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1. 发明授权

US09417237B2 Biosample plate with data storage and wireless communication means 有权
标题翻译：具有数据存储和无线通信手段的Biosample板
公开(公告)号：US09417237B2
公开(公告)日：2016-08-16
申请号：US13151265
申请日：2011-06-01
申请人： Nils Haustein , Thorsten Krause , Anna Wanda Topol , Daniel James Winarski
发明人： Nils Haustein , Thorsten Krause , Anna Wanda Topol , Daniel James Winarski
IPC分类号： B01L3/00 , G01N33/553 , G01N35/00 , G01N33/487 , G06F3/06
CPC分类号： G01N35/00732 , B01L3/50 , B01L3/508 , B01L3/5085 , B01L3/545 , B01L2200/025 , B01L2200/10 , B01L2300/021 , B01L2300/023 , B01L2300/024 , B01L2300/0809 , G01N33/48792 , G01N33/553 , G01N35/00029 , G01N35/00871 , G01N2035/00019 , G01N2035/00089 , G01N2035/00099 , G01N2035/00841 , G06F3/061 , G06F3/0661 , G06F3/0676
摘要： Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.
摘要翻译：本公开的实施例涉及一种生物样本板，其包括用于存储与生物样本，生物样本板和生物样本分析数据相关的信息的存储器组件，以及用于向生物样本板传送信息的无线通信接口。生物样本板可以与诸如电磁带驱动器的分析和数据记录系统一起使用。所公开的生物样品板有利于大量生物样本板和数据之间的相关性，因为当生物样本板正在使用时以及当它们处于储存状态时，数据保留在相应的生物样本上。无线通信接口可以包括设置在生物样本板中的天线，用于通过无线电信号传送到和从生物样本板的数据传输。

2. 发明授权

US09286914B2 Cartridge for storing biosample capillary tubes and use in automated data storage systems 有权
标题翻译：用于存储生物样品毛细管的墨盒，用于自动数据存储系统
公开(公告)号：US09286914B2
公开(公告)日：2016-03-15
申请号：US13151247
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
IPC分类号： C40B60/04 , G11B5/008 , A61B10/00 , G11B23/04 , B01L9/06 , A61B5/15 , G01N35/00 , G01N35/04
CPC分类号： B01L9/065 , A61B5/150305 , A61B10/0096 , B01L2300/0809 , B01L2300/0812 , G01N35/00029 , G01N35/00732 , G01N35/0099 , G01N2035/00762 , G01N2035/00801 , G01N2035/0425 , G11B5/00821 , G11B23/049 , H04B7/24
摘要： Embodiments of the disclosure relate to a cartridge that includes slots for storing biosample capillary tubes. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a cartridge comprising an enclosure that includes a movable door to provide access to a tube holder in the enclosure. The tube holder includes cylindrical holes or slots for receiving capillary tubes which contain biosamples scanned and analyzed an automated tape library.
摘要翻译：本公开的实施例涉及一种盒，其包括用于存储生物样品毛细管的槽。墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。本公开的一个方面涉及一种盒，其包括包括可移动门的外壳，以提供对外壳中的管座的接近。管支架包括用于接收毛细管的圆柱形孔或槽，其包含扫描并分析了自动化磁带库的生物样本。

3. 发明授权

US09034660B2 Detection of analytes via nanoparticle-labeled substances with electromagnetic read-write heads 有权
标题翻译：通过具有电磁读写头的纳米颗粒标记物质检测分析物
公开(公告)号：US09034660B2
公开(公告)日：2015-05-19
申请号：US12888388
申请日：2010-09-22
申请人： Dylan Joseph Boday , Lee Curtis Randall , Stephen Leonard Schwartz , Anna W. Topol , Daniel James Winarski
发明人： Dylan Joseph Boday , Lee Curtis Randall , Stephen Leonard Schwartz , Anna W. Topol , Daniel James Winarski
IPC分类号： G01N33/553 , G01N33/543 , B82Y15/00
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/54326 , G01N33/54333
摘要： A first set of antibodies are bonded to a substrate, and are exposed to and bonded with target antigens. A second set of antibodies are bonded to nanoparticles, and the nanoparticle labeled antibodies are exposed to the targeted antigens. An electromagnetic write-head magnetizes the nanoparticles, and then a read-sensor detects the freshly magnetized nanoparticles. The substrate comprises a flexible film or a Peltier material to allow selective heating and cooling of the antigens and antibodies. Nanoparticles of different magnetic properties may be selectively paired with antibodies associated with different antigens to allow different antigens to be detected upon a single scan by the read-sensor.
摘要翻译：将第一组抗体与底物结合，并暴露于靶抗原并与靶抗原结合。将第二组抗体与纳米颗粒结合，并将纳米颗粒标记的抗体暴露于靶抗原。电磁写头磁化纳米颗粒，然后读取传感器检测新磁化的纳米颗粒。底物包括柔性膜或珀尔帖材料，以允许选择性加热和冷却抗原和抗体。不同磁性的纳米颗粒可以与与不同抗原相关的抗体选择性配对，以允许在读取传感器进行单次扫描时检测不同的抗原。

4. 发明授权

US08694280B2 Servo control circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads 有权
标题翻译：用于通过具有电磁读写头的纳米颗粒标记物质检测分析物的伺服控制电路
公开(公告)号：US08694280B2
公开(公告)日：2014-04-08
申请号：US12888403
申请日：2010-09-22
申请人： Tara L. Awezec , Dylan Joseph Boday , Stephen Leonard Schwartz , Anna W. Topol , Daniel James Winarski
发明人： Tara L. Awezec , Dylan Joseph Boday , Stephen Leonard Schwartz , Anna W. Topol , Daniel James Winarski
IPC分类号： G01C9/00
CPC分类号： G01N33/54346 , B82Y15/00 , G01N33/54326 , G01N33/54333
摘要： A circuit for controlling an electromagnetic head module to detect antigens on a biosample track comprising a processor for receiving position-error-servo signal from the PES read sensor, a write head for magnetizing nanoparticles attached to antigens, and a read sensor for detecting the nanoparticle-labeled antigens. The circuit may further comprise an X-axis actuator for controlling the head module in the direction perpendicular to the track and an Y-axis actuator coupled to the head module and the X-axis actuator for controlling the head module in the direction of the track. Target antigens are attached to the biosample track and nanoparticles via antibodies.
摘要翻译：一种用于控制电磁头模块以检测生物样本轨道上的抗原的电路，包括用于从PES读取传感器接收位置误差伺服信号的处理器，用于磁化附着于抗原的纳米颗粒的写入头和用于检测纳米颗粒的读取传感器标记的抗原。电路还可以包括用于在垂直于轨道的方向上控制头模块的X轴致动器，以及耦合到头模块的Y轴致动器和用于在轨道方向上控制头模块的X轴致动器。靶抗原通过抗体连接到生物样品轨道和纳米颗粒上。

5. 发明授权

US08542991B2 Power-up of device via optical serial interface 有权
标题翻译：通过光串行接口上电设备
公开(公告)号：US08542991B2
公开(公告)日：2013-09-24
申请号：US13453654
申请日：2012-04-23
申请人： Louie Arthur Dickens , Timothy A Johnson , Craig Anthony Klein , Gregg Steven Lucas , Daniel James Winarski
发明人： Louie Arthur Dickens , Timothy A Johnson , Craig Anthony Klein , Gregg Steven Lucas , Daniel James Winarski
IPC分类号： H04B10/08 , H04B17/00 , H04B10/00 , H04J14/00
CPC分类号： H04B10/40
摘要： An optical communication serial interface is employed to power up a device from a powered down state to a powered on state. An optical receiver element receives serial optical signals transmitted by at least one optical fiber and converts the received serial optical signals to electrical signals. A low level reception converter detects and decodes the electrical signals to provide data and control words from detected and decoded normal electrical signals for a high level command processor. A power supply maintains low level power to at least the optical receiver element and the low level reception converter of the optical communication serial interface while the device is in the powered down state. The low level reception converter detects a particular abnormal sequence of electrical signals; and in response to detecting the particular abnormal sequence of electrical signals, asserts a control signal to power up the device controllable power supply.
摘要翻译：采用光通信串行接口将设备从掉电状态加电到上电状态。光接收器元件接收由至少一个光纤传输的串行光信号，并将接收到的串行光信号转换为电信号。低电平接收转换器检测并解码电信号，以提供来自用于高级命令处理器的检测和解码的正常电信号的数据和控制字。当设备处于掉电状态时，电源至少保持光接收器元件和光通信串行接口的低电平接收转换器的低电平功率。低电平接收转换器检测电信号的特定异常序列; 并且响应于检测到电信号的特定异常序列，断言控制信号以使设备可控电源上电。

6. 发明申请

US20120310550A1 IDENTIFICATION OF MOLECULES BASED ON FREQUENCY RESPONSES USING ELECTROMAGNETIC WRITE-HEADS AND MAGNETO-RESISTIVE SENSORS 有权
标题翻译：基于使用电磁写头和磁电阻传感器的频率响应的分子鉴定
公开(公告)号：US20120310550A1
公开(公告)日：2012-12-06
申请号：US13151258
申请日：2011-06-01
申请人： Allen Keith Bates , Anna Wanda Topol , Daniel James Winarski
发明人： Allen Keith Bates , Anna Wanda Topol , Daniel James Winarski
IPC分类号： G06F19/00
CPC分类号： G01R33/091 , G01N27/72 , G01R33/093 , G01R33/1269
摘要： The invention relates to the identification of molecules using electromagnetic write-heads and magneto-resistive sensors. In one embodiment, an electromagnetic write-head magnetically excites a molecule with an alternating magnetic field. A magneto-resistive sensor measures the resonant response of the magnetically excited molecule. A processor compares the resonant response to a table of known responses of different molecules to identify the chemical composition of the target molecule.
摘要翻译：本发明涉及使用电磁写入头和磁阻传感器识别分子。在一个实施例中，电磁写头磁性激发具有交变磁场的分子。磁阻传感器测量磁激发分子的共振响应。处理器将共振响应与不同分子的已知响应表进行比较，以鉴定目标分子的化学组成。

7. 发明申请

US20120309297A1 CARTRIDGE FOR STORING BIOSAMPLE CAPILLARY TUBES AND USE IN AUTOMATED DATA STORAGE SYSTEMS 有权
标题翻译：用于存储生物柴油毛细管的盒子和用于自动数据存储系统
公开(公告)号：US20120309297A1
公开(公告)日：2012-12-06
申请号：US13151247
申请日：2011-06-01
申请人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
发明人： Allen Keith Bates , Nils Haustein , James William Johnson , Thorsten Krause , Stephen Leonard Schwartz , Anna Wanda Topol , Ulf Troppens , Daniel James Winarski
IPC分类号： B01L9/06 , H04B10/10 , G11B5/008 , H04W4/00
CPC分类号： B01L9/065 , A61B5/150305 , A61B10/0096 , B01L2300/0809 , B01L2300/0812 , G01N35/00029 , G01N35/00732 , G01N35/0099 , G01N2035/00762 , G01N2035/00801 , G01N2035/0425 , G11B5/00821 , G11B23/049 , H04B7/24
摘要： Embodiments of the disclosure relate to a cartridge that includes slots for storing biosample capillary tubes. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a cartridge comprising an enclosure that includes a movable door to provide access to a tube holder in the enclosure. The tube holder includes cylindrical holes or slots for receiving capillary tubes which contain biosamples scanned and analyzed an automated tape library.
摘要翻译：本公开的实施例涉及一种盒，其包括用于存储生物样品毛细管的槽。墨盒具有与数据磁带盒相同的外形尺寸，以使墨盒能够通过处理自动磁带库中数据墨盒的相同机器人机构来处理。本公开的一个方面涉及一种盒，其包括包括可移动门的外壳，以提供对外壳中的管座的接近。管支架包括用于接收毛细管的圆柱形孔或槽，其包含扫描并分析了自动化磁带库的生物样本。

8. 发明申请

US20120283976A1 'Method for Calibrating Read Sensors of Electromagnetic Read-Write Heads' 有权
标题翻译： “电磁读写头读取传感器校准方法”
公开(公告)号：US20120283976A1
公开(公告)日：2012-11-08
申请号：US13099360
申请日：2011-05-03
申请人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
发明人： David Berman , Dylan Joseph Boday , Icko E.T. Iben , Wayne Isami Imaino , Stephen Leonard Schwartz , Anna Wanda Topol , Daniel James Winarski
IPC分类号： G06F19/00
CPC分类号： G01R35/00 , G01N27/04 , G01N27/72 , G01N33/53 , G01R33/0035 , G01R33/1207
摘要： Described are embodiments to ensure that the equipment utilized to detect antigens is reliable and accurate. If it is determined that a read sensor is degraded a method of calibrating a read sensor of a read head is described. In one embodiment, a method of calibrating a magnetic read sensor includes measuring a first resistance of the magnetic read sensor upon an application of a forward bias current to the magnetic read sensor and measuring a second resistance of the magnetic read sensor upon an application of a reverse bias current to the magnetic read sensor. A calibration constant is determined based on at least the first measured resistance and the second measured resistance. In one embodiment the method further includes storing the determined calibration constant for the magnetic read sensor in memory. Further, in one embodiment the head module having the magnetic read sensor is swept over at least one nanoparticle to obtain a read response of the magnetic read sensor to the nanoparticle. The read response from the magnetic read sensor of the at least one nanoparticle is adjusted based on the determined calibration constant. Calibration of each individual read sensor allows for uniform read responses from each of the read sensors on a read head, and prevents unreliable an inaccurate detection of analytes due to sensor degradation.
摘要翻译：描述了确保用于检测抗原的设备是可靠和准确的实施方案。如果确定读取传感器劣化，则描述校准读取头的读取传感器的方法。在一个实施例中，一种校准磁性读取传感器的方法包括：在向磁性读取传感器施加正向偏置电流时测量磁性读取传感器的第一个电阻，并测量磁性读取传感器的应用时的第二个电阻反向偏置电流到磁性读取传感器。基于至少第一测量电阻和第二测量电阻来确定校准常数。在一个实施例中，该方法还包括将所确定的磁读取传感器的校准常数存储在存储器中。此外，在一个实施例中，具有磁读取传感器的头模块扫过至少一个纳米颗粒，以获得磁读取传感器对纳米颗粒的读取响应。基于所确定的校准常数来调整来自至少一个纳米颗粒的磁读取传感器的读取响应。每个单独的读取传感器的校准允许来自读取头上的每个读取传感器的均匀的读取响应，并且防止由于传感器劣化而导致的分析物不可靠的检测不可靠。

9. 发明授权

US08245113B2 Convolution-encoded RAID with trellis-decode-rebuild 有权
标题翻译：卷积编码的RAID与格状解码重建
公开(公告)号：US08245113B2
公开(公告)日：2012-08-14
申请号：US12115455
申请日：2008-05-05
申请人： Daniel James Winarski , Craig A. Klein , Nils Haustein
发明人： Daniel James Winarski , Craig A. Klein , Nils Haustein
IPC分类号： G11C29/00
CPC分类号： G06F11/1088
摘要： A Redundant Array of Independent Devices uses convolution encoding to provide redundancy of the striped data written to the devices. No parity is utilized in the convolution encoding process. Trellis decoding is used for both reading the data from the RAID and for rebuilding missing encoded data from one or more failed devices, based on a minimal, and preferably zero, Hamming distance for selecting the connected path through the trellis diagram.
摘要翻译：独立设备的冗余阵列使用卷积编码来提供写入设备的条带数据的冗余。在卷积编码过程中没有使用奇偶校验。基于用于选择通过网格图的连接路径的最小且优选为零的汉明距离，网格解码用于从RAID读取数据和从一个或多个故障设备重建丢失的编码数据。

10. 发明授权

US08180950B2 Apparatus and method to manage information using an optical and holographic data storage medium 失效
标题翻译：使用光学和全息数据存储介质来管理信息的设备和方法
公开(公告)号：US08180950B2
公开(公告)日：2012-05-15
申请号：US11763913
申请日：2007-06-15
申请人： Allen Keith Bates , Susan Encinas , Daniel James Winarski
发明人： Allen Keith Bates , Susan Encinas , Daniel James Winarski
IPC分类号： G11C13/04
CPC分类号： G03H1/30 , G03H1/02 , G03H1/0252 , G03H1/2249 , G03H2001/2244 , G03H2001/2615 , G03H2210/20 , G03H2210/22 , G03H2250/34 , G03H2270/22 , G11B7/24041 , G11B7/24044 , G11B2007/0006
摘要： A hybrid optical and holographic data storage medium is disclosed. In addition, a method is disclosed to manage information using that optical and holographic data storage medium. The method reads information from the optical data storage layer before reading data from, or writing data to, the holographic data storage layer.
摘要翻译：公开了一种混合光学和全息数据存储介质。此外，公开了一种使用该光学和全息数据存储介质来管理信息的方法。该方法在从全息数据存储层读取数据或将数据写入全息数据存储层之前从光学数据存储层读取信息。

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