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1. 发明授权

US07115396B2 Protein scaffolds for antibody mimics and other binding proteins 有权
标题翻译：用于抗体模拟物和其他结合蛋白的蛋白质支架
公开(公告)号：US07115396B2
公开(公告)日：2006-10-03
申请号：US10728078
申请日：2003-12-03
申请人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
发明人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
IPC分类号： A61K38/00
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含免疫球蛋白折叠并且可以用作支架的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

2. 发明申请

US20050255548A1 Protein scaffolds for antibody mimics and other binding proteins 审中-公开
标题翻译：用于抗体模拟物和其他结合蛋白的蛋白质支架
公开(公告)号：US20050255548A1
公开(公告)日：2005-11-17
申请号：US10989723
申请日：2004-11-15
申请人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
发明人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
IPC分类号： G06Q50/00 , C07H21/04 , C07K14/745 , C07K14/78 , C07K16/24 , C12N15/10 , C12N15/62 , C12P21/06 , C12Q1/00 , C40B40/02 , G06Q10/00
CPC分类号： C12N15/1037 , C07K14/78 , C07K16/241 , C07K2317/21 , C07K2318/20 , C07K2319/30 , C12N15/62 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含具有至少一个随机化环的纤连蛋白III型结构域的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

3. 发明授权

US09605039B2 Protein scaffolds for antibody mimics and other binding proteins 有权
公开(公告)号：US09605039B2
公开(公告)日：2017-03-28
申请号：US11543316
申请日：2006-10-03
申请人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
发明人： Dasa Lipovsek , Richard W. Wagner , Robert G. Kuimelis
IPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/24 , C12N15/10 , C12Q1/00 , C40B40/02
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.

4. 发明授权

US09347058B2 Methods for the selection of binding proteins 有权
标题翻译：选择结合蛋白的方法
公开(公告)号：US09347058B2
公开(公告)日：2016-05-24
申请号：US14117689
申请日：2012-05-16
申请人： Dasa Lipovsek
发明人： Dasa Lipovsek
IPC分类号： C40B30/04 , C12N15/10 , G01N33/68
CPC分类号： C12N15/1037 , C40B30/04 , G01N33/6845
摘要： This application provides an improved screening method for the selection of target-binding proteins having desirable biophysical properties. The method combines mRNA display and yeast surface display in a way that takes advantage of the desirable attributes of both processes.
摘要翻译：该应用提供了选择具有所需生物物理性质的靶结合蛋白的改进的筛选方法。该方法结合mRNA显示和酵母表面显示，以利用两个过程的期望属性。

5. 发明授权

US08420098B2 Fibronectin based scaffold domain proteins that bind to PCSK9 有权
标题翻译：结合PCSK9的基于纤连蛋白的支架结构域蛋白
公开(公告)号：US08420098B2
公开(公告)日：2013-04-16
申请号：US13085864
申请日：2011-04-13
申请人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
发明人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
IPC分类号： A61K39/00 , C07K1/00
CPC分类号： C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
摘要： The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
摘要翻译：本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。本发明还涉及包含这种蛋白质的细胞，编码这些蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。

6. 发明申请

US20050038229A1 Protein scaffolds for antibody mimics and other binding proteins 有权
标题翻译：用于抗体模拟物和其他结合蛋白的蛋白质支架
公开(公告)号：US20050038229A1
公开(公告)日：2005-02-17
申请号：US10728078
申请日：2003-12-03
申请人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
发明人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
IPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/24 , C12N15/10 , C12Q1/00 , C40B40/02 , C07K16/18
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含免疫球蛋白折叠并且可以用作支架的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

7. 发明申请

US20110117625A1 Engineered Nucleases and Their Uses for Nucleic Acid Assembly 有权
标题翻译：工程核酸酶及其用于核酸装配的用途
公开(公告)号：US20110117625A1
公开(公告)日：2011-05-19
申请号：US12596546
申请日：2008-04-19
申请人： Shaun Lippow , Dasa Lipovsek , Patricia M. Aha
发明人： Shaun Lippow , Dasa Lipovsek , Patricia M. Aha
IPC分类号： C12N9/16 , C07H21/04
CPC分类号： C12N9/22 , C12N15/62
摘要： Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.
摘要翻译：本发明的方面提供了工程化内切核酸酶，其特征在于识别位点之外的长识别序列和特异性切割。本发明的工程化内切核酸酶可用于操作长的DNA片段。

8. 发明申请

US20080064610A1 Nucleic acid library design and assembly 审中-公开
标题翻译：核酸库设计和装配
公开(公告)号：US20080064610A1
公开(公告)日：2008-03-13
申请号：US11804891
申请日：2007-05-21
申请人： Dasa Lipovsek , Brian Baynes
发明人： Dasa Lipovsek , Brian Baynes
IPC分类号： C40B50/06
CPC分类号： C12N15/1044 , C12N15/10 , C12N15/66
摘要： Aspects of the invention relate to the design and synthesis of nucleic acid libraries. Certain embodiments relate to the design and synthesis of nucleic acid libraries that express polypeptides. In some embodiments, the invention provides methods for analyzing polypeptide sequences and identifying those that may confer undesirable properties in vivo (e.g., poor solubility, high immunogenicity, low stability, etc.). In some embodiments, the invention provides methods for synthesizing a library of nucleic acids having predetermined sequences (e.g., a library of nucleic acids that encode polypeptides having related sequences with predetermined sequence variations).
摘要翻译：本发明的方面涉及核酸文库的设计和合成。某些实施方案涉及表达多肽的核酸文库的设计和合成。在一些实施方案中，本发明提供了分析多肽序列并鉴定可能在体内赋予不期望的性质（例如，差的溶解性，高免疫原性，低稳定性等）的方法。在一些实施方案中，本发明提供了合成具有预定序列的核酸文库（例如，编码具有预定序列变异的相关序列的多肽的核酸文库）的方法。

9. 发明申请

US20080015339A1 High affinity fibronectin derivatives 审中-公开
标题翻译：高亲和力纤连蛋白衍生物
公开(公告)号：US20080015339A1
公开(公告)日：2008-01-17
申请号：US11890645
申请日：2007-08-06
申请人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
发明人： Dasa Lipovsek , Richard Wagner , Robert Kuimelis
IPC分类号： C07K14/78
CPC分类号： C07K14/47 , C07K14/525 , C07K14/78 , C07K16/00 , C07K16/241 , C07K2317/22 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C12N15/1037 , C12Q1/00 , C40B40/02
摘要： Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
摘要翻译：本文公开了包含免疫球蛋白折叠并且可以用作支架的蛋白质。本文还公开了编码这种蛋白质的核酸以及这些蛋白质在诊断方法中的应用和用于进化新型化合物结合物种及其配体的方法。

10. 发明申请

US20050079546A1 Serum albumin scaffold-based proteins and uses thereof 审中-公开
标题翻译：血清白蛋白支架蛋白及其用途
公开(公告)号：US20050079546A1
公开(公告)日：2005-04-14
申请号：US10838311
申请日：2004-05-03
申请人： Dasa Lipovsek , Lin Sun , Alexander Kovtun
发明人： Dasa Lipovsek , Lin Sun , Alexander Kovtun
IPC分类号： C07K14/765 , G01N33/53 , G01N33/543
CPC分类号： C07K14/765
摘要： Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.
摘要翻译：本文公开了源自血清白蛋白支架的候选结合蛋白的文库，可从其中选择对已知和未知靶特异的有用结合蛋白。本文还公开了用于选择具有所需结合特征的基于血清白蛋白支架的候选结合蛋白的方法。

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