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81. 发明申请

US20110204259A1 METHOD AND SYSTEM FOR DETECTING FLUOROCHROMES IN A FLOW CYTOMETER 有权
标题翻译：用于检测流式细胞仪中荧光素的方法和系统
公开(公告)号：US20110204259A1
公开(公告)日：2011-08-25
申请号：US13033299
申请日：2011-02-23
申请人： Clare E. Rogers , Jack T. Ball , Collin A. Rich
发明人： Clare E. Rogers , Jack T. Ball , Collin A. Rich
IPC分类号： G01J1/58
CPC分类号： G01N15/1429 , G01N15/1459
摘要： A method for detecting fluorochromes in a flow cytometer, including: receiving a sample including particles each tagged with at least one of a first fluorochrome and a second fluorochrome, in which the first and second fluorochromes having distinct spillover coefficients; detecting the particles, including detecting the first and second fluorochromes with a first detector and a second detector; forming a data set for detected particles based on the detection of the first and second fluorochromes; characterizing a detected spillover coefficient for each detected fluorochrome from the data set; and sorting the detected particles into predicted fluorochrome populations based on the detected spillover coefficients. A system for detecting fluorochromes in a flow cytometer, including a flow cell, a fixed gain detection system, and a processor that generates a detected spillover coefficient for each detected particle and sorts the detected particle into predicted fluorochrome populations based on the detected spillover coefficient.
摘要翻译：一种用于在流式细胞仪中检测荧光染料的方法，包括：接收包含每个标记有第一荧光染料和第二荧光染料中的至少一种的颗粒的样品，其中第一和第二荧光染料具有不同的溢出系数; 检测颗粒，包括用第一检测器和第二检测器检测第一和第二荧光染料; 基于第一和第二荧光色素的检测形成检测到的颗粒的数据集; 表征来自数据集的每个检测到的荧光染料的检测到的溢出系数; 并且基于检测到的溢出系数将检测到的颗粒分选成预测的荧光染色体群体。一种用于在流式细胞仪中检测荧光染料的系统，包括流动池，固定增益检测系统和处理器，其产生每个检测到的颗粒的检测到的溢出系数，并且基于检测到的溢出系数将检测到的颗粒分解成预测的荧光染色体群。

82. 发明申请

US20110192991A1 MICROPARTICLE ANALYSIS DEVICE AND MICROPARTICLE ANALYSIS METHOD 有权
标题翻译：微波分析装置和微波分析方法
公开(公告)号：US20110192991A1
公开(公告)日：2011-08-11
申请号：US13017554
申请日：2011-01-31
申请人： Atsushi Fukumoto , Mitsuru Toishi
发明人： Atsushi Fukumoto , Mitsuru Toishi
IPC分类号： G01J1/58
CPC分类号： G01J3/1256 , G01J3/4406 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N21/51 , G01N21/645 , G01N2021/4707
摘要： Disclosed herein is a microparticle analysis device including: a light source configured to irradiate a microparticle with light; an acousto-optic modulator configured to diffract fluorescence generated from the microparticle due to the light irradiation; a slit configured to allow transmission of only diffracted light in a diffraction center wavelength region among diffracted light beams from the acousto-optic modulator; and a detector configured to detect the diffracted light in the diffraction center wavelength region transmitted through the slit.
摘要翻译：本发明公开了一种微粒分析装置，其特征在于，包括：被配置为用光照射微粒的光源; 配置为衍射由于光照射而从微粒产生的荧光的声光调制器; 狭缝，被配置为允许在来自声光调制器的衍射光束中的衍射中心波长区域中仅衍射衍射光; 以及检测器，被配置为检测通过狭缝透射的衍射中心波长区域中的衍射光。

83. 发明申请

US20110186436A1 Particle Interrogation Devices and Methods 失效
标题翻译：粒子询问设备和方法
公开(公告)号：US20110186436A1
公开(公告)日：2011-08-04
申请号：US13078999
申请日：2011-04-03
申请人： Igor V. Novosselov , Peter C. Ariessohn , Evan D. Dengler , Michelle Hickner
发明人： Igor V. Novosselov , Peter C. Ariessohn , Evan D. Dengler , Michelle Hickner
IPC分类号： G01N1/28 , H01J49/26 , H01J27/00 , B01D15/08 , G01N30/00 , G01J3/00 , G01J1/58 , G01N27/62 , G01N27/447 , G01N33/00
CPC分类号： B01D15/08 , G01J1/58 , G01J3/00 , G01N1/28 , G01N27/447 , G01N27/62 , G01N30/00 , G01N33/00 , H01J27/00 , H01J49/26 , Y02A50/25
摘要： Devices, apparatus and methods are disclosed for non-contact pneumatic sampling and sampling of surfaces, persons, articles of clothing, buildings, furnishings, vehicles, baggage, packages, mail, and the like, for contaminating aerosols indicative of a hazard or a benefit, where the contaminating aerosols are chemical, radiological, biological, toxic, or infectious in character. In a first device, a central orifice for pulling a suction gas stream is surrounded by a peripheral array of convergingly-directed gas jets, forming a virtual sampling chamber. The gas jets are configured to deliver millisecond pneumatic pulses that erode particles from solid surfaces at a distance. In another aspect of the invention, a suction gas stream is split using an air-to-air concentrator so that a particle-enriched gas flow is directed to a particle trap and any particles immobilized in the particle trap (including any adsorbed vapors associated with the particles) are selectively analyzed to detect trace residues associated with explosives.
摘要翻译：公开的装置，装置和方法用于表面，人员，衣物，建筑物，家具，车辆，行李，包装，邮件等的非接触式气体取样和取样，用于污染指示危险或益处的气溶胶污染气溶胶在化学，放射学，生物学，毒性或传染性方面。在第一装置中，用于拉动吸入气流的中心孔被收敛的气体射流的外围阵列包围，形成虚拟取样室。气体喷射器被配置为传送毫秒的气动脉冲，其从一定距离的实体表面侵蚀颗粒。在本发明的另一方面，使用空气 - 空气浓缩器分离吸入气体流，使得富含颗粒的气体流被引导到颗粒捕获器，并且固定在颗粒捕获器中的任何颗粒（包括与颗粒）被选择性分析以检测与爆炸物相关的痕量残留物。

84. 发明申请

US20110168917A1 FLUORESCENCE DETECTION DEVICE USING INTENSITY-MODULATED LASER LIGHT AND FLUORESCENCE DETECTION METHOD 有权
标题翻译：使用强度调制激光的荧光检测装置和荧光检测方法
公开(公告)号：US20110168917A1
公开(公告)日：2011-07-14
申请号：US13119702
申请日：2009-09-16
申请人： Kyouji Doi , Shigeyuki Nnakada , Hironori Hayashi , Kazuteru Hoshishima
发明人： Kyouji Doi , Shigeyuki Nnakada , Hironori Hayashi , Kazuteru Hoshishima
IPC分类号： G01J1/58
CPC分类号： G01N21/6408 , G01N15/1429 , G01N15/1459
摘要： A fluorescence detection device for a flow site meter emits laser light intensity-modulated in accordance with a modulation signal and acquires a fluorescent signal of fluorescence emitted from a measurement object that passes through a measurement point of the laser light. The fluorescence detection device generates, separately from the modulation signal, a reference signal having a frequency different from a frequency of the modulation signal and a phase in synchronization with a phase of the modulation signal. The fluorescence detection device determines a fluorescent relaxation time of the measurement object from the fluorescent signal by using the reference signal.
摘要翻译：流场现场仪的荧光检测装置根据调制信号发射激光强度调制，并获取从通过激光测量点的测量对象发射的荧光的荧光信号。荧光检测装置与调制信号分离地产生具有与调制信号的频率不同的频率的参考信号和与调制信号的相位同步的相位。荧光检测装置通过使用参考信号从荧光信号确定测量对象的荧光弛豫时间。

85. 发明申请

US20110168912A1 OPTICAL SYSTEM FOR DOSIMETER READER 有权
标题翻译：用于计量器读取器的光学系统
公开(公告)号：US20110168912A1
公开(公告)日：2011-07-14
申请号：US12757214
申请日：2010-04-09
申请人： R. Craig YODER , Mark S. Akselrod
发明人： R. Craig YODER , Mark S. Akselrod
IPC分类号： G01J1/58 , G02B27/14 , G02B7/00
CPC分类号： G01T1/105 , G01T3/00
摘要： Described is an optical system for a dosimeter reader having reduced sensitivity to vibration and motion.
摘要翻译：描述了一种用于剂量计读取器的光学系统，其具有降低的对振动和运动的敏感性。

86. 发明申请

US20110133101A1 MODULAR IMAGING SYSTEM, MODULES FOR THIS SYSTEM AND METHOD IMPLEMENTED USING THIS SYSTEM 有权
标题翻译：模块化成像系统，该系统的模块和使用此系统实现的方法
公开(公告)号：US20110133101A1
公开(公告)日：2011-06-09
申请号：US12987736
申请日：2011-01-10
申请人： Bertrand Viellerobe , Francois Lacombe , Nicolas Boularot , Francois Doussoux , Nicolas Lavillonniere
发明人： Bertrand Viellerobe , Francois Lacombe , Nicolas Boularot , Francois Doussoux , Nicolas Lavillonniere
IPC分类号： G01J1/58 , G02B6/06
CPC分类号： G01N21/6458 , A61B1/00117 , A61B1/00165 , A61B1/00172 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G01N2021/6419 , G01N2021/6421 , G01N2201/024 , G01N2201/0846 , G01N2201/086 , G02B6/29362 , G02B21/16
摘要： An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.
摘要翻译：一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接，扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在图像引导件的远端。照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

87. 发明申请

US20110133100A1 METHOD OF PUMPING QUANTUM DOTS 有权
标题翻译：泵浦量的方法
公开(公告)号：US20110133100A1
公开(公告)日：2011-06-09
申请号：US12961631
申请日：2010-12-07
申请人： Patanjali Kambhampati , Ryan Cooney , Samuel Sewall
发明人： Patanjali Kambhampati , Ryan Cooney , Samuel Sewall
IPC分类号： G01J1/58 , B82Y99/00
CPC分类号： H01L31/035281 , B82Y20/00 , B82Y30/00 , H01L31/0304 , H01L31/035236 , H01L31/073 , H01L31/1828 , H01L31/1852 , Y02E10/543 , Y02E10/544
摘要： Strongly confined semiconductor quantum dots theoretically offer for broadband and continuous tunability of their emitting wavelength based upon simply varying the particle size. However, prior art consistently has demonstrated a lower particle size limit below which optical gain cannot be achieved, for example 2.3 nm for CdSe in toluene. As such the prior art points to combinations of alternative materials and host media as the route to achieving the goal of broadband emission sources using quantum dots. However, according to the invention optical gain can be achieved in quantum dots below these previous experimental limits by resonantly pumping the quantum dots to a specific excitonic state, i.e. electron position relative to the quantum dot, such that the multiexcitonic interferences are minimized. Using this approach optical gain in CdSe of R=2.1 nm and 1.5 nm has been demonstrated in the yellow/amber region of the visible spectrum.
摘要翻译：理论上强烈的限制半导体量子点基于简单地改变粒度来提供其发射波长的宽带和连续可调性。然而，现有技术一直表现出较低的粒径限度，在此以下，不能实现光学增益，例如在甲苯中的CdSe为2.3nm。因此，现有技术指出替代材料和主机介质的组合作为实现使用量子点的宽带发射源目标的途径。然而，根据本发明，通过将量子点共振地泵浦到特定的激子态，即相对于量子点的电子位置，可以在低于这些先前实验极限的量子点中实现光学增益，使得多谐振干扰被最小化。使用这种方法，在可见光谱的黄色/琥珀色区域已经证明了在R = 2.1nm和1.5nm的CdSe中的光学增益。

88. 发明申请

US20110121204A1 TOTAL REFLECTION FLUORESCENCE OBSERVATION DEVICE 有权
标题翻译：总反射荧光观察装置
公开(公告)号：US20110121204A1
公开(公告)日：2011-05-26
申请号：US13055854
申请日：2009-05-20
申请人： Nobutaka Kumazaki , Satoshi Takahashi , Hirokazu Kato , Takanovu Haga
发明人： Nobutaka Kumazaki , Satoshi Takahashi , Hirokazu Kato , Takanovu Haga
IPC分类号： G01J1/58
CPC分类号： G01N21/648 , G02B21/16
摘要： A technique and device for fluorescence observation with good operability, high sensitivity, acid high reliability. The device is used for fluorescence observation using evanescent light. The angle of incidence of the excitation light is adjusted so that the excitation light is always totally reflected from the surface of a substrate irrespective of the angle of the surface of the substrate. The method includes a step of shining the excitation light on the observation substrate while continuously varying the angle of the excitation light with respect to the observation substrate, a step of sensing the shone excitation light by means of optical sensors, and a step of setting the angle of total reflection according to the result of the sensing by the optical sensors. The direction in which the shone excitation light travels varies with the angle of incidence. That is, the excitation light travels as the transmitted light, the reflected light, or the surface propagating light. These lights are sensed by the corresponding optical sensors, and how the angle of incidence of the excitation light is with respect to the critical angle is determined. The angle of incidence of the excitation light is varied depending on the result of the determination, thereby realizing an optimum total reflection angle.
摘要翻译：用于荧光观察的技术和装置，操作性好，灵敏度高，酸度高可靠性。该器件用于使用ev逝光的荧光观察。调节激发光的入射角，使得激发光始终从基板的表面全反射，而与基板的表面的角度无关。该方法包括在观察基板上照射激发光的步骤，同时连续地改变激发光相对于观察基板的角度，通过光学传感器感测照射激发光的步骤，以及将根据光学传感器的感测结果，全反射角度。照射激发光的行进方向随入射角而变化。也就是说，激发光作为透射光，反射光或表面传播光行进。这些光被相应的光学传感器感测，并且确定激发光的入射角相对于临界角如何。激发光的入射角取决于确定的结果而变化，从而实现最佳的全反射角。

89. 发明申请

US20110121202A1 Optical Fiber Imaging System And Method For Generating Fluorescence Imaging 有权
标题翻译：光纤成像系统及产生荧光成像的方法
公开(公告)号：US20110121202A1
公开(公告)日：2011-05-26
申请号：US12623973
申请日：2009-11-23
申请人： Ming-Jun Li , Shenping Li
发明人： Ming-Jun Li , Shenping Li
IPC分类号： G01J1/58
CPC分类号： G01J3/10 , G01J3/4406 , H01S3/0057 , H01S3/0675 , H01S3/06754 , H01S3/06791 , H01S3/2383
摘要： A nonlinear fluorescence imaging system and method for generating fluorescence imaging includes a pulsed laser source for generating laser pulses at a first wavelength and an optical pulse stretcher including one or more optical pulse stretcher fibers having a first dispersion parameter at the first wavelength. The system also includes a probe for interfacing with a sample to deliver the laser pulses and extract fluorescence signals excited in the sample. One or more optical delivery fibers are included for delivering the laser pulses and collecting nonlinear fluorescence signals. The optical delivery fiber has a second dispersion parameter at the first wavelength which is opposite a polarity of the first dispersion parameter. A detector detects images based on the collected fluorescence signals.
摘要翻译：用于产生荧光成像的非线性荧光成像系统和方法包括用于产生第一波长的激光脉冲的脉冲激光源和包括具有第一波长的第一色散参数的一个或多个光脉冲展宽光纤的光脉冲展宽器。该系统还包括用于与样品接口以传送激光脉冲并提取在样品中激发的荧光信号的探针。包括一个或多个光学传递光纤用于传送激光脉冲和收集非线性荧光信号。光传送光纤具有与第一色散参数的极性相反的第一波长的第二色散参数。检测器基于收集的荧光信号检测图像。

90. 发明申请

US20110121198A1 LASER SCANNING MICROSCOPE 有权
标题翻译：激光扫描显微镜
公开(公告)号：US20110121198A1
公开(公告)日：2011-05-26
申请号：US12948937
申请日：2010-11-18
申请人： Tatsuo Nakata , Kosuke TAKAGI
发明人： Tatsuo Nakata , Kosuke TAKAGI
IPC分类号： G01J1/58
CPC分类号： G02B21/004 , G02B21/0076 , G02B21/008
摘要： Provided is a laser scanning microscope with which it is possible to reduce the time required for scanning and to detect light from a sample with high sensitivity. Provided is a laser scanning microscope 100 including a stage 20 that moves a sample 19 placed thereon, a laser light source 1 that emits laser light L, a line-focus optical system 3 that focuses the laser light L into a line shape, a DMD 7 including a plurality of movable micromirrors that are arrayed in the lengthwise direction of the line and that reflect the line-focused laser light L, an irradiation optical system 2 that irradiates the sample 19 with the laser light L reflected by the DMD 7, and a photodetector 17 in which a plurality of channels for detecting light from the sample 19 are arrayed in one column, wherein the DMD 7 is driven so that a plurality of movable micromirrors simultaneously reflect the laser light L and so that the movable micromirrors that reflect the laser light L are sequentially switched, and the stage 20 moves the sample 19 in a direction crossing the array direction of a plurality of light spots formed on the sample 19.
摘要翻译：提供了一种激光扫描显微镜，其可以减少扫描和从高灵敏度的样品检测光所需的时间。提供了一种激光扫描显微镜100，其包括移动放置在其上的样品19的载物台20，发射激光L的激光源1，将激光L聚焦成线状的线聚焦光学系统3，DMD 7包括沿线的长度方向排列并反射线聚焦激光L的多个可移动微镜;照射光学系统2，其用由DMD 7反射的激光L照射样品19;以及其中用于检测来自样品19的光的多个通道被布置在一列中的光电检测器17，其中驱动DMD 7，使得多个可移动微镜同时反射激光L，并且使得反射激光L依次切换，台20沿着与样品19上形成的多个光点的排列方向交叉的方向移动样品19。

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