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    • 4. 发明授权
    • Diminishing detonator effectiveness through electromagnetic effects
    • 通过电磁效应降低雷管效能
    • US09448042B2
    • 2016-09-20
    • US13934377
    • 2013-07-03
    • University of Nevada, Las Vegas
    • Robert A. Schill, Jr.
    • F41H11/136F42D5/04
    • F41H11/136F41H11/12F42B33/06F42D5/04
    • An inductively coupled transmission line with distributed electromotive force source and an alternative coupling model based on empirical data and theory were developed to initiate bridge wire melt for a detonator with an open and a short circuit detonator load. In the latter technique, the model was developed to exploit incomplete knowledge of the open circuited detonator using tendencies common to all of the open circuit loads examined. Military, commercial, and improvised detonators were examined and modeled. Nichrome, copper, platinum, and tungsten are the detonator specific bridge wire materials studied. The improvised detonators were made typically made with tungsten wire and copper (˜40 AWG wire strands) wire.
    • 开发了具有分布式电动势源的电感耦合传输线和基于经验数据和理论的替代耦合模型,用于启动具有开路和短路雷管负载的雷管的桥接线熔体。 在后一种技术中,该模型被开发用于利用所检查的所有开路负载共同的倾向的开环雷管的不完整知识。 对军事,商业和即兴雷管进行了检查和建模。 镍铬,铜,铂和钨是研究的雷管特殊桥线材料。 即兴雷管通常用钨丝和铜(〜40 AWG线股)线制成。
    • 7. 发明授权
    • Synthetic procedure and cancer treatment with cisplatin derivatives
    • 合成程序和顺铂衍生物的癌症治疗
    • US08703756B2
    • 2014-04-22
    • US13404257
    • 2012-02-24
    • Bryan L. SpangeloVan VoPradip K. BhowmikOntida TanthmanathamHaesook Han
    • Bryan L. SpangeloVan VoPradip K. BhowmikOntida TanthmanathamHaesook Han
    • A61K31/555C07F15/00
    • C07F15/0093
    • A method of reducing the in vivo viability of cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells has steps of: a) identifying a prospective patient having cancer cells selected from the group consisting of breast cancer cells, lung cancer cells, prostate cancer cells and melanoma cancer cells; and b) administering a cisplatin derivative to the prospective patient so that the cisplatin derivative will contact the cancer cells; wherein the cisplatin derivative is a 4,4′-bis[RO]-2,2′-bipyridine)PtCl2 where, R is selected from the group consisting of —(CH2)nCH3 where n=2, 3, 4 or 5, and —(CH2)n[O(CH2)m]yO(CH2)zCH3 where n=2, m=2, y=2, z=1. A novel synthetic process for the manufacture of these compounds (and their analogs) is also provided.
    • 降低选自乳腺癌细胞,肺癌细胞,前列腺癌细胞和黑素瘤癌细胞的癌细胞的体内存活力的方法具有以下步骤:a)鉴定具有选自以下的癌细胞的预期患者: 乳腺癌细胞,肺癌细胞,前列腺癌细胞和黑素瘤癌细胞; 和b)向前瞻性患者施用顺铂衍生物,使顺铂衍生物与癌细胞接触; 其中顺铂衍生物是4,4'-双[RO] -2,2'-联吡啶)PtCl 2,其中R选自 - (CH 2)n CH 3,其中n = 2,3,4或5, 和 - (CH 2)n [O(CH 2)m] y O(CH 2)z CH 3,其中n = 2,m = 2,y = 2,z = 1。 还提供了用于制造这些化合物(及其类似物)的新型合成方法。