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1. 发明申请

US20200368425A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20200368425A1
公开(公告)日：2020-11-26
申请号：US16986544
申请日：2020-08-06
申请人： SteadyMed Ltd.
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/145 , A61M5/172 , A61M5/20 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , A61M5/142
摘要： The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

2. 发明授权

US10463847B2 Infusion set 有权
公开(公告)号：US10463847B2
公开(公告)日：2019-11-05
申请号：US14737204
申请日：2015-06-11
申请人： STEADYMED LTD.
发明人： Assaf Shaked , Inna Dekel , Jonathan Guillaume Jamin , Stephen Edward Augustyn , Stewart Maddison Fox , Peter Noymer
IPC分类号： A61M39/12 , A61M5/168 , A61M5/14 , A61M5/145 , A61M39/08 , A61M5/36 , A61M5/50 , A61M39/10
摘要： An exemplary infusion set includes a tubing, a first connector, and a second connector. The first connector connects a first terminus of the tubing to an exit port of an infusion pump, providing fluid communication between fluid being conveyed by the infusion pump and the tubing. The second connector connects a second terminus of the tubing to a delivery module, providing fluid communication between the tubing and the delivery module. Full engagement of the first connector and the exit port of the infusion pump actuates operation of the infusion pump.

3. 发明授权

US08834454B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US08834454B2
公开(公告)日：2014-09-16
申请号：US12299602
申请日：2007-05-06
申请人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61K9/22 , A61M5/20 , A61M5/145 , A61M5/142 , A61M5/172
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
摘要翻译：本申请提供了一种药物递送装置，其包括药物储存室16，其包含与药物施用装置18流体连接的待递送物质，以及电控电池单元10，其包括至少一个位移产生电池单元 19通过联接装置14耦合到药物储存室16，该布置使得从电池单元10获得的位移被耦合装置14输送到药物储存室16，使得物质从药物储存器中排出腔室16朝向药物管理装置18。

4. 发明授权

US07524304B2 Drug infusion device 有权
标题翻译：药物输液装置
公开(公告)号：US07524304B2
公开(公告)日：2009-04-28
申请号：US10544167
申请日：2004-02-02
申请人： Amir Genosar
发明人： Amir Genosar
IPC分类号： A61M5/20
CPC分类号： A61M5/1454 , A61M5/14248 , A61M5/16804 , A61M2005/14204 , A61M2005/14513
摘要： The invention provides a drug delivery infusion device comprising an injection means (18) in fluid connection with a drug reservoir chamber (12) and pressure-generation means (10) coupled to both the drug reservoir (12) and to a liquid-filled control chamber (13), wherein the coupling is such that the liquid-filled control chamber (13) serves to constrain the motion of the pressure-generation means (10), thereby controlling the drug infusion rate, wherein the liquid-filled control chamber (13) is associated with means for controlled depletion of the liquid therein whereby depletion of the volume of liquid in the control chamber enables the pressure-generation means to drive the drug in the reservoir chamber therefrom for infusion thereof.
摘要翻译：本发明提供了一种药物递送输注装置，其包括与药物储存室（12）流体连接的注射装置（18）和联接到药物储存器（12）两者的压力产生装置（10）和与液体填充控制腔室（13），其中联接器使得充满液体的控制室（13）用于约束压力产生装置（10）的运动，从而控制药物输注速率，其中充满液体的控制室 13）与其中的液体的可控耗尽的装置相关联，由此在控制室中的液体体积的减少使得压力产生装置能够驱动储存室中的药物用于其输注。

5. 发明授权

US11013855B2 Fluid-connection mechanism and methods for patch-pumps 有权
公开(公告)号：US11013855B2
公开(公告)日：2021-05-25
申请号：US16377992
申请日：2019-04-08
申请人： SteadyMed Ltd.
发明人： Nir Rotem
IPC分类号： A61M5/142 , A61M5/158 , A61M5/145 , A61M5/162
摘要： Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.

6. 发明申请

US20190060563A1 SIZE-EFFICIENT DRUG-DELIVERY DEVICE 审中-公开
公开(公告)号：US20190060563A1
公开(公告)日：2019-02-28
申请号：US16173069
申请日：2018-10-29
申请人： SteadyMed, Ltd.
发明人： Nir Rotem , Keren Fradkin , Jonathan Goldstein
IPC分类号： A61M5/145 , A61M5/142
摘要： A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.

7. 发明授权

US10071209B2 Enhanced infusion-site pain-reduction for drug-delivery devices 有权
公开(公告)号：US10071209B2
公开(公告)日：2018-09-11
申请号：US14384131
申请日：2013-03-11
申请人： SteadyMed Ltd.
发明人： Ian Solomon , Jacob Rand , Jonathan Rigby
IPC分类号： A61N1/30 , A61M5/42 , A61N1/36 , A61N1/04 , A61M5/142
CPC分类号： A61M5/422 , A61M5/14248 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36021
摘要： The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch.

8. 发明申请

US20170304532A1 FLUID-CONNECTION MECHANISM AND METHODS FOR PATCH-PUMPS 审中-公开
公开(公告)号：US20170304532A1
公开(公告)日：2017-10-26
申请号：US15605420
申请日：2017-05-25
申请人： SteadyMed Ltd.
发明人： Nir Rotem
IPC分类号： A61M5/142 , A61M5/145 , A61M5/158 , A61M5/162
CPC分类号： A61M5/14248 , A61M5/145 , A61M5/158 , A61M5/1626 , A61M2005/14252 , A61M2005/1585 , F04C2270/041
摘要： Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.

9. 发明申请

US20150045718A1 ENHANCED INFUSION-SITE PAIN-REDUCTION FOR DRUG-DELIVERY DEVICES 审中-公开
标题翻译：用于药物递送装置的增强的输注部位减轻疼痛
公开(公告)号：US20150045718A1
公开(公告)日：2015-02-12
申请号：US14384131
申请日：2013-03-11
申请人： SteadyMed Ltd.
发明人： Ian Shlomo , Jacob Rand , Jonathan Rigby
IPC分类号： A61M5/42 , A61N1/36 , A61N1/04
CPC分类号： A61M5/422 , A61M5/14248 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36021
摘要： The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said in fusion-patch.
摘要翻译：本发明提供了一种灌注补片，其包括：套管一个基地所述基底中的至少一个粘合剂区域适于皮肤附着; 所述基座内的至少一个皮肤接近区域; 以及至少一个与所述至少一个皮肤接近区域流体连接的导管，其中与所述至少一个皮肤接近区域流体连接的所述至少一个导管便于在至少第一麻醉容器内的麻醉物质的转移可以可移除地附接并与所述至少一个接触区域流体连接，促进所述麻醉物质递送到所述至少一个皮肤接近区域，并且其中输送到所述皮肤接近区域的所述麻醉物质可以至少部分补充没有在融合贴片中去除。

10. 发明授权

US07918843B2 Controllable drug delivery device 有权
标题翻译：可控药物输送装置
公开(公告)号：US07918843B2
公开(公告)日：2011-04-05
申请号：US12604278
申请日：2009-10-22
申请人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/14248 , A61M5/14593 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2205/0272
摘要： A controllable drug delivery device for delivering a liquid injectable drug, the device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by the battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via the drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of the battery and thereby cause the drug delivery device to deliver a substantially constant drug delivery rate.
摘要翻译：一种用于输送液体可注射药物的可控药物递送装置，所述装置包括药物储存器（22），药物施用装置（28），置换产生电池（20）和耗尽电路（85），其中由于电流由电流消耗电路而从电池中耗尽的电池产生的位移使药物储存器的壁移位，从而使储存器经由药物给药装置排出其中所含的可注射液体，并且其中药物输送装置还包括：控制器（78），其响应于指示由电池产生的位移的测量参数，用于施加跨越电池的可变负载（80），以便提供电池的基本上恒定的电流消耗，从而使药物输送装置提供基本上恒定的药物递送率。

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