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1. 发明申请

US20130122596A1 AUTOMATIC ANALYZER, ANALYSIS METHOD, AND INFORMATION PROCESSOR 审中-公开
标题翻译：自动分析仪，分析方法和信息处理器
公开(公告)号：US20130122596A1
公开(公告)日：2013-05-16
申请号：US13808743
申请日：2011-07-04
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01N21/75 , G06F19/00
CPC分类号： G01N21/75 , B01F11/0266 , B01F15/00214 , G01N21/272 , G01N35/00594 , G01N35/00603 , G01N35/00623 , G01N35/00663 , G01N2035/00465 , G01N2035/00702 , G01N2035/0097 , G16C20/10 , Y10T436/11
摘要： An automatic analyzer includes sample vessels containing samples to be measured and reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
摘要翻译：自动分析仪包括含有要测量样品的样品容器和混合样品和试剂的反应容器。样品分配器5将样品从任何样品容器分配到任何反应容器中。试剂分配器将试剂从试剂容器分配到反应容器中，并且搅拌器搅拌反应容器中包含的样品 - 试剂混合物。提供了一种光度测量单元，用于在混合溶液的反应进程期间获得多个测量数据点。执行至少一个近似公式，并且生成来自测量数据点的近似曲线。根据近似曲线计算形状描述符，并确定基于形状描述符的异常。这不仅允许从每个测量结果准确地检测异常，而且允许识别异常的原因。

2. 发明申请

US20120109534A1 AUTOMATIC ANALYZER AND ANALYSIS METHOD 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US20120109534A1
公开(公告)日：2012-05-03
申请号：US13318535
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G06F19/00
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译：在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于对参数值。

3. 发明申请

US20120076349A1 FLOW TYPE PARTICLE IMAGE ANALYSIS METHOD AND DEVICE 有权
标题翻译：流动型粒子图像分析方法与装置
公开(公告)号：US20120076349A1
公开(公告)日：2012-03-29
申请号：US13375249
申请日：2010-05-17
申请人： Chihiro Manri , Norio Oowada , Satoshi Mitsuyama
发明人： Chihiro Manri , Norio Oowada , Satoshi Mitsuyama
IPC分类号： G06K9/00
CPC分类号： G01N15/1459 , G01N2015/1452
摘要： At each of mutually different multiple focal positions, focal adjustment parameter values are obtained from images of standard particles made of the same substance. Each focal adjustment parameter value is figured out as any one of the ratio between the density value around the center of the standard particle image and the density value around the outline, the difference therebetween, and the density value around the center. The in-focus position is adjusted on the basis of the relationship between the obtained focal adjustment parameter values and the focal positions. Moreover, on the basis of the relationship between the focal adjustment parameter values and the focal positions, the parameter values are converted into focal positions, and the focal positions and dispersion thereof are used to check the displacement of the in-focus position and the thickness of the sample liquid.
摘要翻译：在每个相互不同的多个焦点位置，从相同物质制成的标准颗粒的图像中获得焦点调整参数值。每个焦点调整参数值被计算为标准颗粒图像的中心附近的密度值与轮廓周围的密度值之间的比率，它们之间的差异以及围绕中心的密度值之间的任何一个。基于获得的焦点调整参数值和焦点位置之间的关系来调整对焦位置。另外，根据焦点调整参数值与焦点位置之间的关系，将参数值转换为焦点位置，并将其焦点位置和色散用于检查对焦位置和厚度的位移的样品液体。

4. 发明申请

US20120064636A1 AUTOMATIC ANALYSIS DEVICE AND ANALYSIS METHOD 有权
标题翻译：自动分析装置及分析方法
公开(公告)号：US20120064636A1
公开(公告)日：2012-03-15
申请号：US13321072
申请日：2010-05-10
申请人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
发明人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N21/00 , G01N35/00
CPC分类号： G01N35/00663 , G01N35/00623 , G01N2035/00702 , G01N2035/0097
摘要： Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
摘要翻译：本发明提供一种自动分析装置和自动分析方法，用于根据测定化学成分浓度或酶活性水平时获得的反应过程数据，高精度地确定异常存在或不存在。反应过程数据由功能近似，并且计算表示在反应初期的曲线部分的形状的特征的形状特征量。获得的形状特征量用于确定是否存在异常。

5. 发明授权

US09476893B2 Automatic analysis device and analysis method 有权
标题翻译：自动分析装置及分析方法
公开(公告)号：US09476893B2
公开(公告)日：2016-10-25
申请号：US13321072
申请日：2010-05-10
申请人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
发明人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N35/00
CPC分类号： G01N35/00663 , G01N35/00623 , G01N2035/00702 , G01N2035/0097
摘要： Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
摘要翻译：本发明提供一种自动分析装置和自动分析方法，用于根据测定化学成分浓度或酶活性水平时获得的反应过程数据，高精度地确定异常存在或不存在。反应过程数据由功能近似，并且计算表示在反应初期的曲线部分的形状的特征的形状特征量。获得的形状特征量用于确定是否存在异常。

6. 发明授权

US09310388B2 Automatic analyzer and analysis method 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US09310388B2
公开(公告)日：2016-04-12
申请号：US13318535
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01C19/00 , G01N35/00 , G01N21/27
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译：在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于对参数值。

7. 发明授权

US09110019B2 Analytical apparatus and analytical method 有权
标题翻译：分析仪器及分析方法
公开(公告)号：US09110019B2
公开(公告)日：2015-08-18
申请号：US13809098
申请日：2011-07-08
申请人： Satoshi Mitsuyama , Norio Owada , Chihiro Manri , Sadamitsu Aso
发明人： Satoshi Mitsuyama , Norio Owada , Chihiro Manri , Sadamitsu Aso
IPC分类号： G01J3/28 , G01N21/53 , G01N15/10 , G01N15/14 , G01N21/25 , G01N21/64
CPC分类号： G01N21/53 , G01N15/1012 , G01N15/1459 , G01N21/25 , G01N21/64
摘要： Disclosed is a flow cytometer using a spectral device and a multi-detector, in which setting of an optimum wavelength band prior to measuring fluorescence intensity in real time is supported. A signal processing unit stores the intensities in multiple wavelength bands, the intensities being obtained by measuring a calibration sample, and the distribution of the intensities is calculated and displayed by each of the wavelength bands.
摘要翻译：公开了一种使用光谱装置和多检测器的流式细胞仪，其中支持在实时测量荧光强度之前设置最佳波长带。信号处理单元将强度存储在多个波长带中，通过测量校准样品获得的强度，并且通过每个波长带计算并显示强度分布。

8. 发明授权

US10352864B2 Automatic analyzer for identifying a cause of abnormalities of measurement results 有权
公开(公告)号：US10352864B2
公开(公告)日：2019-07-16
申请号：US13808743
申请日：2011-07-04
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01N35/00 , G01N21/75 , G16C20/10 , B01F15/00 , B01F11/02 , G01N21/27
摘要： An automatic analyzer includes sample vessels containing samples to be measured and; reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.

9. 发明申请

US20130046480A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 审中-公开
标题翻译：自动分析装置及自动分析方法
公开(公告)号：US20130046480A1
公开(公告)日：2013-02-21
申请号：US13641881
申请日：2011-04-05
申请人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
发明人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N21/272 , G01N21/78 , G01N35/00584 , G01N35/00693 , G01N2035/00465
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
摘要翻译：提供了一种用于自动确定或预测在自动分析器中出现在反应曲线中的样品特异性的线范围的技术，用于混合样品和试剂，并测量样品和试剂的混合物随时间的变化。本发明通过功能近似反应曲线数据，并在反应的早期阶段或第二阶段自动确定曲线部分。本发明确定不包括每个样品的曲线部分的线范围，并使用确定的线范围内的吸光度数据计算实验室测试值。本发明还根据通过反应曲线中途的一点获得的吸光度数据自动确定反应初期的起始时间，基于线的结束时间和计划的预测线范围并且基于预测结果来计算预测值。

10. 发明申请

US20120134559A1 PARTICLE IMAGE ANALYSIS APPARATUS 审中-公开
标题翻译：粒子图像分析装置
公开(公告)号：US20120134559A1
公开(公告)日：2012-05-31
申请号：US13386846
申请日：2010-07-23
申请人： Akiko Suzuki , Norio Oowada , Miki Taki , Satoshi Mitsuyama , Chihiro Manri
发明人： Akiko Suzuki , Norio Oowada , Miki Taki , Satoshi Mitsuyama , Chihiro Manri
IPC分类号： G06K9/62
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1459 , G01N35/00613 , G01N2015/1409 , G01N2015/1465
摘要： The particle analysis apparatus includes means that perform processes upon image processing of images (110) acquired in a measurement of the sample, simultaneously with a normal image processing for classifying target particles. The means included are: image processing means (110a) for calculating information of RGB density distributions of each whole image; abnormal state determination processing means (110c) for determining whether or not the acquired images are in an abnormal state according to tendencies of the RGB density distributions; and an abnormality judgment process means for making final determination of the existence of an abnormality by calculating an appearance frequency of abnormal images after all measurements for the one sample is completed. These means allow diagnosis of abnormalities to be conducted simultaneously with normal analysis without changing the configuration of the conventional apparatus.
摘要翻译：粒子分析装置包括与用于分类目标粒子的正常图像处理同时进行在样本测量中获取的图像（110）的图像处理的处理。包括的装置是：用于计算每个整个图像的RGB密度分布的信息的图像处理装置（110a）用于根据RGB浓度分布的趋势确定所获取的图像是否处于异常状态的异常状态确定处理装置（110c）; 以及异常判断处理装置，用于通过在完成所述一个样本的所有测量之后计算异常图像的出现频率来最终确定异常的存在。这些装置允许诊断异常与正常分析同时进行，而不改变常规装置的结构。

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