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1. 发明授权

US10098662B2 Surgical tools to facilitate delivery of a neurostimulator into the pterygopalatine fossa 有权
公开(公告)号：US10098662B2
公开(公告)日：2018-10-16
申请号：US14954070
申请日：2015-11-30
申请人： Autonomic Technologies, Inc. , THE CLEVELAND CLINIC FOUNDATION
发明人： Carl Lance Boling , Anthony V. Caparso , Francis A. Papay , Ryan Powell , Jennifer Teng , Morgan Clyburn
IPC分类号： A61N1/00 , A61B17/34 , A61B17/24 , A61B17/3211 , A61N1/05 , A61N1/36 , A61N1/372 , A61B17/02 , A61B17/32 , A61N1/375
摘要： A surgical tool configured to facilitate delivery of a neurostimulator to a craniofacial region of a subject includes a handle portion, an elongate shaft having a contoured distal portion, and an insertion groove on the elongate shaft. The elongate shaft is configured to be advanced under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa. The distal portion includes a distal dissecting tip. The insertion groove is configured to receive, support, and guide a medical device or instrument.

2. 发明授权

US09861295B2 System and method for surgical planning and navigation to facilitate placement of a medical device within a target region of a patient 有权
公开(公告)号：US09861295B2
公开(公告)日：2018-01-09
申请号：US14283420
申请日：2014-05-21
申请人： Autonomic Technologies, Inc.
发明人： Ryan Powell , Brinda Ramachandran , Benjamin David Pless , Anthony Caparso , Kathryn Rosenbluth
IPC分类号： A61B5/05 , A61B5/06 , A61B6/03 , A61B6/00 , A61B34/10 , A61B90/00
CPC分类号： A61B5/066 , A61B6/032 , A61B6/466 , A61B6/501 , A61B6/5223 , A61B34/10 , A61B2034/104 , A61B2090/367
摘要： One aspect of the present disclosure relates to a system that can facilitate delivery of a medical device in proximity to a target region within a patient's body. Data representing an image of a portion of the patient's body can be received. Based on the data representing the image, a first three dimensional (3D) model of the medical device can be generated. A second 3D model of the medical device can be fitted within the first 3D model at a location in proximity to the target region to create a combined 3D model. A two dimensional (2D) projection of the combined 3D model can be created. In some instances, the 2D projection can be used to facilitate delivery of a medical device in proximity to the target region within a patient's body.

3. 发明申请

US20130345716A1 SURGICAL GUIDANCE TOOL TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO A PTERYGOPALATINE FOSSA 有权
标题翻译：手术辅助工具，以便将神经细胞输送给PTERGGALALATINE FOSSA
公开(公告)号：US20130345716A1
公开(公告)日：2013-12-26
申请号：US13923683
申请日：2013-06-21
申请人： Autonomic Technologies, Inc.
发明人： Ryan Powell , Benjamin D. Pless
IPC分类号： A61N1/05
CPC分类号： A61B17/3468 , A61B17/24 , A61B17/3403 , A61B90/16 , A61B2017/3407 , A61N1/05 , A61N1/0546 , A61N1/3605
摘要： One aspect of the present disclosure relates to a surgical guidance tool configured to facilitate delivery of a neurostimulator to a target craniofacial region of a subject. The surgical guidance tool can include a main body, a securing mechanism, and an adjustable guide mechanism. The main body can have a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends. The securing mechanism can be disposed at the distal end and configured to secure a neurostimulator delivery tool to the main body. The guide mechanism can be configured to temporarily mate with a bodily target location of the subject and facilitate positioning of the neurostimulator delivery tool about the target craniofacial region. The guide member can be slidably attached to the distal end and selectively translatable along the longitudinal axis of the main body.
摘要翻译：本公开的一个方面涉及一种被配置为便于将神经刺激器递送到受试者的目标颅面区域的外科引导工具。手术引导工具可以包括主体，固定机构和可调导引机构。主体可以具有在远端和近端之间延伸的远端，近端和纵向轴线。固定机构可以设置在远端并且被配置成将神经刺激器输送工具固定到主体。引导机构可以被配置为暂时与对象的身体目标位置配合，并且促进神经刺激器递送工具围绕目标颅面区域的定位。引导构件可以可滑动地附接到远端并且可以沿着主体的纵向轴线选择性地平移。

4. 发明申请

US20160081716A1 SURGICAL TOOLS TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA 审中-公开
标题翻译：手术工具，以便将神经调节剂输送到PASGGALALATINE FOSSA
公开(公告)号：US20160081716A1
公开(公告)日：2016-03-24
申请号：US14954070
申请日：2015-11-30
申请人： Autonomic Technologies, Inc. , The Cleveland Clinic Foundation
发明人： Carl Lance Boling , Anthony V. Caparso , Francis A. Papay , Ryan Powell , Jennifer Teng , Morgan Clyburn
IPC分类号： A61B17/34 , A61B17/24 , A61N1/372 , A61N1/05 , A61N1/36 , A61B17/02 , A61B17/3211
CPC分类号： A61B17/3468 , A61B17/02 , A61B17/0218 , A61B17/24 , A61B17/3211 , A61B2017/320052 , A61N1/0526 , A61N1/0548 , A61N1/0551 , A61N1/36075 , A61N1/37205 , A61N1/375
摘要： A surgical tool configured to facilitate delivery of a neurostimulator to a craniofacial region of a subject includes a handle portion, an elongate shaft having a contoured distal portion, and an insertion groove on the elongate shaft. The elongate shaft is configured to be advanced under a zygomatic bone along a maxillary tuberosity towards a pterygopalatine fossa. The distal portion includes a distal dissecting tip. The insertion groove is configured to receive, support, and guide a medical device or instrument.
摘要翻译：构造成便于将神经刺激器递送到受试者的颅面区域的手术工具包括手柄部分，具有轮廓远侧部分的细长轴和细长轴上的插入槽。细长轴构造成沿着上颌骨结节朝向翼腭窝向下延伸到z骨下方。远侧部分包括远端解剖尖端。插入槽被构造成接收，支撑和引导医疗装置或器械。

5. 发明申请

US20170007283A1 APPARATUS AND METHOD FOR DELIVERING A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA 审中-公开
标题翻译：将神经细胞输送到番茄黄素FOSSA的装置和方法
公开(公告)号：US20170007283A1
公开(公告)日：2017-01-12
申请号：US15266199
申请日：2016-09-15
申请人： Autonomic Technologies, Inc.
发明人： Carl Lance Boling , Anthony V. Caparso , Ryan Powell , Jennifer Teng , Morgan Clyburn
IPC分类号： A61B17/24 , A61N1/36 , A61N1/375 , A61N1/05
CPC分类号： A61B17/24 , A61B17/02 , A61B17/3211 , A61B17/3468 , A61B2017/320052 , A61N1/0526 , A61N1/0546 , A61N1/0548 , A61N1/36 , A61N1/3605 , A61N1/36057 , A61N1/375
摘要： One aspect of the present disclosure includes a neurostimulator delivery apparatus. The apparatus includes a handle portion, an elongate shaft extending from the handle portion, and a distal deployment portion. The distal deployment portion is configured to releasably mate with a neurostimulator. The neurostimulator is sized and configured for implantation into a craniofacial region of a subject.
摘要翻译：本公开的一个方面包括神经刺激器输送装置。该装置包括手柄部分，从把手部分延伸的细长轴和远端展开部分。远侧展开部分构造成可释放地与神经刺激器配合。神经刺激器的尺寸和构造用于植入受试者的颅面区域。

6. 发明申请

US20160270817A1 SURGICAL GUIDANCE TOOL TO FACILITATE DELIVERY OF A NEUROSTIMULATOR INTO A PTERYGOPALATINE FOSSA 审中-公开
公开(公告)号：US20160270817A1
公开(公告)日：2016-09-22
申请号：US15169896
申请日：2016-06-01
申请人： Autonomic Technologies, Inc.
发明人： Ryan Powell , Benjamin D. Pless
IPC分类号： A61B17/34 , A61B17/24 , A61N1/05
CPC分类号： A61B17/3468 , A61B17/24 , A61B17/3403 , A61B90/16 , A61B2017/3407 , A61N1/05 , A61N1/0546 , A61N1/3605
摘要： One aspect of the present disclosure relates to a surgical guidance tool configured to facilitate delivery of a neurostimulator to a target craniofacial region of a subject. The surgical guidance tool can include a main body, a securing mechanism, and an adjustable guide mechanism. The main body can have a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends. The securing mechanism can be disposed at the distal end and configured to secure a neurostimulator delivery tool to the main body. The guide mechanism can be configured to temporarily mate with a bodily target location of the subject and facilitate positioning of the neurostimulator delivery tool about the target craniofacial region. The guide member can be slidably attached to the distal end and selectively translatable along the longitudinal axis of the main body.

7. 发明申请

US20140350389A1 SYSTEM AND METHOD FOR SURGICAL PLANNING AND NAVIGATION TO FACILITATE PLACEMENT OF A MEDICAL DEVICE WITHIN A TARGET REGION OF A PATIENT 有权
标题翻译：用于手术方案和导航的系统和方法，用于在患者的目标区域中对医疗装置进行辅助放置
公开(公告)号：US20140350389A1
公开(公告)日：2014-11-27
申请号：US14283420
申请日：2014-05-21
申请人： Autonomic Technologies, Inc.
发明人： Ryan Powell , Brinda Ramachandran , Benjamin David Pless , Anthony Caparso , Kathryn Rosenbluth
IPC分类号： A61B5/06 , A61B6/00 , A61B17/00 , A61B6/03 , A61B19/00
CPC分类号： A61B5/066 , A61B6/032 , A61B6/466 , A61B6/501 , A61B6/5223 , A61B34/10 , A61B2034/104 , A61B2090/367
摘要： One aspect of the present disclosure relates to a system that can facilitate delivery of a medical device in proximity to a target region within a patient's body. Data representing an image of a portion of the patient's body can be received. Based on the data representing the image, a first three dimensional (3D) model of the medical device can be generated. A second 3D model of the medical device can be fitted within the first 3D model at a location in proximity to the target region to create a combined 3D model. A two dimensional (2D) projection of the combined 3D model can be created. In some instances, the 2D projection can be used to facilitate delivery of a medical device in proximity to the target region within a patient's body
摘要翻译：本公开的一个方面涉及一种可以促进医疗装置在患者体内的目标区域附近的传送的系统。可以接收表示患者身体的一部分的图像的数据。基于表示图像的数据，可以生成医疗装置的第一三维（3D）模型。医疗设备的第二3D模型可以在靠近目标区域的位置安装在第一3D模型内，以创建组合的3D模型。可以创建组合3D模型的二维（2D）投影。在一些情况下，可以使用2D投影来促进医疗装置在患者体内的目标区域附近的传送

8. 发明授权

US08886325B2 Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism 有权
标题翻译：可植入神经刺激器，具有整体密封电子外壳，电路基板，单片馈通，引线组件和锚定机构
公开(公告)号：US08886325B2
公开(公告)日：2014-11-11
申请号：US13939068
申请日：2013-07-10
申请人： Autonomic Technologies, Inc.
发明人： Carl Lance Boling , Benjamin David Pless , Ryan Powell , Anthony V. Caparso
IPC分类号： A61N1/34 , A61N1/05 , A61N1/375 , A61N1/36
CPC分类号： A61N1/3606 , A61N1/0526 , A61N1/0546 , A61N1/0551 , A61N1/0558 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36075 , A61N1/36078 , A61N1/36082 , A61N1/37217 , A61N1/375 , A61N1/3754 , A61N1/3787
摘要： An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.
摘要翻译：为了抑制或预防患者的疼痛，运动障碍，癫痫症，脑血管疾病，自身免疫疾病，睡眠障碍，自主神经障碍，异常代谢状态，肌肉系统疾病和神经精神障碍，提供了可植入医疗装置。可植入医疗装置可以是构造成植入在脑神经上或附近的神经刺激器，以治疗头痛或其它神经障碍。可植入医疗设备的一个方面是其包括电子外壳，与电子外壳一体的基板，以及与电子外壳和基板成一体的整体式馈通。在一些实施例中，可植入医疗装置可以包括用于将装置附接到患者的固定装置。

9. 发明申请

US20140048977A1 MOLDING OF A NEUROSTIMULATOR FOR DELIVERY INTO THE PTERYGOPALATINE FOSSA 审中-公开
标题翻译：用于输送到西酞普兰FOSSA的神经调节剂的成型
公开(公告)号：US20140048977A1
公开(公告)日：2014-02-20
申请号：US13966402
申请日：2013-08-14
申请人： AUTONOMIC TECHNOLOGIES, INC.
发明人： Ryan Powell , Carl Lance Boling , Jennifer Teng , Morgan Clyburn
IPC分类号： A61N1/36
CPC分类号： A61N1/36075 , A61N1/375
摘要： A method and apparatus for molding a medical device utilizes a rigid outer stiffener and a flexible inner mold that nests with the outer stiffener. The medical device can be a stimulating apparatus used to deliver electrical stimulation to a peripheral, central or autonomic neural structure. More specifically, the medical device can be a neurostimulator apparatus designed to delivery electrical stimulation to the sphenopalatine ganglion (SPG) to treat primary headaches, such as migraines, cluster headaches and/or many other neurological disorders, such as atypical facial pain and/or trigeminal neuralgias.
摘要翻译：用于模制医疗装置的方法和装置利用刚性外部加强件和与外部加强件嵌套的柔性内部模具。医疗装置可以是用于将电刺激递送到外围，中枢或自主神经结构的刺激装置。更具体地，医疗装置可以是设计用于将电刺激递送到蝶腭神经节（SPG）以治疗原发性头痛的神经刺激器装置，例如偏头痛，丛集性头痛和/或许多其它神经障碍，例如非典型性面部疼痛和/或三叉神经痛。

10. 发明申请

US20170165482A1 SURGICAL TOOLS AND METHODS FOR DELIVERING A NEUROSTIMULATOR INTO THE PTERYGOPALATINE FOSSA 审中-公开
公开(公告)号：US20170165482A1
公开(公告)日：2017-06-15
申请号：US15373698
申请日：2016-12-09
申请人： Autonomic Technologies, Inc.
发明人： Tom Luhrs , Alan Cheng , Ryan Powell , Jennifer Teng
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/3605 , A61B17/3468 , A61N1/0526 , A61N1/0551 , A61N1/36075 , A61N1/37205
摘要： One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.

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