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1. 发明申请

US20220213184A1 IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 有权
公开(公告)号：US20220213184A1
公开(公告)日：2022-07-07
申请号：US17373426
申请日：2021-07-12
申请人： NOVARTIS PHARMA AG
发明人： David P. Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
IPC分类号： C07K16/24 , C07K14/54 , G01N33/68 , A61K38/20
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

2. 发明申请

US20220213183A1 IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 有权
公开(公告)号：US20220213183A1
公开(公告)日：2022-07-07
申请号：US17373414
申请日：2021-07-12
申请人： NOVARTIS PHARMA AG
发明人： David P Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
IPC分类号： C07K16/24 , C07K14/54 , G01N33/68 , A61K38/20
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

3. 发明授权

US08802149B2 Systems and processes for spray drying hydrophobic and hydrophilic components 有权
标题翻译：用于喷雾干燥疏水和亲水组分的系统和方法
公开(公告)号：US08802149B2
公开(公告)日：2014-08-12
申请号：US12469634
申请日：2009-05-20
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K9/14 , A61K9/12
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1623 , A61K31/12 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
摘要翻译：制备具有疏水性和亲水性成分的干粉的方法包括组合该组分溶液并在喷雾干燥器中同时喷雾干燥它们。亲水和疏水组分分别溶解在单独的溶剂中并同时通过喷嘴（通常为同轴喷嘴）引入喷雾干燥器。该方法提供具有相对均匀特性的干粉。

4. 发明授权

US08336545B2 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US08336545B2
公开(公告)日：2012-12-25
申请号：US11654212
申请日：2007-01-16
申请人： James B. Fink , John Power , Ehud Ivri , Kevin J. Corkery
发明人： James B. Fink , John Power , Ehud Ivri , Kevin J. Corkery
IPC分类号： A61M16/01 , A61M15/00 , A61M11/00 , A61M11/06
CPC分类号： A61M16/20 , A61M11/005 , A61M15/0085 , A61M16/08 , A61M16/0858 , A61M16/1065 , A61M16/201 , A61M16/208
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Also a method of treating a patient with a pulmonary disease, the method comprising administering an aerosolized first medicament comprising amikacin to the patient and administering, systemically a second medicament comprising an antibiotic to the patient that also treats the pulmonary disease, wherein a resulting amikacin concentration in the lung and/or pulmonary system is therapeutically-effective, and an amount of the systemically administered antibiotics is reduced.
摘要翻译：一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100μg至约500mg药物的雾化气雾剂。还有一种治疗患有肺部疾病的患者的方法，该方法包括向患者施用包含阿米卡星的雾化的第一药物，并全身给予包含抗生素的第二药物，所述抗生素还可治疗肺部疾病，其中得到的阿米卡星浓度在肺和/或肺系统中是治疗有效的，并且减少了全身施用的抗生素的量。

5. 发明申请

US20120114674A1 Molecular Antigen Array 审中-公开
标题翻译：分子抗原阵列
公开(公告)号：US20120114674A1
公开(公告)日：2012-05-10
申请号：US13096970
申请日：2011-04-28
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/00 , A61P37/04
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

6. 发明申请

US20100227833A1 NOVEL NUCLEOSIDE ANALOGS FOR TREATMENT OF VIRAL INFECTIONS 失效
标题翻译：用于治疗病毒感染的新型核苷类似物
公开(公告)号：US20100227833A1
公开(公告)日：2010-09-09
申请号：US12526079
申请日：2008-02-07
申请人： Zheng Yin , Jeyaraj Duraiswamy , Yen Liang Chen
发明人： Zheng Yin , Jeyaraj Duraiswamy , Yen Liang Chen
IPC分类号： A61K31/7064 , C07H19/23 , A61P31/12
CPC分类号： C07H19/23
摘要： This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections.
摘要翻译：本发明涉及具有各种药用应用的新化合物，例如用于治疗和/或预防病毒感染。

7. 发明授权

US07628978B2 Stabilized preparations for use in metered dose inhalers 有权
标题翻译：用于计量吸入器的稳定制剂
公开(公告)号：US07628978B2
公开(公告)日：2009-12-08
申请号：US10644265
申请日：2003-08-19
申请人： Jeffry G. Weers , Ernest G. Schutt , Luis Dellamary , Thomas E. Tarara , Alexey Kabalnov
发明人： Jeffry G. Weers , Ernest G. Schutt , Luis Dellamary , Thomas E. Tarara , Alexey Kabalnov
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K9/14 , A61K38/00 , A61K38/02 , A61K47/42 , A61K31/56 , A61K31/565 , A61K31/567 , A61K31/568 , A61K31/569 , A61K31/57 , A61K31/573 , A61K31/575 , A01N27/00 , A01N29/00 , A01N31/00 , A01N35/00 , A01N33/00
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.
摘要翻译：提供稳定的分散体用于将生物活性剂递送到患者的呼吸道。分散体优选包括分散在通常包含氢氟烷烃推进剂的悬浮介质中的多个穿孔微结构。由于悬浮颗粒和悬浮介质之间的密度变化最小化，微结构之间的吸引力减弱，因此所公开的分散体特别耐降解，例如通过沉降或絮凝。在特别优选的实施方案中，稳定的分散体可以使用计量剂量吸入器施用于患者的肺。

8. 发明申请

US20090246215A1 Amyloid beta1-6 antigen arrays 审中-公开
标题翻译：淀粉样β1-6抗原阵列
公开(公告)号：US20090246215A1
公开(公告)日：2009-10-01
申请号：US11905986
申请日：2007-10-05
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/00 , A61P37/02
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

9. 发明授权

US07575761B2 Spray drying process control of drying kinetics 失效
标题翻译：喷雾干燥过程控制干燥动力学
公开(公告)号：US07575761B2
公开(公告)日：2009-08-18
申请号：US09733269
申请日：2000-12-08
申请人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
发明人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
IPC分类号： A61K9/14
CPC分类号： A61K9/1611 , A61K9/0075 , A61K9/1617 , A61K9/1623
摘要： The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system (10) includes at least one conditioning zone (12) having an inlet (20) to introduce an atomized formulation (18) into the conditioning zone. A controller (14, 16) controls temperature and relative humidity of the airflow into the conditioning zone to allow amorphous-to-crystalline transformation of the atomized formulation. In another embodiment, the formulation is suspended in the conditioning zone for a residence time of sufficient duration to allow surface orientation of surface active components. A dryer (24) is coupled to the conditioning zone to dry the atomized formulation, and a collector (28) collects the formulation in powder form.
摘要翻译：本发明提供用于生产干粉制剂的示例性系统和方法。在一个实施例中，系统（10）包括至少一个调节区（12），其具有将雾化制剂（18）引入调节区的入口（20）。控制器（14,16）控制气流进入调节区域的温度和相对湿度，以允许雾化制剂的无定形 - 晶体转化。在另一个实施方案中，将制剂悬浮在调理区中以保持足够持续时间以允许表面活性组分的表面取向的停留时间。干燥器（24）联接到调理区以干燥雾化制剂，并且收集器（28）以粉末形式收集制剂。

10. 发明授权

US07320793B2 Molecular antigen array 有权
标题翻译：分子抗原阵列
公开(公告)号：US07320793B2
公开(公告)日：2008-01-22
申请号：US10050898
申请日：2002-01-18
申请人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

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