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1. 发明授权

US09607195B2 Patient identification system 有权
公开(公告)号：US09607195B2
公开(公告)日：2017-03-28
申请号：US14211622
申请日：2014-03-14
申请人： Autonomic Technologies, Inc.
发明人： Benjamin Pless
IPC分类号： G06K7/10 , G06F21/35 , G06F21/62 , G07C9/00 , G06K7/01 , A61B90/90 , A61B90/98 , A61B5/0404 , A61B5/11
CPC分类号： G06K7/10396 , A61B5/0404 , A61B5/1113 , A61B90/90 , A61B90/98 , G06F21/35 , G06F21/6254 , G06F2221/2101 , G06F2221/2111 , G06K7/01 , G07C9/00111
摘要： The patient identification system of the preferred embodiments includes a transponder that is affixed to a patient and functions to communicate information that identifies the patient to a device or series of devices. The series of devices includes at least a first device that collects data from the patient and communicates with the transponder. The patient identification system is preferably designed to identify a patient, and more specifically to identify a patient to be associated with the data collected by the device. The patient identification system, however, may be alternatively used in any suitable environment and for any suitable reason.

2. 发明授权

US08886325B2 Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism 有权
标题翻译：可植入神经刺激器，具有整体密封电子外壳，电路基板，单片馈通，引线组件和锚定机构
公开(公告)号：US08886325B2
公开(公告)日：2014-11-11
申请号：US13939068
申请日：2013-07-10
申请人： Autonomic Technologies, Inc.
发明人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
IPC分类号： A61N1/34 , A61N1/05 , A61N1/375 , A61N1/36
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫症，脑血管疾病，自身免疫疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板成一体的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

3. 发明申请

US20140048977A1 MOLDING OF A NEUROSTIMULATOR FOR DELIVERY INTO THE PTERYGOPALATINE FOSSA 审中-公开
标题翻译：用于输送到西酞普兰FOSSA的神经调节剂的成型
公开(公告)号：US20140048977A1
公开(公告)日：2014-02-20
申请号：US13966402
申请日：2013-08-14
申请人： AUTONOMIC TECHNOLOGIES, INC.
发明人： Ryan Powell , Carl Lance Boling , Jennifer Teng , Morgan Clyburn
IPC分类号： A61N1/36
CPC分类号： A61N1/36075 , A61N1/375
摘要： A method and apparatus for molding a medical device utilizes a rigid outer stiffener and a flexible inner mold that nests with the outer stiffener. The medical device can be a stimulating apparatus used to deliver electrical stimulation to a peripheral, central or autonomic neural structure. More specifically, the medical device can be a neurostimulator apparatus designed to delivery electrical stimulation to the sphenopalatine ganglion (SPG) to treat primary headaches, such as migraines, cluster headaches and/or many other neurological disorders, such as atypical facial pain and/or trigeminal neuralgias.
摘要翻译：用于模制医疗装置的方法和装置利用刚性外部加强件和与外部加强件嵌套的柔性内部模具。医疗装置可以是用于将电刺激递送到外围，中枢或自主神经结构的刺激装置。更具体地，医疗装置可以是设计用于将电刺激递送到蝶腭神经节（SPG）以治疗原发性头痛的神经刺激器装置，例如偏头痛，丛集性头痛和/或许多其它神经障碍，例如非典型性面部疼痛和/或三叉神经痛。

4. 发明授权

US08311632B2 Devices, methods, and systems for harvesting energy in the body 有权
标题翻译：用于在体内收获能量的装置，方法和系统
公开(公告)号：US08311632B2
公开(公告)日：2012-11-13
申请号：US12392938
申请日：2009-02-25
申请人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
发明人： Benjamin David Pless , Carl Lance Boling , Barbara Gibb , Adolf van der Heide , Brett M. Wingeier
IPC分类号： A61N1/00
CPC分类号： A61N1/3785 , H02N2/18 , H02N11/002
摘要： In some embodiments, the power generator for converting mechanical energy to electrical energy is described may include a compressible element adapted and configured to be placed in an environment having a variable compressive force such as varying ambient pressures. The compressible element may be compressed by a force applied by the variable pressure to the compressible element. The power generator may further include a transducer that may be coupled to the compressible element and that may convert mechanical energy from the compression of the compressible element to electrical energy. In some embodiments, the power generator may be adapted to be an implantable power generator for converting mechanical energy from a patient to electrical energy, such that the compressible element adapted and configured to be placed between two adjacent tissue layers of the patient and to be compressed by a force applied from the two adjacent tissue layers to the compressible element.
摘要翻译：在一些实施例中，描述了用于将机械能转换成电能的功率发生器可以包括可压缩元件，该可压缩元件适于并被配置为放置在具有可变压缩力（例如变化的环境压力）的环境中。可压缩元件可以通过由可变压力施加到可压缩元件的力而被压缩。发电机还可以包括可耦合到可压缩元件并且可将机械能从可压缩元件的压缩转换为电能的换能器。在一些实施例中，发电机可以适于作为可植入的发电机，用于将来自患者的机械能转换成电能，使得可压缩元件适于并被配置成放置在患者的两个相邻组织层之间并被压缩通过从两个相邻组织层施加到可压缩元件的力。

5. 发明授权

US09662140B2 Surgical guidance tool to facilitate delivery of a neurostimulator into a pterygopalatine fossa 有权
公开(公告)号：US09662140B2
公开(公告)日：2017-05-30
申请号：US13923683
申请日：2013-06-21
申请人： Autonomic Technologies, Inc.
发明人： Ryan Powell , Benjamin D. Pless
IPC分类号： A61B17/34 , A61N1/05 , A61B90/16 , A61B17/24 , A61N1/36
CPC分类号： A61B17/3468 , A61B17/24 , A61B17/3403 , A61B90/16 , A61B2017/3407 , A61N1/05 , A61N1/0546 , A61N1/3605
摘要： One aspect of the present disclosure relates to a surgical guidance tool configured to facilitate delivery of a neurostimulator to a target craniofacial region of a subject. The surgical guidance tool can include a main body, a securing mechanism, and an adjustable guide mechanism. The main body can have a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends. The securing mechanism can be disposed at the distal end and configured to secure a neurostimulator delivery tool to the main body. The guide mechanism can be configured to temporarily mate with a bodily target location of the subject and facilitate positioning of the neurostimulator delivery tool about the target craniofacial region. The guide member can be slidably attached to the distal end and selectively translatable along the longitudinal axis of the main body.

6. 发明授权

US09604057B2 Stimulation method for a sphenopalatine ganglion, sphenopalatine nerve, vidian nerve, or branch thereof for treatment of medical conditions 有权
公开(公告)号：US09604057B2
公开(公告)日：2017-03-28
申请号：US13746038
申请日：2013-01-21
申请人： Anthony V. Caparso
发明人： Anthony V. Caparso
IPC分类号： A61N1/32 , A61N1/36 , A61B17/24 , A61B17/34 , A61N1/05 , A61N1/375 , A61B17/3211 , A61B17/32 , A61B17/00
CPC分类号： A61N1/36071 , A61B17/24 , A61B17/3211 , A61B17/3468 , A61B2017/0073 , A61B2017/320052 , A61N1/0526 , A61N1/0548 , A61N1/0551 , A61N1/36017 , A61N1/36021 , A61N1/3606 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/375
摘要： One aspect of the present disclosure relates to a method for suppressing or preventing a medical condition in a subject. One step of the method can include positioning at least one electrode on or proximate to at least one of a sphenopalatine ganglion (SPG), a sphenopalatine nerve (SPN), a vidian nerve (VN), or a branch thereof, of the subject. Next, the at least one electrode can be activated to apply an electrical signal to at least one of the SPG, the SPN the VN, or the branch thereof. The medical condition can include pain resulting from one or more of atypical odontalgia, cluster tic syndrome, geniculate neuralgia, occipital neuralgia and temporal arteritis.

7. 发明申请

US20140276195A1 METHODS OF USING NERVE EVOKED POTENTIALS TO MONITOR A SURGICAL PROCEDURE 审中-公开
标题翻译：使用神经诱发电位监测外科手术的方法
公开(公告)号：US20140276195A1
公开(公告)日：2014-09-18
申请号：US14205784
申请日：2014-03-12
申请人： Autonomic Technologies, Inc. , THE CLEVELAND CLINIC FOUNDATION
发明人： Francis A. Papay , Mike Hardage , Anthony V. Caparso , Benjamin D. Pless
IPC分类号： A61B5/00 , A61N1/08 , A61N1/05 , A61B5/04
CPC分类号： A61B5/4836 , A61B5/04001 , A61B5/0484 , A61B5/4893 , A61N1/08
摘要： Methods for intra-operatively monitoring nerve evoked potentials such as somatosensory nerve evoked potentials during a surgical procedure. The methods include orthrodromic and antidromic monitoring of nerve evoked potentials. Monitoring includes navigating the surgical pathway to avoid insult to anatomical tissue, minimizing activation of sensory nerves that result in undesirable side effects in a patient, and determining the suitable location for placement of an implantable medical device.
摘要翻译：手术中监测手术过程中神经诱发电位（如体感神经诱发电位）的方法。这些方法包括神经诱发电位的orthrodromic和antidromic监测。监测包括导航外科手术途径以避免侮辱解剖组织，最小化感觉神经的活动，导致患者中不期望的副作用，以及确定用于放置可植入医疗装置的合适位置。

8. 发明申请

US20140155956A1 NEUROMODULATION TO TREAT MENOPAUSE-RELATED CONDITIONS 有权
标题翻译： NEUROMODULATION TO TREAT MENOPAUSE相关条件
公开(公告)号：US20140155956A1
公开(公告)日：2014-06-05
申请号：US14093094
申请日：2013-11-29
申请人： Autonomic Technologies, Inc.
发明人： Benjamin D. Pless , Shannon Schuetz
IPC分类号： A61N1/36
CPC分类号： A61N1/3606 , A61N1/36157 , A61N1/36171 , A61N1/36175
摘要： One aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent a target site of the sympathetic nervous system (SNS) that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.
摘要翻译：本公开的一个方面涉及用于治疗受试者中更年期相关病症的方法。该方法的一个步骤可以包括将治疗递送装置插入到受试者的血管中。接下来，治疗递送装置可以前进到与绝经相关状况相关联的交感神经系统（SNS）的目标部位基本相邻的点。然后可以激活治疗递送装置，以将治疗信号传递给SNS的靶位点，其量足以影响受试者的交感神经活动的改变，从而治疗更年期相关的病症。

9. 发明申请

US20130116745A1 NEUROSTIMULATOR SYSTEM, APPARATUS, AND METHOD 审中-公开
标题翻译：神经细胞系统，装置和方法
公开(公告)号：US20130116745A1
公开(公告)日：2013-05-09
申请号：US13722260
申请日：2012-12-20
申请人： Kellie Fletcher , Patrick Hard , Anthony V. Caparso , Karen Tsuei
发明人： Kellie Fletcher , Patrick Hard , Anthony V. Caparso , Karen Tsuei
IPC分类号： A61N1/36
CPC分类号： A61N1/36075 , A61N1/37241 , A61N1/37247 , A61N1/37282 , A61N1/3787
摘要： The invention relates to a method (200) for conducting a clinical trial with a medical device. The method (200) includes the step (202) of providing a medical device to a trial subject, the medical device being capable of providing an adjustable level of therapy. The method also comprises the step (204) of using the medical device to apply therapy to the trial subject. The method further comprises the step (206) of controlling the application of therapy applied to the trial subject according to a clinical trial design.
摘要翻译：本发明涉及一种用医疗设备进行临床试验的方法（200）。方法（200）包括向试验对象提供医疗装置的步骤（202），该医疗装置能够提供可调节的治疗水平。该方法还包括使用医疗装置对试验对象施加治疗的步骤（204）。该方法还包括根据临床试验设计控制应用于试验对象的治疗应用的步骤（206）。

10. 发明授权

US08283793B2 Device for energy harvesting within a vessel 有权
标题翻译：容器内能量收集装置
公开(公告)号：US08283793B2
公开(公告)日：2012-10-09
申请号：US12545618
申请日：2009-08-21
申请人： Benjamin David Pless
发明人： Benjamin David Pless
IPC分类号： A61F2/06 , H02P9/04
CPC分类号： A61N1/3785 , F03G5/06
摘要： An energy harvesting device is provided that may include any of a number of features. One feature of the energy harvesting device is that it is adapted for insertion into a human blood vessel for converting pulsatile pressure in the blood vessel into electrical energy. The energy harvesting device can provide electrical energy to another electronic or electromechanical on or in the human body. The energy harvesting device can include an electrostatic generator. Methods associated with use of the energy harvesting device are also covered.
摘要翻译：提供了可以包括许多特征中的任何一个的能量收集装置。能量收集装置的一个特征在于其适于插入人体血管，用于将血管中的脉动压力转换为电能。能量收集装置可以向人体上或身体中的另一种电子或机电提供电能。能量收集装置可以包括静电发生器。还涉及与使用能量收集装置相关的方法。

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