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1. 发明授权

US07517900B2 Pyrazole derivatives as cannabinoid receptor modulators 有权
标题翻译：吡唑衍生物作为大麻素受体调节剂
公开(公告)号：US07517900B2
公开(公告)日：2009-04-14
申请号：US10959866
申请日：2004-10-06
申请人： Annapurna Pendri , Samuel Gerritz , Dharmpal S. Dodd , Chongqing Sun
发明人： Annapurna Pendri , Samuel Gerritz , Dharmpal S. Dodd , Chongqing Sun
IPC分类号： A61K31/415 , C07D231/00
CPC分类号： C04B35/632 , C07D231/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10
摘要： The present application describes compounds according to Formula I, wherein A, B, E, R1, R2, R3, R4, Y and Z are described herein. Additionally, the present application describes pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents. Finally, the present application describes methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents.
摘要翻译：本申请描述了式I的化合物，其中A，B，E，R 1，R 2，R 3，R 4，Y和Z在本文中描述。另外，本申请描述了药物组合物，其包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂。最后，本申请描述了单独使用式I化合物和与一种或多种另外的治疗剂组合的治疗方法。

2. 发明授权

US07378418B2 Azabicyclic heterocycles as cannabinoid receptor modulators 有权
标题翻译：氮杂环杂环作为大麻素受体调节剂
公开(公告)号：US07378418B2
公开(公告)日：2008-05-27
申请号：US11016135
申请日：2004-12-17
申请人： Guixue Yu , William R. Ewing , Amarendra B. Mikkilineni , Annapurna Pendri , Philip M. Sher , Samuel Gerritz , Bruce A. Ellsworth , Gang Wu , Yanting Huang , Chongqing Sun , Natesan Murugesan , Zhengxiang Gu , Ying Wang , Doree Sitkoff , Stephen R. Johnson , Ximao Wu
发明人： Guixue Yu , William R. Ewing , Amarendra B. Mikkilineni , Annapurna Pendri , Philip M. Sher , Samuel Gerritz , Bruce A. Ellsworth , Gang Wu , Yanting Huang , Chongqing Sun , Natesan Murugesan , Zhengxiang Gu , Ying Wang , Doree Sitkoff , Stephen R. Johnson , Ximao Wu
IPC分类号： C07D487/04 , A61K31/4162 , A61P3/04 , A61P43/00
CPC分类号： C07D487/04
摘要： The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.
摘要翻译：本申请描述了根据式I的化合物，包含至少一种根据式I的化合物和任选的一种或多种另外的治疗剂的药物组合物和使用根据式I的化合物的治疗方法，其单独和与一种或多种另外的治疗剂。该化合物具有通式I：包括所有前药，药学上可接受的盐和立体异构体，R 1，R 2，R 3，R 3，本文描述了SUP 6，R 7，m和n。

3. 发明授权

US07109186B2 HIV integrase inhibitors 有权
标题翻译： HIV整合酶抑制剂
公开(公告)号：US07109186B2
公开(公告)日：2006-09-19
申请号：US10616031
申请日：2003-07-09
申请人： Michael A. Walker , Zhuping Ma , B. Narasimhulu Naidu , Margaret E. Sorenson , Annapurna Pendri , Jacques Banville , Serge Plamondon , Roger Remillard
发明人： Michael A. Walker , Zhuping Ma , B. Narasimhulu Naidu , Margaret E. Sorenson , Annapurna Pendri , Jacques Banville , Serge Plamondon , Roger Remillard
IPC分类号： A61K31/675 , A61K31/496 , A61K31/4015 , A61K31/541 , C07D403/06 , C07D413/06 , C07D417/06 , C07D207/36
CPC分类号： C07D401/04 , C07D207/38 , C07D317/34 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/06 , C07D413/12
摘要： The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds
摘要翻译：本发明描述抑制HIV整合酶的新颖的式I化合物。本发明还描述了使用这些化合物的AIDS或ARC的组合物和治疗

4. 发明授权

US5965566A High molecular weight polymer-based prodrugs 失效
标题翻译：高分子量聚合物基前药
公开(公告)号：US5965566A
公开(公告)日：1999-10-12
申请号：US914927
申请日：1997-08-20
申请人： Richard B. Greenwald , Annapurna Pendri , Hong Zhao
发明人： Richard B. Greenwald , Annapurna Pendri , Hong Zhao
IPC分类号： A61K31/335 , A61K47/48 , C07D305/14 , C07D491/22 , C08G65/329 , A61K31/44
CPC分类号： A61K47/48215 , A61K31/335 , C07D305/14 , C08G65/329
摘要： The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety;X is an electron withdrawing group;Y and Y' are independently O or S;(n) is zero (0) or a positive integer, preferably from 1 to about 12;wherein: R.sub.1 and R.sub.2 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls and substituted C.sub.1-6 alkyls;wherein: R.sub.3 is a substantially non-antigenic polymer, C.sub.1-12 straight or branched alkyl or substituted allyl, C.sub.5-8 cycloalkyl or substituted cycloalkyl, carboxyalkyl, carboalkoxy alkyl, dialkylaminoalkyl, phenylalkyl, phenylaryl or ##STR2## wherein: R.sub.4 and R.sub.5 are independently selected from the group consisting of H, C.sub.1-6 alkyls, aryls, substituted aryls, aralkyls, heteroalkyls, substituted heteroalkyls, and substituted C.sub.1-6 alkyls or jointly form a cyclic C.sub.5 -C.sub.7 ring. In preferred embodiments, the prodrugs contain a polyethylene glycol having a molecular weight of at least about 20,000.
摘要翻译：本发明涉及下式的组合物：其中：D是生物活性部分的残基; X是吸电子基团; Y和Y'独立地为O或S; （n）为零（0）或正整数，优选1至约12; 其中：R 1和R 2独立地选自H，C 1-6烷基，芳基，取代的芳基，芳烷基，杂烷基，取代的杂烷基和取代的C 1-6烷基; 其中：R3是基本上非抗原性的聚合物，C1-12直链或支链烷基或取代的烯丙基，C5-8环烷基或取代的环烷基，羧基烷基，烷氧基烷基，二烷基氨基烷基，苯基烷基，苯基芳基或其中：R4和R5独立地选自由H，C 1-6烷基，芳基，取代的芳基，芳烷基，杂烷基，取代的杂烷基和取代的C 1-6烷基组成的基团或共同形成环状C 5 -C 7环。在优选的实施方案中，前药包含分子量为至少约20,000的聚乙二醇。

5. 发明授权

US08741884B2 Compounds for the treatment of hepatitis C 有权
公开(公告)号：US08741884B2
公开(公告)日：2014-06-03
申请号：US13086704
申请日：2011-04-14
申请人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , Annapurna Pendri , Guo Li , Samuel Gerritz , Weixu Zhai , Paul Michael Scola , Li-Qiang Sun , Eric Mull
发明人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , Annapurna Pendri , Guo Li , Samuel Gerritz , Weixu Zhai , Paul Michael Scola , Li-Qiang Sun , Eric Mull
IPC分类号： A61K31/33 , C07D487/00
CPC分类号： C07D498/06
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

6. 发明申请

US20120093766A1 Compounds for the Treatment of Hepatitis C 有权
公开(公告)号：US20120093766A1
公开(公告)日：2012-04-19
申请号：US13086036
申请日：2011-04-13
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D498/08 , A61K38/13 , A61K38/20 , A61P31/14 , C07D487/08 , A61K38/21
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

7. 发明授权

US08119808B2 Tetrahydroquinoline derivatives as cannabinoid receptor modulators 有权
标题翻译：四氢喹啉衍生物作为大麻素受体调节剂
公开(公告)号：US08119808B2
公开(公告)日：2012-02-21
申请号：US12984628
申请日：2011-01-05
申请人： Chongqing Sun , Doree Sitkoff , William R. Ewing , Yanting Huang , Bruce A. Ellsworth , Richard B. Sulsky , Annapurna Pendri , Samuel Gerritz , Natesan Murugesan , Zhengxiang Gu
发明人： Chongqing Sun , Doree Sitkoff , William R. Ewing , Yanting Huang , Bruce A. Ellsworth , Richard B. Sulsky , Annapurna Pendri , Samuel Gerritz , Natesan Murugesan , Zhengxiang Gu
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D417/06 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic disorders, obesity, cognitive disorders, neurological disorders, pain disorders, inflammation disorders, in the promotion of smoking cessation and for the treatment of other psychiatric disordersAlso provided are pharmaceutical compositions containing such compounds and pharmaceutical combinations of the compounds of the invention with other therapeutic agents.
摘要翻译：本发明提供式I化合物，其中取代基如本文所述。还提供了使用这些化合物治疗进食障碍，代谢紊乱，肥胖症，认知障碍，神经障碍，疼痛障碍，炎症障碍，促进戒烟和治疗其他精神障碍的方法。还提供药物含有这些化合物的组合物和本发明化合物与其它治疗剂的药物组合。

8. 发明申请

US20110086858A1 Compounds for the Treatment of Hepatitis C 有权
标题翻译：用于治疗丙型肝炎的化合物
公开(公告)号：US20110086858A1
公开(公告)日：2011-04-14
申请号：US12904264
申请日：2010-10-14
申请人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
发明人： Tao Wang , Annapurna Pendri , Zhongxing Zhang , Weixu Zhai , Guo Li , Samuel Gerritz , Paul Michael Scola , Li-Qiang Sun , Qian Zhao , Eric Mull
IPC分类号： A61K31/53 , C07D245/00 , C07D267/00 , A61P31/14
CPC分类号： C07D487/08 , C07D498/08
摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
摘要翻译：本公开提供式I化合物，包括药学上可接受的盐，以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

9. 发明授权

US07897647B2 Releasable polymeric conjugates based on aliphatic biodegradable linkers 失效
标题翻译：基于脂肪族可生物降解接头的可释放聚合物共轭物
公开(公告)号：US07897647B2
公开(公告)日：2011-03-01
申请号：US11502108
申请日：2006-08-09
申请人： Hong Zhao , Richard B. Greenwald , Annapurna Pendri
发明人： Hong Zhao , Richard B. Greenwald , Annapurna Pendri
IPC分类号： A01N33/08
CPC分类号： C07D333/34 , A61K38/00 , A61K47/60 , C07C271/16 , C07C271/20 , C07C271/22 , C07C317/28 , C07D207/452 , C07D277/16 , C07K14/43595
摘要： Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
摘要翻译：公开了活性聚合物双金属衍生物，以及由其制备的缀合物。还公开了制备和使用双金属衍生物的方法。

10. 发明授权

US07884113B2 Tetrahydroquinoline derivatives as cannabinoid receptor modulators 有权
标题翻译：四氢喹啉衍生物作为大麻素受体调节剂
公开(公告)号：US07884113B2
公开(公告)日：2011-02-08
申请号：US12108616
申请日：2008-04-24
申请人： Chongqing Sun , Doree Sitkoff , William R. Ewing , Yanting Huang , Bruce A. Ellsworth , Richard B. Sulsky , Annapurna Pendri , Samuel Gerritz , Natesan Murugesan , Zhengxiang Gu
发明人： Chongqing Sun , Doree Sitkoff , William R. Ewing , Yanting Huang , Bruce A. Ellsworth , Richard B. Sulsky , Annapurna Pendri , Samuel Gerritz , Natesan Murugesan , Zhengxiang Gu
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D417/06 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders, metabolic disorders, obesity, cognitive disorders, neurological disorders, pain disorders, inflammation disorders, in the promotion of smoking cessation and for the treatment of other psychiatric disorders Also provided are pharmaceutical compositions containing such compounds and pharmaceutical combinations of the compounds of the invention with other therapeutic agents.
摘要翻译：本发明提供式I化合物，其中取代基如本文所述。还提供了使用这些化合物治疗进食障碍，代谢紊乱，肥胖症，认知障碍，神经障碍，疼痛障碍，炎症障碍，促进戒烟和治疗其他精神疾病的方法。还提供含有这些化合物的药物组合物和本发明化合物与其它治疗剂的药物组合。

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