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1. 发明授权

US11510905B1 Pleuromutilin (E)-4-(1-imidazoylmethyl)cinnamic acid ester with anti-drug resistant bacteria activity and a method of preparing the same 有权
公开(公告)号：US11510905B1
公开(公告)日：2022-11-29
申请号：US17239583
申请日：2021-04-24
申请人： Chengyuan Liang , Wenjing Yang , Qianqian Zhao , Liang Xin , Jingyi Li , Dan Yang , Ruina Bian , Jie Zhang , Yuqing Zhao , Han Li , Bin Tian , Yongbo Wang , Liang Qi , Gennian Mao
发明人： Chengyuan Liang , Wenjing Yang , Qianqian Zhao , Liang Xin , Jingyi Li , Dan Yang , Ruina Bian , Jie Zhang , Yuqing Zhao , Han Li , Bin Tian , Yongbo Wang , Liang Qi , Gennian Mao
IPC分类号： C07D233/60 , A61K31/4164 , A61P31/04
摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

2. 发明授权

US10941120B1 6-aminouracil cassic acid ester with antibacterial activity and a method of preparing the same 有权
公开(公告)号：US10941120B1
公开(公告)日：2021-03-09
申请号：US16909862
申请日：2020-06-23
申请人： Han Li , Nan Hui , Chengyuan Liang , Xingke Ju , Guaiping Qiao , Juan Li , Yuanyuan He , Bin Tian , Yongbo Wang , Jingwen Xu , Liang Qi , Dan Yang , Qianqian Zhao , Yanjun Li , Qiao Zeng , Gennian Mao , Limei Wang
发明人： Han Li , Nan Hui , Chengyuan Liang , Xingke Ju , Guaiping Qiao , Juan Li , Yuanyuan He , Bin Tian , Yongbo Wang , Jingwen Xu , Liang Qi , Dan Yang , Qianqian Zhao , Yanjun Li , Qiao Zeng , Gennian Mao , Limei Wang
IPC分类号： C07D239/545
摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

3. 发明授权

US08803810B2 Multiple use education and entertainment device for young users 有权
标题翻译：多用途教育和娱乐设备为年轻用户
公开(公告)号：US08803810B2
公开(公告)日：2014-08-12
申请号：US13091354
申请日：2011-04-21
申请人： Dan Dan Yang
发明人： Dan Dan Yang
IPC分类号： G09G5/00
CPC分类号： G06F1/1675 , A63H33/086
摘要： A device which has both educational and entertainment purposes. The device has a housing which allows multiple instances of the device to be stacked together. The device has a CPU, memory, storage, and a wireless module which allows communications with a base computer. The device also has a flat touch screen which serves as the user interface. The touch screen also serves as the video display for the device. Each device is approximately the size of a conventional building block. Variants include having some sides equipped with protuberance and some sides are equipped with voids. The protuberances of one device is constructed and arranged to interlockingly mate with the voids of another device. The device may be used in conjunction with multiple types of applications which have both educational and entertainment uses. The device may be used to receive images, data, commands, etc. from the base computer and the device may be used in conjunction with other similar devices.
摘要翻译：具有教育和娱乐目的的设备。该装置具有壳体，其允许装置的多个实例被堆叠在一起。该设备具有CPU，存储器，存储器和无线模块，其允许与基本计算机通信。该设备还具有用作用户界面的平面触摸屏。触摸屏也可用作设备的视频显示。每个装置大约是传统结构件的尺寸。变体包括有一些侧面装有凸起，有些侧面配有空隙。一个装置的突起被构造和布置成与另一装置的空隙互锁地配合。该设备可以与具有教育和娱乐用途的多种类型的应用结合使用。该设备可以用于从基本计算机接收图像，数据，命令等，并且该设备可以与其他类似的设备结合使用。

4. 发明申请

US20140108034A1 CONTINUOUS AUTOMATED HEALTHCARE ENTERPRISE RESOURCE ASSIGNMENT SYSTEM AND METHOD 审中-公开
标题翻译：连续自动化医疗保健企业资源配置系统与方法
公开(公告)号：US20140108034A1
公开(公告)日：2014-04-17
申请号：US14044326
申请日：2013-10-02
申请人： Kunter Seref Akbay , Srinivas Bollapragada , Andrew Phelps Day , Ilkin Onur Dulgeroglu , David S. Toledano , Bex George Thomas , Marcia Peterson , Dan Yang
发明人： Kunter Seref Akbay , Srinivas Bollapragada , Andrew Phelps Day , Ilkin Onur Dulgeroglu , David S. Toledano , Bex George Thomas , Marcia Peterson , Dan Yang
IPC分类号： G06Q10/06 , G06Q50/22
CPC分类号： G06Q10/06315 , G06Q50/22 , G16H40/20
摘要： Current resource data may be continuously and automatically received indicative of a current state of resources that are used to deliver healthcare to a plurality of patients associated with a healthcare enterprise. The current resource data may be automatically used to update a healthcare enterprise simulation model. The healthcare enterprise simulation model may be executed to automatically generate a predicted future state of the resources. A resource request may then be received, and a resource assignment engine may automatically assign a particular resource to the resource request based at least in part on the predicted future state of the resources.
摘要翻译：可以连续地且自动地接收当前资源数据，指示用于向与医疗保健企业相关联的多个患者提供医疗保健的资源的当前状态。可以自动使用当前资源数据来更新医疗保健企业仿真模型。可以执行医疗保健企业模拟模型以自动生成资源的预测未来状态。然后可以接收资源请求，并且资源分配引擎可以至少部分地基于资源的预测未来状态来自动地向资源请求分配特定资源。

5. 发明申请

US20140021596A1 WAFER-LEVEL DEVICE PACKAGING 有权
标题翻译：水平装置包装
公开(公告)号：US20140021596A1
公开(公告)日：2014-01-23
申请号：US13551610
申请日：2012-07-18
申请人： Yat Kit Tsui , Dan Yang , Pui Chung Law
发明人： Yat Kit Tsui , Dan Yang , Pui Chung Law
IPC分类号： H01L23/485 , H01L21/60 , H01L23/08
CPC分类号： H01L27/14618 , H01L23/3114 , H01L24/03 , H01L24/05 , H01L24/11 , H01L24/13 , H01L24/16 , H01L24/17 , H01L24/19 , H01L24/20 , H01L24/32 , H01L24/81 , H01L24/92 , H01L24/94 , H01L24/97 , H01L25/0657 , H01L25/50 , H01L27/14632 , H01L27/14687 , H01L2224/03464 , H01L2224/0401 , H01L2224/04105 , H01L2224/05155 , H01L2224/05644 , H01L2224/10156 , H01L2224/1132 , H01L2224/1182 , H01L2224/1183 , H01L2224/11849 , H01L2224/12105 , H01L2224/131 , H01L2224/13147 , H01L2224/1319 , H01L2224/13565 , H01L2224/1369 , H01L2224/16106 , H01L2224/16108 , H01L2224/16148 , H01L2224/16157 , H01L2224/16168 , H01L2224/16225 , H01L2224/16227 , H01L2224/16238 , H01L2224/17181 , H01L2224/2101 , H01L2224/211 , H01L2224/214 , H01L2224/215 , H01L2224/32225 , H01L2224/73203 , H01L2224/81191 , H01L2224/81192 , H01L2224/81193 , H01L2224/81447 , H01L2224/81801 , H01L2224/8185 , H01L2224/81895 , H01L2224/9202 , H01L2224/92222 , H01L2224/92224 , H01L2224/94 , H01L2224/97 , H01L2225/06513 , H01L2225/06517 , H01L2225/06541 , H01L2225/06555 , H01L2225/06589 , H01L2924/10156 , H01L2924/12042 , H01L2924/00012 , H01L2924/014 , H01L2924/0665 , H01L2924/00014 , H01L2224/81 , H01L2224/03 , H01L2224/11 , H01L2224/19 , H01L21/78 , H01L2924/00
摘要： The present invention relates to a semiconductor device packaged at the wafer level such that an entire packaged device is formed prior to separation of individual devices. The semiconductor device package includes a semiconductor chip having one or more bonding pads associated with the chip and a protective layer bonded over the semiconductor chip. An insulation layer is positioned on at least side edges and a lower surface of the semiconductor chip. Interconnection/bump metallization is positioned adjacent one or more side edges of the semiconductor chip and is electrically connected to at least one bonding pad. A compact image sensor package can be formed that is vertically integrated with a digital signal processor and memory chip along with lenses and a protective cover.
摘要翻译：本发明涉及在晶片级封装的半导体器件，使得在分离各个器件之前形成整个封装器件。半导体器件封装包括具有与芯片相关联的一个或多个焊盘和半导体芯片上粘合的保护层的半导体芯片。绝缘层位于半导体芯片的至少侧边缘和下表面上。互连/凸起金属化位于与半导体芯片的一个或多个侧边相邻并且与至少一个接合焊盘电连接。可以形成紧凑的图像传感器封装，其与数字信号处理器和存储器芯片一起与透镜和保护盖垂直集成。

6. 发明授权

US08576563B2 Handle for a touch screen computing device 有权
标题翻译：处理触摸屏计算设备
公开(公告)号：US08576563B2
公开(公告)日：2013-11-05
申请号：US12892052
申请日：2010-09-28
申请人： Dan Dan Yang , Cecile Lu , Zibin Lu
发明人： Dan Dan Yang , Cecile Lu , Zibin Lu
IPC分类号： H05K5/00 , H05K7/00 , B65D85/00
CPC分类号： G06F1/1626 , A45C2011/003 , A45F2200/0525 , A61J17/001 , A63H33/006 , G06F1/1656
摘要： A handle for a computing device having a touch screen, wherein the handle is affixed to the computing device, and the handle is made of material that is suitable for gripping by an infant and the handle is of a specific size range such that the handle is capable of being gripped by an infant.
摘要翻译：一种具有触摸屏的计算设备的手柄，其中所述手柄固定到所述计算设备，并且所述手柄由适于由婴儿抓握的材料制成，并且所述手柄具有特定尺寸范围，使得所述手柄是能够被婴儿抓住。

7. 发明申请

US20130244944A1 Synthetic Ion Channels 有权
标题翻译：合成离子通道
公开(公告)号：US20130244944A1
公开(公告)日：2013-09-19
申请号：US13731971
申请日：2012-12-31
申请人： Dan Yang , Xiang Li , Huiyan Zha
发明人： Dan Yang , Xiang Li , Huiyan Zha
IPC分类号： C07C335/16 , C07C259/06 , C07C275/28 , C07K5/062
CPC分类号： C07C335/16 , C07B2200/07 , C07C237/22 , C07C239/08 , C07C239/20 , C07C259/06 , C07C271/22 , C07C275/28 , C07D213/63 , C07D213/79 , C07D213/81 , C07K5/06034
摘要： Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
摘要翻译：本文提供了可以在脂质双层或细胞膜中形成离子通道的自组装化合物和包含自组装化合物的离子通道形成组合物。还提供了制造和使用由多个自组装化合物分子形成的离子通道的方法。此外，提供了治疗或预防与离子通道功能障碍（包括氯化物通道）相关的病症和疾病的方法。

8. 发明申请

US20120100518A1 TOUCH-SCREEN BASED INTERACTIVE GAMES FOR INFANTS AND TODDLERS 审中-公开
标题翻译：基于触屏的基于互动游戏的婴儿和老虎机
公开(公告)号：US20120100518A1
公开(公告)日：2012-04-26
申请号：US12908390
申请日：2010-10-20
申请人： Dan Dan Yang
发明人： Dan Dan Yang
IPC分类号： G09B5/00
CPC分类号： G09B5/00
摘要： Methods and software applications targeted to and for use by infant users. Various activities are presented to infant users through a touch-screen based monitor and, depending on the input entered by infant users, emotionally positive or emotionally negative indications are presented to the infant user. The emotionally positive indications are designed to reinforce desirable results caused by the infant user's input while the emotionally negative indications are designed to discourage undesirable result from the infant user's input. Various environments and activities based on these environments and areas are provided to the infant user by way of the monitor.
摘要翻译：针对婴幼儿用户使用的方法和软件应用程序。通过基于触摸屏的监视器向婴儿用户呈现各种活动，并且根据婴儿用户输入的输入，向婴儿用户呈现情绪上或情绪上的负面迹象。情绪积极的指示旨在加强由婴儿用户输入引起的理想结果，而情绪负面的指示被设计成阻止婴儿用户输入的不良结果。通过监视器向婴儿用户提供基于这些环境和区域的各种环境和活动。

9. 发明授权

US08148423B2 Fluorophore compounds 有权
标题翻译：荧光团化合物
公开(公告)号：US08148423B2
公开(公告)日：2012-04-03
申请号：US12417640
申请日：2009-04-03
申请人： Dan Yang , Tao Peng
发明人： Dan Yang , Tao Peng
IPC分类号： A61K31/352 , C07D311/78 , C07D407/02
CPC分类号： C07D493/10 , G01N33/582
摘要： Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.
摘要翻译：本文提供了可用作荧光标记和/或荧光探针的罗丹明和罗丹明化合物的荧光团化合物及其制备方法。本文还提供了可用于跟踪，测量，检测或筛选生物物种如蛋白质，DNA，酶，抗体，细胞器，细胞，组织，药物，激素，核苷酸，核酸，多糖或脂质在生物中的方法生物体。具体地说，这些方法包括使本文公开的任何荧光团化合物，罗丹明化合物和罗丹明化合物与生物物质接触以形成一种或多种荧光化合物，并测量荧光化合物的荧光性质的步骤。本文还提供了用于检测或筛选生物物种的高通量筛选荧光方法。

10. 发明授权

US07895062B2 System for optimization of insurance underwriting suitable for use by an automated system 有权
标题翻译：适用于自动化系统的保险承保优化制度
公开(公告)号：US07895062B2
公开(公告)日：2011-02-22
申请号：US10173039
申请日：2002-06-18
申请人： Piero Patrone Bonissone , Richard Paul Messmer , Angela Neff Patterson , Dan Yang , Marc Pavese , Rajesh Venkat Subbu , Kareem Sherif Aggour
发明人： Piero Patrone Bonissone , Richard Paul Messmer , Angela Neff Patterson , Dan Yang , Marc Pavese , Rajesh Venkat Subbu , Kareem Sherif Aggour
IPC分类号： G06Q40/00 , G06Q10/00 , G06Q50/00
CPC分类号： G06Q10/10 , G06Q40/08 , G06Q50/22
摘要： A robust system for automating the tuning and maintenance of decision-making systems is described. A configurable multi-stage mutation-based evolutionary algorithm optimally tunes the decision thresholds and internal parameters of fuzzy rule-based and case-based systems that decide the risk categories of insurance applications. The tunable parameters have a critical impact on the coverage and accuracy of decision-making, and a reliable method to optimally tune these parameters is critical to the quality of decision-making and maintainability of these systems.
摘要翻译：描述了用于自动化决策系统的调整和维护的强大系统。可配置的基于多阶段突变的进化算法最佳地调整了基于模糊规则和基于案例的系统的决策阈值和内部参数，以决定保险应用的风险类别。可调参数对决策的覆盖面和准确性有重要的影响，而对这些参数进行最佳调优的可靠方法对于这些系统的决策和维护的质量至关重要。

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