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1. 发明授权

US3920668A Antiphlogistic 1-(hydroxy or carboxylic acyloxy)-3-(2{40 -halo-4-biphenylyl) 失效
标题翻译：消炎性1-（羟基或羧酰氧基）-3-（2（40-卤代-4-联苯基）
公开(公告)号：US3920668A
公开(公告)日：1975-11-18
申请号：US47418174
申请日：1974-05-29
申请人： BOEHRINGER SOHN INGELHEIM
发明人： NICKL JOSEF , TEUFEL HELMUT , ENGEL WOLFHARD , SEEGER ERNST , ENGELHARDT GUNTHER
IPC分类号： C07C69/007 , C07C45/00 , C07C49/20 , C07C49/82 , C07C51/00 , C07C59/84 , C07C67/00 , C07C69/76 , C07D213/79 , C07D213/80 , C07D307/85 , C07D213/30 , A61K31/44
CPC分类号： C07D213/79 , C07C45/513 , C07C69/63 , C07D213/80 , C07D307/85 , Y10S514/925 , C07C49/245
摘要： Compounds of the formula

WHEREIN R1 is hydrogen or halo, R2 is hydrogen or lower alkyl of 1 to 3 carbon atoms and R3 is hydrogen or organic acyl, with the proviso that R1 and R2 are not hydrogen at the same time, if R3 is hydrogen or acetyl, or OPTICALLY ACTIVE ANTIPODES THEREOF; THE COMPOUNDS AS WELL AS THEIR OPTICALLY ACTIVE ANTIPODES ARE USEFUL AS ANTIPHLOGISTICS WITH A SURPRISINGLY SMALL ULCEROGENIC SIDE EFFECT.
摘要翻译：式WHERE R1的化合物是氢或卤素，R 2是氢或1至3个碳原子的低级烷基，R 3是氢或有机酰基，条件是R 1和R 2不同时为氢，如果R 3是氢或乙酰基或其光活性抗体; 化合物，因为它们的光学活性抗体作为具有令人惊讶的小的致癌作用的抗生素有用。

2. 发明授权

US3907996A Pharmaceutical composition containing a 2-amino-4,5,7,8-tetrahydro-6H-thiazolo or -oxazolo 5,4-D azepine and method of use 失效
标题翻译：含有2-氨基-4,5,7,8-四氢-6H-噻唑并 - 恶唑并[4,5-d]吖庚因的药物组合物及其使用方法
公开(公告)号：US3907996A
公开(公告)日：1975-09-23
申请号：US43571974
申请日：1974-01-23
申请人： BOEHRINGER SOHN INGELHEIM
发明人： GRISS GERHART , KLEEMAN MANFRED , GRELL WOLFGANG , BALLHAUSE HELMUT
IPC分类号： C07D513/04 , C07D498/04
CPC分类号： C07D513/04
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula

wherein R1 is hydrogen, straight or branched alkyl of 1 to 4 carbon atoms, hydroxy-alkyl of 1 to 4 carbon atoms, allyl, cycloalkyl, hexahydrobenzyl, phenyl, phenethyl, benzyl, mono- or dihalobenzyl, mono-, di- or tri-methoxybenzyl, trifluoromethylbenzyl or (alkyl of 1 to 3 carbon atoms)-benzyl, and R2 is hydrogen, straight or branched alkyl of 1 to 5 carbon atoms, allyl, cycloalkyl, phenyl, benzyl or phenethyl, OR A NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALT THEREOF; AND A METHOD OF USING THE SAME AS HYPOTENSIVES, SEDATIVES, ANTITUSSIVES AND ANTIPHLOGISTICS.
摘要翻译：含有下式化合物作为活性成分的药物组合物：其中R 1是氢，1至4个碳原子的直链或支链烷基，其中R 1是氢，具有1至4个碳原子的直链或支链烷基，其中R 1是氢，C 1 -C 4烷基，，1至4个碳原子的羟基 - 烷基，烯丙基，环烷基，六氢苄基，苯基，苯乙基，苄基，一或二 - 卤代苄基，一或二 - 或三 - 甲氧基苄基三氟甲基苄基或（1至3个碳原子的烷基） - 苄基，R2为氢，1至5个碳原子的直链或支链烷基，烯丙基，环烷基，苯基，苄基或苯乙基，或非毒性，药理学上可接受的酸添加盐; 和使用它们作为HYPTENSIVES，SEDATIVES，ANTITUSSIVES和抗体的方法。

3. 发明授权

US3901927A 2-(4-biphenylyl)-tetrahydrofurans 失效
标题翻译： 2-（4-二苯基） - 丙酮
公开(公告)号：US3901927A
公开(公告)日：1975-08-26
申请号：US38780373
申请日：1973-08-13
申请人： BOEHRINGER SOHN INGELHEIM
发明人： SEEGER ERNST , TEUFEL HELMUT , ENGEL WOLFHARD , NICKL JOSEF
IPC分类号： B01J27/00 , B01J31/00 , C07B61/00 , C07D307/06 , C07D307/10 , C07D5/04
CPC分类号： C07D307/10 , C07D307/06
摘要： 2-(4-BIPHENYLYL-TETRAHYDROFURANS OF THE FORMULA

WHEREIN R1 is hydrogen or halogen; as well as methods of combatting inflammation utilizing an antiphlogistic amount of the 2-(4-biphenylyl)-tetrahydrofurans.

4. 发明授权

US3901925A 2-carboxy-4-oxo-4h,10h-(2)-benzopyrano-(4,3-g)-(1)-benzopyrans and salts thereof 失效
标题翻译： 2-氧羰基-4-氧代-4H，10H-（2） - 苯并吡喃-4-（4,3-G） - （1） - 苯并二氮及其盐
公开(公告)号：US3901925A
公开(公告)日：1975-08-26
申请号：US39218273
申请日：1973-08-28
申请人： BOEHRINGER SOHN INGELHEIM
发明人： DEVLIN JOHN , STEWART PATRICK BRIAN , FRETER KURT
IPC分类号： C07D493/02 , C07D311/80 , C07D493/04 , C07D311/78
CPC分类号： C07D493/04 , C07D311/80
摘要： WHEREIN R1 is hydrogen or lower alkyl, R2, R4 and R5, which may be identical to or different from each other, are each hydrogen, lower alkyl, hydroxyl, lower alkoxy, acyloxy, halogen, nitro or -SO3H, and R3 and R6, which may be identical to or different from each other, are each hydrogen, lower alkyl, hydroxyl, lower alkoxy, acyloxy, halogen, nitro, -SO3H, hydroxycarbonyl-methoxy, Beta -hydroxy-ethoxy or Beta -amino-ethoxy, AND SALTS THEREOF; THE COMPOUNDS AS WELL AS THE SALTS ARE USEFUL AS ANTIALLERGICS.

Compounds of the formula

D R A W I N G

5. 发明授权

US3887552A 5-Oxo-2,3-dihydro-imidazo(1,2-a)-s-triazines 失效
标题翻译： 5-氧代-2,3-二氢 - 咪唑并（1,2-a）-s-三嗪
公开(公告)号：US3887552A
公开(公告)日：1975-06-03
申请号：US45028974
申请日：1974-03-12
申请人： BOEHRINGER SOHN INGELHEIM
发明人： STAHLE HELMUT , KOPPE HERBERT , KUMMER WERNER , HOEFKE WOLFGANG
IPC分类号： C07D403/04 , A61K31/53 , A61P1/04 , A61P3/00 , A61P7/10 , A61P9/12 , A61P25/04 , A61P25/24 , A61P25/26 , C07D487/04 , C07D57/34
CPC分类号： A61K31/53 , C07D487/04
摘要： Compounds of the formula

WHEREIN R1 is phenyl or mono-, di- or tri-substituted phenyl, THE SUBSTITUENTS BEING EACH HALOGEN, METHYL, METHOXY OR TRIFLUOROMETHYL, AND R2 is hydrogen, phenyl or halo-phenyl; THE COMPOUNDS ARE USEFUL AS ANTIDEPRESSANTS.
摘要翻译：式WHEREIN R 1的化合物是苯基或单 - ，二 - 或三 - 取代的苯基，每个卤素，甲基，甲氧基或三氟甲基的取代基，R 2是氢，苯基或卤代 - 苯基; 化合物作为抗生素有用。

6. 发明授权

US3872090A 3-(amino-methylene)-5-phenyl-1,4-benzodiazepin-2-ones 失效
标题翻译： 3-（氨基 - 甲基）-5-苯基-1,4-苯并二苯并[2-ONES]
公开(公告)号：US3872090A
公开(公告)日：1975-03-18
申请号：US37637873
申请日：1973-07-05
申请人： BOEHRINGER SOHN INGELHEIM
发明人： PIEPER HELMUT , KRUGER GERD , KECK JOHANNES , NOLL KLAUS-REINHOLD , KAHLING JOACHIM
IPC分类号： A61K20060101 , A61K31/33 , A61K31/5513 , C07D20060101 , C07D243/00 , C07D243/14 , C07D243/26 , C07D53/06
CPC分类号： Y10S514/906
摘要： Compounds of the formula

WHEREIN R1 and R2, which may be identical to or different from each other, are each hydrogen cycloalkyl, phenyl, -A-Y where A is alkyl of 1 to 5 carbon atoms or alkenyl of 1 to 5 carbon atoms, and Y is furyl, dialkylamino, hydroxyl, carbalkoxy or carbamido, OR, TOGETHER WITH EACH OTHER AND THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, PYRROLIDINO, PIPERIDINO, HEXAMETHYLENEIMINO, MORPHOLINO, THIOMORPHOLINO, THIOMORPHOLINO-S-oxide or N''-alkylpiperazino, R3 is halogen, nitro or trifluoromethyl, R4 is hydrogen, halogen or trifluoromethyl, and R5 is hydrogen, alkyl, cycloalkyl-methyl, alkyl-amino-alkyl, dialkylamino-alkyl or trifluoro-methyl-alkyl; THE COMPOUNDS ARE USEFUL AS SEDATIVES, TRANQUILIZERS, MUSCLERELAXANTS AND ANTICONVULSIVES.
摘要翻译：可以相同或不同的式WHEREIN R 1和R 2的化合物各自为氢环烷基，苯基，其中A为1至5个碳原子的烷基或1至5个碳原子的烯基，Y为 OR是与其他任何其它的氮原子和与它们连接的氮原子，吡咯烷酮，哌啶子，十六烷基二咪基，吗啉，噻唑啉基，噻唑啉-3-氧化物或N'-烷基哌嗪子基， R3是卤素，硝基或三氟甲基，R4是氢，卤素或三氟甲基，R5是氢，烷基，环烷基 - 甲基，烷基 - 氨基 - 烷基，二烷基氨基 - 烷基或三氟 - 甲基 - 烷基; 该化合物有效地作为SEDATIVES，TRANQUILIZERS，MUSCLE-RELAXANTS和ANTICONVULSIVES。

7. 发明授权

US3859256A Halogenated 3-(4'-biphenylyl)-butanols 失效
标题翻译：氢化3-（4'-二苯基） - 丁醇
公开(公告)号：US3859256A
公开(公告)日：1975-01-07
申请号：US38780273
申请日：1973-08-13
申请人： BOEHRINGER SOHN INGELHEIM
发明人： TEUFEL HELMUT , ENGEL WOLFHARD , SEEGER ERNEST
IPC分类号： C07C29/136 , C07C27/00 , C07C29/10 , C07C29/132 , C07C29/14 , C07C29/141 , C07C29/147 , C07C29/149 , C07C29/17 , C07C29/40 , C07C29/60 , C07C33/24 , C07C33/26 , C07C33/28 , C07C33/46 , C07C33/48 , C07C43/178 , C07C45/71 , C07C67/00 , C07C233/08 , C07C31/14
CPC分类号： C07C43/1786 , C07C29/10 , C07C29/14 , C07C29/149 , C07C29/17 , C07C29/40 , C07C29/60 , C07C33/24 , C07C33/26 , C07C33/28 , C07C33/46 , C07C33/486 , C07C45/71 , C07C49/84
摘要： (4-Biphenylyl)-alcohols of the formula

WHEREIN A is one of the following divalent radicals:

WHERE Z is hydrogen or methyl, and R1 is halogen or also hydrogen when A is

AS WELL AS METHODS OF COMBATTING INFLAMMATION UTILIZING AN ANTIPHLOGISTIC AMOUNT OF THE ABOVE (4-BIPHENYLYL)-ALCOHOLS.

8. 发明授权

US3846549A Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl -2)-n-phenyl-piperazine 失效
标题翻译：含有N-（1-双环芳基丙基）-2 - 苯基 - 哌嗪的药物组合物
公开(公告)号：US3846549A
公开(公告)日：1974-11-05
申请号：US37691073
申请日：1973-07-05
申请人： BOEHRINGER SOHN INGELHEIM
发明人： MENTRUP A , ZEILE K , GUENARD J , RENTH E , DANNEBERG P , SCHROMM K , STOTZER H
IPC分类号： A61K31/00 , A61K31/495 , A61K31/505 , C01B3/40 , C07D295/02 , C07D295/03 , C07D317/56 , A61K27/00
CPC分类号： C07D295/03 , A61K31/00 , A61K31/495 , A61K31/505 , C01B3/40 , C01B2203/1052 , C01B2203/1064 , C01B2203/1082 , C07D317/56 , A61K31/435 , A61K31/415 , A61K2300/00
摘要： Pharmaceutical compositions containing as an active ingredient a racemic or optically active compound of the formula WHEREIN Ar is 3,4-methylenedioxy-phenyl, indanyl, naphthyl or 1,4-benzodioxanyl, and R1 and R2 are each hydrogen, halogen, amino, acetyl-amino, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkyl-carbonyl of 1 to 4 carbon atoms or alkylthio of 1 to 4 carbon atoms, OR A NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALT THEREOF; AND METHODS OF USING THEM AS CENTRAL NERVOUS SYSTEM DEPRESSANTS AND ANTIHYPERCHOLESTEREMICS.
摘要翻译：作为活性成分含有式WHEREIN Ar为3,4-亚甲二氧基 - 苯基，茚满基，萘基或1,4-苯并二氧杂环戊烷的外消旋或旋光活性化合物的药物组合物，R 1和R 2各自为氢，卤素，氨基，乙酰基氨基，三氟甲基，1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷基 - 羰基或1至4个碳原子的烷硫基，或非毒性，药理学上可接受的酸添加盐其中以及将其用作中枢神经系统损伤和抗胆碱药物的方法。

9. 发明授权

US3835184A Formamide derivatives 失效
标题翻译：甲酰胺衍生物
公开(公告)号：US3835184A
公开(公告)日：1974-09-10
申请号：US25611572
申请日：1972-05-23
申请人： BOEHRINGER SOHN INGELHEIM
发明人： JERCHEL D , OST W , THOMAS K
IPC分类号： C07C233/00 , C07C233/16 , C07C103/38
CPC分类号： C07C233/00 , C07C233/16
摘要： OR B. PHENYLENE, OR PHENYLENE HAVING 1 TO 4 HALOGEN, 1 TO 2 LOWER ALKYL OR 1 TO 2 LOWER ALKOXY SUBSTITUENTS ATTACHED THERETO; THE COMPOUNDS ARE USEFUL AS BIOCIDAL AGENTS, ESPECIALLY AS SYSTEMIC FUNGICIDAL AGENTS AGAINST ALL TYPES OF PHYTOPATHOGENIC FUNGI, SUCH AS MILDEW, PLANT RUST AND Fusaria.
Compounds of the formula

WHEREIN X and Y are each oxygen, sulfur, -SO- or -SO2-; and A is A. STRAIGHT OR BRANCHED ALKYLENE OF 2 TO 10 CARBON ATOMS, WHOSE CARBON CHAIN IS INTERRUPTED BY PHENYLENE, OR BY PHENYLENE HAVING SUBSTITUENTS ATTACHED THERETO, SAID SUBSTITUENTS BEING SELECTED FROM THE GROUP CONSISTING OF 1 TO 2 CHLORINE OR BROMINE ATOMS, OR
摘要翻译：式WHEREIN X和Y的化合物各自为氧，硫，-SO-或-SO 2 - ; A是A.直接或分配2至10个碳原子的亚烷基，碳链被苯乙烯中断或由连接的替代物的苯乙烯中断，所述替代物由包含1至2个氯或溴原子的基团选择，或或B.苯乙烯或具有1至4个卤素的苯乙烯，1至2个低级烷基或1至2个下降的碱性取代基; 该化合物作为生物制剂有用，特别是作为系统性杀真菌剂的所有类型的植物病原菌真菌，如MILDEW，植物和Fusaria。

10. 发明授权

US3829426A (5-nitro-2-furyl)-pyridines 失效
标题翻译：（5-硝基-2-呋喃基） - 吡啶
公开(公告)号：US3829426A
公开(公告)日：1974-08-13
申请号：US29033472
申请日：1972-09-19
申请人： BOEHRINGER SOHN INGELHEIM
发明人： SCHRODER L , THOMAS K , GOETH H
IPC分类号： A61K31/44 , C07D307/52 , C07D405/04 , C07D31/30
CPC分类号： C07D405/04 , A61K31/44 , C07D307/52
摘要： COMPOUNDS OF THE FORMULA

2-A,R,(5-(O2N-)-FUR-2-YL)-PYRIDINE

WHEREIN A IS HYDROXYL, CHLORINE, ALKOXY OF 1 TO 10 CARBON ATOMS, DIMETHYLAMINO-ETHOXY OR DIETHYLAMINO-ETHOXY, AND R IS HYDROGEN, ALKYL OR 1 TO 4 CARBON ATOMS, PYRIDYL, PHENYL OR CHLORO-, HYDROXY- AND/OR NITRO-SUBSTITUTED PHENYL; THE COMPOUNDS ARE USEFUL AS ANTIMICROBIAL AGENTS, ESPECIALLY AGAINST GRAMNEGATIVE MICROORGANISMS, FOR THE TREATMENT OF INFECTIONS OF THE INTESTINAL AND UROGENITAL TRACT.

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