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1. 发明授权

US09042953B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US09042953B2
公开(公告)日：2015-05-26
申请号：US11681730
申请日：2007-03-02
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
IPC分类号： A61B5/145 , A61B5/05 , A61B5/00 , C12Q1/54 , A61B5/1486 , A61M5/172 , H01L23/31 , H01L23/495 , G06F19/00 , A61B5/01 , A61B5/1495 , A61B5/1473
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

2. 发明授权

US09014773B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US09014773B2
公开(公告)日：2015-04-21
申请号：US11683371
申请日：2007-03-07
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
IPC分类号： A61B5/1486 , A61B5/1473 , A61B5/145 , A61M5/172 , H01L23/31 , H01L23/495 , G06F19/00 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

3. 发明授权

US09011331B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US09011331B2
公开(公告)日：2015-04-21
申请号：US11027423
申请日：2004-12-29
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05 , A61B5/145 , A61B5/1486 , H01L23/31 , H01L23/495 , G06F19/00 , A61B5/1473
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

4. 发明申请

US20150102257A1 SUB-STOICHIOMETRIC, CHALCOGEN-CONTAINING-GERMANIUM, TIN, OR LEAD ANODES FOR LITHIUM OR SODIUM ION BATTERIES 有权
标题翻译：用于锂离子电池或钠离子电池的低分子量，含氯化钠，锡或铅阳极
公开(公告)号：US20150102257A1
公开(公告)日：2015-04-16
申请号：US14513951
申请日：2014-10-14
申请人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
发明人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
IPC分类号： H01M4/58
CPC分类号： H01M4/581 , H01B1/02 , H01G11/30 , H01G11/50 , H01M4/134 , H01M4/136 , H01M4/405 , H01M4/5815 , H01M10/05 , H01M10/0525 , H01M10/054 , H01M2004/021 , Y02E60/13 , Y02T10/7022
摘要： The disclosure relates to an anode or an electrolytic capacitor electrode including an active anode material containing a chalcogen-containing-germanium composition in which the germanium:chalcogen atom ratio is between 80:20 and 98:2. The disclosure also relates to an anode including an active anode material containing a lithium and germanium-containing alloy wherein the lithium:germanium atom ratio is 22:5 or less. The anode also includes a non-cycling lithium chalcogenide. The disclosure further relates to lithium ion batteries including such anodes. The disclosure additionally relates to capacitor electrodes containing similar materials and capacitors containing such electrodes.
摘要翻译：本公开涉及一种阳极或电解电容器电极，其包括含有含硫族元素的锗组合物的活性阳极材料，其中锗：硫属原子比为80:20至98:2。本公开还涉及包含含有锂和锗的合金的活性阳极材料的阳极，其中锂：锗原子比为22:5或更小。阳极还包括非循环锂硫属化物。本公开还涉及包括这种阳极的锂离子电池。本公开另外涉及包含类似材料的电容器电极和包含这种电极的电容器。

5. 发明授权

US08828204B2 Redox polymers 有权
公开(公告)号：US08828204B2
公开(公告)日：2014-09-09
申请号：US13215007
申请日：2011-08-22
申请人： Fei Mao , Adam Heller
发明人： Fei Mao , Adam Heller
IPC分类号： C07F15/00 , G01N27/327
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , C07F9/005 , C07F15/0026 , C07F15/0053 , C07F15/025 , C07F15/065 , C08F8/42 , C08F8/44 , C09B57/10 , C12Q1/004
摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.

6. 发明授权

US08795490B2 Redox polymers 有权
标题翻译：氧化还原聚合物
公开(公告)号：US08795490B2
公开(公告)日：2014-08-05
申请号：US13214999
申请日：2011-08-22
申请人： Fei Mao , Adam Heller
发明人： Fei Mao , Adam Heller
IPC分类号： C07F15/00 , G01N27/327
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , C07F9/005 , C07F15/0026 , C07F15/0053 , C07F15/025 , C07F15/065 , C08F8/42 , C08F8/44 , C09B57/10 , C12Q1/004
摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
摘要翻译：描述了铁，钴，钌，锇和钒的新型过渡金属络合物。过渡金属络合物可用作酶基电化学传感器中的氧化还原介质。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的二咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。还描述了连接到聚合物主链上的过渡金属络合物。

7. 发明授权

US08761857B2 Analyte sensor, and associated system and method employing a catalytic agent 有权
标题翻译：分析物传感器，以及使用催化剂的相关系统和方法
公开(公告)号：US08761857B2
公开(公告)日：2014-06-24
申请号：US13437692
申请日：2012-04-02
申请人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
发明人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/686 , A61B5/14514 , A61B5/14528 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/004 , C12Q1/005 , C12Q1/006
摘要： An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
摘要翻译：描述了与生物流体结合使用的分析物传感器。分析物传感器可以包括生物流体和生物流体的衍生物之间的任何合适的界面以及关于分析物的任何合适的信息传感器。在界面的区域或附近提供至少一种催化剂。催化剂，例如蛋白质剂或非蛋白质的有机金属剂，足以催化可能存在于界面附近的活性氧和/或氮物质的降解。还描述了分析物感测套件和感测分析物的方法。

8. 发明授权

US08744545B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08744545B2
公开(公告)日：2014-06-03
申请号：US12397293
申请日：2009-03-03
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Fredric C. Colman
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

9. 发明申请

US20140102883A1 CARBON DIOXIDE ENRICHMENT DEVICE 审中-公开
标题翻译：二氧化碳浓缩装置
公开(公告)号：US20140102883A1
公开(公告)日：2014-04-17
申请号：US14122377
申请日：2012-05-29
申请人： Ryo Kamai , Michio Suzuka , Shuji Nakanishi , Kazuhito Hashimoto , Adam Heller , Yong Zhao
发明人： Ryo Kamai , Michio Suzuka , Shuji Nakanishi , Kazuhito Hashimoto , Adam Heller , Yong Zhao
IPC分类号： C25B11/03
CPC分类号： C25B11/035 , B01D53/229 , B01D53/326 , B01D53/62 , B01D2257/504 , C01B32/50 , Y02C10/04 , Y02P20/126 , Y02P20/152
摘要： A carbon dioxide enrichment device, comprising: first and second gas diffusion electrodes; and an electrolytic solution existing between them to be in contact with them, wherein the electrolytic solution contains solvent and solute dissolved in it, and the solute is dissolved to form a dissolved inorganic carbon containing carbonic acid, hydrogen carbonate ions, or carbonic acid ions; oxygen is consumed by an oxygen reduction reaction on the first gas diffusion electrode, whereby a dissolved inorganic carbon is formed by a dissolution and ionization reaction of carbon dioxide in the solvent; the dissolved inorganic carbon derived from the solute or the dissolved inorganic carbon is transported to the second gas diffusion electrode; and oxygen is formed from the solvent in the vicinity of the second gas diffusion electrode by an oxidation reaction of the solvent on it, and carbon dioxide is formed from the dissolved inorganic carbon.
摘要翻译：一种二氧化碳浓缩装置，包括：第一和第二气体扩散电极; 和它们之间存在的与其接触的电解液，其中所述电解液含有溶解在其中的溶质和溶质，并且所述溶质被溶解以形成含有碳酸，碳酸氢根离子或碳酸离子的溶解的无机碳; 在第一气体扩散电极上通过氧还原反应消耗氧，由此二氧化碳在溶剂中的溶解和离子化反应形成溶解的无机碳; 来自溶质或溶解的无机碳的溶解的无机碳被输送到第二气体扩散电极; 并且通过其上的溶剂的氧化反应在第二气体扩散电极附近从溶剂形成氧，并且由溶解的无机碳形成二氧化碳。

10. 发明授权

US08649841B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08649841B2
公开(公告)日：2014-02-11
申请号：US11695607
申请日：2007-04-03
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Aria Behrad , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Aria Behrad , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

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