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1. 发明授权

US11217439B2 Mass spectrometer 有权
公开(公告)号：US11217439B2
公开(公告)日：2022-01-04
申请号：US17022899
申请日：2020-09-16
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Takashi Umemoto
IPC分类号： H01J49/42 , G01N30/72 , H01J49/24 , H01J49/06 , G01N30/02
摘要： A vacuum chamber 11 for forming a vacuum space has two side walls opposite to each other across an ion beam axis extending within the vacuum space. One of those side walls is openable and closeable. An ion optical element 21 is placed on a base 33, which is located on the bottom surface of the vacuum chamber. A fixation band 213 fixes the ion optical element on the base by holding the element between the base and the fixation band so as to press the element onto the base. A band-catching portion 10d, located on an inside face of a side wall of the vacuum chamber on the opposite side from the openable-and-closeable side wall, catches one end of the fixation band. A band-fixing portion 214, located on the base on the side where the openable-and-closeable side wall is present, fixes the other end of the fixation band to the base.

2. 发明授权

US11099161B2 Ionizer and mass spectrometer 有权
公开(公告)号：US11099161B2
公开(公告)日：2021-08-24
申请号：US16339089
申请日：2016-11-29
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/16 , G01N30/72 , G01N27/62 , H01J49/04 , H01J49/10
摘要： An ionizer includes an ionization probe (21) provided with a capillary (211), a metallic slender tube (212), and a nebulizing gas pipe (213). The ionization probe (21) is equipped to perform ESI-based ionization of components in a liquid sample. An electroconductive capillary (22) is disposed at a position forward in a flow direction of a nebulized flow of the liquid sample from the ionization probe (21). A high voltage from a high voltage power supply (23) is applied to the electroconductive capillary (22) to induce corona discharge so that the components in the liquid sample are ionized by the APCI as well. At the time of tuning the ionizer, a standard sample solution is provided through the electroconductive capillary (22), and a high voltage from the high voltage power supply (23) is applied to the electroconductive capillary (22) so that components in the standard sample solution are ionized by the ESI or due to an ion molecular reaction with solvent molecular ions produced in the ionization probe (21). Thus, components in a standard sample can be ionized and subjected to mass spectrometry without pipe rearranging operations or without switch to and from different flow paths using a valve.

3. 发明授权

US09761432B2 Tandem quadrupole mass spectrometer 有权
公开(公告)号：US09761432B2
公开(公告)日：2017-09-12
申请号：US14718842
申请日：2015-05-21
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/4215 , G01N30/7266 , H01J49/004 , H01J49/005 , H01J49/24
摘要： A dwell time calculation table (51a) showing a correspondence relation between a CID gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the CID gas pressure becomes higher, the dwell time becomes longer. When an instruction to execute an MRM measurement mode is given, the controller (50) determines the dwell time in accordance with the currently set CID gas pressure, and controls a data collector (41) to accumulate detection signals from an ion detector (34) during the determined dwell time and obtain the accumulated value. If the CID gas pressure inside the collision cell (31) is high, a decrease in ion speed becomes remarkable, and the rising of the ion intensity becomes slow. However, if the dwell time becomes long, influences of the slow rising on the accumulated value are relatively reduced, and the accuracy of the accumulated value is enhanced. Accordingly, the quantitative accuracy can be enhanced.

4. 发明授权

US10935528B2 Analysis device 有权
公开(公告)号：US10935528B2
公开(公告)日：2021-03-02
申请号：US16307650
申请日：2016-06-28
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Jun Watanabe
IPC分类号： G01N30/86 , G01N30/72 , G01N30/88 , G01N30/62
摘要： The detection of minute amounts of components that have been undetectable due to an influence of a mobile phase or reagents or the like added to the mobile phase is realized in LC-MS. At the outset, blank measurement is executed, and an m/z value MBG of a background signal derived from a mobile phase or the like is extracted on a mass spectrum obtained by the blank measurement (S2-S4). An analysis method is then created that executes scanning measurement in a plurality of divided m/z ranges in which the m/z value MBG of the background signal has been excluded from a predetermined m/z range. An LC/MS analysis of the target sample is executed according to the analysis method (S5-S6). When a total ion chromatogram (TIC) is created from data obtained by the LC/MS analysis, influence of the background signal hardly appears in the TIC, and the base line is lowered.

5. 发明授权

US11189478B2 Mass spectrometer 有权
公开(公告)号：US11189478B2
公开(公告)日：2021-11-30
申请号：US16771397
申请日：2018-02-07
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Kota Nagasao
IPC分类号： H01J49/42 , H01J49/40 , H01J49/24 , H01J49/10
摘要： Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). The fixation band (53) has a coating film layer (532) formed by a black nickel plating process on the entire surface of a main member (531) made from phosphor bronze. The coating film layer (532) has high emissivity, and thus heat transferred from the rod holder (51) to the fixation band (53) is efficiently radiated into the vacuum housing (1). Therefore, heat generated in the rod holder (51) due to dielectric loss is efficiently dissipated, and deformation of the rod holder can be reduced.

6. 发明授权

US11139158B2 Mass spectrometer including a fixation band 有权
公开(公告)号：US11139158B2
公开(公告)日：2021-10-05
申请号：US16771547
申请日：2018-02-07
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Kota Nagasao
IPC分类号： H01J49/42 , H01J49/24 , H01J49/06
摘要： Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). The fixation band (53) is made from phosphor bronze having higher thermal conductivity than thermal conductivity of stainless steel or the like. Therefore, heat generated in the rod holder (51) due to dielectric loss is not only directly transmitted to the holder sustaining stand (52), but also efficiently transmitted to the holder sustaining stand (52) through the fixation band (53). With this, the heat of the rod holder (51) is efficiently dissipated, and non-uniformity of temperature of the rod holder can be reduced.

7. 发明授权

US09466474B2 Triple quadrupole mass spectrometer 有权
标题翻译：三重四极杆质谱仪
公开(公告)号：US09466474B2
公开(公告)日：2016-10-11
申请号：US14909764
申请日：2013-08-08
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/26 , H01J49/42 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/005 , H01J49/06 , H01J49/24
摘要： The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an MRM measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound. Based on the approximate equation read from the storage section, an optimum collision-gas pressure calculator determines the optimum collision-gas pressure for the specified precursor ion or product ion, and sets this pressure as a measurement condition for the apparatus.
摘要翻译：本发明的三重四极杆质谱仪确定了前体离子或产物离子的质荷比等参数与在MRM测量中给出最高信号强度的最佳碰撞气体压力之间的关系，导出表示该关系的近似式，并将表示该方程的信息存储在最佳碰撞气体压力计算信息存储部中。当进行测量时，分析算子输入目标化合物的前体离子或产物离子的质荷比。基于从存储部分读取的近似方程，最佳碰撞气体压力计算器确定用于指定的前体离子或产物离子的最佳碰撞气体压力，并将该压力设定为该装置的测量条件。

8. 发明授权

US11367609B2 Mass spectrometer 有权
公开(公告)号：US11367609B2
公开(公告)日：2022-06-21
申请号：US17262259
申请日：2018-09-13
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda
IPC分类号： H01J49/42 , H01J49/06 , H01J49/16 , H01J49/24
摘要： A mass spectrometer adopting a configuration of a multi-stage differential evacuation system appropriately performs optimization of a direct-current voltage applied to a plurality of ion optical elements for transporting ions. An auto-tuning controller acquires intensity data of ions derived from a predetermined component while changing a direct-current voltage applied to ion guides and the like, and searches for a direct-current voltage at which the intensity is maximized. When the direct-current voltage applied to a certain ion optical element is changed at the time of automatic adjustment, the direct-current voltage applied to all the ion optical elements thereafter is also changed by the same amount. Since the direct-current voltage difference between two adjacent ion optical elements always changes at only one point, the direct-current potential difference can be determined so as to optimize the ion passage efficiency.

9. 发明授权

US11043371B2 Mass spectrometer 有权
公开(公告)号：US11043371B2
公开(公告)日：2021-06-22
申请号：US16771396
申请日：2018-02-07
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Kota Nagasao
IPC分类号： H01J49/06 , H01J49/24 , H01J49/42 , C25D3/12 , C25D11/14
摘要： Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by two rod holders (51). The rod holders (51) are attached to metal holder sustaining stands (52) provided on a bottom surface of a vacuum housing (1). A coating film layer (10) is formed by a black nickel plating process on parts of wall surfaces in the vacuum housing (1), an inlet lens (4), and an outlet lens (6), the parts facing a quadrupole mass filter unit (5). The emissivity of the coating film layer (10) is higher than that of Al or the like, and thus radiant heat from the quadrupole mass filter unit (5) is efficiently absorbed by the coating film layer (10). Therefore, heat generated in the rod holders (51) due to dielectric loss is efficiently dissipated, and deformation of the rod holders can be reduced.

10. 发明授权

US10763095B2 Ionizer and mass spectrometer system 有权
公开(公告)号：US10763095B2
公开(公告)日：2020-09-01
申请号：US16090932
申请日：2016-06-02
申请人： SHIMADZU CORPORATION
发明人： Manabu Ueda , Wataru Fukui
IPC分类号： H01J49/04 , G01N30/72 , H01J49/16 , G01N30/02 , H01J49/42
摘要： In the mass spectrometer system, a tip portion of a cylindrical portion (891) of a capillary (89) is coated with a coating material (892), the tip portion being an injection part for injecting a sample solution to an ionization section. Therefore, it is possible to suppress, by the coating material (892), the deformation of the capillary (89) when the sample solution is injected. In addition, it is possible to suppress the corrosion and the deformation of the capillary (89) by the coating material (892). As a result, the stability of the analysis operation in mass spectrometer system (1) can be improved.

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