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1. 发明授权

US08804133B2 Method and system of adjusting a field of view of an interferometric imaging device 有权
标题翻译：调整干涉测量成像装置的视野的方法和系统
公开(公告)号：US08804133B2
公开(公告)日：2014-08-12
申请号：US12816394
申请日：2010-06-16
申请人： Dvir Yelin , Michal Merman
发明人： Dvir Yelin , Michal Merman
IPC分类号： G01B9/02
CPC分类号： G01B9/02027 , G01B9/0201 , G01B9/02044 , G01B9/0209 , G01B2290/20
摘要： A method of imaging at least a part of an object. The method comprises splitting electro-magnetic radiation to first and second portions, propagating the first and second portions, spectrally dispersing the first portion toward the part and the second portion toward a reference element, combining between reflections of the spectrally dispersed first and second portions to produce an interference signal, capturing an image of the part from the interference, and adjusting at least one of a tilt of said image plane and a curvature of the image by changing a deviation between the phase of at least one spectral component of the first portion and the phase of at least one spectral component of the second portion.
摘要翻译：对物体的至少一部分进行成像的方法。该方法包括将电磁辐射分成第一和第二部分，传播第一和第二部分，将第一部分朝向部分和第二部分光谱扩散到参考元件，将光谱分散的第一和第二部分的反射与产生干扰信号，从干扰中捕获该部分的图像，并且通过改变第一部分的至少一个光谱分量的相位之间的偏差来调整所述图像平面的倾斜和图像的曲率中的至少一个以及第二部分的至少一个光谱分量的相位。

2. 发明申请

US20130066215A1 APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
标题翻译：用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分
公开(公告)号：US20130066215A1
公开(公告)日：2013-03-14
申请号：US13614459
申请日：2012-09-13
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.
摘要翻译：可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上部分重叠。此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

3. 发明授权

US08384907B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US08384907B2
公开(公告)日：2013-02-26
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
IPC分类号： G01B9/02 , G01J3/45
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

4. 发明申请

US20100315652A1 METHOD AND SYSTEM OF ADJUSTING A FIELD OF VIEW OF AN INTERFEROMETRIC IMAGING DEVICE 有权
标题翻译：调整干涉成像装置视场的方法和系统
公开(公告)号：US20100315652A1
公开(公告)日：2010-12-16
申请号：US12816394
申请日：2010-06-16
申请人： Dvir YELIN , Michal Merman
发明人： Dvir YELIN , Michal Merman
IPC分类号： G01B9/02
CPC分类号： G01B9/02027 , G01B9/0201 , G01B9/02044 , G01B9/0209 , G01B2290/20
摘要： A method of imaging at least a part of an object. The method comprises splitting electro-magnetic radiation to first and second portions, propagating the first and second portions, spectrally dispersing the first portion toward the part and the second portion toward a reference element, combining between reflections of the spectrally dispersed first and second portions to produce an interference signal, capturing an image of the part from the interference, and adjusting at least one of a tilt of said image plane and a curvature of the image by changing a deviation between the phase of at least one spectral component of the first portion and the phase of at least one spectral component of the second portion.
摘要翻译：对物体的至少一部分进行成像的方法。该方法包括将电磁辐射分成第一和第二部分，传播第一和第二部分，将第一部分朝向部分和第二部分光谱扩散到参考元件，将光谱分散的第一和第二部分的反射与产生干扰信号，从干扰中捕获该部分的图像，并且通过改变第一部分的至少一个光谱分量的相位之间的偏差来调整所述图像平面的倾斜和图像的曲率中的至少一个以及第二部分的至少一个光谱分量的相位。

5. 发明申请

US20070233396A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20070233396A1
公开(公告)日：2007-10-04
申请号：US11537170
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Brett Bourna
发明人： Guillermo Tearney , Dvir Yelin , Brett Bourna
IPC分类号： G01N33/48
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和布置，用于获得与诸如解剖结构的一部分的样本相关联的信息。可以使用可以基于从样本上的位置获得的信号的第一数据和第二数据来生成信息，其中可以通过将从样本接收的第二信号与第三参考信号组合来获得第二数据。也可以基于该信息生成样本的一部分的图像。例如，第一数据可以与光谱编码显微镜数据相关联，并且第二数据可以与光学相干断层扫描数据相关联。

6. 发明申请

US20060270929A1 System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
标题翻译：可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置
公开(公告)号：US20060270929A1
公开(公告)日：2006-11-30
申请号：US11445131
申请日：2006-05-31
申请人： Brett Bouma , Guillermo Tearney , Dvir Yelin , Seok-Hyun Yun
发明人： Brett Bouma , Guillermo Tearney , Dvir Yelin , Seok-Hyun Yun
IPC分类号： A61B5/05
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0084 , A61B5/7257
摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.
摘要翻译：提供了用于获得三维成像数据的系统，布置和方法。例如，宽带光源可以提供特定的辐射。可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。光谱编码的线可以在大致垂直于线的方向上扫描样品。然后可以基于干扰获得包含三维信息的图像数据。示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

7. 发明授权

US06621613B2 Adaptive pulse compressor 失效
公开(公告)号：US06621613B2
公开(公告)日：2003-09-16
申请号：US10002016
申请日：2001-11-15
申请人： Yaron Silberberg , Doron Meshulach , Dvir Yelin
发明人： Yaron Silberberg , Doron Meshulach , Dvir Yelin
IPC分类号： G02F101
CPC分类号： H01S3/0057 , H01S3/10053
摘要： An adaptive pulse compressor is described, especially for use with ultrashort pulses, wherein the input pulses are modified in an iterative fashion, according to a feedback signal obtained from measurement of the output pulses. The feedback signal is programmed, by means of a programmable spatial light modulator, to allow for independent control of the individual spectral components of the incoming pulses, such that almost arbitrary phase functions can be realized to accomplish efficient compression. One of the main disadvantages associated with prior art pulse compressors, namely, the need for characterization of the uncompressed pulses, is thus eliminated. The compressor is thus capable of handling completely uncharacterized or partially characterized input pulses, or pulses from time varying sources.

8. 发明授权

US08289522B2 Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures 有权
标题翻译：用于提供一个或多个生物结构的多模态显微镜成像的布置和方法
公开(公告)号：US08289522B2
公开(公告)日：2012-10-16
申请号：US12943762
申请日：2010-11-10
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett E. Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett E. Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

9. 发明申请

US20120191163A1 METHOD AND SYSTEM FOR MANIPULATING A CELL 审中-公开
标题翻译：用于操作细胞的方法和系统
公开(公告)号：US20120191163A1
公开(公告)日：2012-07-26
申请号：US13353467
申请日：2012-01-19
申请人： Dvir Yelin , Limor Minai , Daniella Yeheskely-Hayon
发明人： Dvir Yelin , Limor Minai , Daniella Yeheskely-Hayon
IPC分类号： A61N5/06 , C12P21/08 , C12M1/42 , C12N15/07 , C12N15/06 , C12N13/00 , C12N15/02 , B82Y99/00 , B82Y5/00
CPC分类号： B82Y5/00 , A61K47/6849 , A61K47/6923 , A61N5/062 , B82Y40/00 , C12M35/04
摘要： A method of manipulating a living cell is disclosed. The method comprises, directing a pulsed optical field to at least one conductive nanoparticle present in the vicinity of the cell, so as to generate cavitations at or near the conductive nanoparticle at sufficient amount to effect at least one cell modification selected from the group consisting of cell-damage and cell-fusion.
摘要翻译：公开了一种操纵活细胞的方法。该方法包括：将脉冲光场引导到存在于细胞附近的至少一个导电纳米颗粒，以便在足够量的量下在导电纳米颗粒上或其附近产生空穴，以实现至少一种选自以下的细胞修饰：细胞损伤和细胞融合。

10. 发明授权

US08045177B2 Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy 有权
标题翻译：使用光谱编码的内窥镜检查来测量振动的装置和方法
公开(公告)号：US08045177B2
公开(公告)日：2011-10-25
申请号：US12104689
申请日：2008-04-17
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
IPC分类号： G01B11/02
CPC分类号： A61B1/227 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/4504
摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.
摘要翻译：根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。例如，可以在样品的部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。可以获得从样品返回的至少一个第三电磁辐射电磁辐射和从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或颗粒的运动或者在该部分上，而运动由声波中的至少一个来实现。此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。

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