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    • 8. 发明申请
    • INTRACELLUAR TARGETING BIPODAL PEPTIDE BINDER
    • 腹腔内定向双功能胶原蛋白BINDER BINDER
    • US20120309934A1
    • 2012-12-06
    • US13515026
    • 2010-12-03
    • Sang Yong JonSung Hyun KimDaejin Kim
    • Sang Yong JonSung Hyun KimDaejin Kim
    • C07K19/00
    • C07K19/00A61K38/00
    • An intracellular targeting bipodal-peptide binder specifically binding to an intracellular target molecule, comprising: (a) a structure-stabilizing region comprising a parallel amino acid strand, an antiparallel amino acid strand or parallel and antiparallel amino acid strands to induce interstrand non-covalent bonds; (b) target binding regions I and II each binding to each of both termini of the structure-stabilizing region, wherein the number of amino acid residues of the target binding region I is n and the number of amino acid residues of the target binding region II is m; and (c) a cell-penetrating peptide (CPP) linked to the structure-stabilizing region, the target binding region I or the target binding region II. Also contemplated is a method for preparing an intracellular targeting bipodal-peptide binder. The bipodal-peptide binder capable of binding to intracellular targets has applications to drugs, in vivo molecular imaging, in vitro cell imaging, drug delivery targeting and escort molecules.
    • 特异性结合细胞内靶分子的细胞内靶向双齿肽结合物,其包含:(a)包含平行氨基酸链,反平行氨基酸链或平行和反平行氨基酸链的结构稳定区,以诱导链间非共价键 债券 (b)靶结合区域I和II各自与结构稳定区域的两个末端各自结合,其中靶结合区域I的氨基酸残基数目为n,靶结合区域的氨基酸残基数 二是m 和(c)与结构稳定区域连接的细胞穿透肽(CPP),靶结合区域I或靶结合区域II。 还考虑了制备细胞内靶向双齿肽粘合剂的方法。 能够结合细胞内靶标的双峰肽结合物可用于药物,体内分子成像,体外细胞成像,药物递送靶向和护送分子。
    • 10. 发明申请
    • Method to manufacture composite polymer electrolyte membranes coated with inorganic thin films for fuel cells
    • 制造涂覆有燃料电池无机薄膜的复合高分子电解质膜的方法
    • US20070231655A1
    • 2007-10-04
    • US11796469
    • 2007-04-27
    • Heung-Yong HaSoon Jong KwakDaejin KimJuno ShimIn-Hwan OhSeong-Ahn HongTae-Hoon LimSuk-Woo Nam
    • Heung-Yong HaSoon Jong KwakDaejin KimJuno ShimIn-Hwan OhSeong-Ahn HongTae-Hoon LimSuk-Woo Nam
    • H01M8/10
    • C08J5/2287C08J2327/18H01M4/881H01M8/04197H01M8/1023H01M8/1025H01M8/103H01M8/1039H01M8/1055H01M8/1069H01M2300/0094Y02E60/523Y02P70/56
    • The present invention relates to a method for manufacturing composite polymer electrolyte membranes coated with inorganic thin films for fuel cells using a plasma enhanced chemical vapor deposition (PECVD) method or a reactive sputtering method, so as to reduce the crossover of methanol through polymer electrolyte membranes for fuel cells and enhance the performance of the fuel cells. The manufacturing method of composite polymer electrolyte membranes coated with inorganic thin films for fuel cells according to the present invention is characterized to obtain composite membranes by coating the surface of commercial composite polymer electrolyte membranes for fuel cells with inorganic thin films using a PECVD method or a reactive sputtering method. The inorganic materials to form the inorganic thin films are chosen one or more from the group comprising silicon oxide (SiO2), titanium oxide (TiO2), zirconium oxide (ZrO2), zirconium phosphate (Zr(HPO4)2), zeolite, silicalite, and aluminum oxide (Al2O3). The present invention, by coating the polymer electrolyte membranes for fuel cells with inorganic thin films via a PECVD method or a reactive sputtering method, reduces the methanol crossover sizably without seriously reducing the ionic conductivity of polymer electrolyte membranes, thereby, when applied to fuel cells, realizes a high performance of fuel cells.
    • 本发明涉及使用等离子体增强化学气相沉积(PECVD)法或反应溅射法制造涂覆有燃料电池的无机薄膜的复合聚合物电解质膜的方法,从而减少甲醇通过聚合物电解质膜的交叉 用于燃料电池并增强燃料电池的性能。 根据本发明的用于燃料电池的无机薄膜的复合高分子电解质膜的制造方法的特征在于,通过使用PECVD法或无机薄膜将无机薄膜涂覆用于燃料电池的市售复合高分子电解质膜的表面,来获得复合膜 反应溅射法。 形成无机薄膜的无机材料选自一种或多种,​​其中包括氧化硅(SiO 2),氧化钛(TiO 2),氧化锆(ZrO 2) 磷酸锆(Zr(HPO 4)2)),沸石,硅沸石和氧化铝(Al 2 O 3) SUB> O 3 3)。 本发明通过PECVD法或反应溅射法通过用无机薄膜涂覆燃料电池用聚合物电解质膜,可以在不严重降低聚合物电解质膜的离子电导率的情况下,相应地降低甲醇交换,从而当应用于燃料电池 实现燃料电池的高性能化。