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1. 发明申请

US20100034910A1 Spray drying process control of drying kinetics 失效
标题翻译：喷雾干燥过程控制干燥动力学
公开(公告)号：US20100034910A1
公开(公告)日：2010-02-11
申请号：US12462209
申请日：2009-07-29
申请人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
发明人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
IPC分类号： C08J3/12
CPC分类号： A61K9/1611 , A61K9/0075 , A61K9/1617 , A61K9/1623
摘要： The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system (10) includes at least one conditioning zone (12) having an inlet (20) to introduce an atomized formulation (18) into the conditioning zone. A controller (14, 16) controls temperature and relative humidity of the airflow into the conditioning zone to allow amorphous-to-crystalline transformation of the atomized formulation. In another embodiment, the formulation is suspended in the conditioning zone for a residence time of sufficient duration to allow surface orientation of surface active components. A dryer (24) is coupled to the conditioning zone to dry the atomized formulation, and a collector (28) collects the formulation in powder form.
摘要翻译：本发明提供用于生产干粉制剂的示例性系统和方法。在一个实施例中，系统（10）包括至少一个调节区（12），其具有将雾化制剂（18）引入调节区的入口（20）。控制器（14,16）控制气流进入调节区域的温度和相对湿度，以允许雾化制剂的无定形 - 晶体转化。在另一个实施方案中，将制剂悬浮在调理区中以保持足够持续时间以允许表面活性组分的表面取向的停留时间。干燥器（24）联接到调理区以干燥雾化制剂，并且收集器（28）以粉末形式收集制剂。

2. 发明授权

US07575761B2 Spray drying process control of drying kinetics 失效
标题翻译：喷雾干燥过程控制干燥动力学
公开(公告)号：US07575761B2
公开(公告)日：2009-08-18
申请号：US09733269
申请日：2000-12-08
申请人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
发明人： David B. Bennett , Thomas K. Brewer , Robert M. Platz , Herman Snyder
IPC分类号： A61K9/14
CPC分类号： A61K9/1611 , A61K9/0075 , A61K9/1617 , A61K9/1623
摘要： The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system (10) includes at least one conditioning zone (12) having an inlet (20) to introduce an atomized formulation (18) into the conditioning zone. A controller (14, 16) controls temperature and relative humidity of the airflow into the conditioning zone to allow amorphous-to-crystalline transformation of the atomized formulation. In another embodiment, the formulation is suspended in the conditioning zone for a residence time of sufficient duration to allow surface orientation of surface active components. A dryer (24) is coupled to the conditioning zone to dry the atomized formulation, and a collector (28) collects the formulation in powder form.
摘要翻译：本发明提供用于生产干粉制剂的示例性系统和方法。在一个实施例中，系统（10）包括至少一个调节区（12），其具有将雾化制剂（18）引入调节区的入口（20）。控制器（14,16）控制气流进入调节区域的温度和相对湿度，以允许雾化制剂的无定形 - 晶体转化。在另一个实施方案中，将制剂悬浮在调理区中以保持足够持续时间以允许表面活性组分的表面取向的停留时间。干燥器（24）联接到调理区以干燥雾化制剂，并且收集器（28）以粉末形式收集制剂。

3. 发明授权

US06423344B1 Dispersible macromolecule compositions and methods for their preparation and use 有权
公开(公告)号：US06423344B1
公开(公告)日：2002-07-23
申请号：US09498397
申请日：2000-02-04
申请人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
发明人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
IPC分类号： A61K916
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K38/28 , A61M15/0086
摘要： A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

4. 发明授权

US08173168B2 Dispersible macromolecule compositions and methods for their preparation and use 有权
标题翻译：分散性大分子组合物及其制备和使用方法
公开(公告)号：US08173168B2
公开(公告)日：2012-05-08
申请号：US11536348
申请日：2006-09-28
申请人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
发明人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K38/28 , A61M15/0086
摘要： A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.
摘要翻译：制备生物高分子超细粉末的方法包括雾化大分子的液体溶液，干燥雾化步骤中形成的液滴并收集由干燥产生的颗粒。通过适当地控制每个雾化，干燥和收集步骤，可以制备具有特别适合用于治疗和其它目的的肺部递送特征的超细干粉组合物。

5. 发明授权

US06592904B2 Dispersible macromolecule compositions and methods for their preparation and use 失效
公开(公告)号：US06592904B2
公开(公告)日：2003-07-15
申请号：US10007868
申请日：2001-11-09
申请人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
发明人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
IPC分类号： A61K916
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K38/28 , A61M15/0086
摘要： A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

6. 发明授权

US6051256A Dispersible macromolecule compositions and methods for their preparation and use 失效
公开(公告)号：US6051256A
公开(公告)日：2000-04-18
申请号：US644681
申请日：1996-05-08
申请人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
发明人： Robert M. Platz , Thomas K. Brewer , Terence D. Boardman
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K31/00 , A61K38/00 , A61K38/28 , A61M15/00
CPC分类号： A61K9/0075 , A61K38/28 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61M15/0086
摘要： A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

7. 发明授权

US06572893B2 Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients 失效
公开(公告)号：US06572893B2
公开(公告)日：2003-06-03
申请号：US10072407
申请日：2002-02-08
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1623 , A61K9/1694 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715 , B01D1/18 , B01J2/04 , Y10S514/938 , Y10S514/951 , Y10S514/958 , Y10S977/775 , Y10S977/783 , Y10S977/829 , Y10S977/884 , Y10S977/89 , Y10S977/906 , Y10S977/915 , Y10S977/926
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.

8. 发明申请

US20090285905A1 SYSTEMS AND PROCESSES FOR SPRAY DRYING HYDROPHOBIC DRUGS WITH HYDROPHILIC EXCIPIENTS 有权
标题翻译：喷雾干燥疏水性药物与疏水性药物的系统和方法
公开(公告)号：US20090285905A1
公开(公告)日：2009-11-19
申请号：US12469634
申请日：2009-05-20
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1623 , A61K31/12 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
摘要翻译：制备具有疏水性和亲水性成分的干粉的方法包括组合该组分溶液并在喷雾干燥器中同时喷雾干燥它们。亲水和疏水组分分别溶解在单独的溶剂中并同时通过喷嘴（通常为同轴喷嘴）引入喷雾干燥器。该方法提供具有相对均匀特性的干粉。

9. 发明授权

US06365190B1 Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients 有权
标题翻译：用亲水性赋形剂喷雾干燥疏水性药物的系统和方法
公开(公告)号：US06365190B1
公开(公告)日：2002-04-02
申请号：US09528758
申请日：2000-03-17
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1623 , A61K9/1694 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715 , B01D1/18 , B01J2/04 , Y10S514/938 , Y10S514/951 , Y10S514/958 , Y10S977/775 , Y10S977/783 , Y10S977/829 , Y10S977/884 , Y10S977/89 , Y10S977/906 , Y10S977/915 , Y10S977/926
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
摘要翻译：制备具有疏水性和亲水性成分的干粉的方法包括组合该组分溶液并在喷雾干燥器中同时喷雾干燥它们。亲水和疏水组分分别溶解在单独的溶剂中并同时通过喷嘴（通常为同轴喷嘴）引入喷雾干燥器。该方法提供具有相对均匀特性的干粉。

10. 发明授权

US08802149B2 Systems and processes for spray drying hydrophobic and hydrophilic components 有权
标题翻译：用于喷雾干燥疏水和亲水组分的系统和方法
公开(公告)号：US08802149B2
公开(公告)日：2014-08-12
申请号：US12469634
申请日：2009-05-20
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K9/14 , A61K9/12
CPC分类号： A61K9/0075 , A61K9/1611 , A61K9/1623 , A61K31/12 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.
摘要翻译：制备具有疏水性和亲水性成分的干粉的方法包括组合该组分溶液并在喷雾干燥器中同时喷雾干燥它们。亲水和疏水组分分别溶解在单独的溶剂中并同时通过喷嘴（通常为同轴喷嘴）引入喷雾干燥器。该方法提供具有相对均匀特性的干粉。

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