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1. 发明授权

US09888873B2 NIRS sensor assembly including EMI shielding 有权
公开(公告)号：US09888873B2
公开(公告)日：2018-02-13
申请号：US14102004
申请日：2013-12-10
申请人： CAS Medical Systems, Inc.
发明人： Matthew Dalene , Karen Duffy , John Gamelin , Paul Benni , William Kosturko
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14552 , A61B5/6832 , A61B2562/182 , A61B2562/222
摘要： A NIRS sensor assembly includes a light source, a light detector, a first insulating layer, an EMI shielding layer, and a second insulating layer. The first insulating layer covers an exposed portion of the light detector. An optically transparent portion of the first insulating layer is aligned with an active area of the light detector. The EMI shielding layer covers the first insulating layer. An optically transparent portion of the EMI shielding layer is aligned with the active area of the light detector. The second insulating layer covers the EMI shielding layer and the first insulating layer. An optically transparent portion of the second insulating layer is aligned with the active area of the at least one light detector.

2. 发明授权

US09848808B2 Method for spectrophotometric blood oxygenation monitoring 有权
公开(公告)号：US09848808B2
公开(公告)日：2017-12-26
申请号：US14335458
申请日：2014-07-18
申请人： CAS Medical Systems, Inc.
发明人： Paul Benni
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14552 , A61B5/6814 , A61B5/6833 , A61B5/72
摘要： An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting.

3. 发明授权

US08965472B2 Method and apparatus for spectrophotometric based oximetry 有权
标题翻译：基于分光光度法的血氧仪的方法和装置
公开(公告)号：US08965472B2
公开(公告)日：2015-02-24
申请号：US12090671
申请日：2006-10-18
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00 , A61B5/1455
CPC分类号： A61B5/14553
摘要： A near infrared spectrophotometric (NIRS) sensor assembly for non-invasive monitoring of blood oxygenation levels in a subject's body is provided that includes a pad, at least one light source, a near light detector, a far light detector, and a cover. The light source is operative to emit near infrared light signals of a plurality of different wavelengths. The near light detector is separated from the light source by a first distance that is great enough to position the first light detector outside of an optical shunt field extending out from the light source. The far light detector is substantially linearly aligned with the near light detector and light source, and is separated from the near light detector by a second distance, wherein the second distance is greater than the first distance.
摘要翻译：提供了一种近红外分光光度计（NIRS）传感器组件，用于对受试者体内的血氧饱和度进行非侵入性监测，其包括垫，至少一个光源，近光检测器，远光检测器和盖。光源可操作地发射多个不同波长的近红外光信号。近光检测器与光源分离第一距离，其足够大以将第一光检测器定位在从光源延伸出的光分流场的外部。远光检测器与近光检测器和光源基本上线性对准，并且与近光检测器分离第二距离，其中第二距离大于第一距离。

4. 发明授权

US08761851B2 Indicators for a spectrophotometric system 有权
标题翻译：分光光度计系统的指标
公开(公告)号：US08761851B2
公开(公告)日：2014-06-24
申请号：US12096132
申请日：2006-12-06
申请人： Paul B. Benni , Bo Chen , Andrew Kersey
发明人： Paul B. Benni , Bo Chen , Andrew Kersey
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0073 , A61B5/14553 , A61B5/4076 , A61B5/742
摘要： A near-infrared spectrophotometric system (e.g., a cerebral oximeter) includes a sensor portion and a monitor portion. The monitor portion includes a processor that runs an algorithm which utilizes the amount of detected light to determine the value of the oxygen concentration (e.g., the absolute level of oxygen concentration). The monitor portion also includes a visual display that displays the determined oxygen concentration values in various formats. The monitor portion may also include an audible device (e.g., a speaker), that provides audible indications of the determined oxygen concentration values. Various visual indicators may include, for example, color-coded graphs of the determined oxygenation values to alert the system user, for example, whether one hemisphere of the brain, or one or more regions of the brain, is in danger of adverse and potentially permanent damage. Also, data may be pre-processed by selecting the most clinically concerning sensor value (e.g., the sensor with the lowest value), and displaying only that sensor value and its identification on the display screen. Alternatively, an average value of multiple sensor measurements may be displayed. This reduces screen clutter and increases the speed of interpretation by the system user. Also, all sensor values may be averaged, and the average value displayed. The determined oxygenation values may also be provided in an audible format.
摘要翻译：近红外分光光度计（例如，脑血氧计）包括传感器部分和监视部分。监视器部分包括运行算法的处理器，其利用检测到的光量来确定氧浓度的值（例如，氧浓度的绝对水平）。监视器部分还包括以各种格式显示所确定的氧浓度值的视觉显示器。监视器部分还可以包括提供所确定的氧浓度值的可听指示的可听设备（例如扬声器）。各种视觉指标可以包括例如所确定的氧合值的颜色编码图，以警告系统用户，例如，脑的一个半球或脑的一个或多个区域是否具有不利和可能的危险永久性损坏此外，可以通过选择临床上最临近的传感器值（例如，具有最低值的传感器）来预处理数据，并且仅在该显示屏上显示该传感器值及其识别。或者，可以显示多个传感器测量的平均值。这减少了屏幕杂乱并增加了系统用户的解读速度。此外，所有传感器值可以被平均，并且显示平均值。所确定的氧合值也可以以可听到的格式提供。

5. 发明申请

US20140100823A1 SYSTEMS AND METHODS FOR SPECTROSCOPIC MEASUREMENT OF A CHARACTERISTIC OF BIOLOGICAL TISSUE 有权
标题翻译：用于生物组织特征的光谱测量的系统和方法
公开(公告)号：US20140100823A1
公开(公告)日：2014-04-10
申请号：US14041733
申请日：2013-09-30
申请人： CAS Medical Systems, Inc.
发明人： William Kosturko
IPC分类号： G01R29/26 , G01N21/00
CPC分类号： G01R29/26 , A61B5/0075 , A61B5/14553 , A61B5/7225 , A61B2576/026 , G01N21/00
摘要： A method and system for spectroscopic measurement of a characteristic of a biological tissue is provided. The method includes the steps of: (1) using at least one light source to emit light that penetrates the biological tissue; (2) using at least one light detector to detect light emitted by the at least one light source and passed through the biological tissue, and to convert the detected light into a detection signal, the detection signal including an unwanted noise component; and (3) using a processor to process the detection signal and to determine an adjusted peak-to-peak amplitude value that is representative of an amplitude of the detection signal adjusted for the unwanted noise component.
摘要翻译：提供了用于光谱测量生物组织特征的方法和系统。该方法包括以下步骤：（1）使用至少一个光源发射穿透生物组织的光; （2）使用至少一个光检测器来检测由所述至少一个光源发射并通过所述生物组织的光，并将检测到的光转换成检测信号，所述检测信号包括不需要的噪声分量; 和（3）使用处理器来处理检测信号并确定表示针对不需要的噪声分量调整的检测信号的幅度的调整的峰 - 峰振幅值。

6. 发明申请

US20130204105A1 METHOD AND APPARATUS FOR MONITORING A BLOOD OXYGEN SATURATION LEVEL RELATIVE TO A SATURATION THRESHOLD VALUE 有权
标题翻译：用于监测与饱和阈值相关的血氧饱和度水平的方法和装置
公开(公告)号：US20130204105A1
公开(公告)日：2013-08-08
申请号：US13758511
申请日：2013-02-04
申请人： CAS Medical Systems, Inc.
发明人： Paul B. Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14551 , A61B5/14553 , A61B5/7275 , A61B5/7282 , A61B5/743 , A61B5/746 , G06F19/00
摘要： A method and apparatus for monitoring a blood oxygen saturation level within a subject's tissue is provided. The method includes the steps of: a) sensing the subject's tissue using a near infrared spectrophotometric oximeter, and producing a value representative of the oxygen saturation level within the sensed tissue; b) comparing the determined saturation value to a predetermined threshold oxygen saturation value; and c) determining at least one of a time under threshold (TUT) value or an area under threshold (AUT) value using the determined saturation value and the threshold value.
摘要翻译：提供了一种用于监测受检者组织内的血氧饱和度水平的方法和装置。该方法包括以下步骤：a）使用近红外分光光度计测量受检者的组织，并产生代表感测组织内的氧饱和度水平的值; b）将确定的饱和值与预定阈值氧饱和度值进行比较; 以及c）使用所确定的饱和值和所述阈值来确定阈值下的时间（TUT）值或阈值（AUT）值以下的区域中的至少一个。

7. 发明授权

US08396526B2 Method for spectrophotometric blood oxygenation monitoring 有权
标题翻译：分光光度血氧监测方法
公开(公告)号：US08396526B2
公开(公告)日：2013-03-12
申请号：US11914074
申请日：2006-05-10
申请人： Paul Benni
发明人： Paul Benni
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/0261 , A61B5/14546 , A61B5/14552 , A61B5/14553 , A61B5/1495 , A61B5/6814 , G01N21/359 , G01N21/49 , G01N2021/3144
摘要： According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: 1) providing a near infrared spectrophotometric sensor operable to transmit light along a plurality of wavelengths into the subject's tissue; 2) sensing the light transmitted into the subject's tissue using the sensor, and producing signal data representative of the light sensed from the subject's tissue; 3) processing the signal data to account for physical characteristics of the subject; and 4) determining the blood oxygen saturation level within the subject's tissue using a difference in attenuation between the wavelengths. The apparatus includes a sensor having a light source and at least one light detector, which sensor is operably connected to a processor. The sensor is operable to transmit light along a plurality of wavelengths into the subject's tissue, and produce signal data representative of the light sensed from the subject's tissue. The algorithm is operable to process the signal data to account for the physical characteristics of the subject being sensed.
摘要翻译：根据本发明，提供了用于非侵入性地确定受试者组织内的血氧饱和度水平的方法和装置。该方法包括以下步骤：1）提供近红外分光光度传感器，可操作以将多个波长的光透射到被检者的组织中; 2）使用传感器感测传播到被检者组织的光，并且产生代表从被检者组织感测的光的信号数据; 3）处理信号数据以解决被摄体的物理特征; 以及4）使用所述波长之间的衰减差来确定所述受试者组织内的血氧饱和度水平。该装置包括具有光源和至少一个光检测器的传感器，该传感器可操作地连接到处理器。传感器可操作以将多个波长的光传输到被检者的组织中，并且产生表示从受检者组织感测的光的信号数据。该算法可操作以处理信号数据以考虑被感测对象的物理特性。

8. 发明申请

US20120108927A1 METHOD FOR SPECTROPHOTOMETRIC BLOOD OXYGENATION MONITORING 有权
标题翻译：分光光度法血液氧化监测方法
公开(公告)号：US20120108927A1
公开(公告)日：2012-05-03
申请号：US13323479
申请日：2011-12-12
申请人： Bo Chen , Paul B. Benni
发明人： Bo Chen , Paul B. Benni
IPC分类号： A61B5/1455
CPC分类号： A61B5/14553
摘要： A method and apparatus for non-invasively determining the blood oxygenation within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance.
摘要翻译：提供了一种用于非侵入性地确定受试者组织内的血氧饱和的方法和装置，其利用能够将光信号传输到对象的组织中的近红外分光光度计（NIRS）传感器，并且一旦其通过就感测光信号组织通过透光率或反射率。

9. 发明申请

US20090108205A1 NIRS SENSOR MOUNTING APPARATUS 审中-公开
标题翻译： NIRS传感器安装设备
公开(公告)号：US20090108205A1
公开(公告)日：2009-04-30
申请号：US12248556
申请日：2008-10-09
申请人： Karen Duffy , Paul Benni , George Brocksieper
发明人： Karen Duffy , Paul Benni , George Brocksieper
IPC分类号： G01J5/02
CPC分类号： A61B5/14552 , A61B5/14553 , A61B5/6814 , A61B5/6831 , G01N21/359 , G01N21/49
摘要： A near infrared spectrophotometric (NIRS) sensor apparatus is provided that includes at least one NIRS sensor and a mounting device. The sensor has at least one light source, at least one light detector, and a flexible pad. The light source and the light detector are mounted on the flexible pad, which flexible pad has a peripheral edge that extends around the entire periphery of the pad. The light source and light detectors are configured for connection to an electro-optical cable. The mounting device is operable to secure the sensor to a subject, which mounting device is sized to cover the sensor and contact the subject around the entire peripheral edge of the pad. The mounting device includes a light barrier that at least substantially blocks light from passing through the mounting device.
摘要翻译：提供了一种近红外分光光度计（NIRS）传感器装置，其包括至少一个NIRS传感器和安装装置。传感器具有至少一个光源，至少一个光检测器和柔性垫。光源和光检测器安装在柔性垫上，该柔性垫具有围绕垫的整个周边延伸的周边边缘。光源和光检测器被配置为连接到电光缆。安装装置可操作以将传感器固定到被检体，该安装装置的尺寸被设计成覆盖传感器并且将物体接触围绕垫的整个周边边缘。安装装置包括至少基本上阻挡光通过安装装置的光屏障。

10. 发明申请

US20080300474A1 Indicators For A Spectrophotometric System 有权
标题翻译：分光光度计的指标
公开(公告)号：US20080300474A1
公开(公告)日：2008-12-04
申请号：US12096132
申请日：2006-12-06
申请人： Paul B. Benni , Bo Chen , Andrew Kersey
发明人： Paul B. Benni , Bo Chen , Andrew Kersey
IPC分类号： A61B5/1455
CPC分类号： A61B5/6814 , A61B5/0073 , A61B5/14553 , A61B5/4076 , A61B5/742
摘要： A near-infrared spectrophotometric system (e.g., a cerebral oximeter) includes a sensor portion and a monitor portion. The monitor portion includes a processor that runs an algorithm which utilizes the amount of detected light to determine the value of the oxygen concentration (e.g., the absolute level of oxygen concentration). The monitor portion also includes a visual display that displays the determined oxygen concentration values in various formats. The monitor portion may also include an audible device (e.g., a speaker), that provides audible indications of the determined oxygen concentration values. Various visual indicators may include, for example, color-coded graphs of the determined oxygenation values to alert the system user, for example, whether one hemisphere of the brain, or one or more regions of the brain, is in danger of adverse and potentially permanent damage. Also, data may be pre-processed by selecting the most clinically concerning sensor value (e.g., the sensor with the lowest value), and displaying only that sensor value and its identification on the display screen. Alternatively, an average value of multiple sensor measurements may be displayed. This reduces screen clutter and increases the speed of interpretation by the system user. Also, all sensor values may be averaged, and the average value displayed. The determined oxygenation values may also be provided in an audible format.
摘要翻译：近红外分光光度计（例如，脑血氧计）包括传感器部分和监视部分。监视器部分包括运行算法的处理器，其利用检测到的光量来确定氧浓度的值（例如，氧浓度的绝对水平）。监视器部分还包括以各种格式显示所确定的氧浓度值的视觉显示器。监视器部分还可以包括提供所确定的氧浓度值的可听指示的可听设备（例如扬声器）。各种视觉指标可以包括例如所确定的氧合值的颜色编码图，以警告系统用户，例如，脑的一个半球或脑的一个或多个区域是否具有不利和可能的危险永久性损坏此外，可以通过选择临床上最临近的传感器值（例如，具有最低值的传感器）来预处理数据，并且仅在该显示屏上显示该传感器值及其识别。或者，可以显示多个传感器测量的平均值。这减少了屏幕杂乱并增加了系统用户的解读速度。此外，所有传感器值可以被平均，并且显示平均值。所确定的氧合值也可以以可听到的格式提供。

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