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1. 发明授权

US08496874B2 Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
标题翻译：综合离心式血液泵 - 氧合器，体外生命支持系统和一种去冒泡和引发体外生命支持系统的方法
公开(公告)号：US08496874B2
公开(公告)日：2013-07-30
申请号：US11999707
申请日：2007-12-05
申请人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
摘要翻译：一种具有壳体（2）的集成离心血泵 - 氧合器（1），具有血液入口（4）的顶部（3），血液出口（5）和气体入口（6）以及底部（7））具有可旋转地布置在底部（7）的转子壳体（9）中的旋转体（8）。集成离心血泵 - 氧合器（1）还具有设置在壳体（2）的内部（11）中的氧合器膜（10），其中在操作状态下，氧气（12）从气体入口（6）传送，通过氧合膜（10）到气体出口（13），并且血液（14）通过从血液入口泵送具有旋转体（8）的血液（14）而与氧合器膜（10）直接接触 4）到血液出口（5）。旋转体（8）相对于转子壳体（9）以无接触的方式磁性地支承。有一个体外生命支持系统（1000），一种去冒泡和引发体外生命支持系统的方法（1000）。

2. 发明授权

US10258729B2 Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
公开(公告)号：US10258729B2
公开(公告)日：2019-04-16
申请号：US15009702
申请日：2016-01-28
申请人： Thoratec LLC
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
IPC分类号： A61M1/16 , A61M1/10 , A61M1/26
摘要： A method for pumping and oxygenating blood includes receiving a flow of gas including oxygen into a gas inlet manifold via a gas inlet. The flow of gas is passed through the hollow fibers from the gas inlet manifold to a gas outlet manifold. The flow of gas is output from the gas outlet manifold via a gas outlet. An impeller is rotated to generate a flow of blood that flows over the hollow fibers. Oxygen from the flow of gas is transferred to the flow of blood through the hollow fibers. Carbon dioxide is transferred from the flow of blood to the flow of gas through the hollow fibers.

3. 发明申请

US20140037500A1 Integrated Centrifugal Blood Pump-Oxygenator, an Extracorporeal Life Support System and a Method of De-Bubbling and Priming an Extracorporeal Life Support System 有权
标题翻译：综合离心血液泵 - 氧气机，体外生命支持系统和脱气和引发体外生命支持系统的方法
公开(公告)号：US20140037500A1
公开(公告)日：2014-02-06
申请号：US13928324
申请日：2013-06-26
申请人： Thoratec LLC
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
IPC分类号： A61M1/16
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
摘要翻译：一种具有壳体（2）的集成离心血泵 - 氧合器（1），具有血液入口（4）的顶部（3），血液出口（5）和气体入口（6）以及底部（7））具有可旋转地布置在底部（7）的转子壳体（9）中的旋转体（8）。集成离心血泵 - 氧合器（1）还具有设置在壳体（2）的内部（11）中的氧合器膜（10），其中在操作状态下，氧气（12）从气体入口（6）传送，通过氧合膜（10）到气体出口（13），并且血液（14）通过从血液入口泵送具有旋转体（8）的血液（14）而与氧合器膜（10）直接接触 4）到血液出口（5）。旋转体（8）相对于转子壳体（9）以无接触的方式磁性地支承。有一个体外生命支持系统（1000），一种去冒泡和引发体外生命支持系统的方法（1000）。

4. 发明授权

US08591539B2 Expandable conduit-guide and a method for applying and positioning an expandable conduit-guide 有权
标题翻译：可扩展的导管引导件和用于施加和定位可扩展导管的方法
公开(公告)号：US08591539B2
公开(公告)日：2013-11-26
申请号：US11701277
申请日：2007-01-31
申请人： Barry N. Gellman
发明人： Barry N. Gellman
IPC分类号： A61M29/00
CPC分类号： A61B17/3439 , A61B2017/3488 , A61M25/005 , A61M25/0662 , A61M39/06 , A61M2039/0673
摘要： An expandable conduit-guide providing a leak-tight conduit through a skin between an inside of a corpus and an outside of the corpus is disclosed. The conduit-guide includes a body encompassing a lumen extending essentially axially along a center-line, and has a distal-end to be positioned outside of the corpus, and a proximal-end to be positioned inside of the corpus. The body of the conduit-guide is constructed from a braided-wire so that the conduit-guide is capable of actively expanding from a closed diameter to an opened diameter with the placement of the medical device positioned within the lumen (110) and passively collapsing from the opened diameter to the closed diameter upon withdrawal of the medical device under a spring load of the braided-wire. A catheter-sheath and a catheter-sheath-assembly, as well as to a method for applying and positioning an expandable conduit-guide (1), catheter-sheath (8) and a catheter-sheath-assembly (800) are disclosed.
摘要翻译：公开了一种可扩展导管引导件，其提供通过语料库的内部和语料库外部之间的皮肤的密封导管。导管引导件包括主体，该主体包围沿着中心线基本轴向延伸的内腔，并且具有定位在语料库外侧的远端以及定位在语料库内部的近端。导管引导件的主体由编织线构成，使得导管引导件能够通过定位在内腔（110）内的医疗装置的放置而被动地从封闭直径扩展到开口直径，并且被动地折叠在编织线的弹簧载荷下退出医疗装置时从开口直径到封闭直径。公开了一种导管鞘和导管鞘组件，以及用于施加和定位可扩张导管（1），导管鞘（8）和导管鞘组件（800）的方法。

5. 发明授权

US08591538B2 Self-expanding cannula and a method for applying and positioning a self-expanding cannula 有权
标题翻译：自扩张插管和用于施加和定位自扩张插管的方法
公开(公告)号：US08591538B2
公开(公告)日：2013-11-26
申请号：US11701149
申请日：2007-01-31
申请人： Barry N. Gellman
发明人： Barry N. Gellman
IPC分类号： A61M29/00
CPC分类号： A61B17/3439 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/122 , A61M1/3659 , A61M25/005 , A61M25/007 , A61M25/04 , A61M25/0662 , A61M2025/0024
摘要： A self-expanding cannula providing a conduit through a skin between an inside of a corpus and an outside of the corpus is disclosed. The self-expanding cannula includes a body encompassing a lumen, and has a distal-end to be positioned outside of the corpus for attachment to an extracorporeal fluid handling system and having a proximal-end to be positioned inside of the corpus, for attachment to an organ of an human or an animal. The body of the self-expanding cannula is constructed from a braided-wire, so that the self-expanding cannula is capable of expanding from a closed diameter to an opened diameter. A catheter-sheath and a catheter-sheath-assembly as well as to a method for applying and positioning a self-expanding cannula, and a catheter-sheath-assembly are disclosed.
摘要翻译：公开了一种自扩张插管，其提供通过语料库的内部和语料库外部之间的皮肤的导管。自膨胀套管包括一个包围内腔的主体，并且具有一个位于该语料库外侧的远端，用于附接到一个体外流体处理系统，并具有一个位于该语料库内部的近端，用于附接到人或动物的器官。自膨胀套管的主体由编织线构成，使得自膨胀插管能够从闭合直径扩展到开口直径。公开了一种导管鞘和导管鞘组件以及用于施加和定位自扩张插管的方法以及导管鞘组件。

6. 发明授权

US09278168B2 Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
公开(公告)号：US09278168B2
公开(公告)日：2016-03-08
申请号：US13928324
申请日：2013-06-26
申请人： Thoratec LLC
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
IPC分类号： A61M1/16 , A61M1/10 , A61M1/26
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).

7. 发明授权

US08631680B2 Method for the calibration of a flow measurement in a flow system, and flow system for carrying out the method 有权
标题翻译：用于校准流量系统中流量测量的方法，以及用于执行该方法的流量系统
公开(公告)号：US08631680B2
公开(公告)日：2014-01-21
申请号：US12217269
申请日：2008-07-01
申请人： Andreas Fleischli , Thomas Gempp
发明人： Andreas Fleischli , Thomas Gempp
IPC分类号： G01F25/00
CPC分类号： G01F25/0007 , A61M1/101 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/3663 , A61M2205/3334 , G01F1/66
摘要： A flow rate of a fluid in a flow system is determined based on one or more parameters of the flow system, the parameters not including the flow rate itself. The flow rate is also measured with a calibration sensor, and the measured flow rate is used to calibrate how the flow rate is determined.
摘要翻译：基于流系统的一个或多个参数确定流体系统中流体的流速，不包括流量本身的参数。流量也用校准传感器测量，并且测量的流量用于校准如何确定流速。

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