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1. 发明授权

US10005065B2 Adsorbent based on a zeolite and a silica-rich clay, and process for purifying hydrocarbon feeds containing unsaturated molecules 有权
公开(公告)号：US10005065B2
公开(公告)日：2018-06-26
申请号：US14296490
申请日：2014-06-05
申请人： IFP ENERGIES NOUVELLES
发明人： Emmanuelle Bracco , Delphine Marti , Elsa Jolimaitre , Delphine Bazer-Bachi , Joseph Lopez
IPC分类号： B01J20/30 , B01J20/28 , C10G25/03 , B01D53/02 , B01J20/18 , C10G25/05 , B01J20/12
CPC分类号： B01J20/3078 , B01D53/02 , B01D2253/1085 , B01D2253/11 , B01D2256/24 , B01J20/12 , B01J20/183 , B01J20/186 , B01J20/2803 , B01J20/3007 , C10G25/03 , C10G25/05
摘要： The present invention concerns an adsorbent comprising at least one zeolite selected from a zeolite of the 12 MR, 10 MR and 8 MR type and at least one binder comprising a clay with a Si/Al weight ratio of more than 2. It also concerns its preparation process and its use in a process for purifying a hydrocarbon feed comprising unsaturated molecules and at least one impurity comprising at least one heteroatom of the O, S or N type.

2. 外观设计

USD814882S1 Salad box 有权
公开(公告)号：USD814882S1
公开(公告)日：2018-04-10
申请号：US29540932
申请日：2015-09-29
申请人： Joseph Joseph LTD.
设计人： Antony Joseph

3. 外观设计

USD810533S1 Corkscrew 有权
公开(公告)号：USD810533S1
公开(公告)日：2018-02-20
申请号：US29577072
申请日：2016-09-09
申请人： JOSEPH JOSEPH LTD.
设计人： Mark Sanders

4. 发明授权

US09746260B2 Heat exchanger with sections 有权
公开(公告)号：US09746260B2
公开(公告)日：2017-08-29
申请号：US13446383
申请日：2012-04-13
申请人： Manfred Steinbauer , Christiane Kerber , Markus Hammerdinger , Rainer Fluggen
发明人： Manfred Steinbauer , Christiane Kerber , Markus Hammerdinger , Rainer Fluggen
IPC分类号： F28F27/02 , F28D7/16 , F28F7/02 , F28D7/00 , F28D7/02
CPC分类号： F28F27/02 , F25J5/002 , F25J2210/06 , F25J2280/02 , F25J2290/32 , F28D7/0083 , F28D7/024 , F28D7/1669
摘要： The invention relates to a shell and tube heat exchanger (1) having a helical tube bundle (10) within a shell (20), that defines a shell space (200) surrounding the tube bundle (10). The tubes are helically coiled about a core pipe (100) in such a manner that there is formed at least one first section (11) and at least one second section (12), separate from the first section, that surrounds the first section (11). The two sections (11, 12) have in each case at least one associated inlet (E, E′) such that the two sections (11, 12) are able to be charged separately with the first medium.

5. 发明授权

US09163039B2 Process for the preparation of bis(perfluoroalkyl)phosphinic acid anhydrides 有权
标题翻译：制备双（全氟烷基）次膦酸酐的方法
公开(公告)号：US09163039B2
公开(公告)日：2015-10-20
申请号：US14234156
申请日：2012-07-06
申请人： Nikolai (Mykola) Ignatyev , Waldemar Wiebe , Helge Willner
发明人： Nikolai (Mykola) Ignatyev , Waldemar Wiebe , Helge Willner
IPC分类号： C07F9/30 , B01D53/28 , C07F9/44 , C07F9/53 , C07F9/32 , C07F9/34 , B01D53/02 , B01D53/26
CPC分类号： C07F9/30 , B01D53/02 , B01D53/261 , B01D53/28 , B01D2251/61 , C07F9/301 , C07F9/308 , C07F9/32 , C07F9/3294 , C07F9/34 , C07F9/4492 , C07F9/5337
摘要： The invention relates to a process for the preparation of bis(perfluoroalkyl)phosphinic acid anhydrides by reaction of a bis(perfluoroalkyl)phosphinic acid with phosphorus pentoxide, to novel bis(perfluoroalkyl)phosphinic acid anhydrides and to uses of bis(perfluoroalkyl)phosphinic acid anhydrides.
摘要翻译：本发明涉及通过双（全氟烷基）次膦酸与五氧化二磷反应制备双（全氟烷基）次膦酸酐到新型双（全氟烷基）次膦酸酐的方法和双（全氟烷基）次膦酸的用途酸酐。

6. 发明授权

US09151743B2 Use of EEF1A as biomarker and a method of screening MetAP2 inhibitors 有权
标题翻译：使用EEF1A作为生物标志物和筛选MetAP2抑制剂的方法
公开(公告)号：US09151743B2
公开(公告)日：2015-10-06
申请号：US13127834
申请日：2009-10-05
申请人： Roland Kellner , Frank Zenke , Joerg Bomke
发明人： Roland Kellner , Frank Zenke , Joerg Bomke
IPC分类号： G01N33/50 , C12Q1/37
CPC分类号： G01N33/5017 , C12Q1/37 , G01N2333/948 , G01N2800/52
摘要： The invention relates to a method for screening compounds, which inhibit MetAP2 activity, by providing a cellular system or a sample thereof being capable of expressing MetAP2 and/or EEF1A, incubating at least a portion of the system with compounds to be screened, and detecting MetAP2 inhibition by determining EEF1A with N-terminal methionine residue (MetEEF1A). Another object of the invention concerns a method for monitoring physiological and/or pathological conditions, which are caused, mediated and/or propagated by MetAP2 activity, by administering an effective amount of at least a single compound to a mammal in need of such treatment and determining MetEEF1A in a biological sample withdrawn from the mammal. The invention also relates to the use of EEF1A as biomarker.
摘要翻译：本发明涉及通过提供能够表达MetAP2和/或EEF1A的细胞系统或其样品，将至少一部分系统与要筛选的化合物孵育并检测的方法来筛选抑制MetAP2活性的化合物的方法通过测定具有N-末端甲硫氨酸残基（MetEEF1A）的EEF1A的MetAP2抑制。本发明的另一个目的是通过向需要这种治疗的哺乳动物施用有效量的至少一种化合物来监测通过MetAP2活性引起，介导和/或传播的生理和/或病理状态的方法，以及测定从哺乳动物取出的生物样品中的MetEEF1A。本发明还涉及使用EEF1A作为生物标志物。

7. 发明授权

US08299018B2 Proteins with an attached short peptide of acidic amino acids 有权
标题翻译：具有连接的酸性氨基酸短肽的蛋白质
公开(公告)号：US08299018B2
公开(公告)日：2012-10-30
申请号：US12333499
申请日：2008-12-12
申请人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
发明人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
IPC分类号： A61K38/00
CPC分类号： C12N15/625 , C07K2319/02 , C12N9/16
摘要： Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
摘要翻译：公开了包含N-乙酰半乳糖胺-6-硫酸酯硫酸酯酶的融合蛋白质和由其N-末端侧连接到酶上的4-15个酸性氨基酸组成的短肽，含有融合蛋白的药物组合物，使用融合蛋白治疗A型Morquio病。与天然酶蛋白相比，融合蛋白对骨组织的转移能力较高，血液中稳定性提高。

8. 发明授权

US07879314B2 Optical imaging of rheumatoid arthritis 有权
标题翻译：类风湿关节炎的光学成像
公开(公告)号：US07879314B2
公开(公告)日：2011-02-01
申请号：US11476218
申请日：2006-06-28
申请人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
发明人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00
CPC分类号： A61K49/0034 , A61B5/0059 , A61B5/411 , A61B5/4528 , A61B5/6825 , A61K49/0032 , Y02A90/26
摘要： The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.
摘要翻译：本发明涉及吲哚羰花青染料，特别是吲哚红花青染料用于诊断炎症性疾病，特别是类风湿性关节炎，诊断炎性疾病的方法和用于实施诊断方法的设备的用途。

9. 发明授权

US07767455B2 Nucleus export reporter system 失效
标题翻译：核出口记者系统
公开(公告)号：US07767455B2
公开(公告)日：2010-08-03
申请号：US10415483
申请日：2001-10-30
申请人： Ralf Wagner , Marcus Graf
发明人： Ralf Wagner , Marcus Graf
IPC分类号： C12N15/00
CPC分类号： C12N15/1051 , C12N15/1075 , C12N15/85 , C12N2840/44 , C12Q1/6897
摘要： The present invention relates to reporter systems for RNA export, methods for searching for molecules which influence RNA export, and a method, based on these methods, for detecting a viral infection.
摘要翻译：本发明涉及用于RNA输出的报告系统，用于搜索影响RNA输出的分子的方法，以及基于这些方法检测病毒感染的方法。

10. 发明授权

US07700621B2 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations 失效
公开(公告)号：US07700621B2
公开(公告)日：2010-04-20
申请号：US11214988
申请日：2005-08-31
申请人： Ulrich Klar , Wolfgang Schwede , Werner Skuballa , Bernd Buchmann , Jens Hoffmann , Rosemarie Lichtner
发明人： Ulrich Klar , Wolfgang Schwede , Werner Skuballa , Bernd Buchmann , Jens Hoffmann , Rosemarie Lichtner
IPC分类号： A01N43/42 , A01N43/78 , C07D417/00
CPC分类号： C07D493/04 , C07D405/04 , C07D405/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.

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