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1. 发明授权

US09428849B2 Polypeptide electrospun nanofibrils of defined composition 有权
标题翻译：多肽电纺丝纳米纤维的组成
公开(公告)号：US09428849B2
公开(公告)日：2016-08-30
申请号：US13704867
申请日：2011-06-21
申请人： Donald T. Haynie , Lei Zhai
发明人： Donald T. Haynie , Lei Zhai
IPC分类号： D01F6/68 , D01D5/00 , D04H1/728 , D04H3/016 , C08G69/10
CPC分类号： D01F6/68 , C08G69/10 , C08L77/04 , D01D5/0007 , D01D5/003 , D01D5/0038 , D04H1/728 , D04H3/016 , Y10T428/298
摘要： Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
摘要翻译：提供了电纺丝纳米纤丝及其制备方法。电纺丝纳米纤维包含至少一种多肽。可以将多肽溶解于溶液中，并将该溶液电纺丝成纳米纤丝。该溶液可以加入到注射器或注射器泵中，并且可以施加电场以静电纺至少一种多肽。

2. 发明申请

US20130115457A1 POLYPEPTIDE ELECTROSPUN NANOFIBRILS OF DEFINED COMPOSITION 有权
标题翻译：多元醇电子定义的组合物纳米微粒
公开(公告)号：US20130115457A1
公开(公告)日：2013-05-09
申请号：US13704867
申请日：2011-06-21
申请人： Donald T. Haynie , Lei Zhai
发明人： Donald T. Haynie , Lei Zhai
IPC分类号： D01F6/68 , D01D5/00 , C08G69/10
CPC分类号： D01F6/68 , C08G69/10 , C08L77/04 , D01D5/0007 , D01D5/003 , D01D5/0038 , D04H1/728 , D04H3/016 , Y10T428/298
摘要： Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.
摘要翻译：提供了电纺丝纳米纤丝及其制备方法。电纺丝纳米纤维包含至少一种多肽。可以将多肽溶解于溶液中，并将该溶液电纺丝成纳米纤丝。该溶液可以加入到注射器或注射器泵中，并且可以施加电场以静电纺至少一种多肽。

3. 发明申请

US20100028410A1 IMMUNOGENIC COMPOSITIONS AND METHODS OF USE 有权
公开(公告)号：US20100028410A1
公开(公告)日：2010-02-04
申请号：US12573366
申请日：2009-10-05
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： A61K9/70 , A61K9/50 , A61K39/00
CPC分类号： C07K17/00 , B82Y30/00
摘要： Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.

4. 发明授权

US07550557B2 Multilayer films, coatings, and microcapsules comprising polypeptides 有权
标题翻译：多层膜，涂层和包含多肽的微胶囊
公开(公告)号：US07550557B2
公开(公告)日：2009-06-23
申请号：US11586329
申请日：2006-10-25
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： C07K17/00 , C07K2/00
CPC分类号： G01N33/6803 , C07K14/005 , C12N2740/16122 , C12N2770/20022
摘要： Disclosed herein are multilayer films comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more first amino acid sequence motifs has a length of 5 to 15 amino acids residues, and wherein the balance of charge in the first amino acid sequence motif at pH 7 is greater than or equal to approximately one-half of the length of the first amino acid sequence motif, wherein the first layer polypeptide is not a homopolymer. Further, a second layer comprises second layer polyelectrolyte comprising a nonprotein polyelectrolyte having a charge opposite that of the first layer polypeptide.
摘要翻译：本文公开了包含两层或多层聚电解质的多层膜，其中相邻层包含相反电荷的聚电解质。包含一个或多个第一氨基酸序列基序的第一层多肽，其中所述一个或多个第一氨基酸序列基序具有5至15个氨基酸残基的长度，并且其中第一氨基酸序列基序中的电荷余量在pH 7大于或等于第一氨基酸序列基序长度的大约一半，其中第一层多肽不是均聚物。此外，第二层包括第二层聚电解质，其包含具有与第一层多肽相反的电荷的非蛋白质聚电解质。

5. 发明授权

US07411038B2 Artificial red blood cells 有权
标题翻译：人造红细胞
公开(公告)号：US07411038B2
公开(公告)日：2008-08-12
申请号：US11433259
申请日：2006-05-12
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： A61K38/03 , A61K38/16
CPC分类号： G01N33/6803
摘要： An artificial red blood cells are disclosed comprising a thin film encapsulating a core, the core comprising hemoglobin, wherein the film comprises a plurality of layers of polypeptides, opposing layers comprising alternating oppositely charged polypeptides, and wherein at least half of the amino acid residues in the oppositely charged polypeptides have the same charge. In one embodiment, a first layer comprises a first layer polypeptide comprising one or more first amino acid sequence motifs, wherein the one or more amino acid sequence motifs consist of n amino acids, at least x of which are positively charged, or at least x of which are negatively charged, wherein x is greater than or equal to approximately one-half of n.
摘要翻译：公开了人造红细胞，其包括包封芯的薄膜，所述芯包含血红蛋白，其中所述膜包含多层多肽，相对的层包含交替的相反电荷的多肽，并且其中至少一半的氨基酸残基在相反电荷的多肽具有相同的电荷。在一个实施方案中，第一层包含包含一个或多个第一氨基酸序列基序的第一层多肽，其中所述一个或多个氨基酸序列基序由n个氨基酸组成，其中至少x个带正电荷，或至少x 其中x为大于或等于n的大约一半。

6. 发明授权

US07348399B2 Nanofabricated polypeptide multilayer films, coatings, and microcapsules 有权
标题翻译：纳米多肽多层膜，涂层和微胶囊
公开(公告)号：US07348399B2
公开(公告)日：2008-03-25
申请号：US10652364
申请日：2003-08-29
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： C07K2/00 , C07K17/00
CPC分类号： G01N33/6803
摘要： Disclosed herein are films, coatings and microcapsules comprising polypeptides. A thin film, for example, comprises a plurality of layers of polypeptides, the layers comprising alternating oppositely charged polypeptides. A first layer comprises a first layer polypeptide comprising one or more amino acid sequence motifs, wherein the one or more first amino acid sequence motifs consists of n amino acids, wherein a balance of charge in the amino acid sequence motif is greater than or equal to approximately one-half of n, and wherein n is 5 to 15.
摘要翻译：本文公开了包含多肽的膜，包衣和微胶囊。例如，薄膜包含多层多肽，该层包含交替的相反电荷的多肽。第一层包含含有一个或多个氨基酸序列基序的第一层多肽，其中一个或多个第一氨基酸序列基序由n个氨基酸组成，其中氨基酸序列基序中的电荷余量大于或等于约n的一半，其中n为5至15。

7. 发明申请

US20160159981A1 Peptide-Based Materials 有权
标题翻译：基于肽的材料
公开(公告)号：US20160159981A1
公开(公告)日：2016-06-09
申请号：US14561413
申请日：2014-12-05
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： C08G69/14 , C08J5/00 , A01N37/18 , C09D177/02 , C08G69/16 , C08J9/00
CPC分类号： C08G69/14 , A01N37/18 , C08G69/10 , C08G69/16 , C08J5/00 , C08J5/18 , C08J9/00 , C08J2377/02 , C08J2389/00 , C08L89/00 , C09D177/02 , C09D177/04 , D01D5/003 , D01F4/00 , D01F6/68 , C08K5/07
摘要： The subject invention pertains to peptide-based materials comprising cross-linked peptides with random amino acid sequences that are soluble in water or ethanol before crosslinking but insoluble in water after crosslinking.
摘要翻译：本发明涉及基于肽的材料，其包括具有在交联之前可溶于水或乙醇但在交联后不溶于水的无规氨基酸序列的交联肽。

8. 发明申请

US20100028423A1 IMMUNOGENIC COMPOSITIONS AND METHODS OF USE 有权
标题翻译：免疫组化和使用方法
公开(公告)号：US20100028423A1
公开(公告)日：2010-02-04
申请号：US12573296
申请日：2009-10-05
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： A61K39/015 , A61K9/50 , A61K39/002
CPC分类号： C07K17/00 , B82Y30/00
摘要： Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.
摘要翻译：本文公开了包含包含两层或更多层聚电解质层的多层膜的免疫原性组合物，其中相邻层包含相反电荷的聚电解质。第一层聚电解质包括包含与一个或多个抗原决定簇区共价连接的一个或多个表面吸附区的抗原多肽，其中抗原多肽和一个或多个表面吸附区具有相同的极性。免疫原性组合物可用于在脊椎动物生物中引发免疫应答的方法。

9. 发明申请

US20090233074A1 Multilayer Films, Coatings, and Microcapsules Comprising Polypeptides 有权
标题翻译：多层膜，涂层和包含多肽的微胶囊
公开(公告)号：US20090233074A1
公开(公告)日：2009-09-17
申请号：US12421012
申请日：2009-04-09
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： B32B27/32 , B32B9/04 , B32B27/08 , B32B27/34 , B05D5/12
CPC分类号： G01N33/6803 , A61K39/385 , A61K2039/6031 , A61K2039/6093 , A61K2039/64 , C07K14/005 , C12N2740/16122 , C12N2770/20022 , Y10T428/31728 , Y10T428/31768 , Y10T428/31779
摘要： Disclosed herein is a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolye comprises a composite polypeptide comprising one or more surface adsorption regions covalently linked to one or more functional regions forming a single polypeptide chain. The surface adsorption regions comprise one or more amino acid sequence motifs consisting of 5 to 15 amino acid residues. The one or more functional regions comprise 3 to about 250 amino acid residues.
摘要翻译：本文公开了包含两层或多层聚电解质的多层膜，其中相邻层包含相反电荷的聚电解质。第一层聚电解质包含复合多肽，其包含与形成单个多肽链的一个或多个功能区共价连接的一个或多个表面吸附区域。表面吸附区包含一个或多个由5至15个氨基酸残基组成的氨基酸序列基序。一个或多个功能区包含3至约250个氨基酸残基。

10. 发明授权

US07807634B2 Immunogenic compositions and methods of use 有权
标题翻译：免疫原性组合物和使用方法
公开(公告)号：US07807634B2
公开(公告)日：2010-10-05
申请号：US12573296
申请日：2009-10-05
申请人： Donald T. Haynie
发明人： Donald T. Haynie
IPC分类号： A61K38/00
CPC分类号： C07K17/00 , B82Y30/00
摘要： Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises an antigenic polypeptide comprising one or more surface adsorption regions covalently linked to one or more antigenic determinant regions, wherein the antigenic polypeptide and the one or more surface adsorption regions have the same polarity. The immunogenic compositions may be employed in methods of eliciting an immune response in a vertebrate organism.
摘要翻译：本文公开了包含包含两层或更多层聚电解质层的多层膜的免疫原性组合物，其中相邻层包含相反电荷的聚电解质。第一层聚电解质包括包含与一个或多个抗原决定簇区共价连接的一个或多个表面吸附区的抗原多肽，其中抗原多肽和一个或多个表面吸附区具有相同的极性。免疫原性组合物可用于在脊椎动物生物中引发免疫应答的方法。

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