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1. 发明申请

US20070059244A1 Optical imaging of rheumatoid arthritis 有权
标题翻译：类风湿关节炎的光学成像
公开(公告)号：US20070059244A1
公开(公告)日：2007-03-15
申请号：US11476218
申请日：2006-06-28
申请人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
发明人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
IPC分类号： A61K49/00 , A61K31/428
CPC分类号： A61K49/0034 , A61B5/0059 , A61B5/411 , A61B5/4528 , A61B5/6825 , A61K49/0032 , Y02A90/26
摘要： The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.
摘要翻译：本发明涉及吲哚羰花青染料，特别是吲哚红花青染料用于诊断炎症性疾病，特别是类风湿性关节炎，诊断炎性疾病的方法和用于实施诊断方法的设备的用途。

2. 发明授权

US07879314B2 Optical imaging of rheumatoid arthritis 有权
标题翻译：类风湿关节炎的光学成像
公开(公告)号：US07879314B2
公开(公告)日：2011-02-01
申请号：US11476218
申请日：2006-06-28
申请人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
发明人： Kai Licha , Michael Schirner , Axel Vater , Sonja Vollmer
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00
CPC分类号： A61K49/0034 , A61B5/0059 , A61B5/411 , A61B5/4528 , A61B5/6825 , A61K49/0032 , Y02A90/26
摘要： The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.
摘要翻译：本发明涉及吲哚羰花青染料，特别是吲哚红花青染料用于诊断炎症性疾病，特别是类风湿性关节炎，诊断炎性疾病的方法和用于实施诊断方法的设备的用途。

3. 发明申请

US20060239916A1 Use of cyanine dyes for the diagnosis of proliferative diseases 审中-公开
标题翻译：花青染料用于诊断增殖性疾病
公开(公告)号：US20060239916A1
公开(公告)日：2006-10-26
申请号：US11326574
申请日：2006-01-06
申请人： Kai Licha , Michael Schirner , Martin Pessel , Malte Bahner
发明人： Kai Licha , Michael Schirner , Martin Pessel , Malte Bahner
IPC分类号： A61B5/055
CPC分类号： A61K49/0032 , A61K49/0058
摘要： The present invention concerns the use of the cyanine dye SF64 for the diagnosis of proliferative diseases upon administration of less than 5 mg/kg body weight.
摘要翻译：本发明涉及花青染料SF64在施用小于5mg / kg体重时用于诊断增殖性疾病的用途。

4. 发明申请

US20060039863A1 Use of cyanine dyes for the diagnosis of disease associated with angiogenesis 审中-公开
标题翻译：花青染料用于诊断与血管生成有关的疾病
公开(公告)号：US20060039863A1
公开(公告)日：2006-02-23
申请号：US11185025
申请日：2005-07-20
申请人： Michael Schirner , Kai Licha , Peter Hauff , Christin Perlitz
发明人： Michael Schirner , Kai Licha , Peter Hauff , Christin Perlitz
IPC分类号： A61K49/00 , C12Q1/68 , G01N33/574
CPC分类号： A61K49/0058 , A61K49/0032 , G01N33/533 , G01N33/574 , G01N33/582
摘要： This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and/or rheumatoid arthritis, endometriotic lesions, and ocular diseases associated with angiogenesis.
摘要翻译：本发明涉及花青染料与血管生成特异性结合组分的缀合物与EB-D纤连蛋白特异性结合组分的用途，用于诊断微转移和小增殖性病变，特别是原发性肿瘤，癌前病变，发育不良，化生，炎性病变，例如牛皮癣，银屑病关节炎和/或类风湿性关节炎，子宫内膜异位病变和与血管发生相关的眼部疾病。

5. 发明申请

US20050037402A1 Device and process for direct quantitative in vitro determination of a substance that is contained in a sample 审中-公开
标题翻译：用于直接定量体外测定样品中所含物质的装置和方法
公开(公告)号：US20050037402A1
公开(公告)日：2005-02-17
申请号：US10887228
申请日：2004-07-09
申请人： Michael Schirner , Kai Licha
发明人： Michael Schirner , Kai Licha
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/532 , G01N33/542
CPC分类号： G01N33/542
摘要： This invention relates to a device and a process for direct quantitative in vitro determination of a substance that is contained in a sample. The device according to the invention comprises agents, immobilized on a surface, for detecting substances, a free substance-emitter conjugate, and agents, immobilized on a surface, for detecting the emitter. The emitter of the device that is used comprises a portion that reacts with a change in the emission properties in an interaction with the agent for detecting the emitter. By means of the device according to the invention, substances that are selected from antigens, such as proteins, peptides, nucleic acids, oligonucleotides, blood components, serum components, lipids, pharmaceutical agents and compounds of low molecular weight or, in another design, substance-detecting agents, such as, for example, antibodies or fragments thereof, can be determined directly quantitatively, in, e.g., whole-blood samples.
摘要翻译：本发明涉及用于直接定量体外测定样品中所含物质的装置和方法。根据本发明的装置包括固定在表面上用于检测物质的游离物质 - 发射体结合物和固定在表面上的用于检测发射体的试剂。使用的装置的发射器包括与用于检测发射器的试剂的相互作用中与发射性质的变化反应的部分。通过根据本发明的装置，选自抗原的物质，例如蛋白质，肽，核酸，寡核苷酸，血液成分，血清成分，脂质，药物和低分子量的化合物，或者在另一种设计中，物质检测剂，例如抗体或其片段，可直接在例如全血样品中定量测定。

6. 发明申请

US20110065896A1 POLYETHER POLYOL DENDRON CONJUGATES WITH EFFECTOR MOLECULES FOR BIOLOGICAL TARGETING 审中-公开
标题翻译：聚醚多糖与生物指标效应分子结合
公开(公告)号：US20110065896A1
公开(公告)日：2011-03-17
申请号：US12921624
申请日：2009-03-10
申请人： Kai Licha , Malte Bahner , Michael Schirner , Rainer Haag , Timm Heek , Monika Wyszogrodzka
发明人： Kai Licha , Malte Bahner , Michael Schirner , Rainer Haag , Timm Heek , Monika Wyszogrodzka
IPC分类号： C07K7/08 , C07D403/14 , C07D403/08 , C07D471/06 , C07D403/06 , C07D487/22 , C07K16/00 , C07K14/765
CPC分类号： A61K49/0036 , A61K41/0057 , A61K41/0071 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C08G83/004
摘要： Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.
摘要翻译：本发明的主题是包含特定的聚醚多元醇树枝状部分，至少一种特定的荧光效应分子（E）的聚醚多元醇树枝状缀合物。这种聚醚多元醇树突缀合物可以用于诊断和治疗目的，由此由于与聚醚多元醇树突缀合物的连接，至少一种某种荧光效应分子的光学性质得到增强。

7. 发明授权

US08877171B2 Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis 有权
标题翻译：聚阴离子多价大分子用于细胞内靶向增殖和蛋白质合成
公开(公告)号：US08877171B2
公开(公告)日：2014-11-04
申请号：US13576779
申请日：2011-01-31
申请人： Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
发明人： Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
IPC分类号： A61K31/74 , C08G83/00 , A61K49/00 , A61K41/00 , C07D487/22 , A61K49/08 , C07C237/14 , C07D403/14 , C07D403/10 , C07D405/12 , A61K47/48 , A61K49/12 , C07H21/02 , A61K51/06
CPC分类号： C07D487/22 , A61K41/0071 , A61K47/59 , A61K49/0032 , A61K49/0041 , A61K49/0054 , A61K49/085 , A61K49/124 , A61K51/065 , C07C237/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07H21/02 , C08G83/003
摘要： The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.
摘要翻译：本发明一般涉及使用聚阴离子多价大分子靶向参与活化细胞的增殖和蛋白质合成的细胞内分子的方法和组合物。特别地，与多元醇连接的多个硫酸酯基特异性靶向增殖和激活细胞的细胞质和细胞核。本发明还包括新颖的聚阴离子大分子化合物和制剂。

8. 发明申请

US20130095035A1 POLYANIONIC MULTIVALENT MACROMOLECULES FOR INTRACELLULAR TARGETING OF PROLIFERATION AND PROTEIN SYNTHESIS 有权
标题翻译：用于增殖和蛋白质合成的细胞内靶向的多功能多功能大分子
公开(公告)号：US20130095035A1
公开(公告)日：2013-04-18
申请号：US13576779
申请日：2011-01-31
申请人： Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
发明人： Kai Licha , Michael Schirner , Pia Welker , Rainer Haag , Marie Weinhart , Florian Paulus
IPC分类号： C07D487/22 , C07C237/14 , C07D403/10 , C07D405/12 , C07H21/02 , C07D403/14
CPC分类号： C07D487/22 , A61K41/0071 , A61K47/59 , A61K49/0032 , A61K49/0041 , A61K49/0054 , A61K49/085 , A61K49/124 , A61K51/065 , C07C237/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07H21/02 , C08G83/003
摘要： The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.
摘要翻译：本发明一般涉及使用聚阴离子多价大分子靶向参与活化细胞的增殖和蛋白质合成的细胞内分子的方法和组合物。特别地，与多元醇连接的多个硫酸酯基特异性靶向增殖和激活细胞的细胞质和细胞核。本发明还包括新颖的聚阴离子大分子化合物和制剂。

9. 发明申请

US20100166659A1 USE OF CYANINE DYES FOR THE DIAGNOSIS OF PROLIFERATIVE DISEASES 审中-公开
标题翻译：用于诊断增殖性疾病的氰基染料的使用
公开(公告)号：US20100166659A1
公开(公告)日：2010-07-01
申请号：US12687378
申请日：2010-01-14
申请人： Kai Licha , Michael Schirner , Martin Pessel , Malte Bahner
发明人： Kai Licha , Michael Schirner , Martin Pessel , Malte Bahner
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0058
摘要： The present invention concerns the use of the cyanine dye SF64 for the diagnosis of proliferative diseases upon administration of less than 5 mg/kg body weight.
摘要翻译：本发明涉及花青染料SF64用于在施用小于5mg / kg体重时诊断增殖性疾病的用途。

10. 发明申请

US20050064512A1 Emitter-binding peptides that produce a change in the spectral emission properties of the emitter 审中-公开
标题翻译：产生发射体的光谱发射特性变化的发射体结合肽
公开(公告)号：US20050064512A1
公开(公告)日：2005-03-24
申请号：US10887231
申请日：2004-07-09
申请人： Michael Schirner , Kai Licha , Andreas Menrad
发明人： Michael Schirner , Kai Licha , Andreas Menrad
IPC分类号： C07K16/44 , C12N15/13 , G01N33/542 , G01N33/53 , C07K16/46
CPC分类号： C07K16/44 , C07K2317/21 , C07K2317/56 , G01N33/542
摘要： This invention relates to emitter-binding peptides that produce a change in the spectral emission properties of the emitter in the case of an interaction of its antigen-binding pocket with the emitter. The emitter-binding peptides of the invention are in particular components of antibodies and antibody fragments.
摘要翻译：本发明涉及发射体结合肽，其在其抗原结合口袋与发射体的相互作用的情况下产生发射体的光谱发射特性的变化。本发明的发射体结合肽特别是抗体和抗体片段的组分。

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