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1. 发明申请

US20070081986A1 Beta-glucuronidase with an attached short peptide of acidic amino acids 审中-公开
标题翻译： β-葡萄糖醛酸酶与附着的酸性氨基酸短肽
公开(公告)号：US20070081986A1
公开(公告)日：2007-04-12
申请号：US11245424
申请日：2005-10-07
申请人： Shunji Tomatsu , Ken'jchi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada , Jeffrey Grubb
发明人： Shunji Tomatsu , Ken'jchi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada , Jeffrey Grubb
IPC分类号： A61K38/47 , C12N9/24 , C12N9/42
CPC分类号： C12Y302/01031 , A61K38/00 , C07K2319/31 , C12N9/2402 , C12N9/96
摘要： Disclosed are a fusion protein comprising enzyme β-glucuronidase and short peptide consisting 4-15 acidic amino acids attached to the enzyme on its N-terminal side, pharmaceutical composition containing the fusion protein, and a method for treatment of type VII mucopolysaccharidosis using the fusion protein. Compared with the native enzyme, the fusion protein exhibits higher stability in the blood.
摘要翻译：公开了包含酶β-葡糖醛酸糖苷酶和短肽的融合蛋白，所述短肽与其N-末端侧的酶连接4-15个酸性氨基酸，含有融合蛋白的药物组合物和使用该融合物治疗VII型粘多糖贮积病的方法蛋白。与天然酶相比，融合蛋白在血液中表现出更高的稳定性。

2. 发明授权

US07863238B2 Proteins with an attached short peptide of acidic amino acids 有权
标题翻译：具有连接的酸性氨基酸短肽的蛋白质
公开(公告)号：US07863238B2
公开(公告)日：2011-01-04
申请号：US10864758
申请日：2004-06-10
申请人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
发明人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
IPC分类号： A61K38/00
CPC分类号： C12N15/625 , C07K2319/02 , C12N9/16
摘要： Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
摘要翻译：公开了包含N-乙酰半乳糖胺-6-硫酸酯硫酸酯酶的融合蛋白质和由其N-末端侧连接到酶上的4-15个酸性氨基酸组成的短肽，含有融合蛋白的药物组合物，使用融合蛋白治疗A型Morquio病。与天然酶蛋白相比，融合蛋白对骨组织的转移能力较高，血液中稳定性提高。

3. 发明授权

US07609070B2 Manufacturing method and controlling method of electronic device 失效
标题翻译：电子设备的制造方法和控制方法
公开(公告)号：US07609070B2
公开(公告)日：2009-10-27
申请号：US11902392
申请日：2007-09-21
申请人： Tomohiro Kagiyama , Yasuhiro Tosaka , Norikazu Iwagami
发明人： Tomohiro Kagiyama , Yasuhiro Tosaka , Norikazu Iwagami
IPC分类号： G01R31/12 , G01R31/08 , G01R31/26
CPC分类号： G01R31/028 , Y10T29/435
摘要： A manufacturing method of an electronic device includes applying a direct voltage having a first polarity to a capacitor that has an insulating layer including nitrogen and silicon as a capacitor dielectric layer, testing the capacitor to which the direct voltage having the first polarity is applied and determining a nondefective capacitor and a defective capacitor, and applying a direct voltage having a second polarity to the nondefective capacitor. The second polarity is opposite to the first polarity.
摘要翻译：一种电子设备的制造方法，包括将具有第一极性的直流电压施加到具有包括氮和硅的绝缘层的电容器作为电容器电介质层，测试施加具有第一极性的直流电压的电容器，并确定无损电容器和有缺陷的电容器，并且向无损电容器施加具有第二极性的直流电压。第二极性与第一极性相反。

4. 发明授权

US07644978B2 Vehicle floor structure for a motor vehicle 有权
标题翻译：机动车辆的车辆地板结构
公开(公告)号：US07644978B2
公开(公告)日：2010-01-12
申请号：US12145955
申请日：2008-06-25
申请人： Yasuhiro Tosaka , Nobuyoshi Suzuki
发明人： Yasuhiro Tosaka , Nobuyoshi Suzuki
IPC分类号： B62D21/15 , B62D25/20
CPC分类号： B62D21/157 , B60N2/005 , B62D25/025 , B62D25/2036
摘要： A cross member passes a longitudinal member. The cross member is connected, on its outer end, to a side sill assembly and includes a connecting portion that divides the cross member into a remote cross member portion from the outer end of the cross member, and the other cross member portion. A reinforcement element extends through the connecting portion into the remote cross member portion and terminates in at its inner end spaced by a gap from a top wall of the longitudinal member, and it extends into the other cross member portion and terminates in at its outer end in the neighborhood of the side sill assembly. It is connected to an upper inner wall of the remote cross member portion, but spaced from an upper inner wall of the other cross member portion.
摘要翻译：横向构件通过纵向构件。横向构件在其外端部连接到下纵梁组件，并且包括连接部分，该连接部分将横向构件从横向构件的外端和另一横向构件部分分成远侧横向构件部分。加强元件延伸穿过连接部分进入远端横向构件部分，并且在其内端处终止于与纵向构件的顶壁间隔开的间隙，并且其延伸到另一横向构件部分中并终止于其外端在旁边的大底座附近。其连接到远侧横向构件部分的上部内壁，但与另一个横向构件部分的上部内壁间隔开。

5. 发明申请

US20050276796A1 Proteins with an attached short peptide of acidic amino acids 有权
标题翻译：具有连接的酸性氨基酸短肽的蛋白质
公开(公告)号：US20050276796A1
公开(公告)日：2005-12-15
申请号：US10864758
申请日：2004-06-10
申请人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
发明人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
IPC分类号： A61K38/00 , C12N9/16 , C12N15/62 , A61K38/46
CPC分类号： C12N15/625 , C07K2319/02 , C12N9/16
摘要： Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
摘要翻译：公开了包含N-乙酰半乳糖胺-6-硫酸酯硫酸酯酶的融合蛋白质和由其N-末端侧连接到酶上的4-15个酸性氨基酸组成的短肽，含有融合蛋白的药物组合物，使用融合蛋白治疗A型Morquio病。与天然酶蛋白相比，融合蛋白对骨组织的转移能力较高，血液中稳定性提高。

6. 发明授权

US06761394B2 Vehicle front body structure 有权
标题翻译：车前体结构
公开(公告)号：US06761394B2
公开(公告)日：2004-07-13
申请号：US10405649
申请日：2003-04-03
申请人： Kiyoshi Gennai , Yasuhiro Tosaka
发明人： Kiyoshi Gennai , Yasuhiro Tosaka
IPC分类号： B60K3700
CPC分类号： B62D25/2036 , B62D25/025 , B62D25/2045
摘要： A vehicle front body structure which includes a dash panel, a dash side panel joined to the dash panel and a side sill joined to the dash side panel. The dash panel is provided with a flange on its transversely outer side. The dash side panel includes an upstanding portion which has a substantially channel-shaped section open outward and includes a front wall on its front side, and a base portion which extends rearward from the upstanding portion. The side sill includes a sill inner joined to the base portion of the dash side panel. The flange of the dash panel extends along the front wall of the upstanding portion of the dash side panel to be joined to the front wall.
摘要翻译：一种车辆前体结构，其包括仪表板，连接到前围板的前围板和与前围板侧板连接的下纵梁。仪表板的横向外侧设有凸缘。前围板包括直立部分，其具有向外敞开的大致通道状部分，并且包括前侧的前壁和从直立部向后延伸的基部。侧框架包括连接到前围边框的基部的门框内部。仪表板的凸缘沿着仪表板侧面的直立部分的前壁延伸，以连接到前壁。

7. 发明申请

US20110027242A1 METHOD FOR PRODUCTION OF TRANSFECTED CELL 审中-公开
标题翻译：生产转移细胞的方法
公开(公告)号：US20110027242A1
公开(公告)日：2011-02-03
申请号：US12934843
申请日：2009-03-27
申请人： Ikuei Nukaya , Yumi Goto , Yasuhiro Tosaka , Junichi Mineno , Ikunoshin Kato
发明人： Ikuei Nukaya , Yumi Goto , Yasuhiro Tosaka , Junichi Mineno , Ikunoshin Kato
IPC分类号： A61K35/12 , C12N5/10 , A61P37/00
CPC分类号： C12N15/63 , A61K35/17 , C12N5/0636
摘要： Disclosed is a method for producing a cell population into which a desired gene is introduced, which is characterized by comprising the following steps (1) and (2): (1) culturing a cell population containing a T-cell and/or a progenitor cell of a T-cell in a vessel containing fibronectin or a fragment thereof and a CD3 ligand; and (2) adding a vector carrying the desired gene to the vessel of the step (1). By carrying out both the steps (1) and (2) in the same vessel, the gene transfer can be achieved with high efficiency.
摘要翻译：公开了一种产生所需基因导入的细胞群的方法，其特征在于包括以下步骤（1）和（2）：（1）培养含有T细胞和/或祖细胞的细胞群含有纤连蛋白或其片段的血管和CD3配体的T细胞的细胞; 和（2）将携带所需基因的载体加入到步骤（1）的容器中。通过在同一容器中进行步骤（1）和（2），可以高效地实现基因转移。

8. 发明申请

US20080074119A1 Manufacturing method and controlling method of electronic device 失效
标题翻译：电子设备的制造方法和控制方法
公开(公告)号：US20080074119A1
公开(公告)日：2008-03-27
申请号：US11902392
申请日：2007-09-21
申请人： Tomohiro KAGIYAMA , Yasuhiro TOSAKA , Norikazu IWAGAMI
发明人： Tomohiro KAGIYAMA , Yasuhiro TOSAKA , Norikazu IWAGAMI
IPC分类号： G01R31/12 , H01G4/00
CPC分类号： G01R31/028 , Y10T29/435
摘要： A manufacturing method of an electronic device includes applying a direct voltage having a first polarity to a capacitor that has an insulating layer including nitrogen and silicon as a capacitor dielectric layer, testing the capacitor to which the direct voltage having the first polarity is applied and determining a nondefective capacitor and a defective capacitor, and applying a direct voltage having a second polarity to the nondefective capacitor. The second polarity is opposite to the first polarity.
摘要翻译：一种电子设备的制造方法，包括将具有第一极性的直流电压施加到具有包括氮和硅的绝缘层的电容器作为电容器电介质层，测试施加具有第一极性的直流电压的电容器，并确定无损电容器和有缺陷的电容器，并且向无损电容器施加具有第二极性的直流电压。第二极性与第一极性相反。

9. 发明授权

US08299018B2 Proteins with an attached short peptide of acidic amino acids 有权
标题翻译：具有连接的酸性氨基酸短肽的蛋白质
公开(公告)号：US08299018B2
公开(公告)日：2012-10-30
申请号：US12333499
申请日：2008-12-12
申请人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
发明人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
IPC分类号： A61K38/00
CPC分类号： C12N15/625 , C07K2319/02 , C12N9/16
摘要： Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
摘要翻译：公开了包含N-乙酰半乳糖胺-6-硫酸酯硫酸酯酶的融合蛋白质和由其N-末端侧连接到酶上的4-15个酸性氨基酸组成的短肽，含有融合蛋白的药物组合物，使用融合蛋白治疗A型Morquio病。与天然酶蛋白相比，融合蛋白对骨组织的转移能力较高，血液中稳定性提高。

10. 发明申请

US20090175839A1 PROTEINS WITH AN ATTACHED SHORT PEPTIDE OF ACIDIC AMINO ACIDS 有权
标题翻译：蛋白质与氨基酸的氨基酸连接
公开(公告)号：US20090175839A1
公开(公告)日：2009-07-09
申请号：US12333499
申请日：2008-12-12
申请人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
发明人： Shunji Tomatsu , Ken'ichi Miyamoto , Masamichi Yamada , Yasuhiro Tosaka , Mana Yamada
IPC分类号： A61K38/46
CPC分类号： C12N15/625 , C07K2319/02 , C12N9/16
摘要： Disclosed are a fusion protein comprising enzyme N-acetylgalactosamine-6-sulfate sulfatase and a short peptide consisting of 4-15 acidic amino acids attached to the enzyme on its N-terminal side, a pharmaceutical composition containing the fusion protein, and a method for treatment of type A Morquio disease using the fusion protein. Compared with the native enzyme protein, the fusion protein exhibits higher transferability to bone tissues and improved, higher stability in the blood.
摘要翻译：公开了包含N-乙酰半乳糖胺-6-硫酸酯硫酸酯酶的融合蛋白质和由其N-末端侧连接到酶上的4-15个酸性氨基酸组成的短肽，含有融合蛋白的药物组合物，使用融合蛋白治疗A型Morquio病。与天然酶蛋白相比，融合蛋白对骨组织的转移能力较高，血液中稳定性提高。

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