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1. 发明申请

US20130344614A1 Kit 有权
公开(公告)号：US20130344614A1
公开(公告)日：2013-12-26
申请号：US13872589
申请日：2013-04-29
申请人： Eppendorf AG
发明人： Judith Lucke , Jens-Peter Kroog , Helmut Knofe
IPC分类号： G01N35/10
CPC分类号： G01N35/10 , B01L3/52 , B01L9/00 , B01L9/06 , B01L2200/16 , B01L2200/18 , B01L2300/042 , B01L2300/0609 , B01L2300/0809 , B65B5/06 , Y10S436/815 , Y10S436/817 , Y10T436/25
摘要： A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.

2. 发明申请

US20120009609A1 DEVICES AND METHODS FOR DETECTING AMNIOTIC FLUID IN VAGINAL SECRETIONS 有权
标题翻译：用于检测阴道分泌物中的有毒液体的装置和方法
公开(公告)号：US20120009609A1
公开(公告)日：2012-01-12
申请号：US13213735
申请日：2011-08-19
申请人： Boris Fuks , Dmitrii D. Petrunin , Evgeny I. Zaraisky , Marina N. Boltovskaya , Svetlana V. Nazimova , Nelly A. Starosvetskaya , Alexandr Konstantinov , Margarita I. Marshiskaia
发明人： Boris Fuks , Dmitrii D. Petrunin , Evgeny I. Zaraisky , Marina N. Boltovskaya , Svetlana V. Nazimova , Nelly A. Starosvetskaya , Alexandr Konstantinov , Margarita I. Marshiskaia
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/6854 , G01N33/558 , G01N33/577 , G01N33/689 , G01N2333/471 , G01N2800/36 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/81 , Y10S436/811 , Y10S436/815 , Y10S436/817
摘要： The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.
摘要翻译：本发明涉及一种用于检测阴道内少量羊水的诊断方法。更具体地，本发明涉及使用抗PAMG-1抗体检测阴道内PAMG-1。

3. 发明授权

US07682836B2 Selective binding materials 失效
标题翻译：选择性装订材料
公开(公告)号：US07682836B2
公开(公告)日：2010-03-23
申请号：US10381593
申请日：2001-10-04
申请人： Sergiy Anatoliyovich Piletsky , Olena Volodimirivna Piletska , Khalku Karim , Anthony Peter Francis Turner , Alessandra Bossi
发明人： Sergiy Anatoliyovich Piletsky , Olena Volodimirivna Piletska , Khalku Karim , Anthony Peter Francis Turner , Alessandra Bossi
IPC分类号： G01N33/551
CPC分类号： G01N33/531 , G01N2600/00 , Y10S436/815 , Y10S436/816 , Y10S436/817 , Y10S436/818 , Y10S436/901
摘要： A template (a molecule preferably of molecular size >500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or electrophoresis, or mechanically) to leave an “imprinted” frozen fluid. This is capable of selectively adsorbing the template substance. It is usable as a separation medium, a recognition element in sensors and assays, and as a catalyst.
摘要翻译：将模板（优选分子大小> 500Da的分子，或更大的实体如细胞，病毒或组织样品）溶解或悬浮在流体中。将流体冷冻，并且去除模板（例如通过溶解或电泳或机械地）以留下“印迹”的冷冻流体。这能够选择性地吸附模板物质。它可用作分离介质，传感器和测定中的识别元件以及催化剂。

4. 发明申请

US20090257915A1 PREWETTING LATERAL FLOW TEST STRIP 有权
标题翻译：预测横向流量测试条
公开(公告)号：US20090257915A1
公开(公告)日：2009-10-15
申请号：US12426777
申请日：2009-04-20
申请人： Robert K. Dinello , Alan J. Polito , Stella S. Quan
发明人： Robert K. Dinello , Alan J. Polito , Stella S. Quan
IPC分类号： G01N31/22 , B32B37/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0867 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817 , Y10T156/1089
摘要： A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added.
摘要翻译：用于检测样品中存在的分析物的测试条和方法。所述测试条包括：可以添加缓冲液的缓冲添加区; 靠近缓冲添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 位于所述一个或多个测试区域的末端缓冲液流动区域，所述吸收区域相对于所述缓冲添加区域定位，并且具有相对于所述测试条带的其它区域的吸收能力，使得当预定缓冲液测试条的体积范围被添加到缓冲添加区域中，缓冲区的远端扩散前沿从缓冲添加区扩散到末端缓冲液流动区域内的远端扩散点，然后相对于一个或多个测试区域扩散 ; 以及可以添加样品的末端缓冲液流动区域的远端的样品添加区域。

5. 发明授权

US07575861B2 Compositions and method for accurate early pregnancy diagnosis 有权
标题翻译：准确早期妊娠诊断的组成和方法
公开(公告)号：US07575861B2
公开(公告)日：2009-08-18
申请号：US10496164
申请日：2002-11-20
申请人： Matthew C. Lucy , Nagappan Mathialagan
发明人： Matthew C. Lucy , Nagappan Mathialagan
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , G01N33/743 , G01N2800/368 , Y10S436/814 , Y10S436/817
摘要： The invention provides improved assays for detection of pregnancy. In the assays, pregnancy associated glycoproteins are analyzed in conjunction with progesterone analysis. The techniques of the invention overcome limitations in the prior art by reducing the rate of false positive results. The assays provided by the invention can be implemented to increase the efficiency of commercial animal breeding programs.
摘要翻译：本发明提供了用于检测妊娠的改进的测定法。在测定中，与孕激素分析结合分析妊娠相关糖蛋白。本发明的技术通过降低假阳性结果的比例来克服现有技术中的局限性。可以实施本发明提供的测定以提高商业动物育种程序的效率。

6. 发明授权

US07432107B2 Cardiac hormones for assessing cardiovascular risk 有权
标题翻译：用于评估心血管风险的心脏激素
公开(公告)号：US07432107B2
公开(公告)日：2008-10-07
申请号：US11297923
申请日：2005-12-08
申请人： Eberhard Spanuth
发明人： Eberhard Spanuth
IPC分类号： G01N33/00 , G01N33/53
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2800/32 , Y10S436/817
摘要： The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the cardiovascular risk of a patient who is a candidate for adminitstration of a cox-2-inhibiting compound, in particular an NSAID, selective cox-2 inhibitior, or steroid. More particularly, the present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for diagnosing the cardiovascular risk of a patient who is a candidate for administration of a selective cox-2 inhibitor, comprising the steps of (a) measuring, preferably in vitro, the level of a cardiac hormone, (b) diagnosing the risk of the patient by comparing the measured level to known levels associated with different grades of risk in a patient. The most preferred cardiac hormone in the context of the present invention is NT-proBNP. Furthermore, the present invention relates to a method for diagnosing the risk of a patient to suffer from a cardiovascular complication as a consequence of administration of a cox-2 inhibiting compound, comprising the steps of (a) measuring the level of a cardiac hormone, (b) diagnosing the risk of the patient by comparing the measured level to known levels associated with different grades of risk in a patient.
摘要翻译：本发明涉及心脏激素，特别是利尿钠肽用于诊断作为治疗cox-2抑制化合物，特别是NSAID，选择性cox-2抑制剂的候选者的患者的心血管风险的用途，或类固醇。更具体地说，本发明涉及使用心脏激素，特别是利尿钠肽来诊断作为选择性cox-2抑制剂的候选者的患者的心血管风险，其包括以下步骤：（a）优选在体外，心脏激素的水平，（b）通过将患者的不同等级风险相关的测量水平与已知水平进行比较来诊断患者的风险。本发明上下文中最优选的心脏激素是NT-proBNP。此外，本发明涉及一种用于诊断作为施用cox-2抑制化合物的结果的患有心血管并发症的患者的风险的方法，包括以下步骤：（a）测量心脏激素的水平，（b）通过将患者的不同等级风险相关的测量水平与已知水平进行比较来诊断患者的风险。

7. 发明申请

US20070248953A1 Pressure Transduced Chemical Assay and Method 审中-公开
标题翻译：压力转换化学测定和方法
公开(公告)号：US20070248953A1
公开(公告)日：2007-10-25
申请号：US11744792
申请日：2007-05-04
申请人： Theodore Sand
发明人： Theodore Sand
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/28 , C12Q1/30 , C12Q1/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N7/14
CPC分类号： G01N33/54386 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/527 , C12Q1/58 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/817
摘要： An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that generates an electrical signal in response to a pressure change in the chamber that is caused by a reaction between the analyte and a reagent.
摘要翻译：测定系统具有接收其上已经放置了包含分析物的样品的测试条的室。该室与压电材料气态连通，该压电材料响应于由分析物和试剂之间的反应引起的室中的压力变化而产生电信号。

8. 发明授权

US07255995B2 Analyte assay using particulate labels 有权
标题翻译：使用颗粒标签的分析物测定
公开(公告)号：US07255995B2
公开(公告)日：2007-08-14
申请号：US10947636
申请日：2004-09-22
申请人： Juan Yguerabide , Evangelina E. Yguerabide , David E. Kohne , Jeffrey T. Jackson
发明人： Juan Yguerabide , Evangelina E. Yguerabide , David E. Kohne , Jeffrey T. Jackson
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/54313 , C12Q1/6816 , C12Q1/6834 , G01N15/14 , G01N15/1425 , G01N15/1459 , G01N33/585 , G01N2015/0038 , G01N2015/1493 , Y10S436/805 , Y10S436/817 , C12Q2563/103
摘要： Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in which light scattered from one or more particles can be detected by a human eye with less than 500 times magnification and without electronic amplification. The method also includes detecting the light scattered by any such particles under those conditions as a measure of the presence of the analytes.
摘要翻译：用于特定检测样品中一种或多种分析物的方法。该方法包括将样品中的任何一种或多种分析物与散射光可检测的颗粒相关联，在产生来自颗粒的散射光并且其中从一种或多种颗粒散射的光的条件下用光照射与分析物相关的任何颗粒由人眼检测，放大倍数小于500倍，无电子放大。该方法还包括在这些条件下检测由任何这样的颗粒散射的光作为分析物存在的量度。

9. 发明授权

US07214531B2 Pressure transduced chemical assay and method 失效
标题翻译：压力传导化学测定法
公开(公告)号：US07214531B2
公开(公告)日：2007-05-08
申请号：US10479782
申请日：2002-04-15
申请人： Mahmoud Ladjevardi , Theodore Sand
发明人： Mahmoud Ladjevardi , Theodore Sand
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , C12Q1/00 , C12Q1/26 , C12Q1/28 , C12Q1/527 , C12Q1/58 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/817
摘要： An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that generates an electrical signal in response to a pressure change in the chamber that is caused by a reaction between the analyte and a reagent.
摘要翻译：测定系统具有接收其上已经放置了包含分析物的样品的测试条的室。该室与压电材料气态连通，该压电材料响应于由分析物和试剂之间的反应引起的室中的压力变化而产生电信号。

10. 发明授权

US07101682B2 Simultaneous screening of multiple analytes 有权
标题翻译：同时筛选多种分析物
公开(公告)号：US07101682B2
公开(公告)日：2006-09-05
申请号：US11268323
申请日：2005-11-07
申请人： Edwin F. Ullman , Marcel Pirio , Mary C. Ericson , Daniel B. Wagner , Dariush Davalian
发明人： Edwin F. Ullman , Marcel Pirio , Mary C. Ericson , Daniel B. Wagner , Dariush Davalian
IPC分类号： G01N33/53
CPC分类号： G01N33/946 , G01N33/54386 , Y10S435/975 , Y10S436/805 , Y10S436/811 , Y10S436/815 , Y10S436/816 , Y10S436/817 , Y10S436/901
摘要： Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the analytes. A combination is provided comprising in a medium (i) the sample, (ii) a binding partner for each of the analytes, (iii) for each of the analytes, a first reagent comprising a member of a signal producing system, a ligand and an analyte analog, and (iv) a second reagent comprising a binding partner for the ligand. The binding of the binding partner for the ligand is affected by the presence of an analyte and alters the amount of signal produced by the member of the signal producing system. The signal thus is modulated if one or more of the analytes are present in the sample. The amount of the signal is determined and is related to the presence of one or more of the analytes in the sample. The method may be homogeneous or heterogeneous.
摘要翻译：公开了方法，组合物和试剂盒。该方法旨在确定怀疑含有多种分析物中的任何一种的样品中一种或多种分析物的存在。提供的组合包括在介质（i）样品中，（ii）每种分析物的结合配偶体，（iii）对于每种分析物，包含信号产生系统的成员的第一试剂，配体和分析物类似物，和（iv）包含配体的结合配偶体的第二试剂。配体的结合配偶体的结合受到分析物的存在的影响，并改变由信号产生系统的成员产生的信号量。如果一个或多个分析物存在于样品中，则信号因此被调制。确定信号的量，并与样品中一种或多种分析物的存在相关。该方法可以是均匀的或不均匀的。

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