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1. 发明授权

US06810103B1 Gantry for combined tomography scanner 失效
标题翻译：龙门架用于联合层析扫描仪
公开(公告)号：US06810103B1
公开(公告)日：2004-10-26
申请号：US10197059
申请日：2002-07-16
申请人： Andrew P. Tybinkowski , Robert F. Riemer , Ronald E. Swain , Eric Bailey , Robert M. Williams
发明人： Andrew P. Tybinkowski , Robert F. Riemer , Ronald E. Swain , Eric Bailey , Robert M. Williams
IPC分类号： A61B600
CPC分类号： A61B6/037 , A61B6/032 , A61B6/4266 , A61B6/463 , A61B6/5235
摘要： A gantry of a combined tomography scanner including an annular outer support, an annular drum concentrically positioned within the outer support rotatable about a rotation axis of the drum, and an annular disk extending radially inwardly from an inner circumferential surface of the drum. At least one of the disk and the drum include structural members for receiving and supporting tomography scanning components on opposing first and second sides of the disk. Among other features and benefits, the gantry can be used for a combined tomography scanner system, e.g., combining an x-ray CT scanner and a PET scanner in a single machine.
摘要翻译：联合层析成像扫描仪的台架，包括环形外部支撑件，同心地定位在可围绕滚筒的旋转轴线旋转的外部支撑件内的环形滚筒以及从滚筒的内圆周表面径向向内延伸的环形盘。盘和鼓中的至少一个包括用于在盘的相对的第一和第二侧上接收和支撑层析成像扫描部件的结构构件。除了其他特征和益处之外，台架可用于组合层析成像扫描仪系统，例如在单个机器中组合X射线CT扫描仪和PET扫描仪。

2. 发明授权

US06763262B2 Method and apparatus for detecting tumorous tissue 失效
标题翻译：检测肿瘤组织的方法和装置
公开(公告)号：US06763262B2
公开(公告)日：2004-07-13
申请号：US09860365
申请日：2001-05-18
申请人： Alexander Hohla , Gunther Leipert
发明人： Alexander Hohla , Gunther Leipert
IPC分类号： A61B600
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0084 , A61B5/0086 , G01N21/645
摘要： The present invention relates to an apparatus for detecting tumorous tissue comprising at least one excitation light source 12, which first excitation light source 12 emits a first excitation light 34 of a wavelength of between 300 nm and 314 nm and includes at least one optical fiber 14 for guiding the first excitation light 34 to an object field 18 of the tissue 16 to be examined, and at least one lens 24 for projecting an auto-fluorescence signal and/or a remission signal 20 of the tissue 16, generated by the first excitation light 34, to a CCD or ICCD chip of a camera 22, as well as a data processing system 28 for processing the signals transmitted by the camera 22, said lens 24 being capable of processing UV light and being designed such that at least two images 48, 50 from different spectral regions of the fluorescent object field 18 are generated and projected to the CCD or ICCD chip, of which at least one image 48, 50 represents the UV range and another, different wavelength range of the auto-fluorescence signal and/or of the remission signal 20 of said object field 18. The invention is further directed to a method for detecting tumorous tissue.
摘要翻译：本发明涉及一种用于检测肿瘤组织的装置，其包括至少一个激发光源12，第一激发光源12发射波长在300nm和314nm之间的第一激发光34，并且包括至少一个光纤14 用于将第一激发光34引导到要检查的组织16的物场18，以及至少一个用于投射由第一激发产生的组织16的自发荧光信号和/或缓冲信号20的透镜24 光34到相机22的CCD或ICCD芯片，以及用于处理由相机22发送的信号的数据处理系统28，所述透镜24能够处理UV光并被设计成使得至少两个图像生成荧光物场18的不同光谱区域的48,50，并将其投影到CCD或ICCD芯片，其中至少一个图像48,50表示UV范围，另外一个不同的波长 nge的自发荧光信号和/或所述对象场18的缓解信号20.本发明还涉及一种用于检测肿瘤组织的方法。

3. 发明授权

US06744846B2 Method and apparatus for automatic exposure control in CT scanning 有权
标题翻译： CT扫描中自动曝光控制的方法和装置
公开(公告)号：US06744846B2
公开(公告)日：2004-06-01
申请号：US10255356
申请日：2002-09-26
申请人： Stefan Popescu , Christoph Suess , Heiko Wolf , Dietmar Hentschel
发明人： Stefan Popescu , Christoph Suess , Heiko Wolf , Dietmar Hentschel
IPC分类号： A61B600
CPC分类号： A61B6/032 , A61B6/027 , A61B6/542 , A61B6/544 , H05G1/34
摘要： In a computed tomography apparatus and a method for automatic exposure control in computed tomography scanning, an exposure controller, during a first half of a revolution of an X-ray focus around a subject, calculates an actual attenuation profile of a slice of the subject from electrical signals generated by the radiation detector in the first half of the revolution, and calculates an extrapolated attenuation profile of the slice for a second half of the revolution from the actual attenuation profile, and adjusts an operating parameter of the X-ray source, such as the tube current, to modify the radiation dose emitted by the X-ray source during the second half of the revolution dependent on the extrapolated attenuation profile.
摘要翻译：在计算机断层摄影装置和计算机断层摄影扫描中的自动曝光控制的方法中，曝光控制器在被摄体周围的X射线焦点的旋转的前半部分期间计算被摄体的切片的实际衰减曲线在旋转的前半部分由辐射检测器产生的电信号，并且根据实际衰减曲线计算出旋转的后半部分的切片的外推衰减曲线，并且调整X射线源的操作参数，作为管电流，根据外推的衰减分布来修改在旋转的后半段期间由X射线源发射的辐射剂量。

4. 发明授权

US06718196B1 Multimodality instrument for tissue characterization 有权
标题翻译：用于组织表征的多模式仪器
公开(公告)号：US06718196B1
公开(公告)日：2004-04-06
申请号：US09652299
申请日：2000-08-28
申请人： Robert W. Mah , Russell J. Andrews
发明人： Robert W. Mah , Russell J. Andrews
IPC分类号： A61B600
CPC分类号： A61B5/7264 , A61B1/00165 , A61B5/0073 , A61B5/0084 , A61B5/0261 , A61B5/031 , A61B5/0476 , A61B5/1473 , A61B5/7267 , A61B8/08 , A61B8/4218 , A61B10/0233 , A61B34/10 , A61B90/06 , A61B90/10 , A61B90/11 , A61B2017/00022 , A61B2017/3409 , A61B2090/064 , Y10S128/924
摘要： A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration. The use of this system will make surgical procedures safer, more accurate, and more efficient. Other applications of this system include the detection, prognosis and treatment of breast cancer, prostate cancer, spinal diseases, and use in general exploratory surgery.
摘要翻译：具有用于组织识别的多模式仪器的系统包括具有多感应尖端的计算机控制的马达驱动的启发式探头。对于神经外科应用，仪器安装在立体定向框架上，用于探针以精确控制的方式穿透大脑。通过附接到探针尖端的小型化应变仪来连续监测穿透的脑组织的电阻。其他形态传感器可以安装在探针尖端附近以提供实时组织表征和检测血管接近的能力，从而消除通常与术前扫描对照，组织肿胀，弹性组织变形，人的判断相关的错误等等，并使外科手术更安全，更准确，更有效率。神经网络程序在手术过程中自适应地学习正常脑组织的电阻和其他特征信息，并提供近乎实时的建模。神经网络程序的模糊逻辑接口融合了学习过程中的专家医学知识。通过检测变化和与先前学习的异常脑组织模型的比较来确定异常脑组织的鉴定。仪器的操作通过用户友好的图形界面进行控制。患者数据以3D立体显示显示。可选地提供所选信息的声反馈。当检测到紧邻血管或异常脑组织时，计算机控制的马达立即停止探针穿透。使用该系统将使外科手术更安全，更准确，更有效率。该系统的其他应用包括乳腺癌，前列腺癌，脊髓疾病的检测，预后和治疗，以及一般探索性手术中的应用。

5. 发明授权

US06701181B2 Multi-path optical catheter 有权
标题翻译：多路光导管
公开(公告)号：US06701181B2
公开(公告)日：2004-03-02
申请号：US09871770
申请日：2001-05-31
申请人： Jing Tang , Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Andres Zuluaga
发明人： Jing Tang , Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Andres Zuluaga
IPC分类号： A61B600
CPC分类号： A61B1/0615 , A61B1/00096 , A61B1/00183 , A61B1/3137 , A61B5/0084 , A61B5/6853
摘要： First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.
摘要翻译：安装在导管上的第一和第二光学重定向器沿着分离的第一和第二路径将辐射耦合到目标。第一或第二光学重定向器或两者都可以包括用于选择第一和/或第二路径的转向机构。

6. 发明授权

US06674834B1 Phantom and method for evaluating calcium scoring 失效
标题翻译：评估钙评分的幽灵和方法
公开(公告)号：US06674834B1
公开(公告)日：2004-01-06
申请号：US09541157
申请日：2000-03-31
申请人： Kishore C. Acharya , Thad A. Heinold
发明人： Kishore C. Acharya , Thad A. Heinold
IPC分类号： A61B600
CPC分类号： A61B6/583 , A61B6/032
摘要： A method is described for evaluating substance scoring, the scoring based on imaging system-generated images of an object having regions of interest due to possible presence of the substance, the method including the steps of simulating the regions of interest using a phantom having a plurality of volumes, each volume having dimensions simulating dimensions of a region of interest, each volume having a density representative of a substance density; generating images of the phantom; scoring the substance based on the phantom images; and comparing results of the substance scoring to expected phantom-image results. The above-described phantom and method allow a scoring system user to verify substance scoring accuracy and to compare scores resulting from different imaging systems, scanning methods and reconstruction algorithms.
摘要翻译：描述了用于评估物质评分的方法，基于由于物质的可能存在而具有感兴趣区域的对象的成像系统产生的图像的评分，该方法包括以下步骤：使用具有多个物体的体模来模拟感兴趣区域的体积，每个体积具有模拟感兴趣区域的尺寸的尺寸，每个体积具有表示物质密度的密度; 生成幻影的图像; 基于幻影图像对该物质进行评分; 并将物质评分的结果与预期幻影图像结果进行比较。上述幻影和方法允许评分系统用户验证物质评分精度，并比较由不同成像系统，扫描方法和重建算法得到的分数。

7. 发明授权

US06671539B2 Method and apparatus for fabricating orthognathic surgical splints 有权
公开(公告)号：US06671539B2
公开(公告)日：2003-12-30
申请号：US09970139
申请日：2001-10-03
申请人： Jaime Gateno , John F. Teichgraeber , James Xia
发明人： Jaime Gateno , John F. Teichgraeber , James Xia
IPC分类号： A61B600
CPC分类号： A61B17/6433 , A61B90/16 , A61B90/36 , A61B90/39 , A61B2090/364 , A61B2090/3904 , A61B2090/3983 , A61C5/007 , A61C5/30 , A61C7/002 , A61C7/08 , A61C9/0053 , B33Y80/00
摘要： A method of forming a surgical splint to receive a patient's dentition and thereby align the upper jaw and the lower jaw during surgery includes generating a CT computer model of bone structure, generating a digital dental computer model of the patient's dentition, and then combining the CT computer model and the digital dental computer model to form a composite computer model. The composite computer model may be displayed, and at least one of the upper jaw and lower jaw repositioned relative to the patient's skull and the composite computer model to form a planned position computer model. Using this desired position computer model, a computer model surgical splint of the patient's dentition may be formed, which is then input into a fabrication machine to form a surgical splint. The method also includes forming and displaying the composite computer model. A workstation includes a CT machine, a digital scanner, a computer, an input command mechanism, a display, and a fabricating machine.

8. 发明授权

US06668186B1 Cellular surgery utilizing confocal microscopy 有权
标题翻译：使用共焦显微镜的细胞手术
公开(公告)号：US06668186B1
公开(公告)日：2003-12-23
申请号：US09438065
申请日：1999-11-10
申请人： James M. Zavislan , Roger J. Greenwald
发明人： James M. Zavislan , Roger J. Greenwald
IPC分类号： A61B600
CPC分类号： G02B26/12 , A61B18/20 , A61B18/203 , A61B90/20 , A61B2018/00452 , A61B2018/00636 , A61B2562/0242 , G02B21/0012 , G02B21/0028
摘要： An improved system for cellular surgery which includes a laser for producing a laser beam, and confocal optics for scanning and focusing the laser beam in tissue and generating confocal images of the tissue in accordance with returned light from the tissue. The confocal images are visualized on a display. The system includes a controller for enabling the operator to select one or more cells of the tissue in the displayed confocal images for surgical treatment. The controller operates the laser and confocal optics in a first mode to treat the tissue when the confocal optics focus the laser beam at least one region associated with the selected cells in the tissue, but at all other times operates the laser and confocal optics in a second mode which does not damage the tissue. The treatment may be localized to concentrate the energy of the laser to the region including the selected cell or cells, or the treatment may be non-localized to distribute the energy of the laser to the region which includes the selected cell(s) and also the cells of the tissue surrounding such selected cell(s). In another embodiment, an apparatus is provided having a confocal imaging system, which focuses a first laser beam through confocal optics to tissue and provides confocal images of the tissue, and a treatment system which focuses a second laser beam through the confocal optics coaxial with the first laser beam for treating at one or more selected locations in the imaged tissue.
摘要翻译：一种用于细胞手术的改进的系统，其包括用于产生激光束的激光器和用于在组织中扫描和聚焦激光束并根据来自组织的返回光产生组织的共聚焦图像的共聚焦光学器件。共焦图像在显示器上可视化。该系统包括用于使操作者能够选择所显示的共聚焦图像中的组织的一个或多个细胞用于外科治疗的控制器。控制器以第一模式操作激光和共聚焦光学器件，以在共焦光学器件将激光束聚焦到与所选择的细胞相关联的至少一个区域在组织中时处理组织，但是在所有其它时间将激光和共聚焦光学器件操作在不损伤组织的第二模式。治疗可以被定位以将激光的能量集中到包括所选择的细胞或细胞的区域，或者治疗可以非局部化以将激光的能量分布到包括所选细胞的区域，并且还围绕这样选择的细胞的组织的细胞。在另一个实施例中，提供一种具有共焦成像系统的设备，该共焦成像系统将第一激光束通过共聚焦光学器件聚焦到组织并提供组织的共聚焦图像;以及处理系统，其将第二激光束通过与第一激光束用于在成像组织中的一个或多个选定位置处理。

9. 发明授权

US06665557B1 Sprectroscopic and time-resolved optical methods and apparatus for imaging objects in turbed media 失效
标题翻译：用于在混浊介质中成像物体的分光学和时间分辨的光学方法和装置
公开(公告)号：US06665557B1
公开(公告)日：2003-12-16
申请号：US09597505
申请日：2000-06-20
申请人： Robert R. Alfano , Swapan Kumar Gayen , Manuel E. Zevallos
发明人： Robert R. Alfano , Swapan Kumar Gayen , Manuel E. Zevallos
IPC分类号： A61B600
CPC分类号： A61B5/0091 , A61B5/4312
摘要： Method and apparatus for imaging objects in turbid media. In one embodiment, the method comprises illuminating at least a portion of the turbid medium with substantially monochromatic light of at least two wavelengths in the 600-1500 nm spectral range. A first of the at least two wavelengths is equal to a resonance wavelength for an optical property of an object in the illuminated portion of the turbid medium but is not equal to a resonance wavelength for the turbid medium. A second of the at least two wavelengths is not equal to a resonance wavelength for either the object or the turbid medium. Light emergent from the turbid medium following each of the foregoing illuminations comprises a ballistic component, a snake component and a diffuse component. A direct shadowgram image may be obtained by preferentially passing from the emergent light, following each illumination. the ballistic and snake components thereof and detecting the preferentially passed light. Alternatively, an inverse reconstruction image may be obtained by determining, following each illumination, the intensity of the diffuse component at a plurality of points in time and then using these pluralities of intensity determinations and a mathematical inversion algorithm to form an image of the object in the turbid medium. An image of the object with higher contrast and better quality may be obtained by using the ratio or difference of the images recorded with resonant light and non-resonant light.
摘要翻译：用于在浑浊介质中成像物体的方法和装置。在一个实施例中，该方法包括以600-1500nm光谱范围内的至少两个波长的基本上单色的光照亮混浊介质的至少一部分。至少两个波长中的第一个等于混浊介质的照射部分中的物体的光学性质的共振波长，但不等于混浊介质的共振波长。至少两个波长中的第二个不等于物体或混浊介质的共振波长。每个前述照明后从混浊介质出射的光包括弹道组件，蛇组件和漫射分量。可以在每个照明之后优先通过出射光获得直接阴影图像。弹道和蛇组件，并检测优先通过的光。或者，可以通过在每个照明之后确定多个时间点上的漫射分量的强度，然后使用这些多个强度确定和数学反演算法来形成对象的图像，来获得反重建图像混浊介质。通过使用用共振光和非共振光记录的图像的比率或差异可以获得具有较高对比度和更好质量的对象的图像。

10. 发明授权

US06665556B1 Method and apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation 失效
标题翻译：使用由可见光到红外光激发诱发的光谱翼发射来检查组织的方法和装置
公开(公告)号：US06665556B1
公开(公告)日：2003-12-16
申请号：US09493939
申请日：2000-01-28
申请人： Robert R. Alfano , Stavros G. Demos , Gang Zhang
发明人： Robert R. Alfano , Stavros G. Demos , Gang Zhang
IPC分类号： A61B600
CPC分类号： A61B5/0084 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B5/0071 , A61B5/0075
摘要： Method and an apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation. In one aspect, the method is used to characterize the condition of a tissue sample and comprises the steps of (a) photoexciting the tissue sample with substantially monochromatic light having a wavelength of at least 600 nm; and (b) using the resultant far red and near infrared spectral wing emission (SW) emitted from the tissue sample to characterize the condition of the tissue sample. In one embodiment, the substantially monochromatic photoexciting light is a continuous beam of light, and the resultant steady-state far red and near infrared SW emission from the tissue sample is used to characterize the condition of the tissue sample. In another embodiment, the substantially monochromatic photoexciting light is a light pulse, and the resultant time-resolved far red and near infrared SW emission emitted from the tissue sample is used to characterize the condition of the tissue sample. In still another embodiment, the substantially monochromatic photoexciting light is a polarized light pulse, and the parallel and perpendicular components of the resultant polarized time-resolved SW emission emitted from the tissue sample are used to characterize the condition of the tissue sample.
摘要翻译：使用由可见光与红外光激发诱发的光谱机翼发射来检查组织的方法和装置。在一个方面，该方法用于表征组织样本的状况，并且包括以下步骤：（a）用波长至少为600nm的基本上单色的光对组织样品进行光激发; 和（b）使用从组织样品发射的所得的远红外和近红外光谱机翼发射（SW）来表征组织样品的状况。在一个实施例中，基本单色的光激发光是连续的光束，并且使用来自组织样本的所得稳态远红和近红外SW发射来表征组织样本的状况。在另一个实施例中，基本上单色的光激发光是光脉冲，并且使用从组织样本发射的所得时间分辨的远红外和近红外SW发射来表征组织样本的状况。在又一个实施例中，基本上单色的光激发光是偏振光脉冲，并且使用从组织样本发射的所得偏振时间分辨SW扫描的平行和垂直分量来表征组织样本的状况。

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