号：US16089521
申请日：2016-03-31
申请人： SHIMADZU CORPORATION
发明人： Shinji Kanazawa
IPC分类号： G01N30/86
摘要： A peak detecting method according to the present invention includes a first peak detecting step (S1) of detecting, with a first detection sensitivity, one or more peaks in object data whose peak is to be detected; and a second peak detecting step (S5) of detecting one or more peaks in the object data with a second detection sensitivity that is different from the first detection sensitivity. With this method, since two kinds of detection are performed at the different detection sensitivities, a shoulder peak (or a non-shoulder peak) candidate can be chosen from peaks that are detected with one of the detection sensitivities but are not detected with the other detection sensitivity, and thus, a shoulder peak can be appropriately detected with ease.

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