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1. 发明授权

US08439681B2 Method of assessing oral health risk 有权
标题翻译：评估口腔健康风险的方法
公开(公告)号：US08439681B2
公开(公告)日：2013-05-14
申请号：US12718746
申请日：2010-03-05
申请人： Andreas Mandelis , Stephen Abrams
发明人： Andreas Mandelis , Stephen Abrams
IPC分类号： A61C5/00
CPC分类号： A61C19/04
摘要： A method of oral health risk assessment is provided in which diagnostic data from an oral health detection device and patient risk factor data is processed to provide a integrated risk measure relating to a patient's dental health. The patient risk factor data preferably includes risk factor data such as pathological risk factors, protective risk factors, historical factors, self care factors, behavioral factors, and extrinsic factors. The integrated risk assessment and patient data is preferably provided to a remote server for access by various authorized stakeholders.
摘要翻译：提供了一种口腔健康风险评估方法，其中处理来自口腔健康检测装置和患者危险因素数据的诊断数据，以提供与患者牙齿健康有关的综合风险度量。患者危险因素数据优选包括风险因素数据，如病理危险因素，保护性危险因素，历史因素，自我护理因素，行为因素和外在因素。综合风险评估和患者数据优选地被提供给远程服务器以供各种授权利益相关者访问。

2. 发明申请

US20130102865A1 SYSTEMS AND METHODS FOR FREQUENCY-DOMAIN PHOTOACOUSTIC PHASED ARRAY IMAGING 审中-公开
标题翻译：用于频域光电相位阵列成像的系统和方法
公开(公告)号：US20130102865A1
公开(公告)日：2013-04-25
申请号：US13660771
申请日：2012-10-25
申请人： Andreas MANDELIS , Sergey TELENKOV , Bahman LASHKARI
发明人： Andreas MANDELIS , Sergey TELENKOV , Bahman LASHKARI
IPC分类号： A61B5/00 , A61B5/1455 , G03B42/06
CPC分类号： A61B5/0095 , A61B5/14551 , A61B5/14552 , A61B5/7235 , A61B5/7257 , G01N21/1702 , G01N21/314 , G01N21/39 , G01N21/4795 , G03B42/06
摘要： Systems and methods of frequency-domain photoacoustic imaging are provided utilizing an ultrasonic phased array probe and intensity modulated optical excitation with coding to improve signal-to-noise ratio. Embodiments employ frequency-domain photoacoustic imaging methodologies such as the photoacoustic radar, coupled with a multi-element ultrasonic sensor array to deliver spatially-resolved correlation images of photoacoustic sources, which may be employed to image optical heterogeneities within tissue-like scattering media.
摘要翻译：利用超声波相控阵探头和具有编码的强度调制光激励来提供频域光声成像的系统和方法，以提高信噪比。实施例采用频域光声成像方法，例如光声雷达，与多元超声波传感器阵列耦合，以提供光声源的空间分辨相关图像，其可用于在组织样散射介质内成像光学异质性。

3. 发明申请

US20100292547A1 SYSTEM AND METHOD FOR NON-INVASIVE PHOTOTHERMAL RADIOMETRIC MEASUREMENT 失效
标题翻译：非侵入式光电放射测量的系统和方法
公开(公告)号：US20100292547A1
公开(公告)日：2010-11-18
申请号：US12782277
申请日：2010-05-18
申请人： Andreas Mandelis , Sergey Telenkov
发明人： Andreas Mandelis , Sergey Telenkov
IPC分类号： A61B5/1455
CPC分类号： A61B5/01 , A61B5/0091 , A61B5/14532 , A61B5/7228
摘要： There is provided a glucose monitoring method and apparatus based on the principle of Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR). Two intensity modulated laser beams operating in tandem at specific mid-infrared (IR) wavelengths and current-modulated synchronously by two electrical waveforms 180 degrees out-of-phase, are used to interrogate the tissue surface. The laser wavelengths are selected to absorb in the mid infrared range (8.5-10.5 μm) where the glucose spectrum exhibits a discrete absorption band. The differential thermal-wave signal generated by the tissue sample through modulated absorption between two specific wavelengths within the band (for example, the peak at 9.6 and the nearest baseline at 10.5 μm) lead to minute changes in sample temperature and to non-equilibrium blackbody radiation emission. This modulated emission is measured with a broadband infrared detector. The detector is coupled to a lock-in amplifier for signal demodulation. Any glucose concentration increases will be registered as differential photothermal signals above the fully suppressed signal baseline due to increased absorption at the probed peak or near-peak of the band at 9.6 μm at the selected wavelength modulation frequency. The emphasis is on the ability to monitor blood glucose levels in diabetic patients in a non-invasive, non-contacting manner with differential signal generation methods for real-time baseline corrections, a crucial feature toward precise and universal calibration (independent of person-to-person contact, skin, temperature or IR-emission variations) in order to offer accurate absolute glucose concentration readings.
摘要翻译：提供了基于波长调制差分激光光热辐射计（WM-DPTR）原理的葡萄糖监测方法和装置。两个强度调制的激光束在特定的中红外（IR）波长下串联工作，并通过180度异相的两个电波同步电流调制，用于询问组织表面。选择激光波长在中等红外范围（8.5-10.5μm）下吸收，其中葡萄糖光谱呈现离散的吸收带。由组织样品通过带内两个特定波长之间的调节吸收产生的差分热波信号（例如，9.6处的峰值和10.5μm处的最接近的基线）导致样品温度和非平衡黑体的微小变化辐射发射。这种调制的发射是用宽带红外探测器测量的。检测器耦合到锁定放大器进行信号解调。任何葡萄糖浓度增加将被记录为高于完全抑制的信号基线上的差示光热信号，这是由于在所选波长调制频率处的9.6μm波段的探测峰值或近峰值处的吸收增加。重点在于以非侵入式非接触方式监测糖尿病患者血糖水平的能力，使用差分信号生成方法进行实时基线校正，这是精确和通用校准的关键特征（独立于人 - 人员接触，皮肤，温度或红外发射变化），以提供准确的绝对葡萄糖浓度读数。

4. 发明授权

US06584341B1 Method and apparatus for detection of defects in teeth 有权
标题翻译：用于检测牙齿缺陷的方法和装置
公开(公告)号：US06584341B1
公开(公告)日：2003-06-24
申请号：US09628812
申请日：2000-07-28
申请人： Andreas Mandelis , Stephen H. Abrams , Lena Nicolaides , Jose Agustin Garcia-Hecules
发明人： Andreas Mandelis , Stephen H. Abrams , Lena Nicolaides , Jose Agustin Garcia-Hecules
IPC分类号： A61B600
CPC分类号： A61B5/0088
摘要： There is provided a metrologic methodology and instrument, useful for a high-spatial-resolution dynamic diagnostic metrology and instrument, which can provide simultaneous measurements of laser-induced frequency-domain infrared photothermal radiometry (FD-PTR) and alternating-current (ac) modulated luminescence (FD-LM) signals from defects and caries in teeth intraorally. The combination of the luminescence and radiometric frequency scan techniques for inspection of defects and caries in teeth involves irradiating the tooth with a modulated (direct-current (dc) to 100 kHz) excitation source (laser) emitting in the near-ultraviolet, visible, or near-infrared spectral range, generating blackbody Planck-radiation (infrared radiometry) and ac luminescence, and comparing the obtained (amplitude and phase) luminescence and radiometric signals to those obtained from a well characterized sample (reference) to provide the clinician with numerical information on the status of a tooth. The method and device is used to scan teeth intraorally to detect caries and classify caries or the integrity of the enamel or cementum surface, classify the health and integrity of the enamel at the base of occlusal fissures, classify the health and integrity of enamel or cementum surface of the tooth and defects around the margins of restorations, locate the presence of cracks on the enamel or cementum surface, and locate and characterize cracks in dentin on prepared teeth.
摘要翻译：提供了一种用于高空间分辨率动态诊断计量和仪器的计量方法和仪器，可以提供激光诱导的频域红外光热辐射测量（FD-PTR）和交流（ac）调制发光（FD-LM）信号从牙齿中的缺陷和龋齿。用于检查牙齿中的缺陷和龋齿的发光和辐射测量频率扫描技术的组合包括用在近紫外线，可见光区域中发射的调制（直流（dc）至100kHz）激发源（激光）照射牙齿，或近红外光谱范围，产生黑体普朗克辐射（红外辐射测量）和交流发光，并将获得的（振幅和相位）发光和辐射信号与从良好表征的样品（参考）获得的信号进行比较，以向临床医生提供数字关于牙齿状况的信息。该方法和装置用于口内扫描牙齿以检测龋齿和分类龋齿或釉质或牙骨质表面的完整性，将牙釉质基底处的牙釉质的健康和完整性分类，分类牙釉质或牙骨质的健康和完整性牙齿表面和修复边缘周围的缺陷，定位在牙釉质或牙骨质表面上存在裂纹，并定位并表征牙齿上的牙质上的裂纹。

5. 发明授权

US09584771B2 Systems and methods for thermophotonic dynamic imaging 有权
标题翻译：热激光动态成像系统和方法
公开(公告)号：US09584771B2
公开(公告)日：2017-02-28
申请号：US13522936
申请日：2012-01-20
申请人： Andreas Mandelis , Nima Tabatabaei , Stephen Abrams
发明人： Andreas Mandelis , Nima Tabatabaei , Stephen Abrams
IPC分类号： G01N21/71 , H04N7/18 , A61B5/00
CPC分类号： H04N7/183 , A61B5/0073 , A61B5/0088 , G01N21/71
摘要： Systems and methods for improved thermophotonic imaging are provided in which both amplitude and phase image information is obtained with a high signal to noise ratio and depth-resolved capabilities. Image data obtained from an imaging camera is dynamically averaged and subsequently processed to extract amplitude and/or phase image data. The system may be configured for a wide range of imaging modalities, including single frequency modulation (thermophotonic lock-in imaging), Thermal-Wave Radar imaging or Thermophotonic Radar imaging involving chirp modulation, and Binary Phase Coded Modulation. Such imaging modalities may find application in many diverse areas, including non-destructive testing and biomedical diagnostic imaging including the imaging of teeth and monitoring changes in the tooth over time which are due to pathology such as dental caries or erosion.
摘要翻译：提供了用于改进的热光子成像的系统和方法，其中以高信噪比和深度分辨能力获得幅度和相位图像信息。从成像摄像机获得的图像数据被动态地平均并随后被处理以提取幅度和/或相位图像数据。该系统可以被配置用于广泛的成像模式，包括单频调制（热荧光锁定成像），热波雷达成像或涉及啁啾调制的热磷光雷达成像和二进制相位编码调制。这种成像方式可以应用于许多不同的领域，包括非破坏性测试和生物医学诊断成像，包括牙齿的成像以及由于诸如龋齿或侵蚀的病理学造成的牙齿随时间的变化。

6. 发明授权

US09131170B2 Method and apparatus for performing heterodyne lock-in imaging and quantitative non-contact measurements of electrical properties 有权
标题翻译：用于执行外差锁定成像和电性能的定量非接触测量的方法和装置
公开(公告)号：US09131170B2
公开(公告)日：2015-09-08
申请号：US13827110
申请日：2013-03-14
申请人： Andreas Mandelis , Alexander Melnikov
发明人： Andreas Mandelis , Alexander Melnikov
IPC分类号： H04N5/33 , G01N21/64 , G01N21/95
CPC分类号： H04N5/33 , G01N21/6489 , G01N21/9501
摘要： Methods are provided for producing optical carrierographic images of a semiconductor sample. Focused and spatially overlapped optical beams excite carriers across within the semiconductor sample, where the optical beams are modulated such that a beat frequency is substantially less than either modulation frequency. An infrared detector detects infrared radiation emitted from the semiconductor sample in response to absorption of the optical beams, thereby obtaining a plurality of carrierographic signals at different points in time during at least one beat period, which are processed with a lock-in amplifier, with a reference signal at the beat frequency, to obtain an amplitude signal and a phase signal. Carrierographic lock-in images of the sample are obtained in a scanning configuration, or in an imaging format using an imaging detector. The images carry quantitative information about recombination lifetimes in substrate Si wafers and electrical parameters in solar cells, namely photogeneration current density, diode saturation current density, ideality factor, and maximum power photovoltage.
摘要翻译：提供了用于制造半导体样品的光学摄影图像的方法。聚焦和空间重叠的光束在半导体样品内激发载流子，其中调制光束使得拍频大大小于任一调制频率。红外检测器响应于光束的吸收而检测从半导体样品发射的红外辐射，从而在至少一个拍摄周期期间的不同时间点获得多个载波信号，该拍频周期由锁定放大器处理，以拍频为参考信号，得到振幅信号和相位信号。以扫描配置或使用成像检测器的成像格式获得样品的Carrierographic锁定图像。这些图像携带有关基板Si晶片的复合寿命和太阳能电池中的电参数的定量信息，即光生电流密度，二极管饱和电流密度，理想因子和最大功率光电压。

7. 发明申请

US20130141558A1 HANDPIECE WITH INTEGRATED OPTICAL SYSTEM FOR PHOTOTHERMAL RADIOMETRY AND LUMINESCENCE MEASUREMENTS 有权
标题翻译：具有集成光学系统用于光热辐射测量和发光测量的HANDPIECE
公开(公告)号：US20130141558A1
公开(公告)日：2013-06-06
申请号：US13697747
申请日：2011-05-13
申请人： Jin-Seok Jeon , Andreas Mandelis , Stephen Abrams , Anna Matvienko , Koneswaran Sivagurunathan , Josh Silvertown , Adam Hellen
发明人： Jin-Seok Jeon , Andreas Mandelis , Stephen Abrams , Anna Matvienko , Koneswaran Sivagurunathan , Josh Silvertown , Adam Hellen
IPC分类号： G01J5/10 , A61B1/24 , A61B6/14 , G01N21/63 , H04N7/18
CPC分类号： G01J5/10 , A61B1/00177 , A61B1/05 , A61B1/24 , A61B5/0088 , A61B5/0093 , A61B6/14 , A61B2018/202 , A61B2560/0233 , G01J1/0233 , G01J1/58 , G01J3/0272 , G01J5/048 , G01N21/63 , H04N7/18
摘要： An apparatus is provided for performing photothermal measurements on a object. The apparatus, which may be provided as a handpiece, houses optical components including a laser, an infrared detector, a dichroic beamsplitter, and focusing and beam directing optics for the delivery of a laser beam to, and the collection of photothermal radiation from, a measured object. Some of the optical components may be provided on an optical bench that is directly attached to a thermally conductive tip portion for the passive heat sinking of internal optical components. The apparatus may further include a sampling optical element and a photodetector for the detection of luminescence, and a camera for obtaining an image of the object during a diagnostic procedure. The apparatus may be employed for the scanning of a tooth to determine an oral health status of the tooth.
摘要翻译：提供了一种用于对物体进行光热测量的装置。可以设置为手持件的装置容纳光学部件，包括激光器，红外检测器，二向色分束器以及聚焦和光束引导光学器件，用于将激光束传送到光热辐射和从其中收集光热辐射测量对象。一些光学部件可以设置在光学台上，其直接附接到用于内部光学部件的被动散热的导热末端部分。该装置还可以包括用于检测发光的取样光学元件和光电检测器，以及用于在诊断过程期间获得物体的图像的照相机。该装置可用于扫描牙齿以确定牙齿的口腔健康状况。

8. 发明授权

US07729734B2 Non-invasive biothermophotonic sensor for blood glucose monitoring 有权
标题翻译：用于血糖监测的非侵入式生物光电传感器
公开(公告)号：US07729734B2
公开(公告)日：2010-06-01
申请号：US11368698
申请日：2006-03-07
申请人： Andreas Mandelis , Sergey Telenkov
发明人： Andreas Mandelis , Sergey Telenkov
IPC分类号： A61B5/145
CPC分类号： A61B5/01 , A61B5/0091 , A61B5/14532 , A61B5/7228
摘要： There is provided a glucose monitoring method and apparatus based on the principle of Wavelength-Modulated Differential Laser Photothermal Radiometry (WM-DPTR). Two intensity modulated laser beams operating in tandem at specific mid-infrared (IR) wavelengths and current-modulated synchronously by two electrical waveforms 180 degrees out-of-phase, are used to interrogate the tissue surface. The laser wavelengths are selected to absorb in the mid infrared range (8.5-10.5 μm) where the glucose spectrum exhibits a discrete absorption band. The differential thermal-wave signal generated by the tissue sample through modulated absorption between two specific wavelengths within the band (for example, the peak at 9.6 and the nearest baseline at 10.5 μm) lead to minute changes in sample temperature and to non-equilibrium blackbody radiation emission. This modulated emission is measured with a broadband infrared detector. The detector is coupled to a lock-in amplifier for signal demodulation. Any glucose concentration increases will be registered as differential photothermal signals above the fully suppressed signal baseline due to increased absorption at the probed peak or near-peak of the band at 9.6 μm at the selected wavelength modulation frequency. The emphasis is on the ability to monitor blood glucose levels in diabetic patients in a non-invasive, non-contacting manner with differential signal generation methods for real-time baseline corrections, a crucial feature toward precise and universal calibration (independent of person-to-person contact, skin, temperature or IR-emission variations) in order to offer accurate absolute glucose concentration readings.
摘要翻译：提供了基于波长调制差分激光光热辐射计（WM-DPTR）原理的葡萄糖监测方法和装置。两个强度调制的激光束在特定的中红外（IR）波长下串联工作，并通过180度异相的两个电波同步电流调制，用于询问组织表面。选择激光波长在中等红外范围（8.5-10.5μm）下吸收，其中葡萄糖光谱呈现离散的吸收带。由组织样品通过带内两个特定波长之间的调节吸收产生的差分热波信号（例如，9.6处的峰值和10.5μm处的最接近的基线）导致样品温度和非平衡黑体的微小变化辐射发射。这种调制的发射是用宽带红外探测器测量的。检测器耦合到锁定放大器进行信号解调。任何葡萄糖浓度增加将被记录为高于完全抑制的信号基线上的差示光热信号，这是由于在所选波长调制频率处的9.6μm波段的探测峰值或近峰值处的吸收增加。重点在于以非侵入式非接触方式监测糖尿病患者血糖水平的能力，使用差分信号生成方法进行实时基线校正，这是精确和通用校准的关键特征（独立于人 - 人员接触，皮肤，温度或红外发射变化），以提供准确的绝对葡萄糖浓度读数。

9. 发明授权

US07525661B2 Laser photo-thermo-acoustic (PTA) frequency swept heterodyned lock-in depth profilometry imaging system 有权
标题翻译：激光光热声（PTA）频率扫描外差锁定深度轮廓测量成像系统
公开(公告)号：US07525661B2
公开(公告)日：2009-04-28
申请号：US11058233
申请日：2005-02-16
申请人： Andreas Mandelis , Alex Vitkin , Sergey Telenkov , Ying Fan
发明人： Andreas Mandelis , Alex Vitkin , Sergey Telenkov , Ying Fan
IPC分类号： G01B9/02
CPC分类号： G01N21/1702 , G01B21/085 , G01N21/4795 , G01N29/0609 , G01N29/07 , G01N29/11 , G01N29/46 , G01N2291/02475 , G01N2291/02872 , G01N2291/0421
摘要： A method and apparatus for biomedical subsurface imaging and measurement of thickness, elastic and optical properties of industrial and biomedical materials based on laser Photo-Thermo-Acoustic (PTA) frequency-swept heterodyne depth profilometry, In particular, the invention relates to biomedical imaging and measure of tissue and tumour thickness, L, speed of sound, cs, acoustic attenuation coefficient, γ, optical absorption coefficient, μa, and optical scattering coefficient, μs. The method and apparatus involves providing for a sample of the material to be characterized; irradiating the material for a selected period of time with an excitation waveform from a modulated optical excitation source wherein a photo-thermo-acoustic emission is responsively emitted from said solid; detecting said emitted photo-thermo-acoustic emission; processing the electronic signal to convert the frequency-domain signal into time-domain and perform depth profilometric imaging and determining thermoelastic and optical properties of the material sample.
摘要翻译：基于激光光热声（PTA）频扫外差深度轮廓测量法的工业和生物医学材料的厚度，弹性和光学性质的生物医学地下成像和测量的方法和装置，特别地，本发明涉及生物医学成像和组织和肿瘤厚度的测量，L，声速，cs，声衰减系数，γ，光吸收系数，mua和光散射系数。该方法和装置包括提供要表征的材料的样品; 用来自调制光激发源的激发波形照射材料一段选定的时间，其中从所述固体响应地发射光热声发射; 检测所述发射的光热声发射; 处理电子信号以将频域信号转换成时域并执行深度轮廓测量成像并确定材料样品的热弹性和光学性质。

10. 发明授权

US11231358B2 Systems and methods for performing enhanced truncated-correlation photothermal coherence tomography 有权
公开(公告)号：US11231358B2
公开(公告)日：2022-01-25
申请号：US16900471
申请日：2020-06-12
申请人： Andreas Mandelis , Koneswaran S. Sivagurunathan , Pantea Tavakolian
发明人： Andreas Mandelis , Koneswaran S. Sivagurunathan , Pantea Tavakolian
IPC分类号： A61B5/01 , G01N21/17 , G06T11/00 , A61B5/00
摘要： Systems and methods are provided for performing thermophotonic imaging using cross-correlation and subsequent time-gated truncation. Photothermal radiation is detected with an infrared camera while exciting a sample with a chirped set of incident optical pulses and time-dependent photothermal signal data is processed using a method that involves performing cross-correlation and subsequent time-gated truncation. The post-cross-correlation truncation method results in depth-resolved images with axial and lateral resolution beyond the well-known thermal-diffusion-length-limited, depth-integrated nature of conventional imaging modalities. An axially resolved photothermal image sequence can be obtained, capable of reconstructing three-dimensional visualizations of photothermal features in wide classes of materials.

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