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1. 发明授权

US08496874B2 Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
标题翻译：综合离心式血液泵 - 氧合器，体外生命支持系统和一种去冒泡和引发体外生命支持系统的方法
公开(公告)号：US08496874B2
公开(公告)日：2013-07-30
申请号：US11999707
申请日：2007-12-05
申请人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang , Bartley P. Griffith
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).
摘要翻译：一种具有壳体（2）的集成离心血泵 - 氧合器（1），具有血液入口（4）的顶部（3），血液出口（5）和气体入口（6）以及底部（7））具有可旋转地布置在底部（7）的转子壳体（9）中的旋转体（8）。集成离心血泵 - 氧合器（1）还具有设置在壳体（2）的内部（11）中的氧合器膜（10），其中在操作状态下，氧气（12）从气体入口（6）传送，通过氧合膜（10）到气体出口（13），并且血液（14）通过从血液入口泵送具有旋转体（8）的血液（14）而与氧合器膜（10）直接接触 4）到血液出口（5）。旋转体（8）相对于转子壳体（9）以无接触的方式磁性地支承。有一个体外生命支持系统（1000），一种去冒泡和引发体外生命支持系统的方法（1000）。

2. 发明申请

US20080199357A1 Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
标题翻译：综合离心式血液泵 - 氧合器，体外生命支持系统和一种去冒泡和引发体外生命支持系统的方法
公开(公告)号：US20080199357A1
公开(公告)日：2008-08-21
申请号：US11999707
申请日：2007-12-05
申请人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang
发明人： Barry N. Gellman , Andrew Koert , Zhongjun Wu , Juntao Zhang
IPC分类号： A61M1/10 , A61M1/14
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1015 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2205/3334
摘要： The invention relates to an integrated centrifugal blood pump-oxygenator (1) comprising a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further comprises an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to an gas outlet (13) and a blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) by the rotational body (8) from the blood inlet (4) to the blood outlet (5). According to the invention, the rotational body (8) is magnetically journalled in a contact free manner with respect to the rotor-housing (9). The invention is also related to an extracorporeal life support system (1000) and a method of de-bubbling and priming a extracorporeal life support system (1000) in accordance with the present invention.
摘要翻译：本发明涉及一种集成式离心血泵 - 氧合器（1），其包括具有血液入口（4），血液出口（5）和气体入口（6）的顶部（3）的壳体（2）底部（7）具有可旋转地布置在底部（7）的转子壳体（9）中的旋转体（8）。集成离心血泵 - 氧合器（1）还包括设置在壳体（2）的内部（11）中的氧合器膜（10），其中在操作状态下，氧气（12）从气体入口（6）转移，通过氧合膜（10）到气体出口（13），血液（14）通过旋转体（8）从血液入口泵送血液（14）而与氧合器膜（10）直接接触（4）到血液出口（5）。根据本发明，旋转体（8）相对于转子壳体（9）以无接触的方式被磁性地轴颈安装。本发明还涉及根据本发明的体外生命支持系统（1000）和除泡和引发体外生命支持系统（1000）的方法。

3. 发明授权

US09878087B2 Pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 有权
公开(公告)号：US09878087B2
公开(公告)日：2018-01-30
申请号：US13349462
申请日：2012-01-12
申请人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
发明人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
IPC分类号： A61M1/12 , A61M25/00 , A61M1/36 , A61M1/10 , B33Y80/00 , B33Y70/00
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system. The pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to the blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein the body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.

4. 发明申请

US20120220815A1 Pump-Inflow-Cannula, A Pump-Outflow-Cannula And A Blood Managing System 有权
标题翻译：泵 - 流入 - 插管，泵 - 流出 - 插管和血液管理系统
公开(公告)号：US20120220815A1
公开(公告)日：2012-08-30
申请号：US13349462
申请日：2012-01-12
申请人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
发明人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
IPC分类号： A61M1/12
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system. The pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to the blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein the body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及提供从心脏（2）和/或从相关血管到外部血液处理系统的血液导管的泵流入套管（1）。泵入流套管包括主体（3），其包围基本上轴向延伸的流入腔（4），其具有用于将流入腔（4）附接到血液处理系统的远端（5）并且具有近端（6），用于将来自心脏（2）的血液和/或从相关血管引入流入腔（4），其中至少一个突起（7）设置在近端 - （6）使心脏肌肉偏转进入流入腔（4），其中泵入流套管的主体（3）包括加强装置（8）。本发明还涉及一种泵 - 流出 - 套管（19）和一种血液管理系统，其包括根据本发明的泵 - 流入套管和泵 - 流出 - 套管。

5. 发明授权

US08118723B2 Pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 有权
标题翻译：泵流入套管，泵流出套管和血液管理系统
公开(公告)号：US08118723B2
公开(公告)日：2012-02-21
申请号：US11698322
申请日：2007-01-26
申请人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
发明人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
IPC分类号： A61M25/00 , A61N1/362
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system. The pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to the blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein the body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及提供从心脏（2）和/或从相关血管到外部血液处理系统的血液导管的泵流入套管（1）。泵入流套管包括主体（3），其包围基本上轴向延伸的流入腔（4），其具有用于将流入腔（4）附接到血液处理系统的远端（5）并且具有近端（6），用于将来自心脏（2）的血液和/或从相关血管引入流入腔（4），其中至少一个突起（7）设置在近端 - （6）使心脏肌肉偏转进入流入腔（4），其中泵入流套管的主体（3）包括加强装置（8）。本发明还涉及一种泵 - 流出 - 套管（19）和一种血液管理系统，其包括根据本发明的泵 - 流入套管和泵 - 流出 - 套管。

6. 发明申请

US20070197856A1 Pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 审中-公开
标题翻译：泵流入套管，泵流出套管和血液管理系统
公开(公告)号：US20070197856A1
公开(公告)日：2007-08-23
申请号：US11699163
申请日：2007-01-26
申请人： Barry N. Gellman , J. Scott Richardson , John D. Marks , Andrew Koert
发明人： Barry N. Gellman , J. Scott Richardson , John D. Marks , Andrew Koert
IPC分类号： A61M1/12
CPC分类号： A61M25/007 , A61M1/10 , A61M1/1001 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3659 , A61M25/0075 , A61M2025/0076 , A61M2025/0078 , A61M2027/004
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system, said pump-inflow-cannula (1) comprising a body (3), encompassing an inflow-lumen (4), extending essentially axially along a center-line (5), having a distal-end (6) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (7) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4). At the proximal-end (7) at least one angled-hole (8), extending around a longitudinal hole-axis (9) is provided, and said hole-axis (9) includes a presettable hole-angle (α) with the center-line (5) of the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula (1) comprises a reinforcement-means (10). The invention is also related to a pump-outflow-cannula (23) and to a blood managing system comprising a pump-inflow-cannula (1) and a pump-outflow-cannula (23) in accordance with the present invention.
摘要翻译：本发明涉及提供从心脏（2）和/或从相关血管到外部血液处理系统的血液导管的泵流入套管（1），所述泵流入套管（1）包括主体（包括沿中心线（5）基本轴向延伸的流入腔（4），其具有用于将流入腔（4）附接到所述血液处理系统的远端（6），以及具有近端（7），用于将来自心脏（2）的血液和/或从相关血管引入流入腔（4）。在近端（7）处，提供了围绕纵向孔轴线（9）延伸的至少一个角度孔（8），并且所述孔轴线（9）包括可预设的孔角（α），其中流入腔（4）的中心线（5），其中所述泵流入套管（1）的所述主体（3）包括加强装置（10）。本发明还涉及一种泵 - 流出 - 插管（23）以及包括根据本发明的泵 - 流入 - 插管（1）和泵 - 流出 - 套管（23）的血液管理系统。

7. 发明申请

US20070197855A1 Pump-inflow-cannula, a pump-outflow-cannula and a blood managing system 有权
标题翻译：泵流入套管，泵流出套管和血液管理系统
公开(公告)号：US20070197855A1
公开(公告)日：2007-08-23
申请号：US11698322
申请日：2007-01-26
申请人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
发明人： J. Scott Richardson , Barry N. Gellman , Andrew Koert , Kurt Dasse
IPC分类号： A61M1/12
CPC分类号： A61M1/3653 , A61M1/10 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/3659 , A61M1/3666 , B33Y70/00 , B33Y80/00
摘要： The invention relates to a pump-inflow-cannula (1) providing a blood conduit from a heart (2) and/or from an associated vessel to an external blood handling system. Said pump-inflow-cannula comprises a body (3), encompassing an essentially axially extending inflow-lumen (4), having a distal-end (5) for an attachment of the inflow-lumen (4) to said blood handling system, and having a proximal-end (6) for an introduction of blood from the heart (2) and/or from the associated vessel into the inflow-lumen (4), wherein at least one projection (7) is provided at the proximal-end (6) to deflect a heart muscle from intruding into the inflow-lumen (4), wherein said body (3) of the pump-inflow-cannula comprises a reinforcement-means (8). The invention is also related to a pump-outflow-cannula (19) and to a blood managing system comprising a pump-inflow-cannula and a pump-outflow-cannula in accordance with the present invention.
摘要翻译：本发明涉及提供从心脏（2）和/或从相关血管到外部血液处理系统的血液导管的泵流入套管（1）。所述泵入流套管包括主体（3），其包围基本上轴向延伸的流入腔（4），其具有用于将流入腔（4）附接到所述血液处理系统的远端（5）并且具有近端（6），用于将来自心脏（2）的血液和/或从相关血管引入流入腔（4），其中至少一个突起（7）设置在近端 - （6）使心脏肌肉偏转进入流入腔（4），其中所述泵流入套管的所述主体（3）包括加强装置（8）。本发明还涉及一种泵 - 流出 - 套管（19）和一种血液管理系统，其包括根据本发明的泵 - 流入套管和泵 - 流出 - 套管。

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