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1. 发明申请

US20130165419A1 COMBINATION ANTI-INFLAMMATORY OPHTHALMIC COMPOSITIONS 审中-公开
公开(公告)号：US20130165419A1
公开(公告)日：2013-06-27
申请号：US13333534
申请日：2011-12-21
申请人： Richard L. Lindstrom , Kamran Hosseini , Lyle M. Bowman
发明人： Richard L. Lindstrom , Kamran Hosseini , Lyle M. Bowman
IPC分类号： A61K31/573 , A61P27/02 , A61P31/12 , A61P31/04 , A61P27/12 , A61P27/06 , A61P35/00 , A61P33/02 , A61P31/10 , A61P29/00 , A61P27/14
CPC分类号： A61K31/573 , A61K9/0048 , A61K9/08 , A61K31/196 , A61K31/57 , A61K45/06 , A61K2300/00
摘要： Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.

2. 发明授权

US07795231B2 Concentrated aqueous azalide formulations 有权
标题翻译：浓盐水配方
公开(公告)号：US07795231B2
公开(公告)日：2010-09-14
申请号：US11905854
申请日：2007-10-04
申请人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
发明人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
IPC分类号： A61K31/00
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/351 , A61K31/573 , A61K31/7052 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
摘要翻译：本发明涉及浓氮ide啶抗生素的制剂及其制备和使用方法。具体地说，本发明涉及一种治疗感染的方法，其包括对有需要的患者施用有效量的根据包括将含有强酸的水溶液中的氮杂抗生素溶解的方法制备的浓氮唑类抗生素制剂。本发明还涉及用于制备用于肺部感染，鼻咽感染，耳部感染，眼部感染，皮肤或阴道感染的浓盐酸阿糖苷类抗生素制剂的方法。本发明还涉及通过将azalide抗生素溶解在包含强酸的水溶液中制备的浓氮唑类抗生素制剂。

3. 发明授权

US07732415B2 Topical treatment or prevention of ocular infections 有权
标题翻译：局部治疗或预防眼部感染
公开(公告)号：US07732415B2
公开(公告)日：2010-06-08
申请号：US10898170
申请日：2004-07-26
申请人： Chandler R. Dawson , Lyle M. Bowman
发明人： Chandler R. Dawson , Lyle M. Bowman
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/02 , A61K31/573 , A61K31/7048 , A61K31/7052 , A61K47/26 , A61K47/38 , Y02A50/411 , A61K2300/00
摘要： The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.
摘要翻译：将azalide抗生素如阿奇霉素局部应用于眼睛可用于治疗或预防眼部感染。在一个实施方案中，将阿扎利德抗生素供应给贮存库中的眼睛用于持续释放。还可以通过使用适当的贮库来提供更方便的给药方案。此外，还提供了含有药物组合的组合物。

4. 发明授权

US5332582A Stabilization of aminosteroids for topical ophthalmic and other applications 失效
标题翻译：用于局部眼科和其他应用的氨基甾体的稳定化
公开(公告)号：US5332582A
公开(公告)日：1994-07-26
申请号：US984445
申请日：1992-12-02
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00 , A61K47/28 , A61K31/59 , A61K37/22 , A61K37/52
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers; Stabilized and stabilized/solubilized pharmaceutical compositions adapted for various routes of administration are also described.
摘要翻译：本发明提供了使用有效稳定量的轻度交联的含羧基聚合物在局部眼用和其它药物制剂中稳定氨基取代的类固醇治疗剂的方法; 还描述了适用于各种给药途径的稳定和稳定/溶解的药物组合物。

5. 发明授权

US5192535A Ophthalmic suspensions 失效
标题翻译：眼科悬浮液
公开(公告)号：US5192535A
公开(公告)日：1993-03-09
申请号：US544518
申请日：1990-06-27
申请人： Jeffrey P. Davis , Santosh K. Chandrasekaran , Yansheng Su , Roy D. Archibald , Joseph R. Robinson
发明人： Jeffrey P. Davis , Santosh K. Chandrasekaran , Yansheng Su , Roy D. Archibald , Joseph R. Robinson
IPC分类号： A61K9/107 , A61F2/14 , A61K9/00 , A61K9/64 , A61K9/70 , A61K31/765 , A61K47/32
CPC分类号： A61K9/0048 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/915 , Y10S514/944 , Y10S514/953 , Y10S514/954
摘要： Lightly crosslinked polymers, preferably ones prepared by suspension or emulsion polymerizing at least about 90% by weight of a carboxyl-containing monoethylenically unsaturated monomer such as acrylic acid with from about 0.1% to about 5% by weight of a polyfunctional, and preferably difunctional, crosslinking agent such as divinyl glycol (3,4-dihydroxy-1,5-hexadiene), having a particle size of not more than about 50 .mu.m in equivalent spherical diameter, when formulated with an ophthalmic medicament, e.g., fluorometholone, into suspensions in aqueous medium in which the amount of polymer ranges from about 0.1% to about 6.5% by weight, based on the total weight of the aqueous suspension, the pH is from about 3.0 to about 6.5, and the osmotic pressure (osmolality or tonicity) is from about 10 mOsM to about 400 mOsM, provide new topical ophthalmic medicament delivery systems having suitably low viscosities which permit them to be easily administered to the eye in drop form, and hence be comfortably administrable in consistent, accurate dosages. These suspension will rapidly gel in the eye after coming into contact with the eye's tear fluid to a substantially greater viscosity than that of the originally-introduced suspension and thus remain in place for prolonged periods of time to provide sustained release of the ophthalmic medicament.
摘要翻译：轻度交联的聚合物，优选通过悬浮或乳液聚合至少约90重量％的含羧基的单烯属不饱和单体如丙烯酸与约0.1重量％至约5重量％的多官能，优选双官能的，当与眼科药物（例如氟米龙）一起配制成悬浮液时，具有当量球形直径不大于约50μm的粒度的二乙烯基二醇（3,4-二羟基-1,5-己二烯）等交联剂在水性介质中，其中聚合物的量为约0.1％至约6.5％（重量），基于水性悬浮液的总重量，pH为约3.0至约6.5，渗透压（渗透压或渗透压）提供了约10mOsM至约400mOsM的新型局部眼科药物递送系统，其具有适当的低粘度，使得它们能够以滴剂形式容易地施用于眼睛，因此是以一致，准确的剂量舒适地管理。在与眼睛的泪液接触之后，这些悬浮液将在眼睛中快速凝胶至比最初引入的悬浮液的粘度显着更大的粘度，并因此保持在适当位置以延长时间以提供眼药物的持续释放。

6. 发明授权

US5124154A Aminosteroids for ophthalmic use 失效
标题翻译：用于眼科用途的氨基磷酸酯
公开(公告)号：US5124154A
公开(公告)日：1992-06-23
申请号：US537062
申请日：1990-06-12
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C. Si , Santosh K. Chandrasekran
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48 , A61P27/02 , C07J41/00
CPC分类号： B82Y5/00 , A61K31/56 , A61K31/58 , A61K38/08 , A61K47/48969 , A61K9/0048 , Y10S514/801 , Y10S514/887 , Y10S514/912 , Y10S514/913 , Y10S514/944
摘要： Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.
摘要翻译：用于预防或治疗眼科疾病或病症的方法和组合物，其中将眼科有效量的式XI的C20至C26氨基甾体及其药物，可接受的盐，水合物或溶剂合物施用于惰性载体中以阻止对眼睛造成损害的氧化过程。

7. 发明申请

US20150190407A1 METHODS FOR TREATMENT OF POSTOPERATIVE INFLAMMATION WITH REDUCED INTRAOCULAR PRESSURE 审中-公开
标题翻译：用减少内分泌压治疗术后炎症的方法
公开(公告)号：US20150190407A1
公开(公告)日：2015-07-09
申请号：US14149743
申请日：2014-01-07
申请人： Insite Vision Incorporated
发明人： Kamran HOSSEINI , Lyle M. BOWMAN
IPC分类号： A61K31/573 , A61K31/568 , A61K47/36 , A61K9/00 , A61K47/32
CPC分类号： A61K31/573 , A61K9/0048 , A61K31/568 , A61K31/78 , A61K47/32 , A61K47/36 , A61K2300/00
摘要： Methods of treating a subject after ocular surgery are disclosed. The methods include administering to an eye of a subject in need thereof a composition comprising at least one corticosteroid or an ophthalmically acceptable salt thereof in an ophthalmically acceptable vehicle that can provide a sustained release of the at least one corticosteroid or an ophthalmically acceptable salt thereof. Advantageously, the composition does not result in a statistically significant elevation in intraocular pressure in a statistically significant number of subject eyes when administered twice daily over a period of two weeks.
摘要翻译：公开了在眼外科手术后治疗受试者的方法。所述方法包括向有需要的受试者的眼睛施用包含至少一种皮质类固醇或其眼科可接受的盐的眼科可接受的载体中的组合物，其可提供所述至少一种皮质类固醇或其眼用可接受的盐的持续释放。有利地，当在两周的时间内每天两次施用时，组合物在统计学上显着数目的受试者眼睛中不会导致统计学上的眼压升高。

8. 发明申请

US20100305054A1 CONCENTRATED AQUEOUS AZALIDE FORMULATIONS 审中-公开
标题翻译：浓缩水杨酸盐配方
公开(公告)号：US20100305054A1
公开(公告)日：2010-12-02
申请号：US12855096
申请日：2010-08-12
申请人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
发明人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
IPC分类号： A61K31/7052 , A61P33/02 , A61P31/04 , A61P29/00
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/351 , A61K31/573 , A61K31/7052 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
摘要翻译：本发明涉及浓氮ide啶抗生素的制剂及其制备和使用方法。具体地说，本发明涉及一种治疗感染的方法，其包括对有需要的患者施用有效量的根据包括将含有强酸的水溶液中的氮杂抗生素溶解的方法制备的浓氮唑类抗生素制剂。本发明还涉及用于制备用于肺部感染，鼻咽感染，耳部感染，眼部感染，皮肤或阴道感染的浓盐酸阿糖苷类抗生素制剂的方法。本发明还涉及通过将azalide抗生素溶解在包含强酸的水溶液中制备的浓氮唑类抗生素制剂。

9. 发明申请

US20040266702A1 Topical treatment or prevention of ocular infections 有权
标题翻译：局部治疗或预防眼部感染
公开(公告)号：US20040266702A1
公开(公告)日：2004-12-30
申请号：US10898170
申请日：2004-07-26
申请人： INSITE VISION INCORPORATED
发明人： Chandler R. Dawson , Lyle M. Bowman
IPC分类号： A61K031/7048
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/02 , A61K31/573 , A61K31/7048 , A61K31/7052 , A61K47/26 , A61K47/38 , Y02A50/411 , A61K2300/00
摘要： The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.

10. 发明授权

US5252319A Aminosteroids for ophthalmic use 失效
公开(公告)号：US5252319A
公开(公告)日：1993-10-12
申请号：US836866
申请日：1992-02-19
申请人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C.-C. Si , Santosh K. Chandrasekaran
发明人： John C. Babcock , Jon R. Polansky , Lyle M. Bowman , Sheng-Wan Tsao , Erwin C.-C. Si , Santosh K. Chandrasekaran
IPC分类号： A61K9/00 , A61K31/58 , A61K47/28 , A61K37/22
CPC分类号： B82Y5/00 , A61K31/58 , A61K9/0048 , Y10S514/801 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944
摘要： Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.

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