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1. 发明授权

US10292507B2 Interchangeable image display system and method to create 有权
公开(公告)号：US10292507B2
公开(公告)日：2019-05-21
申请号：US14543956
申请日：2014-11-18
申请人： Raymond Charles Baker
发明人： Raymond Charles Baker
IPC分类号： A47G1/06 , G06Q30/06
摘要： An interchangeable image display system includes a rigid hard backboard including a backboard front side coated with a protective finish and including at least one photo area, and a backboard back side opposite the backboard front side; one or more rigid hard photo tiles including a photo tile front including an image infused into metal; and a photo tile back; two or more first polarity magnets fixedly attached to the back board front side in each photo area in a first pattern; and two or more second polarity magnets fixedly attached to each of the photo tiles on the photo tile back in a second pattern the mirror image of the first pattern; the second polarity magnets attracted, and removeably attachable to the first polarity magnets.

2. 发明申请

US20150040658A1 Multiphase Flowmeter and a Correction Method for such a Multiphase Flowmeter 审中-公开
标题翻译：多相流量计和这种多相流量计的校正方法
公开(公告)号：US20150040658A1
公开(公告)日：2015-02-12
申请号：US14355952
申请日：2012-07-30
申请人： Kyrre Aksnes , Sabah Al-Abbas , Andrew Charles Baker , Alexandre Lupeau , Jean-Francois Noel , Rolf Rustad , Lars Seime , Oleg Zhdaneev
发明人： Andrij Abyzov , Kyrre Aksnes , Sabah Al-Abbas , Andrew Charles Baker , Alexandre Lupeau , Jean-Francois Noel , Rolf Rustad , Lars Seime , Oleg Zhdaneev
IPC分类号： G01F1/74 , G01F25/00 , G01F15/08 , G01T1/16 , G01F15/02
CPC分类号： G01F1/74 , E21B47/10 , G01F15/02 , G01F15/08 , G01F25/00 , G01F25/003 , G01N9/24 , G01T1/1606
摘要： A reference measurement apparatus for a multiphase flow meter comprising: a sampling and measuring chamber coupled to a sampling port via a sample transfer line for extracting the sample having at least one of the gas phase and the liquid phase from the multiphase fluid mixture flowing through the pipe section; a pressure and temperature regulation arrangement arranged to maintain the sample from the sampling port to the sampling and measuring chamber at a pressure/temperature substantially similar to the pressure/temperature of the multiphase fluid mixture flowing through the pipe section; and a second fraction measurement device arranged to estimate a linear attenuation related to the at least one of the gas phase and the liquid phase extracted from the sample, said linear attenuation being used to correct the estimated representative fraction for the at least one of the gas phase and the liquid phase of the multiphase fluid mixture.
摘要翻译：一种用于多相流量计的参考测量装置，包括：采样和测量室，其经由样品输送管线连接到取样口，用于从流过所述多相流量计的多相流体混合物提取具有至少一个气相和液相的样品管段; 压力和温度调节装置被布置成将样品从采样端口维持到采样和测量室，其压力/温度基本上类似于流过管段的多相流体混合物的压力/温度; 以及第二分数测量装置，其布置成估计与从样品提取的气相和液相中的至少一个相关的线性衰减，所述线性衰减用于校正所述气体中的至少一个气体的估计代表分数相和液相的多相流体混合物。

3. 发明授权

US08939033B2 Flow meter system and method for measuring an amount of liquid in a largely gaseous multiphase flow 有权
标题翻译：用于测量大部分气体多相流中的液体量的流量计系统和方法
公开(公告)号：US08939033B2
公开(公告)日：2015-01-27
申请号：US13814134
申请日：2011-07-20
申请人： Andrew Charles Baker , Cosan Ayan
发明人： Andrew Charles Baker , Cosan Ayan
IPC分类号： G01F1/74 , G01F1/44 , G01F1/704 , G01F25/00
CPC分类号： G01F1/74 , G01F1/44 , G01F1/704 , G01F25/0007
摘要： Both a flow meter system and method are provided for accurately measuring the percentage amounts of liquid and gas phases in a multiphase flow through a conduit when the liquid phase constitutes a small minority portion (e.g., less than about 20%) of the multiphase flow. The system includes a flow meter that includes a differential pressure sensor connected across a Venturi in the conduit, and a dual energy fraction meter, each of which is operably connected to a digital processor. The system further includes a pump connected to the conduit upstream of the flow meter that introduces at least one pulse of a known quantity of liquid, the pulse being sufficient in volume to temporarily increase the liquid phase by a detectable amount. After the liquid pulse is introduced into the multi-phase flow, the digital processor computes the changes in the percentage amounts of the liquid and gas phases which should have occurred as a result of the pulse, and compares the computed changes with the actual changes measured by the flow meter in order to calibrate the flow meter. The measured increase in the liquid flow is then subtracted from the total measured liquid flow to determine the actual percentage of liquid flow.
摘要翻译：提供了一种流量计系统和方法，用于当液相构成多相流的少量部分（例如，小于约20％）时，精确地测量通过导管的多相流中的液相和气相的百分比量。该系统包括流量计，该流量计包括连接在管道中的文氏管两端的差压传感器，以及双能量分数表，每个能量分数表可操作地连接到数字处理器。该系统还包括连接到流量计上游的导管的泵，其引入已知量的液体的至少一个脉冲，该脉冲的体积足以临时将液相增加可检测量。在将液体脉冲引入多相流之后，数字处理器计算作为脉冲结果应该发生的液相和气相百分比的变化，并将计算出的变化与测量的实际变化进行比较通过流量计来校准流量计。然后从总测量的液体流中减去所测量的液体流量的增加，以确定液体流量的实际百分比。

4. 发明申请

US20130319132A1 Apparatus for Measuring at Least One Characteristic Value of a Multiphase Fluid Mixture 审中-公开
标题翻译：用于测量多相流体混合物的至少一个特征值的装置
公开(公告)号：US20130319132A1
公开(公告)日：2013-12-05
申请号：US13990797
申请日：2011-06-27
申请人： Alexandre Lupeau , Andrew Charles Baker
发明人： Alexandre Lupeau , Andrew Charles Baker
IPC分类号： G01F1/36
CPC分类号： G01F1/36 , G01F1/74 , G01N33/2823
摘要： An apparatus (1) for measuring at least one characteristic value of a multiphase fluid mixture (13) comprises: a pipe section (20) having a main flow path through which the multiphase fluid mixture (13) flows, the main flow path comprising a throat (22) between an upstream part (21) and a downstream part (23) of the main flow path such as to generate a pressure drop between the upstream part (21) and the downstream part (23); a first sensing arrangement (28, 33, 29, 34, 35, 36) to measure a first characteristic value of the multiphase fluid mixture (13) flowing into the main flow path; -a channel (25) being positioned within the wall of the pipe section (20) such as to maintain similar operating conditions as in the main flow path, the channel (25) being coupled to the main flow path by an inlet (24) at the up-stream part (21), or the throat (22), and by an outlet (26) at the downstream part (23), or the throat (22), such that the pressure drop generates an aspiration effect diverting a sample of the multiphase fluid mixture (13) flowing through the main flow path into the channel (25), the channel (25) having an internal diameter (70) such that said multiphase fluid mixture sample flows in successive separated enriched phase samples (42, 52) within the channel (25); and a second sensing arrangement (30) to measure a second characteristic value of one of the phase of the multiphase fluid mixture sample flowing into the channel (25).
摘要翻译：一种用于测量多相流体混合物（13）的至少一个特征值的装置（1），包括：具有多个流体混合物（13）流过的主流路的管段（20），所述主流路包括在主流路的上游部分（21）和下游部分（23）之间的喉部（22），以在上游部分（21）和下游部分（23）之间产生压降; 第一感测装置（28,33,29,34,35,36），用于测量流入主流路的多相流体混合物（13）的第一特征值; - 通道（25）定位在管部分（20）的壁内，以便保持与主流路相似的操作条件，通道（25）通过入口（24）联接到主流路，在上游部分（21）或喉部（22）处，以及通过下游部分（23）或喉部（22）处的出口（26），使得压力下降产生吸入效应，流过主流路的多相流体混合物（13）的样品进入通道（25），通道（25）具有内径（70），使得所述多相流体混合物样品在连续分离的富相阶段样品（42 ，52）; 以及第二感测装置（30），用于测量流入通道（25）的多相流体混合物样品的相的一个的第二特征值。

5. 发明授权

US08486635B2 Detecting and treating dementia 有权
标题翻译：检测和治疗痴呆症
公开(公告)号：US08486635B2
公开(公告)日：2013-07-16
申请号：US12302691
申请日：2007-05-30
申请人： Michael L. Hutton , Matthew Charles Baker , Jennifer Mae Gass , Rosa Rademakers , Jason Eriksen , Stuart M. Pickering-Brown , Ian Reid Alexander Mackenzie , Howard Feldman , Samir Kumar-Singh , Christine Van Broeckhoven , Marc Cruts , Ashley Diane Cannon
发明人： Michael L. Hutton , Matthew Charles Baker , Jennifer Mae Gass , Rosa Rademakers , Jason Eriksen , Stuart M. Pickering-Brown , Ian Reid Alexander Mackenzie , Howard Feldman , Samir Kumar-Singh , Christine Van Broeckhoven , Marc Cruts , Ashley Diane Cannon
IPC分类号： C12Q1/68
CPC分类号： A61K48/005 , C07K14/435 , C12Q1/6809 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
摘要翻译：本文件涉及用于检测可与痴呆相关的突变的方法和材料。例如，提供了用于检测PGRN核酸内的一个或多个突变的方法和材料。本文件还提供了检测颗粒体蛋白前体表达水平的方法和材料。此外，本文件涉及用于治疗具有神经变性疾病（例如痴呆）的哺乳动物的方法和材料。例如，提供用于增加哺乳动物中PGRN多肽水平的方法和材料，以及用于鉴定可用于增加哺乳动物中PGRN多肽水平的试剂的方法和材料。

6. 发明申请

US20130116289A1 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS 有权
标题翻译： 5-（联苯-4-基）-3-苯基-1,2,4-氧杂二唑衍生物作为配位体1-磷酸酯（SIP）受体的配体
公开(公告)号：US20130116289A1
公开(公告)日：2013-05-09
申请号：US13809013
申请日：2011-07-06
申请人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
发明人： Agnes Bombrun , Anna Quattropani , Jerome Gonzalez , Jerome Dorbais , Chris Knight , Charles Baker-Glenn
IPC分类号： A61K31/4245 , C07D271/12 , A61K31/70
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
摘要翻译：本发明提供作为选择性S1P1抑制剂的式（I）化合物及其用于治疗多发性硬化症和其它疾病的用途。

7. 发明授权

US08354420B2 Aminopyrimidine derivatives as LRRK2 inhibitors 有权
标题翻译：氨基嘧啶衍生物作为LRRK2抑制剂
公开(公告)号：US08354420B2
公开(公告)日：2013-01-15
申请号：US13150929
申请日：2011-06-01
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
IPC分类号： A61K31/505 , C07D239/28
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

8. 发明申请

US20120157427A1 PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS 有权
标题翻译：作为LRRK2调节剂的吡咯氨基嘧啶衍生物
公开(公告)号：US20120157427A1
公开(公告)日：2012-06-21
申请号：US13292668
申请日：2011-11-09
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
IPC分类号： A61K31/506 , A61P25/16 , A61K31/5377 , C07D403/12 , C07D413/14
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

9. 发明申请

US20110301141A1 AMINOPYRIMIDINE DERIVATIVES AS LRRK2 INHIBITORS 有权
标题翻译：作为LRRK2抑制剂的氨基嘧啶衍生物
公开(公告)号：US20110301141A1
公开(公告)日：2011-12-08
申请号：US13150929
申请日：2011-06-01
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Janet Gunzner-Toste , Daniel Shore , Zachary Sweeney , Shumei Wang , Guiling Zhao
IPC分类号： A61K31/5377 , C07D401/12 , C07D401/14 , A61P25/16 , A61K31/506 , A61K31/5386 , A61K31/553 , C07D413/12 , C07D403/12
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

10. 发明申请

US20080091585A1 System for pricing financial instruments 有权
公开(公告)号：US20080091585A1
公开(公告)日：2008-04-17
申请号：US11986390
申请日：2007-11-20
申请人： Jason MacQueen , Gary Gastineau , Terry Norman , Clifford Weber , Carol Alexander , Charles Baker
发明人： Jason MacQueen , Gary Gastineau , Terry Norman , Clifford Weber , Carol Alexander , Charles Baker
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q40/00 , G06Q40/06
摘要： A method of determining an estimate of the market value of a traded unit of a financial instrument, and apparatus for carrying out the method, said instrument comprising a fund of individually priced securities and the exact composition of said fund being withheld from the market, said method comprising selecting a plurality of mutually independent risk factors, each risk factor being representative of market behaviour estimated to be significant to the price behaviour of the traded unit, obtaining information from a third party holding information regarding the composition of said fund regarding the actual significance of said risk factors to the value of said traded unit, and calculating a value for said traded unit on the basis of said significances.

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