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1. 发明申请

US20180307017A1 APERTURE SCANNING FOURIER PTYCHOGRAPHIC IMAGING 审中-公开
公开(公告)号：US20180307017A1
公开(公告)日：2018-10-25
申请号：US15959050
申请日：2018-04-20
申请人： California Institute of Technology
发明人： Roarke W. Horstmeyer , Guoan Zheng , Xiaoze Ou , Changhuei Yang
IPC分类号： G02B21/00 , G01T1/185 , G02B21/36 , G02B21/16 , G01N23/205 , G01T3/00 , G02B27/46 , G02B27/58
CPC分类号： G02B21/008 , G01N23/205 , G01T1/185 , G01T3/008 , G02B21/0032 , G02B21/0048 , G02B21/0056 , G02B21/006 , G02B21/16 , G02B21/367 , G02B27/46 , G02B27/58
摘要： Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of an optical arrangement, and a detector that can acquire lower resolution intensity images for different aperture locations, and wherein a higher resolution complex image may be constructed by iteratively updating regions in Fourier space with the acquired lower resolution images.

2. 发明授权

US10027855B2 System for synchronization in a line scanning imaging microscope 有权
公开(公告)号：US10027855B2
公开(公告)日：2018-07-17
申请号：US13704748
申请日：2011-06-29
申请人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
发明人： Witold Bula , Pavel A. Fomitchov , Steve Goodson , Erwen Mei , Yang Zhang
IPC分类号： H04N5/04 , G02B21/00 , H04N1/113 , H04N1/195
CPC分类号： H04N5/04 , G02B21/0048 , H04N1/113 , H04N1/195 , H04N2201/04715 , H04N2201/04755
摘要： A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.

3. 发明授权

US10018817B2 Adaptive optics for imaging through highly scattering media in oil reservoir applications 有权
公开(公告)号：US10018817B2
公开(公告)日：2018-07-10
申请号：US15061056
申请日：2016-03-04
申请人： Aramco Services Company , SAUDI ARABIAN OIL COMPANY , TRUSTEES OF BOSTON UNIVERSITY
发明人： Thomas Bifano , Shannon L. Eichmann , Bennett B. Goldberg , Mazen Kanj , Hari P. Paudel , William Shain
IPC分类号： G01J1/58 , G02B21/00 , G02B21/02 , G01N21/64 , G02B27/00 , G02B21/36
CPC分类号： G02B21/0028 , G01N21/6458 , G01N2201/0675 , G02B21/002 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/008 , G02B21/02 , G02B21/367 , G02B27/0068
摘要： Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system.

4. 发明申请

US20180129031A1 RESONANT SCANNER INTEROPERATION WITH MOVABLE STAGE 审中-公开
公开(公告)号：US20180129031A1
公开(公告)日：2018-05-10
申请号：US15730668
申请日：2017-10-11
申请人： CALIBER IMAGING & DIAGNOSTICS, INC.
发明人： KEITH AARON HADLEY , JASON WILLIAM FAULRING , PAUL MICHAEL HEMMER , JAMES VINCENT MASSARO
IPC分类号： G02B21/26 , G02B21/00 , G01N33/483
CPC分类号： G02B21/26 , G01N33/4833 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/008
摘要： A system, apparatus and method and method for controlling interoperation between a resonant scanner and a movable stage. The movable stage being employed to position a specimen for optical scanning by the resonant scanner. The invention providing high resolution scanning of specimen tissue at a rate of ten times or more faster than other known methods of optically scanning a specimen.

5. 发明申请

US20180120549A1 MICROSCOPE APPARATUS 审中-公开
公开(公告)号：US20180120549A1
公开(公告)日：2018-05-03
申请号：US15728726
申请日：2017-10-10
申请人： OLYMPUS CORPORATION
发明人： Susumu HONDA
IPC分类号： G02B21/00 , G02B27/28 , G02F1/01
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/0048 , G02B21/0068 , G02B27/283 , G02F1/0102
摘要： A microscope apparatus includes: an objective lens; an observation optical system that makes the specimen be irradiated with excitation light by the objective lens, and acquires image information of the specimen; a first stimulation optical system that includes a scanning section which scans stimulus light, makes the scanning section scan an irradiation position of the stimulus light and applies an optical stimulus to the specimen; a second stimulation optical system that includes an SLM arranged at a pupil conjugate position of the objective lens and capable of modulating a phase of the stimulus light, selectively switches the irradiation position of the stimulus light by the SLM and applies the optical stimulus to the specimen; and a light path selecting section that selects at least one of a light path of the first stimulation optical system and a light path of the second stimulation optical system.

6. 发明授权

US09924863B2 Optical coherence tomography systems integrated with surgical microscopes 有权
公开(公告)号：US09924863B2
公开(公告)日：2018-03-27
申请号：US15246578
申请日：2016-08-25
申请人： Bioptigen, Inc.
发明人： Eric L. Buckland , Nestor O. Farmiga , Robert H. Hart , Andrew Murnan , Christopher Saxer
IPC分类号： A61B3/14 , A61B3/00 , A61B3/10 , G01B9/02 , A61B3/13 , G02B21/00 , G02B21/02 , G02B27/00 , G02B27/09 , G02B27/14 , A61B5/00 , G02B1/11
CPC分类号： A61B3/102 , A61B3/13 , A61B3/132 , A61B5/0066 , G01B9/02039 , G01B9/02091 , G02B1/11 , G02B21/0012 , G02B21/0048 , G02B21/006 , G02B21/02 , G02B21/025 , G02B27/0031 , G02B27/0955 , G02B27/141
摘要： Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.

7. 发明申请

US20180078129A1 IMAGING DEVICE AND METHOD FOR IMAGING SPECIMENS 审中-公开
公开(公告)号：US20180078129A1
公开(公告)日：2018-03-22
申请号：US15553181
申请日：2016-02-24
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , SINGAPORE HEALTH SERVICES PTE LTD
发明人： Murukeshan Vadakke Matham , Shinoj Vengalathunadakal Kuttinarayanan , Xun Jie Jesmond Hong , Baskaran Mani , Tin Aung
IPC分类号： A61B3/00 , A61B3/14 , A61B3/13 , G02B21/00 , G02B27/09
CPC分类号： A61B3/0008 , A61B3/00 , A61B3/102 , A61B3/117 , A61B3/13 , A61B3/14 , G01N21/6458 , G02B5/001 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/36 , G02B27/0927 , G02B27/0955
摘要： According to various embodiments, there is provided an imaging device including a Bessel beam generator configured to provide a Bessel beam; a scanning mirror configured to scan the Bessel beam across a two-dimensional plane; a scan lens configured to receive the Bessel beam from the scanning mirror, a centre of the scan lens being at least substantially a focal length of the scan lens away from the scanning mirror; an illumination tube lens configured to receive the Bessel beam from the scan lens, a centre of the illumination tube lens being at least substantially a sum of the focal length of the scan lens and a focal length of the illumination tube lens away from the centre of the scan lens; an illumination objective lens positioned in direct line-of-sight to a specimen, the illumination objective lens configured to receive the Bessel beam from the illumination tube lens and further configured to illuminate the specimen with the Bessel beam, wherein a centre of the illumination objective lens is at least substantially the focal length of the illumination tube lens away from the centre of the illumination tube lens; and a detection optics arrangement configured to receive a reflected beam (emitted fluorescence beam) from the specimen.

8. 发明申请

US20180003938A1 SCANNING MICROSCOPE 审中-公开
公开(公告)号：US20180003938A1
公开(公告)日：2018-01-04
申请号：US15629539
申请日：2017-06-21
申请人： OLYMPUS CORPORATION
发明人： Chika NAKAMOTO , Yosuke TANI
IPC分类号： G02B21/00 , G01B11/25
CPC分类号： G02B21/0084 , G01B11/2518 , G02B21/0024 , G02B21/0048
摘要： A scanning microscope includes a two-dimensional scanning device that includes a first scanner and a second scanner for scanning, in oscillation motion and with light, a sample in directions orthogonal to each other, the first scanner scanning the sample at a speed higher than a speed of the second scanner, and a scan controller that controls the two-dimensional scanning device.

9. 发明授权

US09823456B2 Laser scanning microscope 有权
公开(公告)号：US09823456B2
公开(公告)日：2017-11-21
申请号：US15098092
申请日：2016-04-13
申请人： OLYMPUS CORPORATION
发明人： Kanako Kondo , Makio Ueno
IPC分类号： G02B26/08 , G02B21/00 , G02B21/08 , G02B26/10
CPC分类号： G02B21/0048 , G02B21/0032 , G02B21/0076 , G02B21/08 , G02B26/101 , G02B26/105
摘要： In order to allow precise observation of a specimen at an observation point with a desired depth without changing the working distance of an objective optical system while employing a simple configuration, a laser scanning microscope according to the present invention includes an objective lens having a plurality of optical elements that are disposed with gaps therebetween in an optical-axis direction and that condense laser light emitted from a light source onto a specimen and also having an adjustment ring that allows changing of the focal point by moving the optical elements in the optical-axis direction; a scanner that has a galvanometer mirror capable of oscillating about a predetermined oscillation axis and that scans the laser light condensed onto the specimen by the objective lens in accordance with an oscillation angle of the galvanometer mirror; a light detecting unit that obtains image information of the specimen on the basis of return light returned from the specimen scanned with the laser light; and a scanner controlling unit that controls the oscillation angle of the galvanometer mirror so as to maintain an observation range of the specimen observed by the light detecting unit on the basis of the positions of the optical elements moved by the adjustment ring.

10. 发明申请

US20170269000A1 OBSERVATION SYSTEM AND OBSERVATION METHOD 审中-公开
公开(公告)号：US20170269000A1
公开(公告)日：2017-09-21
申请号：US15616995
申请日：2017-06-08
申请人： OLYMPUS CORPORATION
发明人： Yoshioki KANEKO
IPC分类号： G01N21/64 , G02B21/00 , A61B5/00
CPC分类号： G01N21/6458 , A61B1/00186 , A61B1/043 , A61B5/0071 , A61B5/0084 , G01N2021/6478 , G01N2201/0636 , G01N2201/105 , G02B3/0006 , G02B21/0032 , G02B21/0044 , G02B21/0048 , G02B21/0076 , G02B21/361
摘要： Provided is a system for observing an object that emits fluorescence when irradiated with excitation light. The system includes: a hole unit having holes on a plane perpendicular to an optical axis of the objective lens to allow the excitation light to pass through the holes in a direction parallel to the optical axis; and an imaging unit including: an imaging lens configured to focus the fluorescence; a microlens array having microlenses arranged on a plane perpendicular to an optical axis of the imaging lens; and an image sensor having pixels configured to: receive the fluorescence via the objective lens, at least one of the holes, and the microlens array, the fluorescence being emitted when the object is irradiated with the excitation light having passed through at least one of the holes and the objective lens; and output an image signal in accordance with an intensity of the received fluorescence.

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