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81. 发明申请

US20040230057A1 Dye for optical recording medium 审中-公开
标题翻译：光记录介质用染料
公开(公告)号：US20040230057A1
公开(公告)日：2004-11-18
申请号：US10820600
申请日：2004-04-07
发明人： Chao-Nan Kuo , Sung-Kuei Chiang
IPC分类号： C07D209/56 , G11B007/24 , C07D453/02
CPC分类号： G11B7/2472 , C07D401/06 , G11B7/2533 , G11B7/2534 , G11B7/2535 , G11B7/2538
摘要： An optical recording medium dye has the following structure (1): 1 wherein A is an aromatic group or a polycyclic aromatic group; B1 is a hydrogen atom, a hydroxyl group, an alkyloxy group, a halogen, a nitro group, a nitroso group, a substituted and unsubstituted amine group, a substituted or unsubstituted sulfamoyl group (nullSO2NH2); R1, R2 are same or different, substituted or unsubstituted, straight chain or branched alkyl group, alkenyl group, aralkyl group, alkoxycarbonyl group, alkoxycarboxyl group, alkoxyl group, alkyl hydroxyl group, alkylamino group, alkylcarbamoyl group, alkylsulfamoyl group, alkylalkoxyl group, alkyl halide group, alkylsulfonyl group or alkylcarboxyl group; and Xnull is anion.
摘要翻译：光记录介质染料具有以下结构（1）：其中A是芳族基团或多环芳族基团; B1为氢原子，羟基，烷氧基，卤素，硝基，亚硝基，取代或未取代的胺基，取代或未取代的氨磺酰基（-SO2NH2）。 R1，R2相同或不同，取代或未取代的直链或支链烷基，烯基，芳烷基，烷氧基羰基，烷氧基羧基，烷氧基，烷基羟基，烷基氨基，烷基氨基甲酰基，烷基氨磺酰基，烷基烷氧基，烷基卤基，烷基磺酰基或烷基羧基; 而X - 为阴离子。

82. 发明申请

US20030186077A1 Bis- and tris- (di) benzocarbazole-based materials as hole transport materials for organic light emitting devices 审中-公开
标题翻译：双 - 和三（二）苯并咔唑类材料作为有机发光器件的空穴传输材料
公开(公告)号：US20030186077A1
公开(公告)日：2003-10-02
申请号：US10029936
申请日：2001-12-31
发明人： Jian P. Chen
IPC分类号： H05B033/12 , C07D209/56 , C07D49/00
CPC分类号： H01L51/0061 , C07D209/80 , H01L51/0067 , H01L51/0071 , H01L51/5012 , H01L51/5048
摘要： Compounds according to Formula I 1 wherein one or two of Ar1-4 are present, R is selected from the group consisting of H, CH3, OCH3 or halogen, and Ar is an aryl bridge. Such compounds are suitable for use in organic light-emitting devices. These compounds exhibit both hole transport and emissive properties and have a high glass transition temperature and thermal stability.
摘要翻译：其中存在一个或两个Ar1-4的根据式I的化合物，R选自H，CH 3，OCH 3或卤素，Ar是芳基桥。这些化合物适用于有机发光装置。这些化合物表现出空穴传输和发射性质，并且具有高的玻璃化转变温度和热稳定性。

83. 发明申请

US20030153763A1 Pharmaceutically active compounds and methods of use 失效
公开(公告)号：US20030153763A1
公开(公告)日：2003-08-14
申请号：US10321402
申请日：2002-12-17
发明人： N. Laxma Reddy , Michael Maillard , David Berlove , Sharad Magar , Graham J. Durant
IPC分类号： C07D45/02 , C07D403/02 , C07D209/56
CPC分类号： C07D209/08 , C07D209/90 , C07D209/92 , C07D215/08 , C07D215/12 , C07D221/12 , C07D223/22 , C07D225/08 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/36 , C07D277/62 , C07D279/16 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benznullcdnullindolinyl and 5,6-dihydrophenanthridinyl compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

84. 发明授权

US6136612A Sulfo benz[E]indocyanine flourescent dyes 失效
标题翻译：磺化苯并[E]靛蓝荧光染料
公开(公告)号：US6136612A
公开(公告)日：2000-10-24
申请号：US43767
申请日：1998-06-18
申请人： Leopoldo Della Ciana , Andrea Grignani , Mariacristina Cassullo , Giuseppe Caputo
发明人： Leopoldo Della Ciana , Andrea Grignani , Mariacristina Cassullo , Giuseppe Caputo
IPC分类号： C09B23/01 , C09B23/02 , G01N33/533 , C07D209/56
CPC分类号： G01N33/533 , C09B23/0066 , C09B23/02 , Y10S436/80 , Y10S436/817
摘要： The present invention is directed to fluorescent dyes and its valence tautomers of the formula wherein Q represents a conjugated moiety that increases the fluorescent quantum yield of the compound; R.sub.1 is a functionalized group of the formula--(CH.sub.2).sub.j Y, wherein Y is selected from the group consisting of SO.sub.3 H, COOH, NH.sub.2, CHO, NCS, epoxy, phthalimido, and COOZ, wherein Z represents a leaving group; R.sub.2 is a functionalized group of the formula --(CH.sub.2).sub.k Y', wherein Y' is selected from the group consisting of SO.sub.3 H, COOH, NH.sub.2, CHO, NCS, epoxy, phthalimido, and COOZ, wherein Z represents a leaving group; M.sup.+ is a counterion selected from the group consisting of ammonium, alkali metal cations, and alkaline earth metal cations; n=1 to 4; m=1 to 4; j=2 to 10; and k=2 to 10.
摘要翻译： PCT No.PCT / EP96 / 04377 371日期：1998年5月11日 102（e）日期1998年5月11日PCT提交1996年10月8日PCT公布。公开号WO97 / 13810PC。日期1997年04月17日本发明涉及下式的荧光染料及其价态互变异构体：其中Q表示增加化合物的荧光量子产率的共轭部分; R 1是式 - （CH 2）j Y的官能化基团，其中Y选自SO 3 H，COOH，NH 2，CHO，NCS，环氧，邻苯二甲酰亚氨基和COOZ，其中Z表示离去基团; R2是式 - （CH2）kY'的官能化基团，其中Y'选自SO 3 H，COOH，NH 2，CHO，NCS，环氧，邻苯二甲酰亚氨基和COOZ，其中Z表示离去基团; M +是选自铵，碱金属阳离子和碱土金属阳离子的抗衡离子; n = 1〜4; m = 1〜4; j = 2〜10; k = 2〜10。

85. 发明授权

US6060608A Analogs of CC-1065 and the duocarmycins 失效
标题翻译： CC-1065和duocarmins的类似物
公开(公告)号：US6060608A
公开(公告)日：2000-05-09
申请号：US194467
申请日：1999-09-07
申请人： Dale L. Boger
发明人： Dale L. Boger
IPC分类号： C07D209/94 , C07D209/96 , C07D403/06 , C07D417/14 , C07D487/10 , C07D209/56 , C07D417/04 , C07D487/04
CPC分类号： C07D403/06 , C07D209/94 , C07D209/96 , C07D417/14 , C07D487/10
摘要： Analogs of antitumor antibiotics CC-1065 and the duocarmycins are synthesized which possess systematic and extensive modifications in the DNA binding subunits attached to a 1,2,9,9a-tetra-hydro-cyclo-propa[c]benz[e]indol-4-one (CBI) alkylation subunit. The analogs have potent cytotoxic activity and are efficacious antitumor compounds.
摘要翻译： PCT No.PCT / US97 / 09076 Sec。 371 1999年9月7日第 102（e）1999年9月7日PCT PCT 1997年5月30日PCT公布。公开号WO97 / 45411 PCT 日期1997年12月4日合成抗肿瘤抗生素CC-1065和二十多环素的分析物，其与连接于1,2,9,9a-四氢 - 环 - 丙酸[c]苯的DNA结合亚基具有系统和广泛的修饰 [e]吲哚-4-酮（CBI）烷基化亚基。类似物具有有效的细胞毒活性，是有效的抗肿瘤化合物。

86. 发明授权

US5936127A Asymmetric synthesis and catalysis with chiral heterocyclic compounds 失效
标题翻译：用手性杂环化合物进行不对称合成和催化
公开(公告)号：US5936127A
公开(公告)日：1999-08-10
申请号：US6178
申请日：1998-01-13
申请人： Xumu Zhang
发明人： Xumu Zhang
IPC分类号： C07D333/76 , B01J31/02 , C07B53/00 , C07D209/80 , C07D209/86 , C07D209/94 , C07D333/50 , C07D333/78 , C07D487/18 , C07D495/14 , C07D519/00 , C07F9/6568 , C07F9/02 , B01J31/00 , C07D209/56
CPC分类号： C07D209/80 , B01J31/0218 , B01J31/0237 , B01J31/0267 , C07B53/00 , C07C403/20 , C07C67/347 , C07D209/86 , C07D209/94 , C07D333/50 , C07D333/78 , C07F9/65683 , B01J2231/32 , B01J2231/324 , C07B2200/07 , C07C2101/08 , C07C2101/14
摘要： This invention relates to chiral heterocyclic compounds useful for asymmetric synthesis and catalysis. More particularly, the invention relates to chiral heterocyclic phosphine, sulfur, and nitrogen compounds for asymmetric synthesis and catalysis in the production of enantiomerically pure products.
摘要翻译：本发明涉及可用于不对称合成和催化的手性杂环化合物。更具体地说，本发明涉及用于不对称合成和催化制备对映体纯产物的手性杂环膦，硫和氮化合物。

87. 发明授权

US5849781A Tricyclic amides 失效
公开(公告)号：US5849781A
公开(公告)日：1998-12-15
申请号：US942177
申请日：1997-10-01
申请人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
发明人： Michel Langlois , Monique Mathe-Allainmat , Philippe Delagrange , Pierre Renard , Beatrice Guardiola
IPC分类号： A61K31/16 , A61K31/165 , A61K31/17 , A61K31/38 , A61K31/381 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C231/14 , C07C233/06 , C07C233/23 , C07C233/25 , C07C233/32 , C07C233/54 , C07C233/58 , C07C233/60 , C07C273/18 , C07C275/26 , C07C327/42 , C07D209/90 , C07D307/92 , C07D333/74 , A61K31/34 , A61K31/40 , C07D209/56 , C07D307/77
CPC分类号： C07D307/92 , C07C233/06 , C07C233/23 , C07C233/58 , C07C233/60 , C07D209/90 , C07D333/74 , C07C2101/02 , C07C2101/04 , C07C2103/24 , C07C2103/26 , C07C2103/28
摘要： The invention relates to a compound selected from these of formula (I): ##STR1## in which R.sub.7, R.sub.8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.

88. 发明授权

US5756320A Bioactive substances K93-0711 I-1 and I-2 and process for production thereof 失效
标题翻译：生物活性物质K93-0711 I-1和I-2及其生产方法
公开(公告)号：US5756320A
公开(公告)日：1998-05-26
申请号：US785767
申请日：1997-01-21
申请人： Satoshi Omura , Kanki Komiyama , Masahiko Hayashi , Satoshi Takamatsu
发明人： Satoshi Omura , Kanki Komiyama , Masahiko Hayashi , Satoshi Takamatsu
IPC分类号： C12P1/06 , A61K35/74 , A61P35/00 , A61P43/00 , C07D491/04 , C07D491/048 , C07G99/00 , C12N1/20 , C12P17/18 , C12R1/465 , C12P17/00 , C07D209/56 , C12P17/16 , C12P1/20
CPC分类号： C07D491/04 , C12P17/18 , Y10S435/886
摘要： Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis.
摘要翻译：通过在培养基中培养属于链霉菌属的微生物来生产对IL-6活性具有抑制作用的生物活性物质K93-0711 I-1和I-2，由此生物活性物质K93-0711 I-1和I-2 在介质中积累。然后从中分离出这些生物活性物质K93-0711 I-1和I-2。这些物质对于治疗涉及IL-6的疾病如癌症恶病质，多发性骨髓瘤和类风湿性关节炎是有效的。

89. 发明授权

US5753669A Quinolone--and naphthyridonecarboxylic acid derivatives 失效
标题翻译：喹诺酮和萘啶酮羧酸衍生物
公开(公告)号：US5753669A
公开(公告)日：1998-05-19
申请号：US764548
申请日：1996-12-12
申请人： Uwe Peterson , Thomas Schenke , Thomas Jaetsch , Stephan Bartel , Klaus Dieter Bremm , Rainer Endermann , Karl Georg Metzger
发明人： Uwe Peterson , Thomas Schenke , Thomas Jaetsch , Stephan Bartel , Klaus Dieter Bremm , Rainer Endermann , Karl Georg Metzger
IPC分类号： C07D215/56 , A01N43/42 , A01N43/90 , A61K31/40 , A61K31/47 , A61K31/495 , A61K31/535 , A61P31/04 , C07D209/56 , C07D209/90 , C07D215/233 , C07D221/02 , C07D401/04 , C07D471/04 , C07D498/06 , C07D513/04 , C07D513/06 , C07D513/16 , A61K31/435
CPC分类号： C07D401/04 , C07D471/04 , C07D498/06 , C07D513/04 , C07D513/16
摘要： The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a tricyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds.
摘要翻译：本发明涉及通过三环胺基，其盐，其制备方法和包含这些化合物的抗菌组合物在7位上被取代的新的喹诺酮和萘啶酮羧酸衍生物。

90. 发明授权

US5650427A Centrally acting 6,7,8,9-tetrahydro-3H-benz(e) indole heterocyclics 失效
标题翻译：中心作用的6,7,8,9-四氢-3H-苯并（e）吲哚杂环
公开(公告)号：US5650427A
公开(公告)日：1997-07-22
申请号：US460449
申请日：1995-06-02
申请人： Hakan Vilhelm Wikstrom , Per Arvid Emil Carlsson , Bengt Ronny Andersson , Kjell Anders Ivan Svensson , Stig Thomas Elebring , Nils Peter Stjernlof , Arthur Glenn Romero , Susanne R. Haadsma-Svensson , Chiu-Hong Lin , Michael Dalton Ennis
发明人： Hakan Vilhelm Wikstrom , Per Arvid Emil Carlsson , Bengt Ronny Andersson , Kjell Anders Ivan Svensson , Stig Thomas Elebring , Nils Peter Stjernlof , Arthur Glenn Romero , Susanne R. Haadsma-Svensson , Chiu-Hong Lin , Michael Dalton Ennis
IPC分类号： A61K31/40 , A61K31/403 , A61K31/407 , A61K31/435 , A61K31/4427 , A61K31/4433 , A61K31/454 , A61K31/475 , A61P11/14 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D209/56 , C07D209/60 , C07D209/66 , C07D401/06 , C07D401/12 , C07D403/04 , C07D409/12 , C07D413/04 , C07D471/04 , C07D491/04 , C07D491/052 , C07D495/04
CPC分类号： C07D401/12 , C07D209/66 , C07D409/12 , C07D491/04
摘要： A compound of Formula I ##STR1## or pharmaceutically acceptable salts of Formula I, where R.sup.1 is H, C.sub.1 -C.sub.3 alkyl, --(CH.sub.2).sub.n CONH.sub.2 where n is 2 to 6, (CH2).sub.n -1-(4,4-dimethylpiperidine-2,6-dione-yl), or cyclopropylmethyl;R.sup.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl or combined with R.sup.1 to form a C.sub.3 -C.sub.8 cycloalkyl, C.sub.2 -C.sub.8 alkenyl, C.sub.2 -C.sub.8 akynyl, (CH.sub.2).sub.n --X--Ar where X is O, S, or NH, 3,3,3-trifluoropropyl, --(CH.sub.2).sub.m --R.sup.9 where m is 2 or 3 and R.sup.9 is phenyl, 2-thiophenyl or 3-thiophenyl; R.sup.3 is hydrogen, C.sub.1 -C.sub.3 alkyl, 2,2,2-trifluoroethyl, 3,3,3-trifluoropropyl, formyl, CN, halogen, CH.sub.2 OR.sup.2, C(O)C(O)OR.sup.1, C(O)CO NR.sup.1 R.sup.2, --(CH.sub.2).sub.q --NR.sup.1 R.sup.2 where q is 0 to 5, C.dbd.NOR.sup.2, 2(4,5-dihydro)oxazolyl, or COR.sup.10 where R.sup.10 is H, R.sup.1, NR.sup.1 R.sup.2 or CF.sub.3 ; R.sup.4 is hydrogen, C.sub.1 -C.sub.3 alkyl, cyclopropylmethyl, CF.sub.3, 2,2,2-trifluoroethyl, CN, CONR.sup.1 R.sup.2, .dbd.O, 2(4,5-dihydro)imidazolyl, 2(4,5-dihydro)oxazolyl, 2-oxazolyl, 3-oxadiazolyl, or 3,3,3-trifluoropropyl; R.sup.5 is hydrogen, R.sup.1, OCH.sub.3, C(O)CH.sub.3 or C(O)OR.sup.1 ; X is (a) a valence bond, (b) CH.sub.2, or (c) O, S or NR.sup.5 where R.sup.5 is H, C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, benzyl, COR.sup.6 where R.sup.6 is a C.sub.1 -C.sub.3 alkyl, phenyl, or CONR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are independently H or C.sub.1 -C.sub.3 alkyl; andZ is a hydrogen or halogen; provided that when X is CH.sub.2, at least one of R.sub.3 and R.sub.4 is other than hydrogen or C.sub.1 -C.sub.3 alkyl. The compounds of Formula I are suitable for treating disorders of the central nervous system, particularly as 5-HT.sub.1A receptor agonists.
摘要翻译：其中R1为H，C1-C3烷基， - （CH2）nCONH2，其中n为2-6，（CH2）n-1-（4,4-二甲氧基苯基）二甲基哌啶-2,6-二酮基）或环丙基甲基; R2是氢，C1-C8烷基，C3-C8环烷基或与R1结合以形成C 3 -C 8环烷基，C 2 -C 8烯基，C 2 -C 8炔基，（CH 2）n X-Ar，其中X是O，S或NH ，3,3,3-三氟丙基， - （CH 2）m -R 9，其中m为2或3，R 9为苯基，2-噻吩基或3-噻吩基; R3是氢，C1-C3烷基，2,2,2-三氟乙基，3,3,3-三氟丙基，甲酰基，CN，卤素，CH2OR2，C（O）C（O）OR1，C（O） - （CH2）q-NR1R2其中q为0至5，C = NOR2,2（4,5-二氢）恶唑基或COR 10，其中R 10为H，R 1，NR 1 R 2或CF 3; R4是氢，C1-C3烷基，环丙基甲基，CF3,2,2,2-三氟乙基，CN，CONR1R2，= 2,2（4,5-二氢）咪唑基，2（4,5-二氢）恶唑基，恶唑基，3-恶二唑基或3,3,3-三氟丙基; R5是氢，R1，OCH3，C（O）CH3或C（O）OR1; X是（a）价键，（b）CH 2或（c）O，S或NR 5，其中R 5是H，C 1 -C 8烷基，C 3 -C 8环烷基，苄基，COR 6，其中R 6是C 1 -C 3烷基，苯基或CONR 7 R 8，其中R 7和R 8独立地为H或C 1 -C 3烷基; Z为氢或卤素; 条件是当X是CH 2时，R 3和R 4中的至少一个不是氢或C 1 -C 3烷基。式I化合物适用于治疗中枢神经系统疾病，特别是5-HT 1A受体激动剂。

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