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1. 发明申请

US20180179142A1 Novel process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione 审中-公开
公开(公告)号：US20180179142A1
公开(公告)日：2018-06-28
申请号：US15904464
申请日：2018-02-26
申请人： Boehringer Ingelheim International GmbH
发明人： Xiangle JIN , Weitong DONG , Yan FU , Jun LU , Le XIE , Wei XU , Jinsong YANG , Qian ZHU
IPC分类号： C07C69/608 , C07C45/54 , C07C45/67 , C07C59/205 , C07C69/716 , C07C69/757 , C07C67/347
CPC分类号： C07C69/608 , C07C45/54 , C07C45/673 , C07C59/205 , C07C67/347 , C07C69/716 , C07C69/757 , C07C2601/02 , C07C2601/04 , C07C2602/50 , C07C49/443
摘要： This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

2. 发明授权

US09938228B2 Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione 有权
公开(公告)号：US09938228B2
公开(公告)日：2018-04-10
申请号：US15509504
申请日：2015-08-28
申请人： Boehringer Ingelheim International GmbH
发明人： Xiangle Jin , Weitong Dong , Yan Fu , Jun Lu , Le Xie , Wei Xu , Jinsong Yang , Qian Zhu
IPC分类号： C07C69/74 , C07C69/608 , C07C69/757 , C07C69/716 , C07C67/347 , C07C59/205 , C07C45/67 , C07C45/54
CPC分类号： C07C69/608 , C07C45/54 , C07C45/673 , C07C59/205 , C07C67/347 , C07C69/716 , C07C69/757 , C07C2601/02 , C07C2601/04 , C07C2602/50 , C07C49/443
摘要： This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.

3. 发明申请

US20180015317A1 USE OF METAL-ACCUMULATING PLANTS FOR THE PREPARATION OF CATALYSTS THAT CAN BE USED IN CHEMICAL REACTIONS 审中-公开
公开(公告)号：US20180015317A1
公开(公告)日：2018-01-18
申请号：US15661232
申请日：2017-07-27
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
发明人： Claude GRISON , Jose ESCARRE
IPC分类号： A62D3/35 , C07D239/22 , B01J23/06 , B01J23/72 , B01J23/755 , C07C2/86 , C07C209/32 , C07C67/347 , C07C67/02 , C07C45/00 , C07C41/30 , C07C29/62 , C07C17/16 , C07F1/08 , A62D101/04
CPC分类号： A62D3/35 , A62D2101/04 , B01J23/06 , B01J23/72 , B01J23/755 , C07C2/861 , C07C17/16 , C07C29/62 , C07C41/30 , C07C45/00 , C07C67/02 , C07C67/347 , C07C209/32 , C07C2523/04 , C07C2527/122 , C07C2527/128 , C07C2527/138 , C07D239/22 , C07F1/08 , C07C31/36
摘要： A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

4. 发明授权

US09751821B1 Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound 有权
公开(公告)号：US09751821B1
公开(公告)日：2017-09-05
申请号：US15586913
申请日：2017-05-04
申请人： NISSAN CHEMICAL INDUSTRIES, LTD.
发明人： Manabu Yaosaka , Tomohisa Utsunomiya , Yuji Moriyama , Tomohiro Matsumoto , Kazutaka Matoba
IPC分类号： C07C45/72 , C07D413/14 , C07C51/367 , C07C231/12 , C07D213/04 , C07C67/343 , C07D249/08 , C07D233/60 , C07D401/04 , C07D413/12
CPC分类号： C07C45/72 , C07C45/66 , C07C45/74 , C07C49/83 , C07C49/835 , C07C51/353 , C07C51/367 , C07C51/377 , C07C65/40 , C07C67/327 , C07C67/343 , C07C67/347 , C07C69/65 , C07C231/12 , C07C253/30 , C07C319/20 , C07D213/30 , C07D213/50 , C07D213/61 , C07D233/14 , C07D249/08 , C07D261/04 , C07D401/04 , C07C323/22 , C07C235/84 , C07C255/56 , C07C69/76 , C07C49/813 , C07C65/38
摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

5. 发明授权

US09718741B2 Organic compounds 有权
公开(公告)号：US09718741B2
公开(公告)日：2017-08-01
申请号：US15031158
申请日：2014-10-24
申请人： Givaudan, S.A. , Amyris Inc.
发明人： Fridtjof Schroeder , Fabian Ruethi
IPC分类号： C07C261/00 , C07C269/00 , C07C271/00 , C07B37/02 , C07C67/347 , C07B37/08 , C07C2/86 , C07C45/69 , C07C41/30 , B01J31/22
CPC分类号： C07B37/02 , B01J31/2213 , B01J2231/324 , B01J2531/824 , C07B37/08 , C07C2/86 , C07C41/30 , C07C45/69 , C07C49/553 , C07C67/347 , C07C2531/22 , C07C2601/02 , C07C2601/16 , C07C2602/50 , C07C13/04 , C07C69/608 , C07C43/21
摘要： A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.

6. 发明授权

US09676692B2 Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound 有权
公开(公告)号：US09676692B2
公开(公告)日：2017-06-13
申请号：US14584642
申请日：2014-12-29
申请人： NISSAN CHEMICAL INDUSTRIES, LTD.
发明人： Manabu Yaosaka , Tomohisa Utsunomiya , Yuji Moriyama , Tomohiro Matsumoto , Kazutaka Matoba
IPC分类号： C07C45/72 , C07C51/353 , C07C231/12 , C07D213/04 , C07C67/343 , C07D249/08 , C07D233/60 , C07D401/04 , C07D413/12 , C07D413/14 , C07C67/327 , C07C45/66 , C07C45/74 , C07C51/367 , C07C51/377
CPC分类号： C07C45/72 , C07C45/66 , C07C45/74 , C07C49/83 , C07C49/835 , C07C51/353 , C07C51/367 , C07C51/377 , C07C65/40 , C07C67/327 , C07C67/343 , C07C67/347 , C07C69/65 , C07C231/12 , C07C253/30 , C07C319/20 , C07D213/30 , C07D213/50 , C07D213/61 , C07D233/14 , C07D249/08 , C07D261/04 , C07D401/04 , C07C323/22 , C07C235/84 , C07C255/56 , C07C69/76 , C07C49/813 , C07C65/38
摘要： There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.

7. 发明申请

US20170088504A1 BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：US20170088504A1
公开(公告)日：2017-03-30
申请号：US15127969
申请日：2015-03-27
申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.
发明人： Takashi MOTOI , Mitsuharu KITAMURA , Manabu HIRAKAWA
IPC分类号： C07C69/757 , C07C29/141 , C07C45/50 , C07C67/347 , C07C47/347
CPC分类号： C07C69/757 , C07C29/141 , C07C29/149 , C07C45/50 , C07C47/347 , C07C67/347 , C07C2603/86 , C08G64/0208 , C07C31/278
摘要： The present invention is able to provide a bifunctional compound represented by formula (1). (In the formula, R1 represents COOCH3, COOC2H5, COOC3H7, COOC4H9 or CHO; and R2 represents H, CH3 or C2H5.)

8. 发明授权

US09527797B1 Isomer-selective synthesis of methanofullerenes 有权
标题翻译：异构体选择性合成甲基富勒烯
公开(公告)号：US09527797B1
公开(公告)日：2016-12-27
申请号：US15073335
申请日：2016-03-17
申请人： Nano-C, Inc.
发明人： Edward A. Jackson , Henning Richter
IPC分类号： C07C67/317 , C07C69/618 , C07C321/20
CPC分类号： C07C67/317 , C07C67/347 , C07C69/618 , C07C321/20 , C07C381/12 , C07C2104/00 , C07C2604/00
摘要： [6,6]-Phenyl C71 butyric acid derivatives (C70-PCBR3) having a selectivity of greater than 95 wt % of the α-isomer are provided by reacting fullerene C70 with a dialkyl sulfonium tetrafluoroborate having the formula:

9. 发明申请

US20160152539A1 PHOSPHORAMIDITE DERIVATIVES IN THE HYDROFORMYLATION OF UNSATURATED COMPOUNDS 审中-公开
标题翻译：不饱和化合物的氢化反应中的磷酰胺衍生物
公开(公告)号：US20160152539A1
公开(公告)日：2016-06-02
申请号：US14906644
申请日：2014-07-22
申请人： EVONIK DEGUSSA GMBH
发明人： Katrin Marie DYBALLA , Robert FRANKE , Dirk FRIDAG , Eduard BENETSKIY , Armin BÖRNER , Detlef SELENT
IPC分类号： C07C45/50 , B01J31/18 , C07B41/06 , C07F15/00 , C07F9/6571
CPC分类号： C07C45/50 , B01J31/02 , B01J31/186 , B01J2231/321 , B01J2531/821 , B01J2531/822 , B01J2531/827 , B01J2531/845 , C07B41/06 , C07C67/347 , C07F9/657154 , C07F15/0073 , C07C69/716 , C07C47/02
摘要： The invention relates to: a) phosphoramidites of formula (I), wherein Q is selected from substituted or unsubstituted 1,1′-biphenyl groups, R1 stands for hydrogen, and R2 stands for C1-C10 alkyl groups, substituted or unsubstituted C4-C6 cycloalkyl groups, or phenyl groups and wherein R2 is not a tertiary butyl group; b) transition-metal-containing compounds of the formula Me(acac)(CO)L, wherein Me=transition metal and L of the general formula (II): wherein Q is selected from substituted or unsubstituted 1,1′-biphenyl groups, R1 stands for hydrogen, R2 stands for C1-C10 alkyl groups, substituted or unsubstituted C4-C6 cycloalkyl groups, or phenyl groups, and R2 is not a tertiary butyl group and wherein the transition metal Me is selected from ruthenium, cobalt, rhodium, and iridium; c) catalytically active compositions in the hydroformylation, which comprise the compounds mentioned under a) and b); d) method for the hydroformylation of unsaturated compounds by using the catalytically active composition mentioned under c), and e) multi-phase reaction mixture, containing unsaturated compounds, gas mixture, which comprises carbon monoxide and hydrogen, aldehydes, and the catalytically active composition described under c).
摘要翻译：本发明涉及：a）式（I）的亚磷酰胺，其中Q选自取代或未取代的1,1'-联苯基，R1代表氢，R2代表C1-C10烷基，取代或未取代的C4- C6环烷基或苯基，其中R2不是叔丁基; b）式Me（acac）（CO）L的过渡金属的化合物，其中Me =过渡金属和通式（II）的L：其中Q选自取代或未取代的1,1'-联苯基，R1代表氢，R2代表C1-C10烷基，取代或未取代的C4-C6环烷基或苯基，R2不是叔丁基，其中过渡金属Me选自钌，钴，铑，铱; c）加氢甲酰化中的催化活性组合物，其包含a）和b）下提及的化合物; d）通过使用c）所述的催化活性组合物来加氢甲酰化不饱和化合物的方法，以及e）包含不饱和化合物的多相反应混合物，包含一氧化碳和氢气，醛和催化活性组合物的气体混合物描述在c）。

10. 发明授权

US09312041B2 Photolabile pro-fragrances 有权
标题翻译：不透明亲香料
公开(公告)号：US09312041B2
公开(公告)日：2016-04-12
申请号：US14140608
申请日：2013-12-26
申请人： Henkel AG & Co. KGaA
发明人： Thomas Gerke , Christian Kropf , Ursula Huchel , Axel Griesbeck , Olga Mayer
IPC分类号： C11D3/50 , G21K5/00 , A61K8/368 , A61K8/37 , A61Q13/00 , C07C65/38 , C07C69/76 , C07C67/347
CPC分类号： C11D3/50 , A61K8/368 , A61K8/37 , A61K2800/10 , A61Q13/00 , C07C45/673 , C07C65/38 , C07C67/347 , C07C69/76 , C07C2601/16 , C11D3/2072 , C11D3/507 , G21K5/00
摘要： Fragrances having a fresh character are usually very volatile and therefore not very economical in typical applications such as washing or cleaning processes for example. For that reason they have to be used in relatively large amounts in order to bring about appropriate effects. The present invention describes photolabile pro-fragrances of formula (I) that allow for a greatly improved persistence of the fragrance impression, in particular one having a fresh character, in typical applications. Said pro-fragrances attach very readily to target substrates, such as textiles for example. A more economical use of the fragrances in question can be ensured in this way.
摘要翻译：具有新鲜特性的香料通常是非常易挥发的，因此在典型的应用例如洗涤或清洗方法中不是很经济。因此，为了产生适当的效果，必须使用相对较大的量。本发明描述了在典型应用中允许香味印象，特别是具有新鲜特性的香味印象的持久性大大提高的式（I）的不透光性亲香料。所述亲香料非常容易地附着到例如纺织品的目标基材上。以这种方式可以确保更经济地使用所讨论的香料。

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