专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09476893B2 Automatic analysis device and analysis method 有权
标题翻译：自动分析装置及分析方法
公开(公告)号：US09476893B2
公开(公告)日：2016-10-25
申请号：US13321072
申请日：2010-05-10
申请人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
发明人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N35/00
CPC分类号： G01N35/00663 , G01N35/00623 , G01N2035/00702 , G01N2035/0097
摘要： Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
摘要翻译：本发明提供一种自动分析装置和自动分析方法，用于根据测定化学成分浓度或酶活性水平时获得的反应过程数据，高精度地确定异常存在或不存在。反应过程数据由功能近似，并且计算表示在反应初期的曲线部分的形状的特征的形状特征量。获得的形状特征量用于确定是否存在异常。

2. 发明授权

US09310388B2 Automatic analyzer and analysis method 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US09310388B2
公开(公告)日：2016-04-12
申请号：US13318535
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01C19/00 , G01N35/00 , G01N21/27
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译：在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于对参数值。

3. 发明授权

US09110019B2 Analytical apparatus and analytical method 有权
标题翻译：分析仪器及分析方法
公开(公告)号：US09110019B2
公开(公告)日：2015-08-18
申请号：US13809098
申请日：2011-07-08
申请人： Satoshi Mitsuyama , Norio Owada , Chihiro Manri , Sadamitsu Aso
发明人： Satoshi Mitsuyama , Norio Owada , Chihiro Manri , Sadamitsu Aso
IPC分类号： G01J3/28 , G01N21/53 , G01N15/10 , G01N15/14 , G01N21/25 , G01N21/64
CPC分类号： G01N21/53 , G01N15/1012 , G01N15/1459 , G01N21/25 , G01N21/64
摘要： Disclosed is a flow cytometer using a spectral device and a multi-detector, in which setting of an optimum wavelength band prior to measuring fluorescence intensity in real time is supported. A signal processing unit stores the intensities in multiple wavelength bands, the intensities being obtained by measuring a calibration sample, and the distribution of the intensities is calculated and displayed by each of the wavelength bands.
摘要翻译：公开了一种使用光谱装置和多检测器的流式细胞仪，其中支持在实时测量荧光强度之前设置最佳波长带。信号处理单元将强度存储在多个波长带中，通过测量校准样品获得的强度，并且通过每个波长带计算并显示强度分布。

4. 发明授权

US07660676B2 Nucleic acid base sequence determining method and inspecting system 有权
标题翻译：核酸碱基序列测定方法及检测系统
公开(公告)号：US07660676B2
公开(公告)日：2010-02-09
申请号：US10315143
申请日：2002-12-10
申请人： Satoshi Hirata , Satoshi Mitsuyama , Hitoshi Matsuo , Shinichi Fukuzono , Hiroyuki Suzuki
发明人： Satoshi Hirata , Satoshi Mitsuyama , Hitoshi Matsuo , Shinichi Fukuzono , Hiroyuki Suzuki
IPC分类号： G06F19/00
CPC分类号： G01N27/44721
摘要： When the nucleic-acid base sequence of A, C, G, and T (or U) is determined by interpreting fluorescent-light intensity waveform data acquired by measuring nucleic-acid fragments, it is desirable to determine, with a high-accuracy, the base sequence at a location at which the data interpretation is difficult. In order to accomplish this object, the data interpretation is performed by making reference to information acquired by performing the statistical processing to plural pieces of fluorescent-light intensity waveform data corresponding to already-known base sequences. This method allows the determination of the nucleic-acid base sequence at the above-described location.
摘要翻译：当通过解释通过测量核酸片段获得的荧光强度波形数据来确定A，C，G和T（或U）的核酸碱基序列时，希望以高精度确定在数据解释困难的位置的基本序列。为了实现该目的，通过参照通过对与已知的碱基序列相对应的多个荧光强度波形数据进行统计处理获得的信息来进行数据解释。该方法允许在上述位置确定核酸碱基序列。

5. 发明授权

US09562917B2 Automatic analysis device and automatic analysis program 有权
标题翻译：自动分析装置和自动分析程序
公开(公告)号：US09562917B2
公开(公告)日：2017-02-07
申请号：US14117717
申请日：2012-04-17
申请人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
发明人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N31/00 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
摘要翻译：实现了混合样品和试剂以测量混合溶液的时间变化的自动分析装置的精度控制。从样品和试剂的反应过程获取多个测量点数据。用于近似多个测量点数据的近似等式的参数和测试值被累积在存储单元中。基于在存储单元中累积的参数或测试值的预定数量来创建与参数或测试值相对应的参考数据的分布图。接下来，在分配图上单独叠加多个屏幕，将与通过应用多个回归函数获得的多个回归函数候选对应的曲线布置并呈现在显示屏上，以将数据近似为参考数据的分布图。

6. 发明授权

US09488667B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US09488667B2
公开(公告)日：2016-11-08
申请号：US13318819
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01C19/00 , G01N35/00
CPC分类号： G01N35/00613 , G01N2035/0097
摘要： To change a photometric time for each item or to change a measurement time for each specimen so that time required for biochemical measurement can be reduced, an index that indicates an end of a reaction is required. Unfortunately, however, no methods have been available for determining the end of the reaction. In measuring a substance to be measured contained in a sample, a parameter in an approximate expression is calculated using a measured value that changes with time, a degree of convergence of a reaction is determined according to a degree of convergence of the parameter, and a measured value at the end of the reaction is calculated using the parameter at a point in time at which it is determined that the reaction has converged.
摘要翻译：要更改每个项目的光度时间或更改每个样品的测量时间，以便可以减少生物化学测量所需的时间，则需要指示反应结束的指标。然而，不幸的是，没有方法可用于确定反应的结束。在测定样品中含有的待测物质时，使用随时间变化的测定值来计算近似表达式中的参数，根据参数的收敛程度确定反应的收敛程度，使用在确定反应已经收敛的时间点的参数来计算反应结束时的测量值。

7. 发明授权

US08831306B2 Flow type particle image analysis method and device 有权
标题翻译：流式粒子图像分析方法及装置
公开(公告)号：US08831306B2
公开(公告)日：2014-09-09
申请号：US13375249
申请日：2010-05-17
申请人： Chihiro Manri , Norio Oowada , Satoshi Mitsuyama
发明人： Chihiro Manri , Norio Oowada , Satoshi Mitsuyama
IPC分类号： G06K9/00 , G06K9/40 , G01N15/14
CPC分类号： G01N15/1459 , G01N2015/1452
摘要： At each of mutually different multiple focal positions, focal adjustment parameter values are obtained from images of standard particles made of the same substance. Each focal adjustment parameter value is figured out as any one of the ratio between the density value around the center of the standard particle image and the density value around the outline, the difference therebetween, and the density value around the center. The in-focus position is adjusted on the basis of the relationship between the obtained focal adjustment parameter values and the focal positions. Moreover, on the basis of the relationship between the focal adjustment parameter values and the focal positions, the parameter values are converted into focal positions, and the focal positions and dispersion thereof are used to check the displacement of the in-focus position and the thickness of the sample liquid.
摘要翻译：在每个相互不同的多个焦点位置，从相同物质制成的标准粒子的图像中获得焦点调整参数值。每个焦点调整参数值被计算为标准颗粒图像的中心附近的密度值与轮廓周围的密度值之间的比率，它们之间的差异以及围绕中心的密度值之间的任何一个。基于获得的焦点调整参数值和焦点位置之间的关系来调整对焦位置。此外，基于焦点调整参数值与焦点位置之间的关系，参数值被转换为焦点位置，并且其焦点位置和色散用于检查对焦位置和厚度的位移的样品液体。

8. 发明申请

US20140136123A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS PROGRAM 有权
标题翻译：自动分析装置和自动分析程序
公开(公告)号：US20140136123A1
公开(公告)日：2014-05-15
申请号：US14117717
申请日：2012-04-17
申请人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
发明人： Chihiro Manri , Satoshi Mitsuyama , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
摘要翻译：实现了混合样品和试剂以测量混合溶液的时间变化的自动分析装置的精度控制。从样品和试剂的反应过程获取多个测量点数据。用于近似多个测量点数据的近似等式的参数和测试值被累积在存储单元中。基于在存储单元中累积的参数或测试值的预定数量来创建与参数或测试值相对应的参考数据的分布图。接下来，在分配图上单独叠加多个屏幕，将与通过应用多个回归函数获得的多个回归函数候选对应的曲线布置并呈现在显示屏上，以将数据近似为参考数据的分布图。

9. 发明授权

US06549661B1 Pattern recognition apparatus and pattern recognition method 有权
标题翻译：模式识别装置和模式识别方法
公开(公告)号：US06549661B1
公开(公告)日：2003-04-15
申请号：US09331150
申请日：1999-06-17
申请人： Satoshi Mitsuyama , Jun Motoike , Hitoshi Matsuo , Yasuaki Kojima
发明人： Satoshi Mitsuyama , Jun Motoike , Hitoshi Matsuo , Yasuaki Kojima
IPC分类号： G06K962
CPC分类号： G06K9/00127 , G06K9/6217 , G06K9/6263
摘要： Recognizable data storage apparatus stores an image feature parameter of an object and its classification result for those objects for which said classification results are evaluated as having high reliability and recognizable and for which a classification result is outputted by first pattern recognition apparatus, and recognition suspension data storage apparatus stores an image feature parameter for those objects for which said classification results are evaluated as having low reliability and as being suspended from recognition. Pattern recognition method constitution apparatus constructs second pattern recognition apparatus on the basis of the classification result stored in the recognizable data storage apparatus, and re-classification is conducted for those objects recognition of which is to be suspended. A neural network, for example, is used for the second pattern recognition apparatus. Wrong classification of objects due to an individual difference can be reduced and automated pattern recognition having high accuracy without depending on an individual difference can be accomplished.
摘要翻译：可识别数据存储装置存储被评价为具有高可靠性和可识别性的那些对象的对象的图像特征参数及其分类结果，并且由第一模式识别装置输出分类结果，并且识别暂停数据存储装置存储所述分类结果被评估为具有低可靠性并被停止识别的那些对象的图像特征参数。模式识别方法构成装置根据存储在可识别数据存储装置中的分类结果，构建第二模式识别装置，对于要暂停的对象识别进行重新分类。例如，神经网络被用于第二模式识别装置。可以减少由于个体差异导致的对象的错误分类，并且可以实现具有高精度的自动模式识别，而不依赖于个体差异。

10. 发明授权

US09217712B2 Method for assisting judgment of abnormality of reaction process data and automatic analyzer 有权
标题翻译：协助判断反应过程数据异常和自动分析仪的方法
公开(公告)号：US09217712B2
公开(公告)日：2015-12-22
申请号：US12995219
申请日：2009-05-28
申请人： Satoshi Mitsuyama , Yuki Fukuyama , Hidekatsu Takada , Hideyuki Ban , Tomonori Mimura
发明人： Satoshi Mitsuyama , Yuki Fukuyama , Hidekatsu Takada , Hideyuki Ban , Tomonori Mimura
IPC分类号： G06F19/00 , G01N35/00 , G01N21/00 , G01N21/77
CPC分类号： G01N21/77 , G01N21/272 , G01N21/78 , G01N35/00603 , G01N2035/0097
摘要： In the event of a suspected abnormality in the device, sample or reagent, a laboratory technician had to examine the abnormal reaction process data item by item, and infer the cause of the abnormality, which took effort and time in some cases. Abnormality judgment is assisted using: indicator computation means that computes an indicator indicating a feature parameter of a given waveform by applying a pre-defined evaluation formula to time series data of photometric values; relative indicator computation means that computes a value indicating a relationship of the indicator of target data to the indicator computed in the past; and indicator display means that simultaneously displays a value computed by the indicator computation means and the value computed by the relative indicator computation means. According to the present method, which is a method for assisting judgment of abnormality wherein a feature parameter of a given absorbance change is computed, it can be made easier to find certain abnormalities, and it becomes possible to attain more efficient device maintenance and improved device reliability without the addition of any new parts.
摘要翻译：如果装置，样品或试剂中有疑似异常，实验室技术人员必须逐项检查异常反应过程数据，并推断异常的原因，在某些情况下花费时间和精力。协助使用以下方式辅助异常判断：指标计算装置，通过对光度值的时间序列数据应用预定义的评估公式来计算指示给定波形的特征参数的指标; 相对指标计算是指计算出目标数据指标与过去计算出的指标的关系的值; 指示符显示装置，同时显示由指标计算装置计算的值和由相关指标计算装置计算的值。根据本方法，其是计算给定吸光度变化的特征参数的异常判断方法，可以更容易地发现某些异常，并且可以实现更有效的装置维护和改进装置可靠性无需添加任何新零件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式