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1. 发明授权

US07608045B2 Method for noninvasive continuous determination of physiologic characteristics 失效
标题翻译：无创连续测定生理特征的方法
公开(公告)号：US07608045B2
公开(公告)日：2009-10-27
申请号：US10912721
申请日：2004-08-04
申请人： Alexander K. Mills
发明人： Alexander K. Mills
IPC分类号： A61B5/00
CPC分类号： A61B5/6826 , A61B5/02028 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/6838 , A61B2560/0261
摘要： The invention comprises methods for noninvasively monitoring physiological characteristics of a patient's blood. Determinations of blood constituent concentrations may be made by comparing absorbance of radiation at varying parameters, such as path length and blood pressure. Preferably, changes in pressure are effected by changing the height of the probes relative to the patient's heart. Determinations of blood pH may be made by comparing absorbance of the blood at different wavelengths. The temperature of the blood, and thus of the patient's core, may also be accurately determined. Further, cardiac output characteristics and blood pressures may be noninvasively determined using the methods of the invention.
摘要翻译：本发明包括用于非侵入性地监测患者血液的生理特征的方法。可以通过比较不同参数（如路径长度和血压）的辐射吸光度来测定血液成分浓度。优选地，通过改变探针相对于患者心脏的高度来实现压力变化。可以通过比较不同波长的血液的吸光度来测定血液pH。也可以准确地确定血液的温度，从而也可以确定患者的心脏的温度。此外，可以使用本发明的方法非侵入性地确定心输出特征和血压。

2. 发明授权

US07215987B1 Method and apparatus for processing signals reflecting physiological characteristics 失效
标题翻译：用于处理反映生理特征的信号的方法和装置
公开(公告)号：US07215987B1
公开(公告)日：2007-05-08
申请号：US11270241
申请日：2005-11-08
申请人： Bernhard B. Sterling , Alexander K. Mills
发明人： Bernhard B. Sterling , Alexander K. Mills
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： The invention comprises a method and apparatus for processing signals reflecting a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths and subtracting the best estimate of the desired signal from the difference between the signals. Corrected first and second intensity signals are determined by applying a residual derived from a combination of the first and second intensity signals as multiplied by a residual factor and subtracted from a difference between the first and second intensity signals to the first and second intensity signals. In one embodiment, the method and apparatus are used to determine arterial oxygen saturation.
摘要翻译：本发明包括一种用于通过检测在两个波长的组织吸收之后的光的强度来处理反映生理特征的信号的方法和装置，并且从信号之间的差中减去所需信号的最佳估计。通过将从第一和第二强度信号的组合导出的残差乘以残差因子并从第一和第二强度信号之间的差减去第一和第二强度信号来确定校正的第一和第二强度信号。在一个实施例中，使用该方法和装置来确定动脉血氧饱和度。

3. 发明授权

US07184809B1 Pulse amplitude indexing method and apparatus 失效
标题翻译：脉冲幅度分度法和装置
公开(公告)号：US07184809B1
公开(公告)日：2007-02-27
申请号：US11270240
申请日：2005-11-08
申请人： Bernhard B. Sterling , Alexander K. Mills
发明人： Bernhard B. Sterling , Alexander K. Mills
IPC分类号： A61B5/00
CPC分类号： A61B5/14551
摘要： The invention is method and apparatus for determining a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths, estimating the pulse amplitude and indexing a calculated physiological characteristic to the estimated pulse amplitude. In one embodiment, the ratio of logarithms of absorbance signal amplitude is indexed to the pulse amplitude to improve the accuracy of arterial oxygen saturation as determined by a pulse oximeter.
摘要翻译：本发明是通过检测在两个波长的组织吸收之后的光的强度来确定生理特性的方法和装置，估计脉冲幅度并将计算的生理特征指数与估计的脉冲幅度相关。在一个实施例中，将吸光度信号幅度的对数比率指数为脉冲幅度，以提高由脉搏血氧计确定的动脉血氧饱和度的准确度。

4. 发明授权

US07879355B2 Method and system for treatment of eating disorders 有权
标题翻译：饮食失调的治疗方法和系统
公开(公告)号：US07879355B2
公开(公告)日：2011-02-01
申请号：US11270723
申请日：2005-11-08
申请人： Bernhard B. Sterling , Alexander K. Mills
发明人： Bernhard B. Sterling , Alexander K. Mills
IPC分类号： A61K9/24 , C09K3/00 , A61K9/12 , A61K33/10
CPC分类号： A61F2/04 , A61F5/003 , A61F5/0036 , A61F2002/044
摘要： The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
摘要翻译：本发明包括具有由可降解膜形成的袋的胃装置。优选地，袋包含产气材料。胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。优选地，胃装置由食品级材料制成。胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。

5. 发明申请

US20100191080A1 Method for noninvasive continuous determination of physiologic characteristics 审中-公开
标题翻译：无创连续测定生理特征的方法
公开(公告)号：US20100191080A1
公开(公告)日：2010-07-29
申请号：US12589646
申请日：2009-10-26
申请人： Alexander K. Mills
发明人： Alexander K. Mills
IPC分类号： A61B5/1455 , A61B5/0402 , A61B5/02
CPC分类号： A61B5/6826 , A61B5/02028 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/6838 , A61B2560/0261
摘要： The invention comprises methods for noninvasively monitoring physiological characteristics of a patient's blood. Determinations of blood constituent concentrations may be made by comparing absorbance of radiation at varying parameters, such as path length and blood pressure. Preferably, changes in pressure are effected by changing the height of the probes relative to the patient's heart. Determinations of blood pH may be made by comparing absorbance of the blood at different wavelengths. The temperature of the blood, and thus of the patient's core, may also be accurately determined. Further, cardiac output characteristics and blood pressures may be noninvasively determined using the methods of the invention.
摘要翻译：本发明包括用于非侵入性地监测患者血液的生理特征的方法。可以通过比较不同参数（如路径长度和血压）的辐射吸光度来测定血液成分浓度。优选地，通过改变探针相对于患者心脏的高度来实现压力变化。可以通过比较不同波长的血液的吸光度来测定血液pH。也可以准确地确定血液的温度，从而也可以确定患者的心脏的温度。此外，可以使用本发明的方法非侵入性地确定心输出特征和血压。

6. 发明授权

US06819950B2 Method for noninvasive continuous determination of physiologic characteristics 失效
标题翻译：无创连续测定生理特征的方法
公开(公告)号：US06819950B2
公开(公告)日：2004-11-16
申请号：US10008245
申请日：2001-11-07
申请人： Alexander K. Mills
发明人： Alexander K. Mills
IPC分类号： A61B500
CPC分类号： A61B5/6826 , A61B5/02028 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14551 , A61B5/14552 , A61B5/6838 , A61B2560/0261
摘要： The invention comprises methods for noninvasively monitoring physiological characteristics of a patient's blood. Determinations of blood constituent concentrations may be made by comparing absorbance of radiation at varying parameters, such as path length and blood pressure. Preferably, changes in pressure are effected by changing the height of the probes relative to the patient's heart. Determinations of blood pH may be made by comparing absorbance of the blood at different wavelengths. The temperature of the blood, and thus of the patient's core, may also be accurately determined. Further, cardiac output characteristics and blood pressures may be noninvasively determined using the methods of the invention.
摘要翻译：本发明包括用于非侵入性地监测患者血液的生理特征的方法。可以通过比较不同参数（如路径长度和血压）的辐射吸光度来测定血液成分浓度。优选地，通过改变探针相对于患者心脏的高度来实现压力变化。可以通过比较不同波长的血液的吸光度来测定血液pH。也可以准确地确定血液的温度，从而也可以确定患者的心脏的温度。此外，可以使用本发明的方法非侵入性地确定心输出特征和血压。

7. 发明授权

US06537225B1 Device and method for noninvasive continuous determination of physiologic characteristics 失效
标题翻译：非侵入性连续测定生理特征的装置和方法
公开(公告)号：US06537225B1
公开(公告)日：2003-03-25
申请号：US09684104
申请日：2000-10-06
申请人： Alexander K. Mills
发明人： Alexander K. Mills
IPC分类号： A61B502
CPC分类号： A61B5/6826 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/14552 , A61B5/6838 , A61B2560/0261
摘要： The invention comprises devices and methods for the noninvasive monitoring of a physiologic characteristic of a patient's blood, such as blood pressure. One embodiment is a tissue probe combined with a position sensor for determining the relative height of the probe compared to a level corresponding to the patient's heart. Alternatively, the tissue probe can be combined with a movement generator for inducing a height change of the probe with respect to patient's heart. By measuring absorbance characteristics of the blood at varying positions relatively to the level of the patient's heart, characteristics such as arterial and central venous blood pressure and cardiac output can be determined. In yet another embodiment, two probes are used to compute pulse delays between coupled tissues or opposing tissues. Measuring delays in pulse arrival times in coupled organs or members on opposite sides of the body allows the determination of various physiological characteristics.
摘要翻译：本发明包括用于非侵入性监测患者血液的生理特征（诸如血压）的装置和方法。一个实施例是与位置传感器组合的组织探针，用于确定与对应于患者心脏的水平相比的探针的相对高度。或者，组织探针可以与移动发生器组合，用于相对于患者心脏引起探针的高度变化。通过在相对于患者心脏水平的不同位置测量血液的吸光度特性，可以确定动脉和中心静脉血压和心输出量等特征。在另一个实施例中，使用两个探针来计算耦合组织或相对组织之间的脉冲延迟。测量身体相对侧的器官或成员的脉冲到达时间的延迟允许确定各种生理特征。

8. 发明授权

US07674396B2 Method and system for treatment of eating disorders 有权
标题翻译：饮食失调的治疗方法和系统
公开(公告)号：US07674396B2
公开(公告)日：2010-03-09
申请号：US11270397
申请日：2005-11-08
申请人： Bernhard B. Sterling , Alexander K. Mills
发明人： Bernhard B. Sterling , Alexander K. Mills
IPC分类号： C09K3/00 , A61K9/12 , A61K33/10
CPC分类号： A61F2/04 , A61F2002/044 , A61K9/0007 , A61K9/0065 , A61K9/2086
摘要： The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
摘要翻译：本发明包括具有外部区域和气体产生材料的胃装置。胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。优选地，胃装置由食品级材料制成。胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。

9. 发明申请

US20080183232A1 Method and system for determining cardiac function 审中-公开
标题翻译：确定心脏功能的方法和系统
公开(公告)号：US20080183232A1
公开(公告)日：2008-07-31
申请号：US11700328
申请日：2007-01-30
申请人： Gregory I. Voss , Bernhard B. Sterling , Anthony J. Bergman , Alexander K. Mills , Donna Wall
发明人： Gregory I. Voss , Bernhard B. Sterling , Anthony J. Bergman , Alexander K. Mills , Donna Wall
IPC分类号： A61N1/00
CPC分类号： A61B5/02255 , A61B5/02028 , A61B5/02125 , A61B5/024 , A61B5/029 , A61B5/0295 , A61B5/1455
摘要： A method for determining a physiologic characteristic associated with cardiac function in a subject comprising the steps of providing at least one electromagnetic radiation absorption measurement, providing demographic information reflecting the subject's physical condition, determining a temporal plethysmographic value from the electromagnetic radiation absorption measurement, and determining at least one physiologic characteristic from the temporal plethysmographic value and demographic information by using a predetermined phenomenological model that is adapted to provide an estimate of a blood volume-time relationship proximate the heart and compute at least one physiologic characteristic associated with cardiac function based on the estimated blood volume-time relationship.
摘要翻译：一种用于确定与受试者的心脏功能相关的生理特征的方法，包括以下步骤：提供至少一个电磁辐射吸收测量，提供反映受试者的身体状况的人口统计信息，从电磁辐射吸收测量确定时间体积描记值，以及确定通过使用适于提供邻近心脏的血液体积 - 时间关系的估计并计算与心脏功能相关联的至少一个生理特征的预定的现象学模型，来自时间体积描记值和人口统计信息的至少一个生理特征，基于估计血容量 - 时间关系。

10. 发明授权

US06921367B2 Device and method for noninvasive continuous determination of physiologic characteristics 失效
标题翻译：非侵入性连续测定生理特征的装置和方法
公开(公告)号：US06921367B2
公开(公告)日：2005-07-26
申请号：US10773596
申请日：2004-02-06
申请人： Alexander K. Mills
发明人： Alexander K. Mills
IPC分类号： G01N21/27 , A61B5/00 , A61B5/0205 , A61B5/021 , A61B5/022 , A61B5/0245 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/145 , A61B5/1455 , A61B5/02
CPC分类号： A61B5/6826 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/02125 , A61B5/0285 , A61B5/029 , A61B5/0402 , A61B5/0408 , A61B5/14552 , A61B5/6838 , A61B2560/0261
摘要： The invention comprises devices for noninvasively monitoring physiological characteristics of a patient's blood. Generally, probes having radiation emitters and detectors are used to determine absorbance of blood within the patient's tissue to determine various blood parameters. The device also has either a position sensor for determining the position of the probe with respect to the patient's heart or a movement generator for altering the position of the probe with respect to the patient's heart. The invention also comprises methods for noninvasively monitoring the physiological characteristics. In one embodiemnt, induced positional changes create differential hydrostatic pressures to facilitate measurement of blood parameters by absorbance. In a second embodiment, delays in pulse arrival times in coupled organs or members on opposite sides of the body are measured to determine cardiac output. The two methods are such that they can advantageously be used together.
摘要翻译：本发明包括用于非侵入性地监测患者血液的生理特征的装置。通常，使用具有辐射发射器和检测器的探针来确定患者组织内血液的吸光度以确定各种血液参数。该装置还具有用于确定探针相对于患者心脏的位置的位置传感器或用于改变探针相对于患者心脏的位置的移动发生器。本发明还包括用于非侵入性监测生理特征的方法。在一个实施例中，诱导的位置变化产生差异静水压力以便于通过吸光度测量血液参数。在第二实施例中，测量在身体相对侧的耦合的器官或部件中的脉冲到达时间的延迟以确定心输出量。这两种方法使得它们可以有利地一起使用。

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