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1. 发明申请

US20140049632A1 SYSTEMS AND METHODS FOR IMAGING TISSUE 有权
标题翻译：用于成像组织的系统和方法
公开(公告)号：US20140049632A1
公开(公告)日：2014-02-20
申请号：US13963151
申请日：2013-08-09
申请人： Lucid, Inc.
发明人： Paul Hemmer
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/0012 , G02B21/0028 , G02B21/008
摘要： Method and system for imaging tissue, including (i) causing a macroscopic image of a tissue surface to be displayed on a visual display; (ii) receiving a selection of at least one portion of the macroscopic image; (iii) causing a plurality of confocal images captured by a confocal imager at different depths in a portion of the tissue to be displayed; (iv) receiving a selection of at least one target depth image; and (v) for each selected target depth image, instructing the confocal imager to capture a plurality of additional images at different locations and at a common depth with the target depth image. A system for imaging tissue having a macroscopic display module; a first selection module; a confocal display module; a second selection module; and an instruction module for instructing a confocal imager to capture a plurality of images at different locations over a selected region of the tissue.
摘要翻译：用于成像组织的方法和系统，包括（i）使组织表面的宏观图像显示在视觉显示器上; （ii）接收对所述宏观图像的至少一部分的选择; （iii）使由共聚焦成像仪捕获的多个共焦图像在组织的一部分显示的不同深度处; （iv）接收至少一个目标深度图像的选择; 和（v）对于每个所选择的目标深度图像，指示共焦成像器在与目标深度图像不同的位置和共同的深度捕获多个附加图像。一种用于成像具有宏观显示模块的组织的系统; 第一选择模块; 共焦显示模块; 第二选择模块; 以及指示模块，用于指示共焦成像器在组织的选定区域上的不同位置拍摄多个图像。

2. 发明授权

US08121670B2 System for confocal imaging within dermal tissue 有权
标题翻译：真皮组织内共聚焦成像系统
公开(公告)号：US08121670B2
公开(公告)日：2012-02-21
申请号：US11081181
申请日：2005-03-16
申请人： James M. Zavislan
发明人： James M. Zavislan
IPC分类号： A61B6/00
CPC分类号： A61B5/6842 , A61B5/0068 , A61B5/061 , A61B5/441 , A61B5/444 , A61B5/445 , A61B5/6834 , A61B5/6835 , A61B5/6843 , A61B5/704
摘要： An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.
摘要翻译：提供了一种用于患者真皮组织内的共焦成像的改进系统，其通过减少组织相对于系统的共聚焦成像光学器件的相对运动而使共焦图像中的不稳定性最小化。该系统包括用于通过在该区域的边缘处施加力来保持应力下的皮肤组织的面积的机构，以及耦合到该机构的用于对应力皮肤成像的成像头。该机构包括机械结构，例如压板，支架或附件，其均支撑系统的成像头部，并将应力施加到组织的有限表面区域，以使共聚焦成像期间的皮肤运动最小化。

3. 发明授权

US08115918B2 Imaging of surgical biopsies 有权
标题翻译：外科活检成像
公开(公告)号：US08115918B2
公开(公告)日：2012-02-14
申请号：US11788920
申请日：2007-04-23
申请人： James M. Zavislan , Roger J. Greenwald
发明人： James M. Zavislan , Roger J. Greenwald
IPC分类号： G01N21/01
CPC分类号： G02B21/0024 , A61B10/0096 , G01N1/36 , G02B21/34
摘要： Encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by an imaging system (10). The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the imaging system provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The imaging system's display (28) indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof.
摘要翻译：包封的组织被包含在光学透明的盒（34）中。包围盒的盒（34）或端盖（38）标记有基准（40），指示并对应于患者身体上的切除位置。通过成像系统（10）获得优选地是组织样本的表面的表示和样本的内部并且与其表面相邻的垂直部分区域的图像。盒子优选地移动到使得盒子平移的阶段（22）中，使得成像系统的头部（12）在垂直于盒子的壁的方向（也垂直于包裹在盒中的组织的表面）。成像系统的显示器（28）表示在样品表面处和附近的形态及其位置。

4. 发明授权

US07711410B2 System for marking the locations of imaged tissue with respect to the surface of the tissue 有权
标题翻译：用于标记成像组织相对于组织表面的位置的系统
公开(公告)号：US07711410B2
公开(公告)日：2010-05-04
申请号：US10836691
申请日：2004-04-30
申请人： James M. Zavislan , Roger J. Greenwald
发明人： James M. Zavislan , Roger J. Greenwald
IPC分类号： A61B6/00
CPC分类号： G02B21/34 , A61B5/0066 , A61B5/0068 , A61B5/0088 , A61B5/445 , A61B5/6842 , A61B5/6843 , A61B5/704 , G01N2001/282 , G02B21/002
摘要： A system is provided for marking on a recording medium (36), such as a label, the location of imaged tissue with respect to an exposed surface of the tissue (34). Tissue is imaged by a microscope (11) capable of imaging sections of the tissue below the exposed tissue surface through optics. A ring (32) applied to the surface of the tissue stabilizes the tissue to the optics and localizes a portion of the tissue surface through an aperture in the ring. An actuator (38) is connected to both the ring and the microscope for moving the ring to adjust the position of the tissue with respect to the optics, thereby allowing an operator of the system to survey different images of tissue sections with the microscope.
摘要翻译：提供了一种用于在诸如标签的记录介质（36）上标记相对于组织（34）的暴露表面的成像组织的位置的系统。通过显微镜（11）对组织进行成像，该显微镜能够通过光学元件在组织表面下方的组织成像。应用于组织表面的环（32）将组织稳定到光学元件，并通过环中的孔定位组织表面的一部分。致动器（38）连接到环和显微镜两者以移动环以调节组织相对于光学器件的位置，从而允许系统的操作者用显微镜检测组织切片的不同图像。

5. 发明授权

US07227630B1 Imaging of surgical biopsies 有权
标题翻译：外科活检成像
公开(公告)号：US07227630B1
公开(公告)日：2007-06-05
申请号：US09786901
申请日：1999-09-13
申请人： James M. Zavislan , Roger J. Greenwald
发明人： James M. Zavislan , Roger J. Greenwald
IPC分类号： G01N21/01
CPC分类号： G02B21/0028
摘要： In order to determine, rapidly and without the delay required by conventional tissue preparation techniques for pathological examination (freezing, sectioning, staining, etc.), whether, an excision, which may be a biopsy sample, is representative of the morphology of interest of whether an excisional biopsy in which the tissue taken completely removes the abnormality is, in either case, the tissue which is desired to be excisioned, the tissue specimen (18) in encapsulated, preferably as part of the biopsy procedure. The encapsulated tissue is contained in an optically transparent cassette (34). The cassette (34) or an endcap (38) enclosing the cassette is marked with a fiducial (40) indicating and corresponding to the location of the excision on the patient's body. An image, which is preferably a representation of a surface of the tissue specimen and the vertical section(s) area of the tissue internal of the specimen and adjacent to a surface thereof, is obtained by means of an electro-optical imaging system (10), preferably a confocal laser scanning microscope. The cassette is moved, preferably in a stage (22) which rotates the cassette while translating it, so that the head (12) of the confocal microscope (its objective lens) provides a linear scan in a direction perpendicular to the wall of the cassette (also perpendicular to the surface of the tissue encapsulated in the cassette). The display (28) from the microscope indicates the morphology at and in proximity to the surface of the specimen as well as the location thereof. The pathologist and the surgeon is thereby provided with information concerning the specimen and whether the entire abnormality desired to be removed has indeed been removed and/or whether the biopsy is representative of the body region of interest in the case of a biopsy sample.
摘要翻译：为了快速确定传统的组织制备技术用于病理检查（冷冻，切片，染色等）所需的延迟，切除可能是活组织检查样本的代表性是代表感兴趣的形态无论是在所有情况下，组织样本（18）被封装，优选地作为活检程序的一部分，是否完全去除组织的切除活检是否在任何情况下都是希望被切除的组织。封装的组织被包含在光学透明的盒（34）中。包围盒的盒（34）或端盖（38）标记有基准（40），指示并对应于患者身体上的切除位置。通过电光成像系统（10）获得优选地是组织样本的表面的图案和样本内部的组织的垂直截面区域），优选共焦激光扫描显微镜。盒子最好在使盒子旋转的阶段（22）中移动，使得共聚焦显微镜（其物镜）的头部（12）在与盒子的壁垂直的方向上提供线性扫描（也垂直于包封在盒中的组织的表面）。来自显微镜的显示器（28）表示在样品表面上和附近的形态及其位置。因此，病理学家和外科医生提供了关于样本的信息，以及是否确实去除了所有需要去除的整个异常和/或在活组织检查样品的情况下活检是否代表感兴趣的身体区域。

6. 发明授权

US07225010B1 System and method for confocal imaging within dermal tissue 有权
标题翻译：真皮组织内共聚焦成像的系统和方法
公开(公告)号：US07225010B1
公开(公告)日：2007-05-29
申请号：US09658736
申请日：2000-09-11
申请人： James M. Zavislan
发明人： James M. Zavislan
IPC分类号： A61B5/00
CPC分类号： A61B5/6842 , A61B5/0068 , A61B5/061 , A61B5/441 , A61B5/444 , A61B5/445 , A61B5/6834 , A61B5/6835 , A61B5/6843 , A61B5/704
摘要： An improved system for confocal imaging within dermal tissue of a patient is provided which minimizes instability in confocal images by reducing the relative motion of the tissue with respect to the confocal imaging optics of the system. The system includes a mechanism for maintaining an area of skin tissue under stress by application of force at the edges of the area, and an imaging head coupled to this mechanism for imaging the stressed skin. The mechanism includes a mechanical structure, such as a platen, brace, or attachment, which both supports the imaging head of the system and applies stress to a limited surface area of the tissue to minimize skin motion during confocal imaging.
摘要翻译：提供了一种用于患者真皮组织内的共焦成像的改进系统，其通过减少组织相对于系统的共聚焦成像光学器件的相对运动而使共焦图像中的不稳定性最小化。该系统包括用于通过在该区域的边缘处施加力来保持应力下的皮肤组织的面积的机构，以及耦合到该机构的用于对应力皮肤成像的成像头。该机构包括机械结构，例如压板，支架或附件，其均支撑系统的成像头部，并将应力施加到组织的有限表面区域，以使共聚焦成像期间的皮肤运动最小化。

7. 发明授权

US07190990B2 Cellular surgery utilizing confocal microscopy 有权
标题翻译：使用共焦显微镜的细胞手术
公开(公告)号：US07190990B2
公开(公告)日：2007-03-13
申请号：US10698294
申请日：2003-10-31
申请人： James M. Zavislan , Roger J. Greenwald
发明人： James M. Zavislan , Roger J. Greenwald
IPC分类号： A61B6/00
CPC分类号： G02B26/12 , A61B18/20 , A61B18/203 , A61B90/20 , A61B2018/00452 , A61B2018/00636 , A61B2562/0242 , G02B21/0012 , G02B21/0028
摘要： An improved system for cellular surgery which includes a laser for producing a laser beam, and confocal optics for scanning and focusing the laser beam in tissue and generating confocal images of the tissue in accordance with returned light from the tissue. The confocal images are visualized on a display. The system includes a controller for enabling the operator to select one or more cells of the tissue in the displayed confocal images for surgical treatment. The controller operates the laser and confocal optics in a first mode to treat the tissue when the confocal optics focus the laser beam at least one region associated with the selected cells in the tissue, but at all other times operates the laser and confocal optics in a second mode which does not damage the tissue. The treatment may be localized to concentrate the energy of the laser to the region including the selected cell or cells, or the treatment may be non-localized to distribute the energy of the laser to the region which includes the selected cell(s) and also the cells of the tissue surrounding such selected cell(s). In another embodiment, an apparatus is provided having a confocal imaging system, which focuses a first laser beam through confocal optics to tissue and provides confocal images of the tissue, and a treatment system which focuses a second laser beam through the confocal optics coaxial with the first laser beam for treating at one or more selected locations in the imaged tissue.
摘要翻译：一种用于细胞手术的改进的系统，其包括用于产生激光束的激光器和用于在组织中扫描和聚焦激光束并根据来自组织的返回光产生组织的共聚焦图像的共聚焦光学器件。共焦图像在显示器上可视化。该系统包括用于使操作者能够选择所显示的共聚焦图像中的组织的一个或多个细胞用于外科治疗的控制器。控制器以第一模式操作激光和共聚焦光学器件，以在共焦光学器件将激光束聚焦到与所选择的细胞相关联的至少一个区域在组织中时处理组织，但是在所有其它时间将激光和共聚焦光学器件操作在不损伤组织的第二模式。治疗可以被定位以将激光的能量集中到包括所选择的细胞或细胞的区域，或者治疗可以非局部化以将激光的能量分布到包括所选细胞的区域，并且还围绕这样选择的细胞的组织的细胞。在另一个实施例中，提供一种具有共焦成像系统的设备，该共焦成像系统将第一激光束通过共聚焦光学器件聚焦到组织并提供组织的共聚焦图像;以及处理系统，其将第二激光束通过与第一激光束用于在成像组织中的一个或多个选定位置处理。

8. 发明授权

US07110114B2 System and method for enhancing confocal reflectance images of tissue specimens 有权
标题翻译：用于增强组织标本的共焦反射图像的系统和方法
公开(公告)号：US07110114B2
公开(公告)日：2006-09-19
申请号：US10787473
申请日：2004-02-26
申请人： Milind Rajadhyaksha , James M. Zavislan
发明人： Milind Rajadhyaksha , James M. Zavislan
IPC分类号： G01J4/00
CPC分类号： G01N21/21 , G01N21/47 , G01N21/49 , G01N2021/4735 , G01N2021/4792 , G02B21/0032 , G02B21/0048 , G02B21/0068 , G02B21/14 , G02B21/33 , G02B21/36
摘要： A confocal scanning microscope system (10) using cross polarization effects and an enhancement agent (acetic acid) to enhance confocal microscope reflectance images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous call carcinomas) in the confocal reflectance images of excised tumor slices. The confocal scanning microscope system having a laser (11) for generating an illumination beam (12), a polygon mirror (18) for scanning the beam to a tissue sample (22) and for receiving a return beam from the tissue sample and detector (28) for detecting the returned beam to form an image. The system further includes a half-waveplate (13) having a rotatable stage (14) and a quarter-wave plate (21) having a rotatable stage (20) disposed in the optical path of the illumination beam and at least a linear polarizer (24) having a rotatable stage (25) disposed in the optical pat of the returned beam from the tissue sample.
摘要翻译：使用交叉极化效应的共焦扫描显微镜系统（10）和增强剂（乙酸）以增强切除的共聚焦反射图像中BCC（基底细胞癌）和SCC（鳞状细胞癌）的细胞核的共聚焦显微镜反射图像肿瘤切片。具有用于产生照明光束的激光器（11）的共焦扫描显微镜系统，用于将光束扫描到组织样本（22）并用于从组织样本和检测器（22）接收返回光束的多面镜（18） 28），用于检测返回的光束以形成图像。该系统还包括具有可旋转台（14）和四分之一波片（21）的半波片（13），其具有设置在照明光束的光路中的可旋转台（20）和至少一个线性偏振器 24）具有设置在来自组织样本的返回光束的光学拍摄中的可旋转台（25）。

9. 发明授权

US06856458B2 Tissue specimen holder 有权
标题翻译：组织样本架
公开(公告)号：US06856458B2
公开(公告)日：2005-02-15
申请号：US09973109
申请日：2001-10-09
申请人： Roger J. Greenwald , James M. Zavislan
发明人： Roger J. Greenwald , James M. Zavislan
IPC分类号： B01L3/00 , G01N1/36 , G01N21/03 , G02B21/00 , G02B21/34 , G01N21/01
CPC分类号： G01N21/0303 , B01L3/508 , B01L2300/043 , B01L2300/0609 , B01L2300/0654 , B01L2300/0672 , B01L2300/0822 , B01L2400/0683 , G01N1/36 , G01N2021/0339 , G01N2021/0342 , G01N2021/0364 , G02B21/0028 , G02B21/34
摘要： A tray or holder for tissue specimens, especially of excised tissue, such as biopsied specimens, is used with a confocal imaging system. The tray may be disposable after imaging of the specimen carried therein or may archive the specimen. A window supports the specimen. Clamps mounted inside the tray restrain the tissue. A compliant bag is mounted outside the tray on one side of a window of the tray on which the specimen is disposed. During imaging the specimen is immersed in a liquid contained in the tray having an index of refraction which closely matches the index of refraction of the tissue. The bag also contains an index matching liquid preferably having the same index as the liquid in the tray. Selecting an immersion liquid, which equals the refractive index of the near surface tissue, minimizing wavefront distortion which may result from an effectively corrugated surface of the specimen.
摘要翻译：用于组织标本的托盘或保持器，特别是切除的组织，例如活检标本，与共聚焦成像系统一起使用。托盘在其中携带的样本成像后可以是一次性的，或可以归档样品。一个窗口支撑样本。安装在托盘内的夹具限制纸巾。将合适的袋安装在托盘外侧的托盘的一侧，其中放置有试样。在成像期间，将样品浸入包含在托盘中的液体中，该折射率与组织的折射率非常匹配。该袋还包含一种优选地具有与托盘中的液体相同的指数的折射率匹配液体。选择等于近表面组织的折射率的浸液，最小化可能由于样品的有效波纹表面产生的波前畸变。

10. 发明授权

US08260401B2 Non-invasive in-vivo imaging of mechanoreceptors in skin using confocal microscopy 有权
标题翻译：使用共焦显微镜在皮肤中机械感受器的非侵入性体内成像
公开(公告)号：US08260401B2
公开(公告)日：2012-09-04
申请号：US11878638
申请日：2007-07-25
申请人： David Herrmann , Christi Alessi Fox
发明人： David Herrmann , Christi Alessi Fox
IPC分类号： A61B6/00
CPC分类号： G06T7/0012 , G06T2207/10056 , G06T2207/30088
摘要： Meissner's Corpuscles (MCs) are touch-pressure sensation receptors in glabrous skin. They are imaged by reflectance confocal microscopy to provide a non-invasive, in vivo quantification of their density or size to allow screening for, diagnosis or monitoring of sensory neuropathy and other peripheral nervous system disorders related to diabetes, HIV, or other conditions.
摘要翻译： Meissner's Corpuscles（MCs）是无毛皮肤的触感压感受体。它们通过反射共聚焦显微镜成像，以提供其密度或尺寸的非侵入性体内定量，以允许筛查，诊断或监测与糖尿病，HIV或其他病症相关的感觉神经病变和其它周围神经系统疾病。

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