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    • 1. 发明授权
    • Heparin-binding protein modified with heparan sulfate sugar chains, process for producing the same and pharmaceutical compositions containing the same
    • 用硫酸乙酰肝素糖链修饰的肝素结合蛋白,其制备方法和含有它的药物组合物
    • US07741078B2
    • 2010-06-22
    • US11547346
    • 2005-03-31
    • Toru ImamuraMasahiro AsadaMasashi Suzuki
    • Toru ImamuraMasahiro AsadaMasashi Suzuki
    • C12N15/12C12N1/00C12P21/02
    • C07K14/501A61K38/00C07K2319/35
    • A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.
    • 在其分子内具有共价键合的硫酸肝素糖链的肝素结合蛋白是通过将编码可以与硫酸肝素糖链修饰的肽选择性地编码到编码肝素结合蛋白的cDNA并在动物细胞中产生的cDNA来产生的 所得连接的cDNA的基因产物。 这种硫酸乙酰肝素糖链修饰的肝素结合蛋白通过共价键合含有少量硫酸软骨素的糖胺聚糖糖链来官能化。 例如,该肝素结合蛋白质的稳定性优异,例如耐热性,耐酸性,耐碱性和体内稳定性。 此外,硫酸乙酰肝素糖链修饰的肝素结合蛋白对细胞增殖和组织再生有效,具有调节FGFs生理功能的作用。 因此,该肝素结合蛋白作为预防或治疗各种FGF相关疾病的药物是非常有用的。
    • 2. 发明授权
    • Image forming apparatus and method of cooling control thereof
    • 图像形成装置及其冷却控制方法
    • US07738810B2
    • 2010-06-15
    • US11676117
    • 2007-02-16
    • Hitomi Fujita
    • Hitomi Fujita
    • G03G21/20
    • G03G15/2039G03G2215/2045
    • An electrophotographic image forming apparatus includes a fixer for heating a printing paper while feeding the same; a cooling device for cooling the fixer; a paper transport device for supplying the printing paper to the fixer; and a controller for receiving a print command including a specification of printing conditions and controlling the fixer, the cooling device, and the paper transport device, wherein the controller includes: a device that controls the fixer to change the velocity that the fixer feeds the printing paper during a printing job according to the printing conditions, and a device that controls the cooling device to change the cooling performance of the cooling device during the printing job according to the velocity of the fixer.
    • 一种电子照相成像设备,包括一个定影器,用于在给打印纸的同时加热打印纸; 用于冷却定影剂的冷却装置; 用于将打印纸供给到定影剂的纸张传送装置; 以及控制器,用于接收包括打印条件的指定和控制定影剂,冷却装置和纸张传送装置的打印命令,其中控制器包括:控制定影剂以改变定影剂进给打印的速度的装置 在根据打印条件的打印作业期间的纸张以及控制冷却装置以根据定影剂的速度在打印作业期间改变冷却装置的冷却性能的装置。
    • 5. 发明授权
    • Line head and an image forming apparatus using such a line head
    • 线头和使用这种线头的图像形成装置
    • US07733364B2
    • 2010-06-08
    • US11832525
    • 2007-08-01
    • Yujiro NomuraNozomu InoueRyuta KoizumiKen Ikuma
    • Yujiro NomuraNozomu InoueRyuta KoizumiKen Ikuma
    • B41J15/14B41J27/00
    • B41J2/45
    • A line head, includes: a substrate which is provided with a plurality of luminous element groups which respectively include a plurality of luminous elements in a first direction which emit light beams; a lens array which includes a plurality of imaging lenses which are provided corresponding to the plurality of luminous element groups; and a light shielding member which is disposed between the substrate and the lens array and includes a plurality of light guiding holes which correspond to the plurality of luminous element groups, wherein the lens array is away from the light shielding member, an inner diameter of each of the plurality of light guiding holes in the first direction is a first light guiding hole diameter, and a bore diameter of each of the plurality of imaging lenses in the first direction is a first lens diameter, and the first light guiding hole diameter is smaller than the first lens diameter.
    • 行头包括:基板,其设置有分别包括发射光束的第一方向上的多个发光元件的多个发光元件组; 透镜阵列,其包括对应于所述多个发光元件组而设置的多个成像透镜; 以及遮光构件,其设置在所述基板和所述透镜阵列之间,并且包括与所述多个发光元件组对应的多个导光孔,其中所述透镜阵列远离所述遮光构件,每个所述透镜阵列的内径 在第一方向上的多个导光孔的长度为第一导光孔直径,第一方向上的多个摄像透镜的孔径为第一透镜直径,第一导光孔直径较小 比第一透镜直径。
    • 7. 发明授权
    • SET and SEGR resistant delay cell and delay line for Power-On Reset circuit applications
    • SET和SEGR电阻延迟单元和上电复位电路应用的延迟线
    • US07733146B2
    • 2010-06-08
    • US11347903
    • 2006-02-06
    • Matthew Von Thun
    • Matthew Von Thun
    • H03H11/26
    • H03H11/26
    • A delay line appropriate for use in a POR circuit or other integrated circuit in a space environment combines three separate circuit techniques to improve performance without unnecessarily increasing circuit area or adding to manufacturing costs when compared to a simple inverter delay line. The delay line of the present invention uses the selective placement of capacitors throughout the delay line, one-sided current starving, and the incorporation of one-sided Schmitt trigger circuits. Performance of the delay line is substantially immune to SEGR events (“Single Event Gate Rupture”) and SET events (“Single Event Transients”). Spurious signals produced by SEGR and SET events are quickly and substantially attenuated.
    • 适用于空间环境中的POR电路或其他集成电路的延迟线组合了三个单独的电路技术,以便与简单的逆变器延迟线相比,可以提高性能,而不必不必要地增加电路面积或增加制造成本。 本发明的延迟线使用电容器在整个延迟线上的选择性放置,单侧电流挨饿以及单侧施密特触发电路的并入。 延迟线的性能基本上不受SEGR事件(“Single Event Gate Rupture”)和SET事件(“Single Event Transients”)的影响。 由SEGR和SET事件产生的杂散信号快速且基本上衰减。
    • 9. 发明授权
    • Image forming apparatus, image forming method, and image forming system
    • 图像形成装置,图像形成方法和图像形成系统
    • US07729647B2
    • 2010-06-01
    • US11678449
    • 2007-02-23
    • Naoki KoikeHiroshi KatoShinichi Kamoshida
    • Naoki KoikeHiroshi KatoShinichi Kamoshida
    • G03G15/08
    • G03G15/065G03G15/0266G03G15/0818
    • An image forming apparatus includes a developer bearing member for transporting developer to an opposing position opposing an image bearing member. Regularly-disposed concave sections are formed on a surface of the developer bearing member. An alternating voltage that includes a first voltage for moving developer from the developer bearing member toward the image bearing member and a second voltage for moving developer from the image bearing member toward the developer bearing member is applied to the developer bearing member. A cycle period of the alternating voltage is smaller than or equal to a minimum width of the concave section in a circumferential direction of the developer bearing member divided by a moving velocity of a surface of the rotating developer bearing member.
    • 图像形成装置包括用于将显影剂输送到与图像承载部件相对的相对位置的显影剂承载部件。 在显影剂承载部件的表面上形成有常规设置的凹形部分。 包括用于将显影剂从显影剂承载构件朝向图像承载部件移动的第一电压和用于将显影剂从图像承载部件朝向显影剂承载部件移动的第二电压的交流电压被施加到显影剂承载部件。 交流电压的循环周期小于或等于显影剂承载部件的圆周方向上的凹部的最小宽度除以旋转的显影剂承载部件的表面的移动速度。