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1. 发明申请

US20170174582A1 METHOD FOR COUPLING A FIRST AROMATIC COMPOUND TO A SECOND AROMATIC COMPOUND 审中-公开
公开(公告)号：US20170174582A1
公开(公告)日：2017-06-22
申请号：US15129282
申请日：2015-03-27
申请人： Dow Global Technologies LLC , Dow AgroSciences LLC
发明人： Patrick S. Hanley , Gregory T. Whiteker , Matthias S. Ober , William J. Kruper, Jr. , Arkady L. Krasovskiy
IPC分类号： C07C1/32 , C07B37/04 , C07D213/16 , C07C22/04 , C07C233/00 , C07C211/45 , C07C22/08 , C07C15/14 , C07D263/54
CPC分类号： C07C1/322 , C07B37/04 , C07C1/321 , C07C15/14 , C07C17/263 , C07C22/04 , C07C22/08 , C07C41/30 , C07C45/70 , C07C67/343 , C07C211/45 , C07C231/12 , C07C233/00 , C07C253/30 , C07C2531/22 , C07C2531/24 , C07C2531/28 , C07D213/127 , C07D213/16 , C07D263/54 , C07C233/65 , C07C255/50 , C07C43/205 , C07C49/784 , C07C69/76
摘要： In one aspect, there is provided a method of coupling a first aromatic compound having a fluorosulfonate substituent to a second aromatic compound having a boron-containing substituent. In another aspect, there is provided a method of coupling a first aromatic compound having a hydroxyl substituent to a second aromatic compound having a boron-containing substituent in a one-pot reaction.

2. 发明申请

US20150344410A1 ARTICLE COMPRISING A COHESIVE CARBON ASSEMBLY 审中-公开
标题翻译：包含碳钢组件的文章
公开(公告)号：US20150344410A1
公开(公告)日：2015-12-03
申请号：US14824968
申请日：2015-08-12
申请人： YAZAKI CORPORATION
发明人： Leonid GRIGORIAN , Sean Imtiaz BRAHIM
IPC分类号： C07C233/00 , C07C69/00
CPC分类号： C01B32/174 , B82Y30/00 , B82Y40/00 , C01B32/166 , C01B2202/02 , C01B2202/22 , C07C69/00 , C07C233/00 , H01G11/32 , H01M4/0402 , H01M4/583 , H01M4/64 , H01M4/663 , H01M4/8807 , H01M4/8825 , H01M4/8875 , H01M4/96 , Y02E60/13 , Y02E60/50 , Y10T428/26
摘要： Cohesive carbon assemblies are prepared by obtaining a functionalized carbon starting material in the form of powder, particles, flakes, loose agglomerates, aqueous wet cake, or aqueous slurry, dispersing the carbon in water by mechanical agitation and/or refluxing, and substantially removing the water, typically by evaporation, whereby the cohesive assembly of carbon is formed. The method is suitable for preparing free-standing, monolithic assemblies of carbon nanotubes in the form of films, wafers, discs, fiber, or wire, having high carbon packing density and low electrical resistivity. The method is also suitable for preparing substrates coated with an adherent cohesive carbon assembly. The assemblies have various potential applications, such as electrodes or current collectors in electrochemical capacitors, fuel cells, and batteries, or as transparent conductors, conductive inks, pastes, and coatings.
摘要翻译：粘性碳组件通过获得粉末，颗粒，薄片，松散的聚集体，水性湿滤饼或含水浆料形式的官能化碳原料制备，通过机械搅拌和/或回流将碳分散在水中，并基本上除去水，通常通过蒸发，由此形成碳的内聚组合物。该方法适用于制备具有高碳填充密度和低电阻率的薄膜，晶片，圆盘，纤维或线材形式的碳纳米管的独立式整体组件。该方法还适用于制备涂有粘附性内聚碳组件的基材。组件具有各种潜在的应用，例如电化学电容器中的电极或集电器，燃料电池和电池，或者作为透明导体，导电油墨，糊剂和涂层。

3. 发明授权

US09144248B2 Cinnamamides as savory flavorings 有权
标题翻译：肉桂酰胺为咸味香料
公开(公告)号：US09144248B2
公开(公告)日：2015-09-29
申请号：US13480731
申请日：2012-05-25
申请人： Jakob Peter Ley , Katharina Reichelt , Susanne Paetz , Michael Backes , Katja Obst
发明人： Jakob Peter Ley , Katharina Reichelt , Susanne Paetz , Michael Backes , Katja Obst
IPC分类号： A23L1/22 , A23L1/226 , C11B9/00 , A23L2/56 , A61K8/42 , C07C233/00 , A23L1/228 , A23L1/227
CPC分类号： A23L1/22091 , A23F3/163 , A23L2/56 , A23L7/109 , A23L7/113 , A23L23/00 , A23L23/10 , A23L27/10 , A23L27/204 , A23L27/2052 , A23L27/22 , A23L27/63 , A23L27/88 , A23V2002/00 , A23V2200/15 , A23V2200/16 , A61K8/42 , C07C233/00 , C11B9/0069
摘要： The use is described of a compound of Formula (I) As a flavoring or flavoring mixture for imparting, modifying and/or enhancing one, two or all the taste impressions umami, kokumi and salty. Flavoring mixtures, vegetable extracts and preparations according to the invention and associated uses and methods are also described.
摘要翻译：描述了式（I）化合物的用途，作为用于赋予，改变和/或增强一种，两种或全部味道印味鲜味，调味和咸味的调味剂或调味剂混合物。还描述了根据本发明的调味混合物，植物提取物和制剂及相关用途和方法。

4. 发明授权

US09136536B2 Method of making cohesive carbon assembly and its applications 有权
标题翻译：制造凝聚碳装配的方法及其应用
公开(公告)号：US09136536B2
公开(公告)日：2015-09-15
申请号：US13572514
申请日：2012-08-10
申请人： Leonid Grigorian , Sean Imtiaz Brahim
发明人： Leonid Grigorian , Sean Imtiaz Brahim
IPC分类号： H01M4/583 , H01M4/04 , H01M4/66 , H01M4/96 , H01G11/32 , H01M4/88 , H01M4/64 , B82Y30/00 , B82Y40/00
CPC分类号： C01B32/174 , B82Y30/00 , B82Y40/00 , C01B32/166 , C01B2202/02 , C01B2202/22 , C07C69/00 , C07C233/00 , H01G11/32 , H01M4/0402 , H01M4/583 , H01M4/64 , H01M4/663 , H01M4/8807 , H01M4/8825 , H01M4/8875 , H01M4/96 , Y02E60/13 , Y02E60/50 , Y10T428/26
摘要： Cohesive carbon assemblies are prepared by obtaining a functionalized carbon starting material in the form of powder, particles, flakes, loose agglomerates, aqueous wet cake, or aqueous slurry, dispersing the carbon in water by mechanical agitation and/or refluxing, and substantially removing the water, typically by evaporation, whereby the cohesive assembly of carbon is formed. The method is suitable for preparing free-standing, monolithic assemblies of carbon nanotubes in the form of films, wafers, discs, fiber, or wire, having high carbon packing density and low electrical resistivity. The method is also suitable for preparing substrates coated with an adherent cohesive carbon assembly. The assemblies have various potential applications, such as electrodes or current collectors in electrochemical capacitors, fuel cells, and batteries, or as transparent conductors, conductive inks, pastes, and coatings.
摘要翻译：粘性碳组件通过获得粉末，颗粒，薄片，松散的聚集体，水性湿滤饼或含水浆料形式的官能化碳原料制备，通过机械搅拌和/或回流将碳分散在水中，并基本上除去水，通常通过蒸发，由此形成碳的内聚组合物。该方法适用于制备具有高碳填充密度和低电阻率的薄膜，晶片，圆盘，纤维或线材形式的碳纳米管的独立式整体组件。该方法还适用于制备涂有粘附性内聚碳组件的基材。组件具有各种潜在的应用，例如电化学电容器中的电极或集电器，燃料电池和电池，或者作为透明导体，导电油墨，糊剂和涂层。

5. 发明申请

US20130042615A1 Advanced method and apparatus for addressing the serious pollution from existing coal-burning power stations 审中-公开
标题翻译：解决现有燃煤电厂严重污染的先进手段和方法
公开(公告)号：US20130042615A1
公开(公告)日：2013-02-21
申请号：US13199034
申请日：2011-08-18
申请人： Albert Calderon , Richard Owen McCarthy , Terry James Laubis
发明人： Albert Calderon , Richard Owen McCarthy , Terry James Laubis
IPC分类号： F01K13/00 , B01D53/74 , B01D53/50 , B01D53/56 , C22C7/00 , C01B3/02 , B01J19/00 , B01J7/00 , C07C5/00 , C03C3/00 , B01D53/62 , C07C41/01
CPC分类号： C10K1/002 , B01D53/75 , B01D2251/208 , B01D2257/302 , B01D2257/404 , B01D2257/504 , B01D2257/602 , B01D2258/0283 , C01B3/24 , C01B2203/0266 , C01B2203/042 , C01B2203/0465 , C01B2203/06 , C01B2203/061 , C01B2203/062 , C01B2203/0872 , C01B2203/1258 , C05C11/00 , C05D9/00 , C07C231/00 , C07C233/00 , C10B49/02 , C10B53/06 , C10G2300/4043 , C10G2300/405 , C10J3/64 , C10J2300/094 , C10J2300/0956 , C10J2300/0969 , C10K1/004 , C10K1/005 , C10K1/20 , C10K1/32 , C10K3/008 , C10L1/026 , C10L1/04 , F02C3/28 , F23J15/02 , Y02E20/326 , Y02P20/152 , Y02P30/446 , C07C233/56
摘要： The present invention deals with the serious pollution problems from electric power plants that burn coal which may be forced to shut down by virtue of their being uneconomical to be retrofitted with expensive pollution controls. The pollutants from coal-burning power stations comprise SO2, NOx, Hg, Particulate Matter, Ash, and CO2. This invention offers a unique and comprehensive solution that makes possible the prevention of the ill-effects currently caused to health and environment while at the same time would also prevent the closure of these badly needed power generation facilities that provide some 50% of the electricity generated in this country. The herein comprehensive solution converts the six mentioned pollutants into valuable products and thus avoids the discharge of such pollutants into the atmosphere.
摘要翻译：本发明涉及燃煤的严重污染问题，燃煤可能由于不经济而被迫关闭而被加以昂贵的污染控制。燃煤电厂的污染物包括SO2，NOx，Hg，颗粒物，灰分和二氧化碳。本发明提供了一种独特而全面的解决方案，可以预防目前对健康和环境造成的不良影响，同时也可以防止关闭这些急需的发电设施，提供大约50％的电力在这个国家。本综合解决方案将六种上述污染物转化为有价值的产品，从而避免将这些污染物排放到大气中。

6. 发明授权

US5550161A Substituted orally effective ION chelators related to deferoxamine 失效
标题翻译：与去铁胺相关的替代口服有效的ION螯合剂
公开(公告)号：US5550161A
公开(公告)日：1996-08-27
申请号：US144664
申请日：1993-10-28
申请人： Donald E. Green
发明人： Donald E. Green
IPC分类号： A61K31/16 , A61K31/22 , A61K31/23 , A61K31/295 , C07C233/00 , C07C259/06
CPC分类号： A61K31/295 , A61K31/16 , A61K31/22 , A61K31/23 , C07C233/00 , C07C259/06
摘要： Compounds are described of the general formula: ##STR1## wherein: R.sub.1 is acyl of the formula --C(=O)-R.sub.5 : R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7 and R.sub.8 are each selected from the group consisting of hydrogen and acyl of the formula:--C(=O)-R.sub.5wherein R.sub.5 is selected from the group consisting of alkyls, substituted alkyls, alkenyls, substituted alkenyls, cycloalkyls, substituted cycloalkyls, arylalkylenes, substituted arylalkylenes, alkylenecycloalkyls, alkylene substituted cycloalkyls, alkynyls, substituted alkynyls, aryls and substituted aryls, wherein R.sub.2, R.sub.3 and R.sub.4 are selected such that at least one of R.sub.2, R.sub.3 and R.sub.4 is an acyl.When R.sub.2, R.sub.3 and R.sub.4 include one or more acyls that are not identical to the acyl of R.sub.1, these compounds of formula I are novel compounds. The invention also includes processes to produce the compounds of formula I.Compounds of formula I complex and/or chelate tissue tri-valent ions, especially iron and aluminum (Fe.sup.+++, Al.sup.+++), when administered to a human being, and are therefore useful in therapy in the treatment of diseases in which tissue ion levels in the body have increased or toxic levels. These iron-related diseases include, for example, thalassemia major, sideroachrestic anemic, BlacKfan-Diamond anemia, aplastic anemia, sickle cell anemia, hemolytic anemias and hemosiderosis brought about by multiple blood transfusions including treatment for the anemia accompanying conditions requiring kidney dialysis. Aluminum-related diseases or conditions include Alzheimer's disease, senile dementia and dialysis encephalopathy.
摘要翻译：化合物描述于下列通式：其中：R 1是式-C（= O）-R 5的酰基：R 2，R 3，R 4，R 6，R 7和R 8各自选自由氢和下式的酰基组成：-C（= O）-R 5，其中R 5选自烷基，取代的烷基，烯基，取代的烯基，环烷基，取代的环烷基，芳基亚烷基，取代的芳基亚烷基，亚烷基环烷基，亚烷基取代的环烷基，炔基，取代的炔基，芳基和取代的芳基，其中R2，R3和R4被选择为使得R 2，R 3和R 4中的至少一个是酰基。当R 2，R 3和R 4包括一个或多个与R 1的酰基不相同的酰基时，式I化合物是新化合物。本发明还包括制备式I化合物的方法。当给予人类时，式I化合物复合和/或螯合组织三价离子，特别是铁和铝（Fe +++，Al +++）），因此可用于治疗治疗身体中组织离子水平升高或有毒水平的疾病。这些与铁有关的疾病包括，例如，地中海贫血症，铁血性贫血，BlacKfan-Diamond贫血，再生障碍性贫血，镰状细胞性贫血，多种输血引起的溶血性贫血和含铁血黄素沉着症，包括治疗需要肾透析的贫血症。与铝有关的疾病或病症包括阿尔茨海默病，老年性痴呆和透析性脑病。

7. 发明授权

US5073362A Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides) and x-ray contrast media containing them 失效
标题翻译：二羧酸（3,5-DICARBAMOYL-2,4,6-TRIIODOANILIDES）和含有它们的X射线对比介质
公开(公告)号：US5073362A
公开(公告)日：1991-12-17
申请号：US554948
申请日：1990-07-16
申请人： Peter Blaszkiewicz , Ulrich Speck
发明人： Peter Blaszkiewicz , Ulrich Speck
IPC分类号： A61K31/165 , A61K31/166 , A61K49/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/08 , C07C233/00 , C07C233/12 , C07C237/46
CPC分类号： A61K31/165 , A61K31/166 , A61K49/04 , C07C233/00 , C07C233/12
摘要： Dicarboxylic acid bis-(3,5-dicarbomoyl-2,4,6-triiodoanilides) of general formula I ##STR1## wherein the amide radicals --CONR.sup.1 R.sup.2 and --CONR.sup.3 R.sup.4 are different from one another andR.sup.1 is a hydrogen, a lower alkyl radical or R.sup.2,R.sup.2 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.3 is hydrogen, a lower alkyl radical or R.sup.4,R.sup.4 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical,R.sup.5 is hydrogen, a lower alkyl radical or a monohydroxy or polyhydroxy alkyl radical,X is a straight-chain or branched-chain alkylene with 1 to 6 carbon atoms, which optionally can be substituted by 1 to 6 hydroxy or alkoxy groups or interrupted by one or more oxygen atoms,possess good pharmacological and physicochemical properties rendering them outstandingly suitable as radiopaque substances in X-ray contrast media for use in all fields of application for X-ray contrast media.
摘要翻译：通式Ⅰ“IMAGE”的二羧酸双 - （3,5-二甲酰基-2,4,6-三碘代酰苯胺），其中酰胺基-CONR1R2和-CONR3R4彼此不同，R1是氢，低级烷基或R2，R2是直链或支链单羟基或多羟基烷基，R3是氢，低级烷基或R4，R4是直链或支链单羟基或多羟基烷基，R5是氢，低级烷基或单羟基或多羟基烷基，X是具有1至6个碳原子的直链或支链亚烷基，其任选可被1至6个羟基或烷氧基取代或被一个或多个氧中断原子具有良好的药理学和物理化学性质，使得它们在X射线造影剂中非常适合用作X射线造影剂的所有应用领域中的不透射线物质。

8. 发明授权

US4992585A Process for producing .alpha.-chloroacetoacetic acid monomethylamide 失效
标题翻译： α-氯乙酰乙酸单甲酰胺的制备方法
公开(公告)号：US4992585A
公开(公告)日：1991-02-12
申请号：US421572
申请日：1989-10-16
申请人： Flaviano Rigamonti , Pullissery Raghunandan
发明人： Flaviano Rigamonti , Pullissery Raghunandan
IPC分类号： C07B61/00 , B01J31/00 , B01J31/26 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/00 , C07C235/80
CPC分类号： C07C233/00
摘要： In the production of .alpha.-chloroacetoacetic acid monomethylamide by reaction of chlorine with acetoacetic acid monomethylamide in an aqueous medium at temperature of -20 to +10.degree. C. in the presence of urea and alkali metal salts, neutralization of the reaction mixture, separation of solid .alpha.-chloroacetoacetic acid monomethylamide and feeding back of the mother liquor into the next batch, yield and purity of the product are improved by extracting the mother liquor obtained each time after the separation of .alpha.-chloroacetoacetic acid monomethylamide, before the mother liquor is fed back into the next batch, with an inert solvent immiscible with water.
摘要翻译：在α-氯乙酰乙酸单甲酰胺的制备中，通过氯和乙酰乙酸单甲酰胺在水性介质中在-20至+10℃的温度下在脲和碱金属盐的存在下反应，中和反应混合物，分离固体α-氯乙酰乙酸单甲基酰胺并将母液反馈到下一批中，通过在母液进料之前，每次分离出α-氯乙酰乙酸单甲基酰胺后，提取得到的母液，提高了产物的产率和纯度回到下一批，用与水不混溶的惰性溶剂。

9. 发明授权

US4960913A Process for the preparation of pharmaceutical compositions 失效
标题翻译：制备药物组合物的方法
公开(公告)号：US4960913A
公开(公告)日：1990-10-02
申请号：US353657
申请日：1989-05-05
申请人： Erzsebet Szalay , Gyorgy Lugosi , Tamas U. Kallay , Zsuzsanna Nad , Istvan Jelinek , Vilmos Simonidesz , Peter Gyory , Lajos Nagy , Marta Lugosi , Ilona Santa nee Singola , Gabor Besenyei , Laszlo Simandi
发明人： Erzsebet Szalay , Gyorgy Lugosi , Tamas U. Kallay , Zsuzsanna Nad , Istvan Jelinek , Vilmos Simonidesz , Peter Gyory , Lajos Nagy , Marta Lugosi , Ilona Santa nee Singola , Gabor Besenyei , Laszlo Simandi
IPC分类号： B01J27/057 , C07B61/00 , C07C231/12 , C07C233/00 , C07C237/26 , C07D237/26
CPC分类号： C07C233/00
摘要： The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH.sub.3 or .dbd.CH.sub.2 --by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula ##STR2## or by hydrating methacycline or acid addition salts thereof of the formula ##STR3## by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.
摘要翻译： PCT No.PCT / HU88 / 00063 Sec。 371日期1989年5月5日 102（e）日期1989年5月5日PCT提交1988年9月16日PCT公布。公开号WO89 / 02429 1989年3月23日。本发明涉及一种制备式I的四环素衍生物及其酸加成盐的方法，其中R代表-CH 3或= CH 2 - 通过脱氯和氢化氯代甲环素或酸其加成盐具有式 II。或通过水合式（III）的甲卡环素或其酸加成盐。在贵金属合金催化剂存在下，在载体和有机溶剂的存在下，通过氢气处理，其中包括在合金催化剂组成的合金催化剂的作用下，在0.1-1.0MPa的压力下，用合金催化剂和硒和/或碲与起始四环素的量相关的1：0.01-0.5的比例，如果需要，在一步中进行脱卤和氢化。

10. 发明授权

US4950783A Treatment of hypertension 失效
标题翻译：治疗高血压
公开(公告)号：US4950783A
公开(公告)日：1990-08-21
申请号：US922598
申请日：1986-10-24
申请人： Elijah H. Gold , Wei K. Chang
发明人： Elijah H. Gold , Wei K. Chang
IPC分类号： A61K31/60 , C07C233/00
CPC分类号： A61K31/60 , C07C233/00
摘要： Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamide exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
摘要翻译：含有（ - ） - 5 - {（R）-1-羟基-2 [（R）-1-甲基-3-苯基丙基）氨基]乙基}水杨酰胺的组合物显示出有效的血管扩张β-肾上腺素能阻滞性质，可用于治疗高血压。

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