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1. 发明授权

US08880137B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08880137B2
公开(公告)日：2014-11-04
申请号：US10420057
申请日：2003-04-18
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00 , A61B5/1473 , A61B5/1468 , A61B5/145 , G06F19/00 , A61B5/1486 , H01L23/495 , H01L23/31
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

2. 发明授权

US08641619B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08641619B2
公开(公告)日：2014-02-04
申请号：US12643977
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05 , C12Q1/54
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

3. 发明授权

US08473021B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08473021B2
公开(公告)日：2013-06-25
申请号：US12533680
申请日：2009-07-31
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

4. 发明授权

US08409131B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08409131B2
公开(公告)日：2013-04-02
申请号：US11683396
申请日：2007-03-07
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Aria Behrad , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Aria Behrad , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

5. 发明授权

US08346336B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08346336B2
公开(公告)日：2013-01-01
申请号：US12406800
申请日：2009-03-18
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

6. 发明授权

US08275439B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08275439B2
公开(公告)日：2012-09-25
申请号：US12614974
申请日：2009-11-09
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

7. 发明申请

US20120238833A1 Analyte Monitoring Device and Methods of Use 审中-公开
标题翻译：分析物监测装置及使用方法
公开(公告)号：US20120238833A1
公开(公告)日：2012-09-20
申请号：US13429294
申请日：2012-03-23
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/1473 , A61B5/01
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor.
摘要翻译：分析物监测器包括传感器，传感器控制单元和显示单元。传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。

8. 发明授权

US08162829B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08162829B2
公开(公告)日：2012-04-24
申请号：US12414456
申请日：2009-03-30
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

9. 发明授权

US08142643B2 Small volume in vitro analyte sensor 有权
标题翻译：体积小体积分析物传感器
公开(公告)号：US08142643B2
公开(公告)日：2012-03-27
申请号：US12568858
申请日：2009-09-29
申请人： Adam Heller , Benjamin J. Feldman , James Say , Mark S. Vreeke
发明人： Adam Heller , Benjamin J. Feldman , James Say , Mark S. Vreeke
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15105 , A61B5/15113 , A61B5/15144 , A61B5/157 , A61B2560/0223 , A61B2562/0295 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N33/5438 , G01N2333/904
摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.
摘要翻译：设计用于确定体积小于约1μL的样品中分析物的量和浓度的传感器。该传感器具有涂覆有不可浸出的氧化还原介体的工作电极。氧化还原介体作为分析物和电极之间的电子转移剂。此外，可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。氧化还原介体通常是与聚合物结合的氧化还原化合物。优选的氧化还原介体是可空气氧化的。分析物的量可以通过库仑法测定。一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。通过该电流流向或来自分析物的电荷与样品中分析物的量相关。还可以使用其他电化学检测方法，例如电流，伏安和电位技术。本发明可用于测定生物液体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

10. 发明授权

US08136220B2 Method of making an electrochemical sensor 有权
标题翻译：制作电化学传感器的方法
公开(公告)号：US08136220B2
公开(公告)日：2012-03-20
申请号：US11930004
申请日：2007-10-30
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke
IPC分类号： G01R3/00
CPC分类号： A61B5/14735 , A61B5/14532 , A61B5/14865 , A61B2562/0271 , A61B2562/125 , C12Q1/001 , G01N27/3272 , G01N33/5438 , G01N33/54393 , G01N33/66 , Y10T29/42 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49117 , Y10T29/49128 , Y10T29/49155 , Y10T29/49208 , Y10T29/49798 , Y10T156/1064 , Y10T156/1082
摘要： A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.
摘要翻译：一种制造具有可重复表面的小型传感器的方法，包括电化学传感器。一种方法包括在基材的表面中形成通道并在通道中设置导电材料以形成电极。导电材料也可以通过其它冲击和非冲击方法形成在基板上。在优选实施例中，该方法包括切割基底以形成具有连接器部分和经皮部分的传感器，该两个部分具有限定一条连续直线的边缘。

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