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1. 发明授权

US08045177B2 Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy 有权
标题翻译：使用光谱编码的内窥镜检查来测量振动的装置和方法
公开(公告)号：US08045177B2
公开(公告)日：2011-10-25
申请号：US12104689
申请日：2008-04-17
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
IPC分类号： G01B11/02
CPC分类号： A61B1/227 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/4504
摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electro-magnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electro-magnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.
摘要翻译：根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。例如，可以在样品的部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。可以获得从样品返回的至少一个第三电磁辐射电磁辐射和从参考返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或颗粒的运动或者在该部分上，而运动由声波中的至少一个来实现。此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。

2. 发明申请

US20080262314A1 APPARATUS AND METHODS FOR MEASURING VIBRATIONS USING SPECTRALLY-ENCODED ENDOSCOPY 有权
标题翻译：使用光谱内切测量振动的装置和方法
公开(公告)号：US20080262314A1
公开(公告)日：2008-10-23
申请号：US12104689
申请日：2008-04-17
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Saumil Merchant , John Rosowski
IPC分类号： A61B1/00
CPC分类号： A61B1/227 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/4504
摘要： An apparatus and method according to an exemplary embodiment of to the present invention can provide imaging information associated with at least one portion of a sample. For example, at least two first different wavelengths of at least one first electromagnetic radiation within a first wavelength range may be provided on the portion of the sample so as to determine at least one first transverse location of the portion. At least two second different wavelengths of at least one second electromagnetic radiation may also be provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. It is possible to obtain a relative phase between at least one third electromagnetic radiation electromagnetic radiation being returned from the sample and at least one fourth electromagnetic radiation returned from a reference to determine a motion of the portion or of particles within or on the portion, whereas the motion is effectuated by at least one of a sound wave. Further, the imaging information of the portion can be provided based on the first transverse location, the second transverse location and the motion.
摘要翻译：根据本发明的示例性实施例的装置和方法可以提供与样本的至少一部分相关联的成像信息。例如，可以在样品的该部分上提供在第一波长范围内的至少一个第一电磁辐射的至少两个第一不同波长，以便确定该部分的至少一个第一横向位置。还可以在设置在该部分上的第二波长范围内提供至少两个第二不同波长的至少一个第二电磁辐射，以便确定该部分的至少一个第二横向位置。可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从参考物返回的至少一个第四电磁辐射之间的相对相位，以确定该部分或该部分内部或之上的颗粒的运动，而运动由声波中的至少一个来实现。此外，可以基于第一横向位置，第二横向位置和运动来提供该部分的成像信息。

3. 发明申请

US20130066215A1 APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
标题翻译：用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分
公开(公告)号：US20130066215A1
公开(公告)日：2013-03-14
申请号：US13614459
申请日：2012-09-13
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.
摘要翻译：可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上部分重叠。此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

4. 发明授权

US07872759B2 Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures 有权
标题翻译：用于提供一个或多个生物结构的多模态显微镜成像的布置和方法
公开(公告)号：US07872759B2
公开(公告)日：2011-01-18
申请号：US11537343
申请日：2006-09-29
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

5. 发明授权

US07847949B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US07847949B2
公开(公告)日：2010-12-07
申请号：US11537048
申请日：2006-09-29
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

6. 发明授权

US07859679B2 System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
标题翻译：可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置
公开(公告)号：US07859679B2
公开(公告)日：2010-12-28
申请号：US11445131
申请日：2006-05-31
申请人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin , Seok-Hyun Yun
发明人： Brett Eugene Bouma , Guillermo J. Tearney , Dvir Yelin , Seok-Hyun Yun
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0084 , A61B5/7257
摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.
摘要翻译：提供了用于获得三维成像数据的系统，布置和方法。例如，宽带光源可以提供特定的辐射。可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。光谱编码的线可以在大致垂直于线的方向上扫描样品。然后可以基于干扰获得包含三维信息的图像数据。示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

7. 发明授权

US09968245B2 Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s) 有权
公开(公告)号：US09968245B2
公开(公告)日：2018-05-15
申请号：US13614459
申请日：2012-09-13
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07 , A61B5/00 , A61B18/22 , A61B17/00
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

8. 发明授权

US09254089B2 Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample 有权
标题翻译：用于促进至少一个样品上的分散比例的至少部分重叠的装置和方法
公开(公告)号：US09254089B2
公开(公告)日：2016-02-09
申请号：US13054015
申请日：2009-07-14
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
IPC分类号： G01J3/02 , A61B5/00 , G01N21/47 , G02B23/24 , G01J3/18
CPC分类号： A61B1/00172 , A61B1/04 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0084 , G01J3/0218 , G01J3/0256 , G01J3/18 , G01N21/4795 , G02B23/2423 , G02B23/2469
摘要： Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electromagnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.
摘要翻译：提供了根据本公开的设备和方法的示例性实施例。例如，可以提供用于向结构提供电磁辐射的装置。示例性装置可以包括具有至少两个波导的第一装置，所述至少两个波导可被配置成通过至少两个具有彼此具有至少部分不同波长的相应电磁辐射来提供波导。示例性装置还可以包括分散第二装置，其被构造为接收电磁辐射，并将与各个电磁辐射相关联的至少两个分散的辐射转发到该结构的至少一个部分。波导可以相对于分散布置被构造和/或空间布置，以促进结构上分散的辐射的至少部分重叠。此外，可以提供另外的布置，其可以包括至少两个另外的波导，其可被配置为从分散布置接收电磁辐射。每个其它波导可以相对于色散装置构造和/或空间布置，以便于接收这样的电磁辐射中不同的一个作为其波长的函数。

9. 发明申请

US20110237892A1 APPARATUS AND METHODS FOR COLOR ENDOSCOPY 有权
标题翻译：颜色内窥镜的装置和方法
公开(公告)号：US20110237892A1
公开(公告)日：2011-09-29
申请号：US13054015
申请日：2009-07-14
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Dongkyun Kang
IPC分类号： A61B1/06
CPC分类号： A61B1/00172 , A61B1/04 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0084 , G01J3/0218 , G01J3/0256 , G01J3/18 , G01N21/4795 , G02B23/2423 , G02B23/2469
摘要： Exemplary embodiments of apparatus and method according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. The exemplary apparatus can include a first arrangement having at least two wave-guides which can be configured to provide there through at least two respective electro-magnetic radiations with at least partially different wavelengths from one another. The exemplary apparatus can also include a dispersive second arrangement structured to receive the electro-magnetic radiations and forward at least two dispersed radiations associated with the respective electro-magnetic radiations to at least one section of the structure. The wave-guide(s) can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate at least partially overlap of the dispersed radiations on the structure. In addition, another arrangement can be provided which can include at least two further wave-guides which can be configured to receive the electro-magnetic radiations from the dispersive arrangement. Each of the further wave-guides can be structured and/or spatially arranged with respect to the dispersive arrangement to facilitate a receipt of a different one of the such electro-magnetic radiations as a function of wavelengths thereof.
摘要翻译：提供了根据本公开的设备和方法的示例性实施例。例如，可以提供用于向结构提供电磁辐射的装置。示例性装置可以包括具有至少两个波导的第一装置，所述至少两个波导可以被配置成通过至少两个彼此具有至少部分不同波长的相应的电磁辐射来提供它们。示例性装置还可以包括分散第二装置，其被构造为接收电磁辐射，并将与各个电磁辐射相关联的至少两个分散的辐射转发到该结构的至少一个部分。波导可以相对于分散布置被构造和/或空间布置，以促进结构上分散的辐射的至少部分重叠。此外，可以提供另外的布置，其可以包括至少两个另外的波导，其可被配置为从分散布置接收电磁辐射。每个其它波导可以相对于色散装置构造和/或空间布置，以便于接收这样的电磁辐射中不同的一个作为其波长的函数。

10. 发明申请

US20110144504A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20110144504A1
公开(公告)日：2011-06-16
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett Eugene Bouma
IPC分类号： A61B6/00
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

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