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1. 发明申请

US20210338664A1 COMPOSITIONS AND METHODS FOR MITIGATING AFLATOXIN B1-INDUCED LIVER INJURY 有权
公开(公告)号：US20210338664A1
公开(公告)日：2021-11-04
申请号：US16862500
申请日：2020-04-29
申请人： CFD Research Corporation
发明人： Narender Singh
IPC分类号： A61K31/497 , A61P1/16
摘要： A method for providing a therapy to a subject that has been exposed to an Aflatoxin B1 can include administering a compound having a structure of Formula 1 to the subject after exposure to the Aflatoxin B1: wherein: R1, R2, R3, R4, R5 and/or R6 are each individually a chemical moiety and n is 1, 2, 3, 4, or 5. The compound can be Amprenavir or a derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof. The prodrug can be Amprenavir phosphate.

2. 发明申请

US20210280088A1 NON-LETHAL WEAPONS MODULAR HUMAN SURROGATE TESTING DEVICE AND METHOD 有权
公开(公告)号：US20210280088A1
公开(公告)日：2021-09-09
申请号：US16696997
申请日：2019-11-26
申请人： CFD Research Corporation
发明人： David Keith Sedberry , Vincent J. Harrand , Phillip E. Whitley , Andrzej Przekwas
IPC分类号： G09B23/34 , G01N33/00
摘要： A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.

3. 发明申请

US20210269868A1 PCR INCORPORATION OF EXOGENOUS NUCLEIC ACID SEQUENCES ENABLING MELT-BASED DETECTION 有权
公开(公告)号：US20210269868A1
公开(公告)日：2021-09-02
申请号：US17187267
申请日：2021-02-26
申请人： CFD Research Corporation
发明人： David Edwin Gaddes, III , Ketan Harendrakumar Bhatt , Balabhaskar Prabhakarpandian
IPC分类号： C12Q1/6853 , C12Q1/6832 , C12Q1/6816
摘要： A primer composition for amplifying a target nucleic acid of a plurality of target organisms can include: a first primer having in order: 3′-a first target specific sequence; a melt key region; and a first super primer region, wherein the first target specific sequence includes a nucleic acid sequence that specifically hybridizes with a first unique nucleic acid sequence of a first target organism over nucleic acid sequences of other organisms, the melt key region includes a nucleic acid sequence that has less than full identity with a melt key probe and a complement of the melt key region hybridizes with the melt key probe with at least one nucleotide mismatch with the melt key probe, and the first super primer region includes a nucleic acid sequence that is common to the plurality of target organisms.

4. 发明申请

US20210187332A1 DEVICE AND METHOD FOR BREACHING OUTWARD OPENING AND REINFORCED DOORS 有权
公开(公告)号：US20210187332A1
公开(公告)日：2021-06-24
申请号：US17119621
申请日：2020-12-11
申请人： CFD Research Corporation
发明人： Zachary William Wright , William Christopher Krolick , Wyatt Gilbert Ramos
IPC分类号： A62B3/00
摘要： A door breach device can include: an elongate shaft having a first end and an opposite second end; a pivot mechanism at the first end of the shaft; a spearhead rotatably coupled with the pivot mechanism and having a tip on a tip-side of the pivot mechanism and having a shaft cavity on a shaft-side, where the shaft cavity is adapted to receive the shaft therein; a restraint slidably received on the shaft-side of the spearhead and on the shaft; a handle protruding from the shaft; and a hitch at the second end of the shaft. A method of breaching a door can include: forcing the spearhead through a door until the restraint releases the spearhead and the spearhead rotates by the pivot mechanism so as to form an angle with the shaft; and pulling the spearhead against the door until the door is breached.

5. 发明申请

US20210116338A1 FLUIDIC BEAD TRAP AND METHODS OF USE 有权
公开(公告)号：US20210116338A1
公开(公告)日：2021-04-22
申请号：US17074007
申请日：2020-10-19
申请人： CFD RESEARCH CORPORATION
发明人： David Edwin Gaddes, III , Balabhaskar Prabhakarpandian , Ketan Harendrakumar Bhatt
IPC分类号： G01N1/40 , B01L3/00
摘要： A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.

6. 发明申请

US20200083543A1 FLUORINE-BASED CATHODE MATERIALS FOR THERMAL BATTERIES 审中-公开
公开(公告)号：US20200083543A1
公开(公告)日：2020-03-12
申请号：US16503261
申请日：2019-07-03
申请人： CFD Research Corporation
发明人： Pyoungho CHOI , Sameer Singhal , Joe Don Edington
IPC分类号： H01M6/36 , H01M4/06
摘要： A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. The electrolyte composition can be a tertiary electrolyte composition of LiF—LiCl—Li2SO4. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.

7. 发明授权

US10012640B2 Cell culture device with an array of microfluidic networks 有权
公开(公告)号：US10012640B2
公开(公告)日：2018-07-03
申请号：US14768154
申请日：2014-02-14
申请人： CFD Research Corporation
发明人： Kapil Pant , Balabhaskar Prabhakarpandian
IPC分类号： C12M1/00 , C12M3/00 , B01L3/00 , G01N33/50 , C12M3/06 , C12M1/12 , C12M1/34 , C12M1/36 , C12M1/42
CPC分类号： G01N33/5008 , B01L3/5025 , B01L3/502715 , B01L2300/0829 , B01L2300/0861 , B01L2300/0874 , B01L2400/0487 , C12M23/16 , C12M23/34 , C12M25/14 , C12M29/00 , C12M29/04 , C12M35/08 , C12M41/00 , C12M41/48
摘要： A cell culture assay device can include: a substrate having a plurality of discrete microfluidic networks and a plurality of wells over the discrete microfluidic networks, each discrete microfluidic network having one or more wells fluidly coupled thereto, the wells extending upward from the discrete microfluidic networks; and a manifold body coupled with the substrate and having at least one fluid conduit pair for each microfluidic network and/or each well, each fluid conduit pair including a fluid inlet conduit and a fluid outlet conduit fluidly coupled to a corresponding microfluidic network and/or well. The substrate can be formed from a substrate base having the microfluidic networks coupled to a well plate having the wells associated with the microfluidic networks.

8. 发明申请

US20160235912A1 MINIATURIZED ELECTROTHERMAL FLOW INDUCED INFUSION PUMP 有权
标题翻译：微型电热流感诱导泵
公开(公告)号：US20160235912A1
公开(公告)日：2016-08-18
申请号：US14971715
申请日：2015-12-16
申请人： CFD Research Corporation
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： A61M5/142 , A61M5/168
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵在微流体系统中具有应用，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体，例如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。微型泵使用相对于彼此交错的流动室的相对表面上的电极序列。相对表面包括具有相同相位和相同电极序列的交错电极。因为具有相同相位的电极是交错的并且不会被淹没。

9. 发明申请

US20160079608A1 THERMAL BATTERY ELECTROLYTE MATERIALS 审中-公开
标题翻译：热电池电解质材料
公开(公告)号：US20160079608A1
公开(公告)日：2016-03-17
申请号：US14850716
申请日：2015-09-10
申请人： CFD Research Corporation
发明人： Pyoungho Choi , Sameer Singhal
IPC分类号： H01M6/36
CPC分类号： H01M6/36 , H01M4/06 , H01M4/405 , H01M4/5815 , H01M4/582 , H01M2220/20 , H01M2300/0054 , H01M2300/0057 , H01M2300/0062
摘要： An electrolyte composition can be capable of becoming molten when heated sufficiently. The electrolyte can include at least one lithium halide salt; and at least one lithium non-halide salt combined with the at least one lithium halide salt so as to form an electrolyte composition capable of becoming molten when above a melting point about 350° C. A lithium halide salt includes a halide selected from F and Cl. A first lithium non-halide salt can be selected from the group consisting of LiVO3, Li2SO4, LiNO3, and Li2MoO4. A thermal battery can include the electrolyte composition, such as in the cathode, anode, and/or separator region therebetween. The battery can discharge electricity by having the electrolyte composition at a temperature so as to be a molten electrolyte.
摘要翻译：当充分加热时，电解质组合物能够变得熔化。电解质可以包括至少一种卤化锂盐; 和至少一种与所述至少一种卤化锂盐组合的非卤化锂盐，以形成当熔点高于约350℃时能够熔融的电解质组合物。卤化锂盐包括选自F和 Cl。第一种非卤化锂盐可以选自LiVO 3，Li 2 SO 4，LiNO 3和Li 2 MoO 4。热电池可以包括电解质组合物，例如其间的阴极，阳极和/或隔板区域。电池可以通过使电解质组合物处于熔融电解液的温度来放电。

10. 发明申请

US20140255970A1 SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA 审中-公开
标题翻译： HYPOXIA合成微流控系统
公开(公告)号：US20140255970A1
公开(公告)日：2014-09-11
申请号：US14202491
申请日：2014-03-10
申请人： CFD Research Corporation
发明人： Balabhaskar Prabhakarpandian , Kapil Pant
IPC分类号： G01N33/50
CPC分类号： G01N33/5029 , B01L3/5027 , G01N33/5005 , G01N33/5011 , G01N33/5061 , G01N33/5088 , G01N33/86 , G01N2333/4703 , G01N2333/70525
摘要： A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.
摘要翻译：细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。第一细胞类型在中间具有缺血区，与至少一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。在一个方面，内部室和至少一个流体通道由生理特征建模。在一个方面，内部室和至少一个流体通道由理想特征建模。

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