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1. 发明授权

US08426414B2 Modulators of G protein-coupled receptor 88 有权
公开(公告)号：US08426414B2
公开(公告)日：2013-04-23
申请号：US12897004
申请日：2010-10-04
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
IPC分类号： C07D213/56 , C07D241/12 , A61K31/4418 , A61K31/4965 , A61P25/00
CPC分类号： C07D213/56 , C07D241/12
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

2. 发明申请

US20130097537A1 CUSTOMIZED USER INTERFACE FOR SUBORDINATE USERS 有权
标题翻译：自定义用户界面用于次要用户
公开(公告)号：US20130097537A1
公开(公告)日：2013-04-18
申请号：US13613825
申请日：2012-09-13
申请人： Jeffrey David Kimball , John Thurston Wassom, JR. , Christina Ann Rank Dolan
发明人： Jeffrey David Kimball , John Thurston Wassom, JR. , Christina Ann Rank Dolan
IPC分类号： G06F3/0481
CPC分类号： G06F3/048 , G06F3/0481 , G06F3/0484 , G06F17/30867 , G06F17/30899 , Y10S707/99939 , Y10S707/99943
摘要： A user interface including one or more references to content is customized. Several user profiles are provided from which a user may be associated. Each user profile includes user profile information. The user profile associated with a user to whom a user interface will be provided is accessed. A user interface is configured for the user, based at least in part upon the user profile accessed as being associated with the user. Access to content is enabled based on user manipulation of the configured user interface.
摘要翻译：包括对内容的一个或多个引用的用户界面被定制。提供了几个用户简档，用户可以从其中关联。每个用户简档包括用户简档信息。访问与要提供用户界面的用户相关联的用户简档。至少部分地基于被访问为与用户相关联的用户简档来为用户配置用户界面。基于用户操作配置的用户界面启用对内容的访问。

3. 发明申请

US20130097536A1 CUSTOMIZING USER INTERFACES 有权
标题翻译：自定义用户界面
公开(公告)号：US20130097536A1
公开(公告)日：2013-04-18
申请号：US13613763
申请日：2012-09-13
申请人： Jeffrey David Kimball , John Thurston Wassom, JR. , Christina Ann Rank Dolan
发明人： Jeffrey David Kimball , John Thurston Wassom, JR. , Christina Ann Rank Dolan
IPC分类号： G06F3/048
CPC分类号： G06F3/048 , G06F3/0481 , G06F3/0484 , G06F17/30867 , G06F17/30899 , Y10S707/99939 , Y10S707/99943
摘要： A user interface including one or more references to content is customized. Several user profiles are provided from which a user may be associated. Each user profile includes user profile information. The user profile associated with a user to whom a user interface will be provided is accessed. A user interface is configured for the user, based at least in part upon the user profile accessed as being associated with the user. Access to content is enabled based on user manipulation of the configured user interface.
摘要翻译：包括对内容的一个或多个引用的用户界面被定制。提供了几个用户简档，用户可以从其中关联。每个用户简档包括用户简档信息。访问与要提供用户界面的用户相关联的用户简档。至少部分地基于被访问为与用户相关联的用户简档，为用户配置用户界面。基于用户操作配置的用户界面启用对内容的访问。

4. 发明申请

US20090042893A1 KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE 有权
标题翻译：激素抑制剂，包含它们的组合物及其使用方法
公开(公告)号：US20090042893A1
公开(公告)日：2009-02-12
申请号：US12188515
申请日：2008-08-08
申请人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
发明人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins , Dennis S. Rice , Michael Victor Voronkov , Yulian Zhang
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/497 , A61P27/02
CPC分类号： C07D487/04 , C07D519/00
摘要： Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use.
摘要翻译：公开了LIM激酶2的抑制剂，以及包含它们的药物组合物及其使用方法。

5. 发明申请

US20080113922A1 INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE 有权
标题翻译： SODIUM GLUCOSE CO-TRANSPORTER 2的抑制剂及其使用方法
公开(公告)号：US20080113922A1
公开(公告)日：2008-05-15
申请号：US11862690
申请日：2007-09-27
申请人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins
发明人： Bryce Alden Harrison , Spencer David Kimball , Ross Mabon , David Brent Rawlins
IPC分类号： A61K31/7008 , A61K31/7052 , A61K31/445 , C07H17/02 , C07D211/40
CPC分类号： A61K31/7028 , A61K31/7032 , C07D211/46 , C07D309/10 , C07D335/02 , C07D407/12 , C07H7/04 , C07H15/14
摘要： Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
摘要翻译：公开了包含它们的化合物和药物组合物，其可用于治疗诸如糖尿病和肥胖症的疾病和病症。

6. 发明授权

US06613911B2 Process for preparing arylacetylaminothiazoles 有权
标题翻译：制备芳基乙酰氨基噻唑的方法
公开(公告)号：US06613911B2
公开(公告)日：2003-09-02
申请号：US10067723
申请日：2002-02-05
申请人： Bang-Chi Chen , Kyoung S. Kim , S. David Kimball , Raj N. Misra , Joseph E. Sundeen , Rulin Zhao
发明人： Bang-Chi Chen , Kyoung S. Kim , S. David Kimball , Raj N. Misra , Joseph E. Sundeen , Rulin Zhao
IPC分类号： C07D41712
CPC分类号： C07D417/12 , A61K31/427 , A61K31/454 , C07D231/12 , C07D233/56 , C07D249/08 , C07D417/14
摘要： The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula I: or a pharmnaceutically acceptable salt thereof, wherein: R1, R2, R4, R5, R6, R8, R9, R12 and R13 are each independently hydrogen, alkyl, aryl or heteroaryl; R3, R7, R10 and R11 are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy; and X is CH or N, which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention also concerns a new process for the preparation of formylarylacetates and formylarylacetic acids.
摘要翻译：本发明涉及制备式I的5-（2-恶唑基烷硫基）-2-芳基乙酰氨基噻唑化合物的新的，有效的方法：或其药物上可接受的盐，其中：R1，R2，R4，R5，R6，R8， R9，R12和R13各自独立地为氢，烷基，芳基或杂芳基; R3，R7，R10和R11各自独立地为氢，烷基，芳基，杂芳基，卤素，羟基或烷氧基; 而X是CH或N，它们是细胞周期蛋白依赖性激酶（cdks）的新型有效抑制剂。本发明还涉及制备甲酰芳基乙酸酯和甲酰芳基乙酸的新方法。

7. 发明授权

US6107305A Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors 有权
标题翻译：吡唑并[3,4-b]吡啶作为细胞周期蛋白依赖性激酶抑制剂
公开(公告)号：US6107305A
公开(公告)日：2000-08-22
申请号：US209575
申请日：1998-12-11
申请人： Raj N. Misra , S. David Kimball , David B. Rawlins , Kevin R. Webster , Isia Bursuker
发明人： Raj N. Misra , S. David Kimball , David B. Rawlins , Kevin R. Webster , Isia Bursuker
IPC分类号： A61K31/437 , A61P1/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , A61K31/437
摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof for use as inhibitors of cyclin dependent kinases, wherein:X is O, S(O).sub.m ;Y is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl;R.sub.1 is hydrogen or lower alkyl;R.sub.2 is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, --O-alkyl, --O-aryl, --NR.sub.4 R.sub.5 ;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, --O-alkyl, --O-aryl;R.sub.5 is hydrogen, alkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, cycloalkyl, alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, --O-alkyl, --O-aryl; andm is 0, 1 or 2.The compounds of formula I are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, viral diseases and fungal diseases.
摘要翻译：用作细胞周期依赖性激酶抑制剂的式及其可药用盐的化合物，其中：X为O，S（O）m; Y是烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基; R1是氢或低级烷基; R2是烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基，-O-烷基，-O-芳基，-NR4R5; R3是氢或低级烷基; R4是氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基，环烷基烷基，杂环烷基，杂环烷基烷基，-O-烷基，-O-芳基。 R5是氢，烷基，芳基，烷基芳基，杂芳基，烷基杂芳基，环烷基，烷基环烷基，杂环烷基，烷基杂环烷基，-O-烷基，-O-芳基; 并且m为0,1或2.式I化合物为蛋白激酶抑制剂，可用于治疗和预防增殖性疾病，例如癌症，炎症和关节炎。它们也可用于治疗神经变性疾病如阿尔茨海默病，心血管疾病，病毒性疾病和真菌性疾病。

8. 发明授权

US08768965B2 Customized user interface for subordinate users 有权
标题翻译：为下属用户定制用户界面
公开(公告)号：US08768965B2
公开(公告)日：2014-07-01
申请号：US13613825
申请日：2012-09-13
申请人： Jeffrey David Kimball , John Thurston Wassom, Jr. , Christina Ann Rank Dolan
发明人： Jeffrey David Kimball , John Thurston Wassom, Jr. , Christina Ann Rank Dolan
IPC分类号： G06F3/00 , G06F17/30 , G06F3/0484 , G06F3/048 , G06F3/0481
CPC分类号： G06F3/048 , G06F3/0481 , G06F3/0484 , G06F17/30867 , G06F17/30899 , Y10S707/99939 , Y10S707/99943
摘要： A user interface including one or more references to content is customized. Several user profiles are provided from which a user may be associated. Each user profile includes user profile information. The user profile associated with a user to whom a user interface will be provided is accessed. A user interface is configured for the user, based at least in part upon the user profile accessed as being associated with the user. Access to content is enabled based on user manipulation of the configured user interface.
摘要翻译：包括对内容的一个或多个引用的用户界面被定制。提供了几个用户简档，用户可以从其中关联。每个用户简档包括用户简档信息。访问与要提供用户界面的用户相关联的用户简档。至少部分地基于被访问为与用户相关联的用户简档来为用户配置用户界面。基于用户操作配置的用户界面启用对内容的访问。

9. 发明授权

US08304577B2 Modulators of G protein-coupled receptor 88 有权
标题翻译： G蛋白偶联受体的调节剂88
公开(公告)号：US08304577B2
公开(公告)日：2012-11-06
申请号：US12898016
申请日：2010-10-05
申请人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
发明人： Carolyn Diane Dzierba , Richard A. Hartz , Yingzhi Bi , Vijay T. Ahuja , Joanne J. Bronson , Kenneth Carson , Giovanni Cianchetta , Michael Green , David Kimball , S. Roy Kimura , Soojin Kwon , John E. Macor , Yulian Zhang , Greg Zipp
IPC分类号： C07C233/00
CPC分类号： C07D207/40 , C07B2200/07 , C07C233/22 , C07C233/40 , C07C237/06 , C07C2601/02 , C07C2601/08 , C07D213/40 , C07D231/12 , C07D277/32
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
摘要翻译：本公开一般涉及可以调节G蛋白偶联受体88的化合物，包含这些化合物的组合物，以及调节G蛋白偶联受体88的方法。

10. 发明申请

US20110251204A1 Modulators of G Protein-Coupled Receptor 88 有权
公开(公告)号：US20110251204A1
公开(公告)日：2011-10-13
申请号：US12897004
申请日：2010-10-04
申请人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
发明人： Yingzhi Bi , Carolyn Diane Dzierba , Joanne J. Bronson , Cynthia Fink , Michael Green , David Kimball , John E. Macor , Soojin Kwon , Yulian Zhang , Greg Zipp
IPC分类号： A61K31/4418 , C07D405/12 , A61K31/4433 , C07D241/12 , A61K31/4965 , A61P3/10 , A61P3/00 , A61P25/16 , A61P25/30 , A61P25/28 , A61P25/18 , A61P25/00 , C07D213/56 , A61P3/04
CPC分类号： C07D213/56 , C07D241/12
摘要： The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

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