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1. 发明申请

US20050210537A1 Pluripotent mammalian cells 审中-公开
标题翻译：多能哺乳动物细胞
公开(公告)号：US20050210537A1
公开(公告)日：2005-09-22
申请号：US11131703
申请日：2005-05-18
申请人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
发明人： Tanja Dominko , Raymond Page , Alan Colman , Todd Vaught , Vivienne Marshall
IPC分类号： A61K48/00 , C12N5/16 , C12N15/873 , A01K67/027 , C12N5/06 , C12N5/08
CPC分类号： C12N15/873 , A61K48/00 , C12N5/16 , C12N2506/04 , C12N2517/04 , C12N2517/10
摘要： The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the production of pluripotent stem cells from many mammalian species but has particular application in man where pluripotent stem cell production can be customized to particular human individual. The method involves the fusion of donor somatic or stem cells (or their karyoplasts) with cytoplasmic, membrane-delimited fragments of mammalian oocytes or zygotes. After the initial genomic reprogramming occurs, the cells can proliferate and thus multiply in vitro yielding a large number of autologous cells for cell therapy application. The result of this process is a cell population genomically identical to the somatic, differentiated cells derived from an individual patient. However, these cells are pluripotent in that upon application of specific growth factors, the cells are capable of differentiating into specific cell types as required by the sought clinical indication.
摘要翻译：本发明涉及一种制造不涉及早期植入前胚胎或胎儿组织的形成的多能干细胞的方法。该方法在许多哺乳动物物种的多能干细胞的生产中具有普遍的用途，但在人类中具有特殊应用，其中多能干细胞的生产可以根据具体的个体进行定制。该方法涉及供体体细胞或干细胞（或它们的核型）与哺乳动物卵母细胞或合子的细胞质膜分离的片段的融合。在初始基因组重编程发生后，细胞可以增殖并因此在体外繁殖产生大量用于细胞治疗应用的自体细胞。该过程的结果是与来自个体患者的体细胞分化细胞基因相同的细胞群体。然而，这些细胞是多能的，因为在应用特定生长因子时，细胞能够根据寻求的临床适应症的要求将其分化成特定的细胞类型。

2. 发明授权

US06288269B1 Apparatus for introducing fluid into a process stream 有权
标题翻译：将流体引入工艺流的装置
公开(公告)号：US06288269B1
公开(公告)日：2001-09-11
申请号：US09465008
申请日：1999-12-16
申请人： Derek Alan Colman
发明人： Derek Alan Colman
IPC分类号： C07C67055
CPC分类号： B01J19/26 , B01F3/04049 , B01F5/045 , B01F5/0682 , B01J8/008 , B01J8/0278 , B01J2208/00849 , C07C67/05 , Y10T137/9682 , C07C69/15
摘要： Apparatus for introducing a fluid into a process stream such as promoter into the feed stream of a reactor for manufacturing vinyl acetate comprises: (a) a process stream pipe having a bend and (b) a nozzle for introducing the fluid into the process stream downstream of the bend characterised in that the pipe has a flow-correction device downstream of the bend and the nozzle is mounted downstream of the flow-correction device to an end of a support arm which extends into the pipe in a direction substantially parallel to the direction of the pipe downstream of the bend.
摘要翻译：用于将流体（例如助催化剂）引入到用于制造乙酸乙烯酯的反应器的进料流中的装置包括：（a）具有弯曲的工艺流管和（b）用于将流体引入工艺流下游的喷嘴所述弯管的特征在于，所述管道具有在所述弯曲部下游的流量校正装置，并且所述喷嘴安装在所述流量校正装置的下游，直到所述支撑臂的端部沿着基本上平行于所述方向的方向延伸到所述管道中的弯管下游。

3. 发明授权

US06881874B2 Process for the catalytic oxidation of hydrocarbons 失效
标题翻译：烃类催化氧化方法
公开(公告)号：US06881874B2
公开(公告)日：2005-04-19
申请号：US10275343
申请日：2001-04-30
申请人： Derek Alan Colman , Trevor John Hesketh , Ian Allan Beattie Reid , William Terence Woodfin
发明人： Derek Alan Colman , Trevor John Hesketh , Ian Allan Beattie Reid , William Terence Woodfin
IPC分类号： C07D307/60 , B01F3/02 , B01F5/00 , B01F5/04 , B01J8/02 , B01J19/00 , B01J19/26 , C01B3/38 , C07B61/00 , C07C5/333 , C07C5/48 , C07C11/04 , C07C45/33 , C07C51/215 , C07C51/265 , C07C51/31 , C07C67/05 , C07C69/15 , C07C253/24 , C07D301/08 , C07D307/89 , C07C4/02 , C07C2/02 , C07C11/00 , C07C5/33
CPC分类号： C01B3/386 , B01J8/0242 , B01J8/0285 , B01J19/006 , B01J19/26 , B01J2208/00 , B01J2219/00069 , B01J2219/00085 , B01J2219/00155 , B01J2219/00159 , B01J2219/00164 , B01J2219/00243 , B01J2219/0286 , B01J2219/1923 , C01B2203/0261 , C01B2203/1047 , C01B2203/1058 , C01B2203/107 , C01B2203/1247 , C01B2203/1288 , C07C5/48 , C07C45/33 , C07C51/215 , C07C51/265 , C07C51/313 , C07C67/05 , C07C253/24 , C07D301/08 , C07C11/02 , C07C57/145 , C07C63/16 , C07C69/01 , C07C69/15 , C07C255/08
摘要： A process for the production of an olefin comprising partially combusting in a reaction zone a mixture of a hydrocabon and an oxygen-containing gas in the presence of a catalyst which is capable of supporting combustion beyond the fuel rich limit of flammability to produce the olefin. Prior the partial combustion, the mixture of the hydrocabon and the oxygen-containg gas is passed through a heat excahanger, and the heat exchanger provides a pressure drop.
摘要翻译：一种生产烯烃的方法，其包括在催化剂存在下在反应区域中部分地燃烧氢氯酸盐和含氧气体的混合物，所述催化剂能够支持燃料超过燃料的燃烧极限以产生烯烃。在部分燃烧之前，氢化氢和含氧气体的混合物通过热交换器，并且热交换器提供压降。

4. 发明申请

US20080250517A1 Methods 审中-公开
标题翻译：方法
公开(公告)号：US20080250517A1
公开(公告)日：2008-10-09
申请号：US11641644
申请日：2006-12-18
申请人： Alan Colman , Angelika E. Schnieke , Alexander J. Kind , David L. Ayares , Yifan Dai
发明人： Alan Colman , Angelika E. Schnieke , Alexander J. Kind , David L. Ayares , Yifan Dai
IPC分类号： C12N15/87
CPC分类号： A01K67/0275 , A01K2217/05 , A61K48/00 , C12N15/102 , C12N15/907 , C12N2510/00 , C12N2517/10 , C12N2800/60 , C12N2830/00 , C12N2830/42 , C12N2830/85 , C12N2840/203 , H04L41/0213 , H04L41/12 , H04L41/22
摘要： The production of genetically modified animals, in which the genetic modifications are engineered in somatic cells cultured in vitro by gene targeting, is described. Genetically modified cells may then used as nuclear donors to produce, inter alia, live animals. The methods described can also be used to validate loci in animal chromosomes which are suitable sites for transgene addition to cells.
摘要翻译：描述了基因修饰动物的生产，其中通过基因靶向在体外培养的体细胞中对遗传修饰进行工程改造。然后，遗传修饰的细胞可以用作核捐赠者，特别是生产活的动物。所描述的方法也可以用于验证动物染色体中的位点，这是转基因添加到细胞的合适位点。

5. 发明授权

US07807860B2 Autothermal cracking process and reactor 有权
标题翻译：自热裂解过程和反应器
公开(公告)号：US07807860B2
公开(公告)日：2010-10-05
申请号：US10543696
申请日：2004-02-06
申请人： Derek Alan Colman , Michael John Alexander Matthewman , Ian Allan Beattie Reid , Vaughan Clifford Williams , William Terence Woodfin
发明人： Derek Alan Colman , Michael John Alexander Matthewman , Ian Allan Beattie Reid , Vaughan Clifford Williams , William Terence Woodfin
IPC分类号： C07C5/333
CPC分类号： B01J8/0453 , B01J8/0492 , B01J8/0496 , B01J2208/00522 , B01J2219/00094 , B01J2219/00265 , C07C5/48
摘要： The present invention provides a reactor design that enables an auto-thermal cracking process to be conducted at any suitable pressure wherein the gaseous reactants are preheated separately before mixing and then presented to the reaction zone in a uniformly distributed manner. In particular, the present invention-relates to apparatus for reacting a first and second gaseous reactant to form a gaseous product wherein the apparatus comprises at least one first supply means for the first gaseous reactant, at least one second supply means for the second gaseous reactant, a resistance zone and a reaction zone, preferably comprising a catalyst, wherein the first supply means comprises a plurality of first outlets for delivery of the first gaseous reactant, and the second supply means comprises a plurality of second outlets for delivery of the second gaseous reactant, the resistance zone is porous, the reaction zone is positioned downstream of the resistance zone with respect to the flow of the first and second gaseous reactants and wherein the first supply means and the second supply means are arranged such that the first gas and the second gas are contacted in an essentially parallel manner and mixed prior to contacting the resistance zone. The present invention also provides a process for the production of a mono-olefin utilizing said apparatus.
摘要翻译：本发明提供一种反应器设计，使得能够在任何合适的压力下进行自热裂解过程，其中气态反应物在混合之前分别预热，然后以均匀分布的方式呈现给反应区。特别地，本发明涉及用于使第一和第二气体反应物反应以形成气态产物的装置，其中所述装置包括用于第一气态反应物的至少一个第一供应装置，用于第二气态反应物的至少一个第二供应装置，电阻区和反应区，优选包括催化剂，其中第一供应装置包括多个用于输送第一气态反应物的第一出口，第二供应装置包括多个第二出口，用于输送第二气态反应物，电阻区是多孔的，反应区相对于第一和第二气态反应物的流动位于阻力区的下游，并且其中第一供应装置和第二供应装置被布置成使得第一气体和第二气体以基本上平行的方式接触并在接触阻力区之前混合。本发明还提供了利用所述装置生产单烯烃的方法。

6. 发明申请

US20090053117A1 Quench Tube, Apparatus and Process For Catalytic Gas Phase Reactions 审中-公开
标题翻译：淬火管，催化气相反应的设备和工艺
公开(公告)号：US20090053117A1
公开(公告)日：2009-02-26
申请号：US12087923
申请日：2006-12-20
申请人： Derek Alan Colman
发明人： Derek Alan Colman
IPC分类号： B01J19/00 , B01J8/00
CPC分类号： C10G9/38 , B01J8/004 , B01J8/0278 , B01J8/0285 , B01J8/065 , B01J8/12 , B01J8/24 , B01J2208/00336 , B01J2208/00362 , B01J2208/00371 , B01J2208/00805 , B01J2208/00884 , B01J2208/025 , C10G2400/20
摘要： The present invention relates to a quench tube, having a length (L), a diameter (D) and at least one guenchant inlet per tube which inlet passes guenchant into the tube from the side of said tube, and wherein, D is between 0.04 and 0.10 m and L/D is at least 5. The present invention also relates to an apparatus with one or more of said quench tubes wherein said apparatus comprises a catalyst zone which may have a cross sectional area of at least 0, 01 m2. In processes using said tubes and/or said apparatuses a first gaseous reactant stream and a second reactant stream are contacted with a catalyst to produce a product stream which is quenched on exiting the catalyst. A process for producing olefins by autothermal cracking is also claimed.
摘要翻译：本发明涉及一种淬火管，其具有长度（L），直径（D）和至少一个入口，每个入口从管的侧面引入管内，其中D在0.04之间 0.10m和L / D为至少5.本发明还涉及具有一个或多个所述骤冷管的装置，其中所述装置包括可具有至少0.01m 2的横截面积的催化剂区。在使用所述管和/或所述设备的方法中，将第一气态反应物流和第二反应物流与催化剂接触以产生在离开催化剂时淬灭的产物流。还要求一种通过自热裂解生产烯烃的方法。

7. 发明申请

US20060194321A1 Directed differentiation of embryonic stem cells and uses thereof 审中-公开
标题翻译：胚胎干细胞的定向分化及其用途
公开(公告)号：US20060194321A1
公开(公告)日：2006-08-31
申请号：US11342957
申请日：2006-01-30
申请人： Alan Colman , William Sun , Norris Dunn , Blaine Phillips , Hentze Martin , William Rust
发明人： Alan Colman , William Sun , Norris Dunn , Blaine Phillips , Hentze Martin , William Rust
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0676 , C12N2501/11 , C12N2501/119 , C12N2501/12 , C12N2501/148 , C12N2501/15 , C12N2501/155 , C12N2506/02
摘要： The present invention provides methods for the directed differentiation of embryonic stem cells along the endodermal lineage, especially the pancreatic lineage.
摘要翻译：本发明提供了胚胎干细胞沿着内胚层谱系，特别是胰腺谱系的定向分化的方法。

8. 发明授权

US07074838B2 Process for the catalytic oxidation of hydrocarbons 失效
标题翻译：烃类催化氧化方法
公开(公告)号：US07074838B2
公开(公告)日：2006-07-11
申请号：US11044299
申请日：2005-01-28
申请人： Derek Alan Colman , Trevor John Hesketh , Ian Allan Beattie Reid , William Terence Woodfin
发明人： Derek Alan Colman , Trevor John Hesketh , Ian Allan Beattie Reid , William Terence Woodfin
IPC分类号： C07C27/00 , C07C1/02 , C01B3/26
CPC分类号： C01B3/386 , B01J8/0242 , B01J8/0285 , B01J19/006 , B01J19/26 , B01J2208/00 , B01J2219/00069 , B01J2219/00085 , B01J2219/00155 , B01J2219/00159 , B01J2219/00164 , B01J2219/00243 , B01J2219/0286 , B01J2219/1923 , C01B2203/0261 , C01B2203/1047 , C01B2203/1058 , C01B2203/107 , C01B2203/1247 , C01B2203/1288 , C07C5/48 , C07C45/33 , C07C51/215 , C07C51/265 , C07C51/313 , C07C67/05 , C07C253/24 , C07D301/08 , C07C11/02 , C07C57/145 , C07C63/16 , C07C69/01 , C07C69/15 , C07C255/08
摘要： Process for the oxidation of a hydrocarbon comprising partially oxidizing in a reaction zone, a mixture comprising a hydrocarbon and an oxygen-containing gas in the presence of a catalyst which is capable of supporting oxidation of the hydrocarbon. Prior to the partial oxidation, the mixture comprising the hydrocarbon and the oxygen-containing gas is passed through a heat exchanger which provides a pressure drop which acts to even the velocity profile and ensure that the reactants flow uniformly over the catalyst.
摘要翻译：在反应区中部分氧化的烃的氧化方法，包含烃和含氧气体的混合物在能够支持烃的氧化的催化剂存在下进行。在部分氧化之前，包含烃和含氧气体的混合物通过热交换器，该热交换器提供压力降，甚至起到速度分布的作用，并确保反应物均匀地流过催化剂。

9. 发明授权

US06187881B1 Process for polymerizing olefins 失效
标题翻译：烯烃聚合方法
公开(公告)号：US06187881B1
公开(公告)日：2001-02-13
申请号：US09198504
申请日：1998-11-24
申请人： Derek Alan Colman , Pascal Metzinger , Bob Nater
发明人： Derek Alan Colman , Pascal Metzinger , Bob Nater
IPC分类号： C08F1000
CPC分类号： B01J19/24 , B01J10/002 , B01J2219/00065 , B01J2219/00103 , B01J2219/0013 , C08F10/08 , C08F2/06 , C08F2500/03
摘要： Process for producing an olefin polymer of a low polydispersity index having low catalyst residues and low chlorine content, by polymerizing olefins in solution in the presence of a cationic catalyst, in a reactor containing a liquid phase comprising a liquid boiling hydrocarbon polymerization medium and having a vapor space above the liquid phase. The polymerization is carried out in the presence of a non-mechanical agent capable of suppressing foam formation during the polymerization.
摘要翻译：在含有液相沸点烃聚合介质的反应器的反应器中，通过在阳离子催化剂的存在下在溶液中聚合烯烃，制备具有低催化剂残留和低氯含量的低多分散指数的烯烃聚合物的方法，液相之上的蒸汽空间。聚合反应在聚合过程中能够抑制泡沫形成的非机械剂存在下进行。

10. 发明授权

US6057475A Process for the production of acetic acid 失效
标题翻译：乙酸生产工艺
公开(公告)号：US6057475A
公开(公告)日：2000-05-02
申请号：US357371
申请日：1999-07-20
申请人： Derek Alan Colman , Jeremy Bernard Cooper , Andrew Richard Lucy
发明人： Derek Alan Colman , Jeremy Bernard Cooper , Andrew Richard Lucy
IPC分类号： B01J31/04 , B01J10/00 , B01J19/24 , B01J19/26 , C07B61/00 , C07C51/215 , C07C53/08 , C07C51/21
CPC分类号： B01J19/26 , B01J10/00 , B01J19/2465 , C07C51/215 , B01J2219/00103 , B01J2219/0011 , B01J2219/00186 , Y02P20/582
摘要： Process for the liquid phase oxidation of butane to produce acetic acid in which oxygen and butane are reacted in the presence of a cobalt catalyst in a liquid reaction composition in an oxidation reaction zone at a temperature in the reaction zone in the range of 136.degree. to 150.degree. C., while continuously maintaining a concentration of oxygen throughout the reaction zone equivalent to a partial pressure of oxygen greater than two bar. The concentration of cobalt oxidation catalyst in the liquid reaction composition is at least 0.12% by weight cobalt and up to its limit of solubility in the liquid reaction composition.
摘要翻译：丁烷液相氧化制备乙酸的方法，其中氧和丁烷在钴催化剂存在下在反应区的温度在136℃至同时在整个反应区域中持续保持氧浓度相当于大于2巴的氧分压。液体反应组合物中钴氧化催化剂的浓度为至少0.12重量％的钴，直至其在液体反应组合物中的溶解度极限。

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