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1. 发明申请

US20070036793A1 Methods for use of an lkb1/strad7mo25 complex 审中-公开
标题翻译：使用lkb1 / strad7mo25复合物的方法
公开(公告)号：US20070036793A1
公开(公告)日：2007-02-15
申请号：US10565058
申请日：2004-07-16
申请人： David Hardie , Dario Alessi , Jerome Boudeau
发明人： David Hardie , Dario Alessi , Jerome Boudeau
IPC分类号： A61K39/395 , G01N33/53 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , C07K14/82
摘要： A method for identifying a compound for use in modulating, for example promoting, the activation or phosphorylation of AMPK (AMP-activated protein kinase) or AMPK subfamily member in a cell, the method comprising the steps of (1) determining whether a test compound modulates, for example promotes, the protein kinase activity of LKB1 and (2) selecting a compound which modulates, for example promotes, the protein kinase activity of LKB1. The protein kinase activity may be tested using AMPK or an AMPK subfamily member, or a peptide encompassing the T-loop region of AMPK or an AMPK subfamily member. The LKB1 may be in a preparation or complex with STRAD and/or M025, which has much greater kinase activity than LKB1 in the absence of these accessory proteins. The LKB1, STRAD or M025 may be recombinant. The AMPK subfamily member may be AMPKα1, AMPKα2, NUAK1, NUAK2, BRSK1, BRSK2, SIK, QIK, QSK, MARK1, MARK2, MARK3, MARK4 or MELK.
摘要翻译：一种用于鉴定用于调节例如促进细胞中AMPK（AMP-活化蛋白激酶）或AMPK亚族成员的活化或磷酸化的化合物的方法，所述方法包括以下步骤：（1）确定测试化合物调节，例如促进LKB1的蛋白激酶活性，和（2）选择调节，例如促进LKB1的蛋白激酶活性的化合物。可以使用AMPK或AMPK亚族成员或包含AMPK的T环区域或AMPK亚族成员的肽来测试蛋白激酶活性。 LKB1可能与STRAD和/或M025的制备或复合物相比，在没有这些辅助蛋白质的情况下，其具有比LKB1大得多的激酶活性。 LKB1，STRAD或M025可以是重组的。 AMPK亚族成员可以是AMPKalpha1，AMPKalpha2，NUAK1，NUAK2，BRSK1，BRSK2，SIK，QIK，QSK，MARK1，MARK2，MARK3，MARK4或MELK。

2. 发明申请

US20070095546A1 Lubricator valve with rotational flip-flap arm 有权
标题翻译：带旋转翻盖臂的润滑阀
公开(公告)号：US20070095546A1
公开(公告)日：2007-05-03
申请号：US11604509
申请日：2006-11-27
申请人： Graham Farquhar , David Hardie
发明人： Graham Farquhar , David Hardie
IPC分类号： E21B34/10
CPC分类号： E21B33/068 , E21B34/102 , E21B34/14 , E21B2034/005
摘要： An improved lubricator valve arrangement for use within a wellbore to allow the passage of tools, such as perforating guns and the like, into the wellbore while it is live. The inclusion of two, independently controllable flapper-type safety valves within the lubricator valve will permit coordinated testing of fluid pressure both above and below the lubricator valve. The upper flapper valve includes a rotational flip-flap arm arrangement to positively open and close the upper flapper valve. The lower flapper valve is equipped with an integrated poppet-style pressure equalizing valve to allow the lower flapper valve to be opened more easily. The direction of opening of the flapper valves precludes or reduces the risk debris-related problems that might prevent or hinder opening of the flapper valves.
摘要翻译：一种改进的润滑器阀装置，用于在井筒内使用，以允许诸如穿孔枪等的工具在其活着时进入井眼。在润滑器阀门内包含两个可独立控制的挡板式安全阀，将允许对润滑器阀门上下两侧的流体压力进行协调测试。上挡板阀包括用于主动地打开和关闭上挡板阀的旋转翻盖臂装置。下挡板阀配有一个集成的提升式压力平衡阀，以便更轻松地打开下挡板阀。挡板阀的打开方向排除或减少可能阻止或阻碍挡板阀打开的风险碎片相关问题。

3. 发明申请

US20100148799A1 INDUCTIVE PROXIMITY SENSOR AND RELATED METHODS 失效
标题翻译：感应近似传感器及相关方法
公开(公告)号：US20100148799A1
公开(公告)日：2010-06-17
申请号：US12716030
申请日：2010-03-02
申请人： David Hardie
发明人： David Hardie
IPC分类号： G01R27/28
CPC分类号： H03K17/9547 , H03K17/9512 , H03K2217/94026 , Y10T29/49105 , Y10T307/826
摘要： An inductive proximity sensor or switch and a method of using same. The sensor or switch includes an Application Specific Integrated Circuit (“ASIC”) and a plurality of external components. The ASIC is implemented in CMOS technology and has an oscillator. A switch point of the sensor or switch is predetermined by selection of a bias voltage to a potential node of the oscillator.
摘要翻译：感应式接近传感器或开关及其使用方法。传感器或开关包括专用集成电路（“ASIC”）和多个外部组件。 ASIC采用CMOS技术实现，并具有振荡器。通过选择对振荡器的电位节点的偏置电压来预先确定传感器或开关的切换点。

4. 发明授权

US07969141B2 Inductive proximity sensor and related methods 失效
标题翻译：感应式接近传感器及相关方法
公开(公告)号：US07969141B2
公开(公告)日：2011-06-28
申请号：US12716030
申请日：2010-03-02
申请人： David Hardie
发明人： David Hardie
IPC分类号： G01B7/14
CPC分类号： H03K17/9547 , H03K17/9512 , H03K2217/94026 , Y10T29/49105 , Y10T307/826
摘要： An inductive proximity sensor or switch and a method of using same. The sensor or switch includes an Application Specific Integrated Circuit (“ASIC”) and a plurality of external components. The ASIC is implemented in CMOS technology and has an oscillator. A switch point of the sensor or switch is predetermined by selection of a bias voltage to a potential node of the oscillator.
摘要翻译：感应式接近传感器或开关及其使用方法。传感器或开关包括专用集成电路（“ASIC”）和多个外部组件。 ASIC采用CMOS技术实现，并具有振荡器。通过选择对振荡器的电位节点的偏置电压来预先确定传感器或开关的切换点。

5. 发明授权

US07719262B2 Inductive proximity sensor and related methods 有权
标题翻译：感应式接近传感器及相关方法
公开(公告)号：US07719262B2
公开(公告)日：2010-05-18
申请号：US10345206
申请日：2003-01-16
申请人： David Hardie
发明人： David Hardie
IPC分类号： G01B7/14
CPC分类号： H03K17/9547 , H03K17/9512 , H03K2217/94026 , Y10T29/49105 , Y10T307/826
摘要： An inductive proximity sensor or switch and a method of using same. The sensor or switch includes an Application Specific Integrated Circuit (“ASIC”) and a plurality of external components. The ASIC is implemented in CMOS technology and has an oscillator. A switch point of the sensor or switch is predetermined by selection of a bias voltage to a potential node of the oscillator.
摘要翻译：感应式接近传感器或开关及其使用方法。传感器或开关包括专用集成电路（“ASIC”）和多个外部组件。 ASIC采用CMOS技术实现，并具有振荡器。通过选择对振荡器的电位节点的偏置电压来预先确定传感器或开关的切换点。

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